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Vortex-induced vibration (VIV) depends on aerodynamic shapes of bridge girders, which should be treated carefully in the design of long-span bridges. This paper studies the VIV performance of a suspension bridge with the truss girder which contains two separated decks. Although truss girders generally show better VIV performance than box girders, significant vibrations of this type of girders occurred in the wind tunnel tests based on a large-scale sectional model. Several lock-in regions with the same vibration frequency were observed, corresponding to different shedding vortices. Computational fluid dynamics (CFD) simulations were carried out, and monitoring points were set behind different components to study the characteristics of the shed vortices. As the truss girder consists of many members, the results show that various vortices with different dominant frequencies are formed in the wake flow. The vertical VIV of the bridge is probably driven by the vortices behind or above the upper deck, which is related to the guardrails. The torsional VIV of the bridge is probably driven by the vortices behind or below the lower deck, which is related to the service road at lower wind speeds while may be related the vertical stabilizers at higher wind speeds. [ABSTRACT FROM AUTHOR]

Porcine idiopathic vesicular disease (PIVD), one of several clinically indistinguishable vesicular diseases of pigs, is caused by the emerging pathogen Senecavirus A (SVA). Despite the widespread prevalence of porcine SVA infection, no effective commercial vaccines for PIVD prevention and control are available, due to high costs associated with vaccine testing in pigs, considerable SVA diversity, and SVA rapid evolution. In this study, SVA CH/JL/2022 (OP562896), a novel mutant SVA strain derived from an isolate obtained from a pig farm in Jilin Province, China, was inactivated then combined with four adjuvants, MONTANIDETM GEL02 PR (GEL 02), MONTANIDETM ISA 201 VG (ISA 201), MONTANIDETM IMG 1313 VG N (IMS1313), or Rehydragel LV (LV). The resulting inactivated SVA CH/JL/2022 vaccines were assessed for efficacy in mice and found to induce robust in vivo lymphocyte proliferation responses and strong IgG1, IgG2a, and neutralizing antibody responses with IgG2a/IgG1 ratios of <1. Furthermore, all vaccinated groups exhibited significantly higher levels of serum cytokines IL-2, IL-4, IL-6, and IFN as compared to unvaccinated mice. These results indicate that all vaccines elicited both Th1 and Th2 responses, with Th2 responses predominating. Moreover, vaccinated mice exhibited enhanced resistance to SVA infection, as evidenced by reduced viral RNA levels and SVA infection-induced histopathological changes. Collectively, our results demonstrate that the SVA-GEL vaccine induced more robust immunological responses in mice than did the other three vaccines, thus highlighting the potential of SVA-GEL to serve an effective tool for preventing and controlling SVA infection., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Gao, Hu, Huyan, Wang, Cao, Zhao, Lu, Song, Gao, He and Lan.)