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Purpose: 68 Ga-labeled fibroblast activation protein inhibitors, such as [ 68 Ga]Ga-DOTA-FAPI-04 and [ 68 Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types. To broaden the PET tracers of different positron nuclides for imaging studies of FAP-dependent diseases, we herein report the radiosynthesis and preclinical evaluation of two 11 C-labeled FAP inhibitors, 11 C-RJ1101 and 11 C-RJ1102., Methods: Two phenolic hydroxyl precursors based on a quinoline amide core coupled with a 2-cyanopyrrolidine moiety were coupled with [ 11 C]CH 3 I to synthesize 11 C-RJ1101 and 11 C-RJ1102. In vivo small-animal PET and biological distribution studies of 11 C-RJ1101 and 11 C-RJ1102 compared to [ 68 Ga]Ga-DOTA-FAPI-04 were conducted in nude mice bearing U87MG tumor xenografts at 30, 60, and 90min, respectively., Results: 11 C-RJ1101 and 11 C-RJ1102 were synthesized in over 15% radiochemical yields, with specific activities of 67 GBq/μmol and 34 GBq/μmol, respectively, at the end of synthesis and radiochemical purities greater than 99%. In U87MG tumor xenograft PET studies, the three tracers experienced higher specific uptake at the tumor site. However, because of significant differences in metabolism and clearance, [ 68 Ga]Ga-DOTA-FAPI-04 experienced high uptake in the kidney, whereas 11 C-RJ1101 and 11 C-RJ1102 showed high uptake in the liver and intestine. Biodistribution studies revealed significant hepatobiliary excretion of 11 C-RJ1101 and 11 C-RJ1102. 11C-RJ1102 showed higher specific tumor uptake in U87MG xenografts (1.71 ± 0.08% injected dose per Gram of tissue [ID/g]) than 11 C-RJ1101 (1.34 ± 0.10%ID/g) and [ 68 Ga]Ga-DOTA-FAPI-04 (1.29 ± 0.04%ID/g) after 30 min p. i. In orthotopic glioma models, the uptake values were 0.07 ± 0.03% ([ 68 Ga]Ga-DOTA-FAPI-04) and 0.16 ± 0.03% ( 11 C-RJ1102), respectively., Conclusion: 11 C-RJ1101 and 11 C-RJ1102 are interesting candidates for translation to the clinic, taking advantage of the shorter half-life and physical imaging properties of C-11., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Wang, Hu, Ding, Zhao, Du, Lv, Li, Huang and Liu.)