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The limitations of traditional drug therapy have driven the creation and development of novel cell membrane-coated nanoparticle (CMNP) platforms. Since the introduction of the CMNP concept and method in 2011, an increasing number of studies focusing on this field have been widely conducted. Despite the growing body of literature, comprehensive bibliometric analysis in this field is still lacking. This study conducted a bibliometric analysis of CMNP-related publications sourced from the Web of Science Core Collection database, covering the period from January 1, 2011, to December 31, 2023. The analysis included co-authorships, co-citations, and co-occurrences of countries, institutions, authors, references, and keywords. Visualized tools such as Citespace, VOSviewer, and R Package Bibliometrix were employed to present the data. A total of 780 studies were included, with China contributing the highest number of publications (75.64%, n = 590). The number of annual publications increased consistently from 2011 to 2023, indicating a growing global interest in the CMNP field. Prof. Liangfang Zhang from the United States is recognized as the founder and leading figure in this area. The top three academic journals in this field, based on publication volume, are ACS Nano (32 publications, IF 2022 = 17.1), ACS Applied Materials Interfaces (32 publications, IF 2022 = 9.5), and Advanced Functional Materials (31 publications, IF 2022 = 19) among 185 scholarly journals. Reference and keyword analysis revealed that erythrocytes and macrophage membranes are significant research hotspots. The primary diseases targeted by CMNP research are cancer and pulmonary inflammation. In addition, CMNPs are frequently studied in conjunction with photothermal and photodynamic therapy. Furthermore, this study also summarized the timelines for various cell membrane coating methods and the three-step preparation process for CMNP. This comprehensive bibliometric analysis provides valuable insights to guide future research in the CMNP field, highlighting the importance of clinical application. Research on cell membrane-coated nanomaterials, particularly those related to cancer and pulmonary inflammation, is expected to remain a focal point. In addition, there is a need for the further development of other potential cell membrane-coated nanomaterials. This bibliometric analysis serves as a resource for researchers to quickly and comprehensively understand the current hotspots and emerging frontiers in this field.

Abstract Heart sound auscultation plays a crucial role in the early diagnosis of cardiovascular diseases. In recent years, great achievements have been made in the automatic classification of heart sounds, but most methods are based on segmentation features and traditional classifiers and do not fully exploit existing deep networks. This paper proposes a cardiac audio classification method based on image expression of multidimensional features (CACIEMDF). First, a 102-dimensional feature vector is designed by combining the characteristics of heart sound data in the time domain, frequency domain and statistical domain. Based on the feature vector, a two-dimensional feature projection space is constructed by PCA dimensionality reduction and the convex hull algorithm, and 102 pairs of coordinate representations of the feature vector in the two-dimensional space are calculated. Each one-dimensional component of the feature vector corresponds to a pair of 2D coordinate representations. Finally, the one-dimensional feature component value and its divergence into categories are used to fill the three channels of a color image, and a Gaussian model is used to dye the image to enrich its content. The color image is sent to a deep network such as ResNet50 for classification. In this paper, three public heart sound datasets are fused, and experiments are conducted using the above methods. The results show that for the two-classification/five-classification task of heart sounds, the method in this paper can achieve a classification accuracy of 95.68%/94.53% when combined with the current deep network.

This paper systematically investigated the progress of laboratory research and field application of biochemical composite enhanced oil recovery technology in the past 10 years in China and abroad. The synergistic mechanism between oil recovery bacteria， biosurfactants， biopolysaccharides， and chemical oil recovery agents such as surfactants， polymers， and nanoparticles was discussed in terms of improving displacement efficiency and expanding swept volume， respectively. In addition， the system construction and field application effects were analyzed. The results show that the combination of biological bacteria and their metabolites with chemical oil recovery agents has synergistic effects on interfacial tension reduction， emulsification dispersion， mobility ratio control， and viscosity reduction of heavy oil， and the field application has achieved good application results. Bacteria polymer composite profile control and microbial desulfurization and viscosity preservation technologies were explored in Shengli Oilfield， and estimated recoveries reached 9% and 10.3%， respectively. Biological ASP composite technology was applied in Daqing Oilfield， and the recovery of the pilot area has been improved to 22%. The biochemical composite enhanced oil recovery technology has great potential for application in the exploitation of difficult-to-recovery reserves in mature oilfields. The next step is to continue to deepen the synergistic mechanism between biological and chemical systems， innovate the integration and implementation process of biological and chemical oil recovery systems according to the differences between reservoir planes and inter- and intra-layers， refine the implementation plan for different development stages and reservoir spaces， and maximize the advantages of biological and chemical synergistic efficiency enhancement technologies through the three-dimensional balanced development of reservoirs to satisfy the demand for sustainable development of mature oilfields.

Aiming at the offloading requirements of ground users’ computing tasks in edge computing scenario of low earth orbit (LEO) satellites, a joint offloading and resource allocation optimization (JORAO) algorithm was proposed. Considering the limited coverage time of LEO satellites, the offloading strategy, the allocation of communication and computing resources of LEO satellites were jointly optimized to minimize the average service delay of all ground users. The joint optimization problem of task offloading and resource allocation was decomposed into offloading decision and resource allocation sub-problems, and an alternating optimization method was used to obtain the suboptimal solution of the original optimization problem. The task offloading decision sub-problem was modeled as a coalition game model, and when the game reached Nash equilibrium, the ground user offloading strategy that minimized the system delay was obtained. For the resource allocation sub-problem, the Lagrange multiplier method was used to obtain the optimal bandwidth and compute resource allocation results. Moreover, the convergence and stability of the proposed algorithm were also demonstrated. The simulation results show that the proposed algorithm has excellent convergence and can significantly reduce the average service delay of ground users, as well as improve the task offloading success rate.

BackgroundIn China， the structure shift from just one-child family to both one-child and more-than-one-child families is happening. Exploring how the sibling relationships effect between adolescent personality impulsivity and aggressivity is of great significance for promoting adolescent mental health as well as maintaining social harmony and stability.ObjectiveTo investigate the effecting path of sibling relationships between personality impulsivity and aggressivity in adolescents， so as to provide references for the prevention of violent and aggressive behavior in adolescents.MethodsFrom February to April， 2023， a total of 1 200 students with sibling relationships from 12 primary and secondary schools in a county of Sichuan province were included by random sampling. Barratt Impulsivity Scale （BIS-11）， Chinese Version of Buss & Perry Aggression Questionnaire （AQ-CV）， and Sibling Relationship Questionnaire （SRQ） were used for cross-sectional investigation. Pearson Correlation Analysis was used to analyze the correlation between the scores of these scales. Bootstrap method was used to test the effecting path of sibling relationships between personality impulsivity and aggressivity.ResultsThe total score of BIS-11 was positively correlated with that of AQ-CV as well as the scores of conflict and competition dimensions in SRQ （r=0.485、0.276、0.280，P

There are subtle differences between single regions of the same subcategory in fine-grained images. At present, many fine-grained image classification networks often focus on a single region to determine the target category. However, in many cases, most discriminative features in fine-grained images are distributed in multiple local regions of the image, and it is not often enough for fine-grained image to rely solely on one region.To solve these problems, a new method is proposed. This method generates discriminative features through reinforcement learning and obtains complementary regions through complementary network. The reinforcement network and the complementary network learn through adversarial learning and improve the accuracy of fine-grained images classification.The method is tested on CUB200-2011,fine-grained Visual Classification of Aircraft, and Stanford dogs datasets and the results show adequate performance.

An event-triggered adaptive control algorithm is proposed for cooperative tracking control of high-order nonlinear multi-agent systems (MASs) with prescribed performance and full-state constraints. The algorithm combines dynamic surface technology and the backstepping recursive design method, with radial basis function neural networks (RBFNNs) used to approximate the unknown nonlinearity. The barrier Lyapunov function and finite-time stability theory are employed to prove that all agent states are semi-globally uniform and ultimately bounded, with the tracking error converging to a bounded neighborhood of zero in a finite time. Numerical simulations are provided to demonstrate the effectiveness of the proposed control scheme.

With the steady progress of China’s education information technology, learners generate massive learning behavior data during classroom interactions, and behind these data lie learners’ implicit behavioral characteristics. In this paper, we use accounting teaching as an example to deeply mine learners’ behavioral data, from which we extract behavioral features related to learning effects to create an experimental dataset. The Random Forest Important Feature Selection Algorithm uses the Gini index to filter out the learning behavior categories with higher importance among the learning behavior feature items. We extensively mine the learning behavior data to construct learning effect prediction models, establish feedback mechanisms, and intervene in the learning process in real time. The learning effect prediction model, which utilizes the Random Forest important feature selection algorithm, increases model prediction accuracy to 85.35% after cross-validation, as shown in the results. The increased accuracy allows for more accurate prediction of students’ learning effects in future periods, effective identification of student problems, and provision of targeted guidance to different student categories. At the same time, teachers can understand students’ learning status in various classes, make timely adjustments to accounting teaching content, and improve the teaching process. Ultimately, accurate education achieves the goal of teaching students according to their abilities.

In this paper, a legal dispute mediation game model is constructed based on fractal theory, characterized by self-similarity properties in disputes. Secondly, the legal dispute evolution game model is constructed, the dynamic differential equation of frequency or frequency is used, and an adaptive degree dispute evolution stabilization strategy (ESS) is proposed according to the evolution principle. Finally, the simulation and analysis of the dispute evolution game model are carried out with the medical-patient dispute as an example. The results show that when D0 takes the values of 2 and 4, the two sides of the doctor-patient dispute will rapidly gather toward the challenge and form a vicious evolutionary trend. The study of this paper helps to understand the evolutionary process of legal disputes better and provides a reference for resolving disputes.

Biological matrix reference material is a reference material that combines the target material with the biological matrix. The biological matrix reference material has higher consistency with the authentic specimens in forensic toxicology, and its application has a positive effect on improving the accuracy of test results. This paper reviews the research on the matrix reference materials corresponding to three common biological test materials （blood, urine and hair）. In order to provide reference for the development and application of biological matrix reference materials in forensic toxicology, this paper mainly introduces the research progress of preparation technology of biological matrix reference materials and some existing products and their parameters evaluation.

In order to investigate the ballistic performance, failure patterns and energy dissipation of aluminum alloy target plates against the impact of different strength and head shape projectiles, the three-dimensional models of 3 mm thick 6061-T651 aluminum alloy target plates impacted by lightweight-deformable projectiles of different materials were established by Abaqus finite element software, and the modified Johnson-Cook（MJC） constitutive model and the Lode-dependent modified Mhor-Coulomb（MMC） fracture criterion are used for numerical simulation. The results show that the corresponding ballistic limit velocity of the target plates are the highest when the low strength 6061-T651 aluminum alloy are used as the projectile material, and the ballistic limit velocity of the target plates decrease with the increase of the projectiles strength. The impact will cause a more complex failure patterns of the target plates when the projectiles strength is low, and at the same time, the plastic deformation of the projectiles head occur to different degree; the projectiles strength has a significant effect on the energy dissipation ability of the target plates. The ballistic limit velocity corresponding to the lightweight-deformable blunt-head projectiles are higher than that of the ogival-head projectiles.

In order to study the influence of warhead shape on the impact performance of polycarbonate（PC） plate against rod projectile, the impact tests of flat-head, hemispherical-head and ogival-head rod projectile with 12.6 mm diameter were carried out by gas gun. The relationship of initial-residual velocity and ballistic limit were obtained, and the deformation and failure mode of PC plate were analyzed in detail. The results show that in the velocity range of 30～120 m/s, the PC plate has the strongest resistance to hemispherical-nosed projectile, followed by flat-nosed projectile, and the weakest resistance to ogival-nosed projectile. The failure modes of PC plate are different after the three kinds of projectiles impact. The plat-bulge and plug failure occur after impacted by flat-nosed projectile, the cap-bulge and petal failure occur after the impact of hemispherical projectile, however, petal failure always occurs after the impact of ogival-nosed projectile. It is found that the energy consumption by crack propagation of PC thin plate is less, and the main reason for the great difference of ballistic performance is the difficulty in producing initial damage of PC plate for different projectiles.

QPQ (quench-polish-quench) is recognized as an effective surface modification technology which can improve the corrosion and wear resistance of metal materials. However, it is environmentally constrained in real application. In order to explore an environmental friendly and efficient surface modification technology, PNCO (plasma oxynitrocarburising) was developed and compared with QPQ technology for 45 steel. The cross-sectional microstructure, phase composition, microhardness profile, wear and corrosion resistance were tested and analyzed by optical microscopy, SEM, XRD, microhardness tester and wear tester etc. The results show that a compound layer thickness of 20.14 μm and effective hardened layer thickness of 59 μm, surface hardness of 760HV0.05, wear rate of 1.39×10-3 g·N-1·m-1 and corrosion mass loss rate of 0.39% were obtained by PNCO. The XRD results demonstrate that PNCO treated samples mainly contain FexN compound and Fe3O4 oxide. A comparative study between PNCO and QPQ shows that the sectional microhardness, wear and corrosion resistance of the treating layers are the same level. The study provides a feasible research area for environmentally efficient surface modification technology.

Compared to traditional processing techniques, laser additive manufacturing technology has advantages such as short processing cycles, no molds, and is not limited by complex structures. However, the forming quality of GH3625 nickel-base alloy metal parts is affected by various process parameters, in which the distribution characteristics of laser beam energy density, microstructure and mechanical properties play a key role. In order to investigate the influence of beam energy density distribution on the main properties of GH3625 nickel-based alloy metal parts, the beam energy density distribution was changed by controlling the defocusing amount. Then it sets 5 different defocusing parameters to obtain the corresponding energy density distribution characteristics. Observing and analyzing the various properties of alloy powder from the perspectives of different scanning speeds, laser power, and energy density distribution characteristics. The results show that when the laser power is 600 W, the scanning speed is 700 mm/min, and the energy density distribution is characteristic 4, the metal parts have the best performance. Its density is 99.90%, microhardness is 350.44 HV, tensile strength is 1328 Mpa, friction coefficient is about 0.51, and wear rate is 0.55%. This indicates that the laser additive forming method proposed in this study can effectively improve the hardness, density and other properties of GH3625 nickel-based alloy metal parts to achieve the best state, which provides an important reference for the further optimization of the material preparation process.

Offshore wind turbines are usually founded on monopiles. During the operation period, the structure is subjected to complex lateral loading from wind, wave and current. The soils surrounding those monopiles may deform with increasing the number of loading cycles, leading to tilting of the whole structure; hence, it is vital to carry out physical model tests to examine the long-term performance of monopiles. This study proposes an innovative experimental setup for centrifuge modelling of the response of monopiles under complex lateral loading. Hydraulic actuators are adopted to apply lateral loads on model pile, and electrohydraulic servo-valves and associated controllers are used to achieve a closed loop position or load control. A carefully designed spherical hinge and load bars are used to connect the model pile and actuator shafts. This enables that the pile can rotate freely and can move vertically freely. A centrifuge test on a winged monopole subjected to perpendicular lateral loading was carried out at 100g. The experimental results shed light on pile responses in the cyclic loading and constant loading directions.

To promote the construction of ecological civilization and fundamentally solve ecological and environmental problems, it is necessary to form green and low-carbon production and lifestyle. This article focuses on the cognitive system of green and low-carbon production methods and lifestyles, analyzes the key elements of green and low-carbon production methods and lifestyle systems, and proposes typical scenarios and models of energy and electricity promoting terminal green energy consumption from an energy perspective. Based on economic and social perspectives, it constructs green cost guidance mechanisms and green behavior training mechanisms to comprehensively support the development of green and low-carbon production methods and lifestyles, and accelerate the construction of a green background for ecological civilization.

The self-construction of the sustainable development guarantee system for international cooperation and exchange in vocational colleges is an activity that draws on the advanced experience of domestic and foreign vocational colleges, combines reality with the school situation, and localizes and innovates international experience. Each country has its own national conditions, and each vocational college has its own specific situation. International experience cannot be blindly copied, and all universities cannot operate in a homogeneous manner according to a single model, let alone turn internationalization into Westernization. The prerequisite for maintaining vitality through internationalization is localization. Vocational colleges selectively absorb good concepts, ideas, and practices from foreign education, integrate their own characteristics and culture, extract methods and models suitable for national conditions and school conditions, and transform and innovate them. They compile normative institutional documents for implementation, thereby promoting the integration of internationalization and localization.

PTBP1, a widely-studied RNA binding protein, regulates mRNA splicing, translation, stability and localization. PTBP1 participates in a variety of ncRNA acting processes, affects tumorigenesis and tumor progression. In terms of tumor therapy, PTBP1 may act as a key factor to affect the target of targeted drugs and influence tumor resistance. This article reviews the role of PTBP1 in tumor and its research progress in tumor treatment.

Ubiquitin modification and Warburg effect play an important role in the occurrence and development of tumors. The process of tumor ubiquitin modification is closely related to glycolysis, that is, ubiquitin modification in tumor cells can regulate the expression level of substrate proteins related to Warburg effect, then regulate tumor progression and the treatment of drug-resistance. This paper reviews the regulation mechanism of ubiquitin modification of proteins on Warburg effect in tumor cells.

Objective: This study aimed to rapidly detect the residual quantity of thiamendazole in food. Methods: O-aminophenol and o-phenylenediamine were screened as composite functional monomers by ultraviolet spectroscopy. The polymerization and elution conditions were studied by electrochemical analysis, and the performance of the sensor was evaluated. A rapid method for the determination of thiamendam residues in food was established. Results: Under the control of the optimal conditions, the imprinted sensor had the specific adsorption performance for thiamendam and its structural analogues, and the selectivity for thiamendam was the strongest. The linear relationship of this method ranged from 1.0×10-8 to 1.0×10-4 mol/L, and the detection limit was 3.3×10-9 mol/L; The average recoveries of the spiked samples were 88.16%～100.73%, and the relative standard deviations were less than 2.63%. Conclusion: The sensor has excellent imprinting effect, selectivity, reproducibility and stability, and can be used for the rapid detection of thiamendam residues in food.

In order to investigate the impact resistance of the 2A12 aluminum alloy plate, blunt-nosed projectiles were launched with the impact velocity ranging from 120 m/s to 330 m/s to hit aluminum alloy target plates with a thickness of 6 mm, and the influence of the initial impact speed on the impact resistance of targets was analyzed. The ballistic limit and velocity curve of projectiles were obtained by fitting the data of the experiment. The results show that the energy absorption of the target first decreases sharply and then keeps stable with the increase of the initial velocity of the projectile. Meanwhile, the target plate mainly undergoes shear failure, and the structural deformation of the target plate decreases as the velocity of the projectile increases. Moreover, based on the ABAQUS/Explicit finite element software, the modified J-C constitutive relation and fracture criterion were used to calculate the projectile impact target model. And the failure mechanisms of targets were analyzed on the base of verifying the validity of the simulation model.It has been found that the failure mechanisms of targets are similar under different impact speeds, and the initial velocity of the projectile has little effect on the failure mechanism of target.

In order to study the failure mechanism of 6061-T651 aluminum alloy sheet under oblique impact, the impact experiments of a hemispherical projectile slanting into a single aluminum alloy sheet at different impact angles（0°, 15°, 30°, 45°） were carried out with a first-stage light gas gun, and the ballistic limit velocity and damage characteristics of the target plate were obtained. The results show that when the size and shape of projectile and target are the same, the ballistic limit of target decreases first and then increases with the increase of impact angle. When the impact angle is 15°, the ballistic limit of aluminum alloy target is the lowest, and the failure mode of target gradually transits from petal cracking to tensile tearing failure. In addition, at the same impact Angle, the damage of the target plate is also affected by the velocity of the projectile body.

Based on Biot's theory of porous media, this paper proposes a coupled vehicle-track-saturated foundation model to study the dynamic responses of saturated soft soil foundation under high-speed train load via two-and-half dimensional finite element method (2.5D FEM). It is found that the ratio of train speed c and soil Darcy permeability kD(c/kD) determines the extent to which maximum excess pore pressures build up in saturated soft soil under the train load when the load speed is lower than the critical speed. For a saturated soil of a particular stiffness, if c/kD is less than or equal to 3×104, the soil can be regarded as highly permeable relating to the load velocity. In this case, almost no excess pore pressure is developed, and the saturated soil can be modeled using a single-phase medium. There is a critical value of c/kD for the development of excess pore pressure, corresponding to which the maximum excess pore pressure increases with increasing c/kD. Above this critical value of c/kD, the maximum excess pore pressure remains independent of c/kD. The amplitude and influencing zone of effective stress are mainly controlled by the train speed and soil permeability for saturated soft soil foundation. The response of displacement is mainly controlled by the train speed. Significant Mach effects have been induced in the saturated soil foundation by the moving train when the train speed reaches or exceeds the critical velocity of the track-foundation system.

Objective To investigate the nursing knowledge and attitude of pressure injury of nursing students who were about to finish clinical practice, and to provide reference for pressure injury training in schools and clinics. Methods Totally 188 nursing students from 3 hospitals in FuLing district of ChongQing were investigated by questionnaire on nursing knowledge and attitude of pressure injury. Results The total score of nursing knowledge of pressure injury was (43. 26±16. 14) points , 158(84. 04%)cases scored less than 60 points and 30(15. 96%)cases scored 60 or more points. The score of attitude was (41. 07±4. 50) points. There was a significant difference in score of nursing knowledge between nursing students with different number of sources of nursing pressure injury knowledge (P

Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and embryonic development. USP22 has been proved to promote cancer development by regulating multiple signal pathways. This article focuses on the relevant mechanisms of USP22 regulating tumorigenesis and development through deubiquitinating modification.

The pandemic of COVID-19 in China has made the pathogen SARS-CoV-2 become a hot spot. SARS-CoV and MERS-CoV are classified into beta-coronavirus genus and mainly attack respiratory system. This article explores the long-term prognosis of patients with COVID-19 through comparison of patients with SARS and MERS in order to explore potential prevention strategy as well as method.

Objective The short-term clinical effects of two kinds of normal temperature flow root sealers (the calcium silicate-based sealer iRoot SP and the siloxane-based sealer GuttaFlow2) combined with single point filling technology and a frequently-used sealing agent (AH Plus) combined with continuous wave hot tooth filling technology were evaluated. Methods A total of 279 teeth (656 root canals) were randomly divided into three groups: the iRoot SP group, GuttaFlow2 group and AH plus group. We recorded the filling time of each root canal, collected a digital dental film to evaluate the filling effect of each root canal, and conducted a follow-up visit one week and one month after the operation to record the incidence of pain. We used SPSS 18.0 to analyze the above data. Results There was no significant difference in the root canal filling effect among the three groups (P > 0.05). There was no significant difference in the filling time between the iRoot SP group and the GuttaFlow2 group (P > 0.05), but the filling time was significantly shorter in the AH Plus group (P < 0.05). There was no significant difference in the postoperative pain between the iRoot SP group and the GuttaFlow2 group (P > 0.05), and the incidence of pain in the iRoot SP group and the GuttaFlow2 group was lower than that in the AH Plus group (P < 0.05). Conclusions GuttaFlow2 and iRoot SP combined with single point filling technology can save filling time and obtain good clinical effects compared with frequently-used hot tooth filling technology and the incidence of postoperative pain was low.

Objective To explore the relationship between serine hydroxymethyltransferase (SHMT1) gene methylation and ischemic stroke patients. Methods The quantitative methylation-specific PCR was used to measure the level of SHMT1 promoter methylation in 290 healthy control individuals and 141 ischemic stroke patients. Results The results showed that the SHMT1 methylation level in the stroke group was 24.87(16.97~35.46), higher than that in the control group 6.58(2.43~15.14) (P＜0.05). After adjusting for relevant risk factors, SHMT1 methylation was a risk factor for stroke(OR=1.051, 95% CI= 1.034~1.068). Area under the curve was 0.804, 95% CI=0.760~0.849(P＜0.01). The level of uric acid was associated with SHMT1 methylation in the control group(rs=0.17, P＜0.01), and the level of TG was associated with SHMT1 methylation in the stroke group(rs=0.18, P＜0.05). SHMT1 methylation expression was negatively correlated with mRNA expression(r=-0.472, P＜0.01). Conclusions The SHMT1 gene is more methylated and results in low expression in ischemic stroke patients, so SHMT1 hypermethylation is a risk factor for stroke.

Fe-based amorphous alloy has excellent soft magnetic properties; traditionally, Fe-based amorphous alloy such as soft magnetic devices was fabricated by insulation enveloping and suppression molding methods. In this process, the aging of organic envelope materials and the crystallization of Fe-based amorphous alloy were usually occurring, accompanying with low magnetic induction and poor mechanical properties. The direct ink writing (DIW) technique can make complex-shaped parts and needs no heating treatment after forming, which can avoid the effect of traditional molding process. In the present study, varying mass fraction FeSiB/EP composite parts were prepared by the DIW technique with the Fe-based amorphous alloy powder and epoxy resin, in which microscopic morphology, magnetic properties, and mechanical properties of FeSiB/EP soft magnetic composites were studied. The results indicate that the slurry with iron powder mass fraction of 92.3, 92.6, and 92.8 wt% has good printing performance and self-support ability, which is suitable for DIW. The density of the printed parts is about 4.317, 4.449, and 4.537 g/cm3, which is almost similar with the iron powder. The tensile strength and elongation of printing parts are significantly improved compared with the pure epoxy resin. From the photos of microscopic morphology of printing parts, it can be seen that FeSiB powders are evenly dispersed in EP, no pores, and defects, with the proportion increasing of powders; the insulation coating thickness decreases; and the magnetic performance improves. The optimal sample is 92.8 wt% FeSiB/EP, in which saturation magnetic induction strength is 137.9759 emu/g and coercivity is 4.6523 A/m.

C17H8Cl2N2O2, triclinic, P1‾$\overline{1}$ (no. 2), a = 7.9032(2) Å, b = 9.0843(3) Å, c = 10.8051(2) Å, α = 85.2310(10)°, β = 85.0270(10)°, γ = 71.013(2)°, V = 729.54(3) Å3, Z = 2, Rgt (F) = 0.0417, wRref (F2) = 0.1051, T = 293(2) K.

Multimodal analgesic strategy is pivotal for enhanced recovery after surgery. The objective of this trial was to assess the effect of subanesthetic esketamine vs. placebo combined with erector spinae plane block (ESPB) vs. intercostal nerve block (ICNB) on postoperative recovery following thoracoscopic lung resection. This randomized, controlled, 2×2 factorial trial was conducted at a university hospital in Suzhou, China. One hundred adult patients undergoing thoracoscopic lung surgery were randomized to one of four groups (esketamine-ESPB, esketamine-ICNB, placebo-ESPB, and placebo-ICNB) to receive i.v. esketamine 0.3 mg/kg or normal saline placebo combined with ESPB or ICNB using 0.375% ropivacaine 20 mL. All patients received flurbiprofen axetil and patient-controlled fentanyl. The primary outcome was quality of recovery (QoR) at 24 h postoperatively, assessed using the QoR-15 scale, with a minimal clinically important difference of 6.0. The median age was 57 years and 52% were female. No significant interaction effect was found between esketamine and regional blocks on QoR (P=0.215). The QoR-15 score at 24 h was 111.5±5.8 in the esketamine group vs. 105.4±4.5 in the placebo group (difference=6.1, 95% CI, 4.0-8.1; P