11 results on '"Htun Naing Oo"'
Search Results
2. Whole Genomic Analysis of Human G12P[6] and G12P[8] Rotavirus Strains that Have Emerged in Myanmar.
- Author
-
Tomihiko Ide, Satoshi Komoto, Kyoko Higo-Moriguchi, Khaing Win Htun, Yi Yi Myint, Theingi Win Myat, Kyaw Zin Thant, Hlaing Myat Thu, Mo Mo Win, Htun Naing Oo, Than Htut, Mitsutaka Wakuda, Francis Ekow Dennis, Kei Haga, Yoshiki Fujii, Kazuhiko Katayama, Shofiqur Rahman, Sa Van Nguyen, Kouji Umeda, Keiji Oguma, Takao Tsuji, and Koki Taniguchi
- Subjects
Medicine ,Science - Abstract
G12 rotaviruses are emerging rotavirus strains causing severe diarrhea in infants and young children worldwide. However, the whole genomes of only a few G12 strains have been fully sequenced and analyzed. In this study, we sequenced and characterized the complete genomes of six G12 strains (RVA/Human-tc/MMR/A14/2011/G12P[8], RVA/Human-tc/MMR/A23/2011/G12P[6], RVA/Human-tc/MMR/A25/2011/G12P[8], RVA/Human-tc/MMR/P02/2011/G12P[8], RVA/Human-tc/MMR/P39/2011/G12P[8], and RVA/Human-tc/MMR/P43/2011/G12P[8]) detected in six stool samples from children with acute gastroenteritis in Myanmar. On whole genomic analysis, all six Myanmarese G12 strains were found to have a Wa-like genetic backbone: G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 for strains A14, A25, P02, P39, and P43, and G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 for strain A23. Phylogenetic analysis showed that most genes of the six strains examined in this study were genetically related to globally circulating human G1, G3, G9, and G12 strains. Of note is that the NSP4 gene of strain A23 exhibited the closest relationship with the cognate genes of human-like bovine strains as well as human strains, suggesting the occurrence of reassortment between human and bovine strains. Furthermore, strains A14, A25, P02, P39, and P43 were very closely related to one another in all the 11 gene segments, indicating derivation of the five strains from a common origin. On the other hand, strain A23 consistently formed distinct clusters as to all the 11 gene segments, indicating a distinct origin of strain A23 from that of strains A14, A25, P02, P39, and P43. To our knowledge, this is the first report on whole genome-based characterization of G12 strains that have emerged in Myanmar. Our observations will provide important insights into the evolutionary dynamics of spreading G12 rotaviruses in Asia.
- Published
- 2015
- Full Text
- View/download PDF
3. Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar
- Author
-
Yadanar Kyaw, Khin Yi Oo, Yi Yi Myint, Htun Naing Oo, Go Hasegawa, Makoto Naito, Clyde Dapat, Reiko Saito, Hiroshi Suzuki, and Isolde C. Dapat
- Subjects
Pulmonary and Respiratory Medicine ,Oseltamivir ,Epidemiology ,viruses ,Public Health, Environmental and Occupational Health ,Amantadine ,Pandemic influenza ,virus diseases ,Biology ,medicine.disease_cause ,Virology ,H5N1 genetic structure ,Influenza A virus subtype H5N1 ,respiratory tract diseases ,Seasonal influenza ,chemistry.chemical_compound ,Infectious Diseases ,chemistry ,Pandemic ,Human mortality from H5N1 ,medicine ,medicine.drug - Abstract
The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2 months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.
- Published
- 2012
- Full Text
- View/download PDF
4. Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients
- Author
-
Keiji Oguma, Yoshikatsu Kodama, Ni Nengah Dwi Fatmawati, Khaing Win Htun, Shofiqur Rahman, Kyoko Higo-Moriguchi, Faustino C. Icatlo, Sa Van Nguyen, Than Htut, Yi Yi Myint, Htun Naing Oo, Takao Tsuji, Koki Taniguchi, Kouji Umeda, Hlaing Myat Thu, Swe Swe Myint, and Kyaw Thura
- Subjects
Male ,Rotavirus ,Serotype ,medicine.medical_specialty ,Immunoglobulins ,Placebo ,medicine.disease_cause ,Gastroenterology ,Rotavirus Infections ,Mice ,Internal medicine ,medicine ,Animals ,Humans ,General Veterinary ,General Immunology and Microbiology ,biology ,business.industry ,Public Health, Environmental and Occupational Health ,Infant ,Virus Shedding ,Clinical trial ,Diarrhea ,Infectious Diseases ,Immunization ,Supportive psychotherapy ,Diarrhea, Infantile ,Immunology ,biology.protein ,Fluid Therapy ,Molecular Medicine ,Immunoglobulin Y ,Female ,medicine.symptom ,business ,Chickens - Abstract
This study aims to evaluate the effect of hyperimmune immunoglobulin Y (IgY) against human rotavirus (HRV) among pediatric patients receiving standard supportive treatment for rotavirus-associated diarrhea mostly with an enteric non-cholera co-pathogen in a hospital setting. Two natural HRV reassortant clinical strains ATCC VR 2273 and ATCC VR 2274 were used as mixed immunizing antigens in poultry hens to generate anti-HRV IgY (Rotamix IgY). The Rotamix IgY was used in laboratory and clinical studies against control or placebo IgY. The control or placebo IgY was prepared using tissue culture medium from mock-infected MA104 cell line as antigen for poultry immunization. In vitro, Rotamix IgY exhibited multi-serotypic cross neutralization activities along with synergistic effects against major global serotypes G1, G2, G3, G4 and other human or animal rotavirus strains when compared with mono-specific IgY. Suckling mice (ICR strain) pre-treated orally once with Rotamix IgY and then challenged with rotavirus 3h later showed a significant dose-dependent reduction in frequency (p0.05) and duration (p0.05) of diarrhea compared to placebo IgY-treated mice. Out of 114 children aged between 3 and 14 months and with diarrhea upon admission in a Myanmar hospital, 54 dehydrated and rotavirus-positive children were randomized into Rotamix IgY group and placebo IgY group. Of these, only 52 children had complete data with n=26 children per study group. Ninety-two percent of patients in each of these groups were positive for co-infecting enteric non-cholera pathogen and all patients received standard supportive therapy for diarrhea. The patients were monitored for volume and duration of oral rehydration fluid (ORF) and intravenous fluid (IVF) intake, daily stool frequency and overall duration of diarrhea, and frequency and duration of rotavirus shedding. Compared to placebo IgY group, the Rotamix IgY group had statistically significant reduction in mean ORF intake (p=0.004), mean duration of intravenous fluid administration (p=0.03), mean duration of diarrhea from day of admission (p0.01) and mean duration of rotavirus clearance from stool from day of admission (p=0.05). Overall, our novel approach using oral Rotamix IgY for rotavirus-infected children mostly with non-cholera enteric pathogen co-infection appears to be a promising, safe and effective adjunct to management of acute diarrhea in pediatric patients.
- Published
- 2012
- Full Text
- View/download PDF
5. Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries
- Author
-
Takashi Saku, Satoshi Maruyama, Jun Cheng, Faleh A. Sawair, Htun Naing Oo, Minoru Yagi, Phyu Sin Oo, Chan Nyein Maung, Yi Yi Myint, and Manabu Yamazaki
- Subjects
Gynecology ,Cancer Research ,medicine.medical_specialty ,Referral ,business.industry ,digestive, oral, and skin physiology ,Cancer ,Hospital based ,medicine.disease ,Pathology and Forensic Medicine ,Cancer registry ,stomatognathic diseases ,medicine.anatomical_structure ,Otorhinolaryngology ,Tongue ,Internal medicine ,Female patient ,medicine ,Etiology ,Periodontics ,Oral Surgery ,business ,Male predominance - Abstract
J Oral Pathol Med (2011) 40: 20–26 The occurrence of oral cancer is not clearly known in Myanmar, where betel quid chewing habits are widely spread. Since betel quid chewing has been considered to be one of the important causative factors for oral cancer, the circumstantial situation for oral cancer should be investigated in this country. We surveyed oral cancer cases as well as whole body cancers from two cancer registries from Yangon and Mandalay cities, both of which have representative referral hospitals in Myanmar, and we showed that oral cancer stood at the 6th position in males and 10th in females, contributing to 3.5% of whole body cancers. There was a male predominance with a ratio of 2.1:1. Their most frequent site was the tongue, followed by the palate, which was different from that in other countries with betel quid chewing habits. About 90% of male and 44% of female patients had habitual backgrounds of chewing and smoking for more than 15 years. The results revealed for the first time reliable oral cancer frequencies in Myanmar, suggesting that longstanding chewing and smoking habits are etiological backgrounds for oral cancer patients.
- Published
- 2010
- Full Text
- View/download PDF
6. Comparison of Information Dissemination Methods in Inle Lake: A Lesson for Reconsidering Framework for Environmental Education Strategies
- Author
-
Htun Naing Oo, Takayuki Minato, and Pitch Sutheerawatthana
- Subjects
Government ,business.industry ,Communication ,Information sharing ,Information Dissemination ,Context (language use) ,Public relations ,Education ,Environmental education ,Work (electrical) ,Business ,Rural area ,Element (criminal law) ,General Environmental Science - Abstract
This article analyzes the practice of information dissemination regarding pesticide usage in floating gardening in a rural area. The analysis reveals reasons why the current information dissemination methods employed by relevant stakeholders do not work. It then puts forward a proposition that information sharing within organizations of and among information providers is a key element in effective information dissemination. The analysis and proposition are expected to be helpful for government and international nongovernmental organizations in the studied area to adapt their strategies of information dissemination. This article is unique because the studied area is a rural area in Myanmar, a country in which only a few studies on environmental issues in a local context have been undertaken.
- Published
- 2010
- Full Text
- View/download PDF
7. Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
- Author
-
Yasushi Suzuki, Ne Win, Yadanar Kyaw, Htun Naing Oo, Go Hasegawa, Clyde Dapat, Hassan Zaraket, Isolde C. Dapat, Nay Lin, Makoto Naito, Khin Yi Oo, Yi Yi Myint, Reiko Saito, Tatiana Baranovich, Takehiko Saito, Hiroshi Suzuki, and Makoto Nishikawa
- Subjects
Microbiology (medical) ,Epidemiology ,viruses ,Molecular Sequence Data ,zanamivir ,Neuraminidase ,lcsh:Medicine ,Myanmar ,Microbial Sensitivity Tests ,Drug resistance ,medicine.disease_cause ,Antiviral Agents ,lcsh:Infectious and parasitic diseases ,Microbiology ,Viral Matrix Proteins ,Viral Proteins ,chemistry.chemical_compound ,Zanamivir ,Drug Resistance, Viral ,Influenza, Human ,medicine ,Influenza A virus ,Humans ,H3N2 subtype ,lcsh:RC109-216 ,expedited ,Phylogeny ,amantadine ,Viral matrix protein ,biology ,Influenza A Virus, H3N2 Subtype ,antiviral drug resistance ,lcsh:R ,Dispatch ,Amantadine ,virus diseases ,Sequence Analysis, DNA ,Virology ,respiratory tract diseases ,Infectious Diseases ,chemistry ,Mutation ,Mutation (genetic algorithm) ,biology.protein ,DNA ,medicine.drug - Abstract
In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
- Published
- 2010
- Full Text
- View/download PDF
8. High Prevalence of G12 Human Rotaviruses in Children with Gastroenteritis in Myanmar
- Author
-
Keiji Oguma, Than Htut, Mo Mo Win, Koki Taniguchi, Hlaing Myat Thu, Takao Tsuji, Sa Van Nguyen, Satoshi Komoto, Kyaw Zin Thant, Kyoko Higo-Moriguchi, Kouji Umeda, Theingi Win Myat, Htun Naing Oo, Khaing Win Htun, Shofiqur Rahman, Yi Yi Myint, and Tomihiko Ide
- Subjects
0301 basic medicine ,Microbiology (medical) ,Male ,Rotavirus ,Genotype ,Rotavirus Infections ,Myanmar ,Biology ,medicine.disease_cause ,Microbiology ,03 medical and health sciences ,Feces ,Human rotavirus ,medicine ,Prevalence ,Humans ,Typing ,Antigens, Viral ,Phylogeny ,High prevalence ,Reverse Transcriptase Polymerase Chain Reaction ,Infant ,General Medicine ,Acute gastroenteritis ,Virology ,Gastroenteritis ,030104 developmental biology ,Infectious Diseases ,Child, Preschool ,RNA, Viral ,Capsid Proteins ,Female - Abstract
Human rotavirus samples from 54 children with acute gastroenteritis in Myanmar in 2011 were subjected to reverse transcription-PCR to determine their G and P types. On G typing, G2 (24/54; 44.4%) was found to be the most prevalent, followed by G12 (17/54; 31.5%) and G1 (1/54; 1.9%). Mixed cases with G2 and G12 were found in 12 of the 54 (22.2%) samples. On P typing, P[4] was found to be the most predominant (29/54; 53.7%), followed by P[8] (17/54; 31.5%) and P[6] (4/54; 7.4%). Mixed cases with P[4] and P[8] were detected in 4 of 54 (7.4%) samples. Thus, occurrence of G2 and unusual G12 in high proportions was characteristic of human rotaviruses in Myanmar in this study setting.
- Published
- 2015
9. Whole Genomic Analysis of Human G12P[6] and G12P[8] Rotavirus Strains that Have Emerged in Myanmar
- Author
-
Kyoko Higo-Moriguchi, Mitsutaka Wakuda, Keiji Oguma, Mo Mo Win, Koki Taniguchi, Theingi Win Myat, Htun Naing Oo, Satoshi Komoto, Kyaw Zin Thant, Kouji Umeda, Kei Haga, Shofiqur Rahman, Takao Tsuji, Kazuhiko Katayama, Yi Yi Myint, Tomihiko Ide, Khaing Win Htun, Yoshiki Fujii, Than Htut, Sa Van Nguyen, Hlaing Myat Thu, and Francis E. Dennis
- Subjects
Rotavirus ,Genotype ,Sequence analysis ,viruses ,Reassortment ,Molecular Sequence Data ,lcsh:Medicine ,Genome, Viral ,Myanmar ,Biology ,medicine.disease_cause ,Genome ,Phylogenetics ,medicine ,Humans ,lcsh:Science ,Cells, Cultured ,Phylogeny ,Genetics ,Multidisciplinary ,Phylogenetic tree ,Base Sequence ,Strain (biology) ,lcsh:R ,Sequence Analysis, DNA ,Virology ,RNA, Viral ,lcsh:Q ,Research Article - Abstract
G12 rotaviruses are emerging rotavirus strains causing severe diarrhea in infants and young children worldwide. However, the whole genomes of only a few G12 strains have been fully sequenced and analyzed. In this study, we sequenced and characterized the complete genomes of six G12 strains (RVA/Human-tc/MMR/A14/2011/G12P[8], RVA/Human-tc/MMR/A23/2011/G12P[6], RVA/Human-tc/MMR/A25/2011/G12P[8], RVA/Human-tc/MMR/P02/2011/G12P[8], RVA/Human-tc/MMR/P39/2011/G12P[8], and RVA/Human-tc/MMR/P43/2011/G12P[8]) detected in six stool samples from children with acute gastroenteritis in Myanmar. On whole genomic analysis, all six Myanmarese G12 strains were found to have a Wa-like genetic backbone: G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1 for strains A14, A25, P02, P39, and P43, and G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 for strain A23. Phylogenetic analysis showed that most genes of the six strains examined in this study were genetically related to globally circulating human G1, G3, G9, and G12 strains. Of note is that the NSP4 gene of strain A23 exhibited the closest relationship with the cognate genes of human-like bovine strains as well as human strains, suggesting the occurrence of reassortment between human and bovine strains. Furthermore, strains A14, A25, P02, P39, and P43 were very closely related to one another in all the 11 gene segments, indicating derivation of the five strains from a common origin. On the other hand, strain A23 consistently formed distinct clusters as to all the 11 gene segments, indicating a distinct origin of strain A23 from that of strains A14, A25, P02, P39, and P43. To our knowledge, this is the first report on whole genome-based characterization of G12 strains that have emerged in Myanmar. Our observations will provide important insights into the evolutionary dynamics of spreading G12 rotaviruses in Asia.
- Published
- 2015
10. Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar
- Author
-
Clyde, Dapat, Reiko, Saito, Yadanar, Kyaw, Yi Yi, Myint, Htun Naing, Oo, Khin Yi, Oo, Makoto, Naito, Go, Hasegawa, Isolde C, Dapat, and Hiroshi, Suzuki
- Subjects
pandemic influenza ,oseltamivir ,viruses ,antiviral drug resistance ,virus diseases ,Short Articles ,Myanmar ,Part 2 Pandemic H1N1 Papers ,Antiviral Agents ,humanities ,respiratory tract diseases ,Influenza A Virus, H1N1 Subtype ,Short Article ,H1N1 subtype ,Drug Resistance, Viral ,Influenza, Human ,Amantadine ,Humans ,seasonal influenza ,Seasons ,Pandemics ,Phylogeny - Abstract
Please cite this paper as: Dapat et al. (2012) Delayed emergence of oseltamivir‐resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12030. The prevalence and timing of emergence of oseltamivir‐resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir‐resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2 months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug‐resistant seasonal and pandemic A(H1N1) viruses.
- Published
- 2012
11. Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries
- Author
-
Htun Naing, Oo, Yi Yi, Myint, Chan Nyein, Maung, Phyu Sin, Oo, Jun, Cheng, Satoshi, Maruyama, Manabu, Yamazaki, Minoru, Yagi, Faleh A, Sawair, and Takashi, Saku
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Pilot Projects ,Myanmar ,Middle Aged ,Hospitals ,Young Adult ,Age Distribution ,Neoplasms ,Humans ,Female ,Mouth Neoplasms ,Registries ,Aged - Abstract
The occurrence of oral cancer is not clearly known in Myanmar, where betel quid chewing habits are widely spread. Since betel quid chewing has been considered to be one of the important causative factors for oral cancer, the circumstantial situation for oral cancer should be investigated in this country. We surveyed oral cancer cases as well as whole body cancers from two cancer registries from Yangon and Mandalay cities, both of which have representative referral hospitals in Myanmar, and we showed that oral cancer stood at the 6th position in males and 10th in females, contributing to 3.5% of whole body cancers. There was a male predominance with a ratio of 2.1:1. Their most frequent site was the tongue, followed by the palate, which was different from that in other countries with betel quid chewing habits. About 90% of male and 44% of female patients had habitual backgrounds of chewing and smoking for more than 15 years. The results revealed for the first time reliable oral cancer frequencies in Myanmar, suggesting that longstanding chewing and smoking habits are etiological backgrounds for oral cancer patients.
- Published
- 2010
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.