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24 results on '"Hu, Dianxing"'

3. Multi-omics characterization of silent and productive HPV integration in cervical cancer

Author

Fan, Junpeng, Fu, Yu, Peng, Wenju, Li, Xiong, Shen, Yuanming, Guo, Ensong, Lu, Funian, Zhou, Shengtao, Liu, Si, Yang, Bin, Qin, Xu, Hu, Dianxing, Xiao, Rourou, Li, Xi, Yang, Siqi, Yuan, Cunzhong, Shu, Yao, Huang, He, Wan, Ting, Pi, Yanan, Wang, Shuxiang, Chen, Wenjuan, Wang, Haixia, Zhong, Lin, Yuan, Li, Wen, Baogang, Kong, Beihua, Mills, Gordon B., Zou, Dongling, Xia, Bairong, Song, Kun, Chen, Gang, Ma, Ding, and Sun, Chaoyang

Published
2023
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7. Spatial heterogeneity of infiltrating T cells in high-grade serous ovarian cancer revealed by multi-omics analysis

Author

Yang, Bin, Li, Xiong, Zhang, Wei, Fan, Junpeng, Zhou, Yong, Li, Wenting, Yin, Jingjing, Yang, Xiaohang, Guo, Ensong, Li, Xi, Fu, Yu, Liu, Si, Hu, Dianxing, Qin, Xu, Dou, Yingyu, Xiao, Rourou, Lu, Funian, Wang, Zizhuo, Qin, Tianyu, Wang, Wei, Zhang, Qinghua, Li, Shuaicheng, Ma, Ding, Mills, Gordon B., Chen, Gang, and Sun, Chaoyang

Published
2022
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9. BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors

Author

Fu, Yu, primary, Yang, Bin, additional, Cui, Yaoyuan, additional, Hu, Xingyuan, additional, Li, Xi, additional, Lu, Funian, additional, Qin, Tianyu, additional, Zhang, Li, additional, Hu, Zhe, additional, Guo, Ensong, additional, Fan, Junpeng, additional, Xiao, Rourou, additional, Li, Wenting, additional, Qin, Xu, additional, Hu, Dianxing, additional, Peng, Wenju, additional, Liu, Jingbo, additional, Wang, Beibei, additional, Mills, Gordon B, additional, Chen, Gang, additional, and Sun, Chaoyang, additional

Published
2023
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10. Mutation profiles in circulating cell‐free DNA predict acquired resistance to olaparib in high‐grade serous ovarian carcinoma

Author

Hu, Dianxing, primary, Guo, Ensong, additional, Yang, Bin, additional, Qin, Xu, additional, Fu, Yu, additional, Fan, Junpeng, additional, Zhuang, Xucui, additional, Yao, Qianqian, additional, Lu, Funian, additional, Li, Wenting, additional, Xiao, Rourou, additional, Wu, Xue, additional, Yang, Xiaohang, additional, Wang, Zizhuo, additional, Liu, Chen, additional, You, Lixin, additional, Zang, Rongyu, additional, Zhou, Qi, additional, Zhao, Weidong, additional, Chen, Gang, additional, and Sun, Chaoyang, additional

Published
2022
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12. Spatial Heterogeneity of Infiltrating T cells in High-Grade Serous Ovarian Cancer revealed by Multi-omics analysis

Author

Sun, Chaoyang, primary, Yang, Bin, additional, Li, Xiong, additional, Zhang, Wei, additional, Fan, Junpeng, additional, Zhou, Yong, additional, Li, Wenting, additional, Yin, Jingjing, additional, Guo, Ensong, additional, Li, Xi, additional, Fu, Yu, additional, Liu, Si, additional, Hu, Dianxing, additional, Qin, Xu, additional, Dou, Yingyu, additional, Xiao, Rourou, additional, Lu, Funian, additional, Wang, Zizhuo, additional, Qin, Tianyu, additional, Mills, Gordon, additional, Zhang, Qinghua, additional, Li, ShuaiCheng, additional, Ma, Ding, additional, and Chen, Gang, additional

Published
2022
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13. Metagenomic Analysis of the Microbiome of the Upper Reproductive Tract Focuses on Prediction, Prevention, and Personalized Medicine to Combat Ovarian Cancer

Author

Qin, Xu, primary, Zhou, Jianglin, additional, Wang, Zizhuo, additional, Feng, Chenzhao, additional, Fan, Junpeng, additional, Huang, Jia, additional, Hu, Dianxing, additional, Baban, Babak, additional, Wang, Shengqi, additional, Ma, Ding, additional, Sun, Chaoyang, additional, Zhou, Zhe, additional, and Chen, Gang, additional

Published
2022
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14. AZD5153 reverses palbociclib resistance in ovarian cancer by inhibiting cell cycle-related proteins and the MAPK/PI3K-AKT pathway

Author

Liu, Chen, primary, Huang, Yuhan, additional, Qin, Tianyu, additional, You, Lixin, additional, Lu, Funian, additional, Hu, Dianxing, additional, Xiao, Rourou, additional, Qin, Xu, additional, Guo, Ensong, additional, Yang, Bin, additional, Li, Xi, additional, Fan, Junpeng, additional, Li, Xiong, additional, Fu, Yu, additional, Liu, Si, additional, Wang, Zhuozi, additional, Dou, Yingyu, additional, Wang, Wei, additional, Li, Wenting, additional, Yang, Xiaohang, additional, Liu, Jingbo, additional, Peng, Wenju, additional, Zhang, Li, additional, Cui, Yaoyuan, additional, Sun, Chaoyang, additional, and Chen, Gang, additional

Published
2022
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15. The Immunological Role of CDK4/6 and Potential Mechanism Exploration in Ovarian Cancer

Author

Liu, Chen, primary, Huang, Yuhan, additional, Cui, Yaoyuan, additional, Zhou, Jun, additional, Qin, Xu, additional, Zhang, Li, additional, Li, Xi, additional, Li, Yuan, additional, Guo, Ensong, additional, Yang, Bin, additional, Fan, Junpeng, additional, Li, Xiong, additional, Fu, Yu, additional, Liu, Si, additional, Hu, Dianxing, additional, Xiao, Rourou, additional, Wang, Zizhuo, additional, Dou, Yingyu, additional, Wang, Wei, additional, Li, Wenting, additional, Yang, Xiaohang, additional, Liu, Jingbo, additional, Peng, Wenju, additional, Qin, Tianyu, additional, You, Lixin, additional, Lu, Funian, additional, and Sun, Chaoyang, additional

Published
2022
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16. Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors

Author

Qin, Tianyu, primary, Guo, Ensong, additional, Lu, Funian, additional, Fu, Yu, additional, Liu, Si, additional, Xiao, Rourou, additional, Wu, Xue, additional, Liu, Chen, additional, He, Chao, additional, Wang, Zizhuo, additional, Qin, Xu, additional, Hu, Dianxing, additional, You, Lixin, additional, Li, Fuxia, additional, Li, Xi, additional, Huang, Xiaoyuan, additional, Ma, Ding, additional, Xu, Xiaoyan, additional, Yang, Bin, additional, and Fan, Junpeng, additional

Published
2021
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17. WEE1 inhibitor and ataxia telangiectasia and RAD3‐related inhibitor trigger stimulator of interferon gene‐dependent immune response and enhance tumor treatment efficacy through programmed death‐ligand 1 blockade

Author

Wu, Xue, primary, Kang, Xiaoyan, additional, Zhang, Xiaoxiao, additional, Xie, Wan, additional, Su, Yue, additional, Liu, Xiaoyu, additional, Guo, Lili, additional, Guo, Ensong, additional, Li, Fuxia, additional, Hu, Dianxing, additional, Qin, Xu, additional, Fu, Yu, additional, Peng, Wenju, additional, Jia, Jiedong, additional, and Wang, Changyu, additional

Published
2021
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19. Spatial Heterogeneity of Infiltrating T Cells in High-Grade Serous Ovarian Cancer Revealed by Multi-Omics Analysis

Author

Yang, Bin, primary, Li, Xiong, additional, Zhang, Wei, additional, Fan, Junpeng, additional, Zhou, Yong, additional, Li, Wenting, additional, Yin, Jingjing, additional, Guo, Ensong, additional, Li, Xi, additional, Fu, Yu, additional, Liu, Si, additional, Hu, Dianxing, additional, Qin, Xu, additional, Dou, Yingyu, additional, Xiao, Rourou, additional, Lu, Funian, additional, Wang, Zizhuo, additional, Qin, Tianyu, additional, Zhang, Qinghua, additional, Li, Shuaicheng, additional, Ma, Ding, additional, Mills, Gordon B., additional, Chen, Gang, additional, and Sun, Chaoyang, additional

Published
2021
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20. Synergistic Effect of PARP Inhibitor and BRD4 Inhibitor in Multiple Models of Ovarian Cancer

Author

Huang, Yuhan, primary, Liu, Chen, additional, Li, Xi, additional, Hu, Dianxing, additional, Xiao, Rourou, additional, Qin, Xu, additional, Guo, Ensong, additional, Yang, Bin, additional, Fan, Junpeng, additional, Li, Xiong, additional, Fu, Yu, additional, Liu, Si, additional, Wang, Zizhuo, additional, Qin, Tianyu, additional, Lu, Funian, additional, Dou, Yingyu, additional, Wang, Wei, additional, Li, Wenting, additional, Yang, Xiaohang, additional, Liu, Jingbo, additional, Peng, Wenju, additional, Zhang, Li, additional, Cui, Yaoyuan, additional, Sun, Chaoyang, additional, and Chen, Gang, additional

Published
2021
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21. Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection

Author

Sun, Chaoyang, primary, Fan, Junpeng, additional, Huang, Jia, additional, Guo, Ensong, additional, Fu, Yu, additional, Liu, Si, additional, Xiao, Rourou, additional, Liu, Chen, additional, Lu, Funian, additional, Qin, Tianyu, additional, He, Chao, additional, Wang, Zizhuo, additional, Qin, Xu, additional, Hu, Dianxing, additional, You, Lixin, additional, Li, Xi, additional, Wang, Tian, additional, Wu, Peng, additional, Chen, Gang, additional, Zhou, Jianfeng, additional, and Li, Kezhen, additional

Published
2020
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23. Prognostic value of immune‐related genes and immune cell infiltration analysis in the tumor microenvironment of head and neck squamous cell carcinoma.

Author

Wang, Zizhuo, Yuan, Huangbo, Huang, Jia, Hu, Dianxing, Qin, Xu, Sun, Chaoyang, Chen, Gang, and Wang, Beibei

Subjects
PROGNOSIS, SQUAMOUS cell carcinoma, TUMOR microenvironment, CELL analysis, HEAD tumors
Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the few malignant tumors that respond well to immunotherapy. We aimed to investigate the immune‐related genes and immune cell infiltration of HNSCC and construct a predictive model for its prognosis. Methods: We calculated the stromal/immune scores of patients with HNSCC from The Cancer Genome Atlas using the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data algorithm and investigated the relationship between the scores and patients' prognosis. Three machine learning algorithms (LASSO, Random Forest, and Rbsurv) were performed to screen key immune‐related genes and constructed a predictive model. The immune cell infiltrating was calculated by the Tumor Immune Estimation Resource algorithm. Results: The stromal and immune scores significantly correlated with prognosis. A 6‐gene signature was selected and displayed a robust predictive effect. The expressions of key genes were associated with immune infiltrating. GSE65858 validated the results. Conclusion: Our study comprehensively analyzed the tumor microenvironment of HNSCC and constructed a robust predictive model, providing a basis for further investigation of therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Akkermansiasupplementation reverses the tumor-promoting effect of the fecal microbiota transplantation in ovarian cancer

Author

Wang, Zizhuo, Qin, Xu, Hu, Dianxing, Huang, Jia, Guo, Ensong, Xiao, Rourou, Li, Wenting, Sun, Chaoyang, and Chen, Gang

Abstract

Ovarian cancer (OC) remains a clinical challenge for its difficulty in early diagnosis and insensitivity to treatments. Gut microbiota modulate multiple carcinoma progression through immunoregulation. The relationship between OC and gut microbiota has not been fully characterized. We find that the feces of patients with OC demonstrate different characteristics from benign controls. After fecal microbiota transplantation (FMT) from patients with OC into OC-bearing mice, the tumor development accelerates. Further, an Akkermansiasupplementation with FMT significantly suppresses OC progression in mice. RNA sequencing of tumors shows that T cell activation pathways are upregulated after Akkermansiasupplementation with FMT. Moreover, acetate accumulation accompanies Akkermansiaabundance elevation, which is associated with enhanced interferon γ (IFNγ) secretion of CD8+T cells and also its tumor-killing property. This work highlights the importance of protective gut microbiome in immune surveillance of OC, which connects accumulation of acetate and the cytotoxic function of CD8+T cells by increasing IFNγ secretion.

Published
2022
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