3,201 results on '"Hua, J."'
Search Results
2. STCF Conceptual Design Report: Volume 1 -- Physics & Detector
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Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Instrumentation and Detectors - Abstract
The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.
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- 2023
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3. STCF conceptual design report (Volume 1): Physics & detector
- Author
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Achasov, M., Ai, X. C., An, L. P., Aliberti, R., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, X., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X., Chen, X. F., Chen, X. R., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Cheng, T. G., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Dias, J. M., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Gao, Y. N., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gou, B., Gradl, W., Gu, J. L., Guevara, A., Gui, L. C., Guo, A. Q., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, W. H., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X., Li, X. H., Li, X. Q., Li, X. H., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liang, Y. T., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, D. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, K., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, J. X., Lu, N., Lü, Q. F., Lu, Y., Lu, Y., Lu, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Ma, Y. M., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tian, Y., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, K. P., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. W., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yuan, Z. Y., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, Q. A., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. J., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y., Zhang, Y., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Y. X., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. P., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
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- 2024
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4. Adherence to guidelines and central-line-associated bloodstream infection occurrence during insertion and maintenance of intravascular catheters: evidence from 20 tertiary hospitals
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Zang, F., Liu, J., Wen, Y., Jin, X., Yang, Y., Li, L., Di, J., Tang, H., Wu, J., Liu, H., Huang, J., Zhang, J., Li, S., Yang, L., Wang, X., Geng, S., Xing, H., Xie, J., Hua, J., Xue, X., Zhao, Y., Ouyang, L., Song, P., Zhuang, G., and Chen, W.
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- 2024
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5. Associations Between Primary Residence and Mental Health in Global Marginalized Populations
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Knutson, D., Irgens, M. S., Flynn, K. C., Norvilitis, J. M., Bauer, L. M., Berkessel, J. B., Cascalheira, C. J., Cera, J. L., Choi, N.-Y., Cuccolo, K., Danielson, D. K., Dascano, K. N., Edlund, J. E., Fletcher, T., Flinn, R. E., Gosnell, C. L., Heermans, G., Horne, M., Howell, J. L., Hua, J., Ijebor, E. E., Jia, F., McGillivray, S., Ogba, K. T. U., Shane-Simpson, C., Staples, A., Ugwu, C. F., Wang, S. C., Yockey, A., Zheng, Z., and Zlokovich, M. S.
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- 2023
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6. Associations of social cohesion and quality of life with objective and perceived built environments: a latent profile analysis among seniors
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Hua, J, Mendoza-Vasconez, AS, Chrisinger, BW, Conway, TL, Todd, M, Adams, MA, Sallis, JF, Cain, KL, Saelens, BE, Frank, LD, and King, AC
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Public Health ,Health Sciences ,Built Environment ,Humans ,Quality of Life ,Residence Characteristics ,Social Cohesion ,Social Environment ,environment ,older people ,Public Health and Health Services ,Epidemiology ,Health services and systems ,Public health - Abstract
BackgroundHealthy aging requires support from local built and social environments. Using latent profile analysis, this study captured the multidimensionality of the built environment and examined relations between objective and perceived built environment profiles, neighborhood social cohesion and quality of life among seniors.MethodsIn total, 693 participants aged 66-97 were sampled from two US locales in 2005-2008 as part of the Senior Neighborhood Quality of Life Study (SNQLS). Perceived social cohesion and quality of life were assessed using validated surveys. Six objective (geographic information system (GIS)-based) and seven perceived built environment latent profiles generated in previous SNQLS publications were used for analyses. Mixed-effects models estimated social cohesion and quality of life separately as a function of the built environment profiles.ResultsMore walkable and destination-rich perceived built environment profiles were associated with higher social cohesion and quality of life. Objective built environment profiles were not associated with social cohesion and only positively associated with quality of life in only one locale (Baltimore/DC).ConclusionsLatent profile analysis offered a comprehensive approach to assessing the built environment. Seniors who perceived their neighborhoods to be highly walkable and recreationally dense experienced higher neighborhood social cohesion and quality of life, which may set the stage for healthier aging.
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- 2022
7. D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation
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Hu Q, Fu XL, Dong YY, Ma J, Hua J, Li JT, Liu KX, Yang J, and Yu CX
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rheumatoid arthritis ,koumine ,microemulsion ,permeability ,oral administration ,Medicine (General) ,R5-920 - Abstract
Qing Hu,1,2,* Xiao-Ling Fu,1,* Yi-Yan Dong,1,2 Ju Ma,1 Jian Hua,1 Jia-Ting Li,1 Kai-Xin Liu,1 Jian Yang,1,2 Chang-Xi Yu1,2 1School of Pharmacy, Fujian Medical University, Fuzhou, People’s Republic of China; 2Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chang-Xi Yu; Jian Yang, School of Pharmacy, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350122, People’s Republic of China, Tel +86-0591-22862016, Email changxiyu@mail.fjmu.edu.cn; fjmukent@mail.fjmu.edu.cnIntroduction: Koumine (KME) is the most abundant active ingredient separated from Gelsemium elegans Benth and exhibits a significant therapeutic effect on rheumatoid arthritis (RA). It is a lipophilic compound with poor aqueous solubility, and there is an urgent need to develop novel dosage forms of KME and promote its clinical application for the treatment of RA. The aim of this study was to design and develop KME-loaded microemulsions (KME-MEs) for the effective management of RA.Methods: The composition of the microemulsion was selected by carrying out a solubility study and generating pseudoternary phase diagrams, and further optimized by D-Optimal design. The optimized KME-MEs was evaluated for particle size, viscosity, drug release, storage stability, cytotoxicity, cellular uptake, Caco-2 cell transport and everted gut sac investigations. In vivo fluorescence imaging and the therapeutic effects of KME and KME-MEs on collagen-induced arthritis (CIA) rats were also evaluated.Results: The optimized microemulsion contained 8% oil, 32% Smix (surfactant/cosurfactant) and 60% water and was used for in vivo and in vitro studies. The optimal KME-MEs exhibited a small globule size of 18.5 ± 0.14 nm and good stability over 3 months, and the release kinetics followed a first-order model. These KME-MEs had no toxic effect on Caco-2 cells but were efficiently internalized into the cytoplasm. Compared to KME, the KME-MEs displayed significantly increased permeability and absorption in Caco-2 cell monolayer assay and ex vivo everted gut sac experiment. As expected, the KME-MEs attenuated the progression of RA in CIA rats and were more effective than free KME with a reduced frequency of administration.Conclusion: The KME-MEs improved the solubility and therapeutic efficacy of KME by employing formulation technology. These results provide a promising vehicle for the oral delivery of KME to treat RA and have attractive potential for clinical translation.Graphical Abstract: Keywords: rheumatoid arthritis, koumine, microemulsion, permeability, oral administration
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- 2023
8. A THREE-DIMENSIONAL CADMIUM MIXED LIGANDS COORDINATION POLYMER WITH CO2 ADSORPTION ABILITY
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Hua, J., Wang, M., Zhang, D., Pei, X., Zhao, X., and Ma, X.
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- 2022
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9. Phase space dynamics of a plasma wakefield dechirper for energy spread reduction
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Wu, Y. P., Hua, J. F., Zhou, Z., Zhang, J., Liu, S., Peng, B., Fang, Y., Nie, Z., Ning, X. N., Pai, C. H., Du, Y. C., Lu, W., Zhang, C. J., Mori, W. B., and Joshi, C.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Plasma-based accelerators have made impressive progress in recent years. However, the beam energy spread obtained in these accelerators is still at ~ 1 % level, nearly one order of magnitude larger than what is needed for challenging applications like coherent light sources or colliders. In plasma accelerators, the beam energy spread is mainly dominated by its energy chirp (longitudinally correlated energy spread). Here we demonstrate that when an initially chirped electron beam from a linac with a proper current profile is sent through a low-density plasma structure, the self wake of the beam can significantly reduce its energy chirp and the overall energy spread. The resolution-limited energy spectrum measurements show at least a threefold reduction of the beam energy spread from 1.28 % to 0.41 % FWHM with a dechirping strength of ~ 1 (MV/m)/(mm pC). Refined time-resolved phase space measurements, combined with high-fidelity three-dimensional particle-in-cell simulations, further indicate the real energy spread after the dechirper is only about 0.13 % (FWHM), a factor of 10 reduction of the initial energy spread.
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- 2019
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10. Risk factors analysis and establishment of predictive nomogram of extranodal B-cell lymphoma of mucosal-associated lymphoid tissue
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Hua, J., Li, Z., Ma, C., Zhang, X., Li, Q., Duan, X., Xiao, T., and Geng, X.
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- 2023
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11. Prevalence of Sleep Disorder in Chinese Preschoolers: A National Population-Based Study
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Hua J, Lyu J, and Du W
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sleep disorder ,chinese preschooler ,national prevalence ,the children’s sleep habits questionnaire ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Jing Hua,1,* Jiajun Lyu,1,* Wenchong Du2 1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2NTU Psychology, Nottingham Trent University, Nottingham, UK*These authors contributed equally to this workCorrespondence: Wenchong Du, NTU Psychology, Nottingham Trent University, Burton Street, Nottingham, NG1 4BU, UK, Email vivienne.du@ntu.ac.uk Jing Hua, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 2699 Gaoke Road, Shanghai, People’s Republic of China, Email Jinghua@tongji.edu.cnStudy Objectives: This study provides data on the prevalence of clinical sleep disorders in Chinese preschoolers aged 3– 5 years old and examined their sleep behaviours and problems with a nationally representative sample.Methods: A national population-based cohort study was conducted with 114,311 children aged 3– 5 years old from 551 cities in China. Children’s daily sleep hours and pediatric sleep disorders defined by the Children’s Sleep Habits Questionnaire (CSHQ) were reported by parents.Results: The estimated sleep disorder prevalence was 76.78% (95% CI:76.54%, 77.03%). Rates of specific disorders were as follows: Bedtime resistance (97.00%, 95% CI:96.90%, 97.10%), Daytime sleepiness (77.68%,95% CI:77.43%, 77.92%), Sleep duration (70.24%,95% CI:69.97%, 70.50%), Parasomnia (58.52%,95% CI:58.23%, 58.80%), Sleep anxiety (55.53%,95% CI:55.24%, 55.81%), Sleep onset delay (51.99%,95% CI:51.70%, 52.28%) Night wakings (30.37%,95% CI:30.10%, 30.63%) and Sleep-disordered breathing (21.86%, 95% CI: 21.62%, 22.09%). The prevalence of sleep disorder, daily sleep hours and rates of specific disorder varied across children of different sex and ages.Conclusion: A high prevalence of sleep disorder was found in Chinese preschoolers, and the specific sleep problems of Chinese preschoolers vary from other cultures. A local standard may be required when using the CSHQ to define sleep disorders in children in China. An in-depth investigation into the reasons for the high sleep disorder prevalence should be conducted and supportive intervention should be provided to preschoolers in China.Keywords: sleep disorder, Chinese preschooler, national prevalence, the Children’s Sleep Habits Questionnaire
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- 2022
12. A Novel Tetrameric Heptomolybdate with Reactive Oxygen Species Catalytic Ability
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Hua, J. A., Ma, X., Niu, J., Xia, B. X., Gao, X. Y., Niu, Y. L., and Ma, P. T.
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- 2022
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13. Staged laser acceleration of high quality protons from a tailored plasma
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Wan, Y., Andriyash, I. A., Hua, J. F., Pai, C. -H., Lu, W., Mori, W. B., Joshi, C., and Malka, V.
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Physics - Plasma Physics - Abstract
A new scheme of proton acceleration from a laser-driven near-critical-density plasma is proposed. Plasma with a tailored density profile allows a two-stage acceleration of protons. The protons are pre-accelerated in the laser-driven wakefields, and are then further accelerated by the collisionless shock, launched from the rear side of the plasma. The shock has a small transverse size, and it generates a strong space-charge field, which defocuses protons in such a way, that only those protons with the highest energies and low energy spread remains collimated. Theoretical and numerical analysis demonstrates production of high-energy proton beams with few tens of percents energy spread, few degrees divergence and charge of few nC. This scheme indicates the efficient generation of quasi-monoenergetic proton beams with energies up to several hundreds of MeV with PW-class ultrashort lasers.
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- 2018
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14. A near-ideal dechirper for plasma-based electron and positron acceleration using a hollow channel plasma
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Wu, Y. P., Hua, J. F., Pai, C. H., An, W., Xu, X. L., Zhang, C. J., Li, F., Wan, Y., Nie, Z., Zhou, Z., Zhang, J., Liu, S., Zhou, S. Y., Peng, B., Fang, Y., Lu, W., Mori, W. B., and Joshi, C.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Plasma-based electron and positron wakefield acceleration has made great strides in the past decade. However one major challenge for its applications to coherent light sources and colliders is the relatively large energy spread of the accelerated beams, currently at a few percent level. This energy spread is usually correlated with particle position in the beam arising from the longitudinal chirp of the wakefield amplitude. Therefore a dechirper is highly desirable for reducing this spread down to $\sim0.1\%$ level, while at the same time for maintaining the emittance of the accelerated beam. Here we propose that a low-density hollow channel plasma can act as a near-ideal dechirper for both electrons and positrons. We demonstrate the concept through large-scale three-dimensional particle-in-cell simulations. We show that the initial positive correlated energy spread (chirp) on the beam exiting a plasma accelerator can be compensated by the nearly linear self-wake induced by the beam in the hollow channel from few percent level down to $\leq 0.1\%$. Meanwhile, the beam emittance can be preserved due to the negligible transverse field inside the channel. This passive method may significantly improve the beam quality of plasma-based accelerators, paving the way for their applications to future compact free electron lasers and colliders., Comment: 13 pages, 5 figures
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- 2018
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15. Temporal diagnostics of femtosecond electron bunches with complex structures using sparsity-based algorithm
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Su, Q. Q., Hua, J. F., Nie, Z., Ma, Y., Liu, S., Zheng, Y. F., Pai, C. -H., and Lu, W.
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Physics - Accelerator Physics - Abstract
Femtosecond electron bunches with complex temporal structures play a crucial role in THz generation, free-electron lasers and plasma wakefield accelerators. The ultrashort electron pulse duration can be reconstructed from the coherent transition radiation (CTR) spectrum based on prior knowledge. A weighted greedy sparse phase retrieval (WGESPAR) algorithm is developed to reduce the ambiguities for reconstructing the distribution of the beam current. This algorithm achieves better performance than iterative algorithms, especially for truncated noisy spectra of multibunch structures. Based on the WGESPAR algorithm, the complex temporal structures of femtosecond electron bunches generated from laser wakefield accelerators can be successfully reconstructed.
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- 2018
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16. Enhanced photocatalytic H2 evolution based on a polymer/TiO2 film heterojunction
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Wei, G., Niu, F., Wang, Z., Liu, X., Feng, S., Hu, K., Gong, X., and Hua, J.
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- 2022
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17. Ion acceleration with an ultra-intense two-frequency laser tweezer
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Wan, Y., Andriyash, I. A., Pai, C. -H., Hua, J. F., Zhang, C. J., Li, F., Wu, Y. P., Nie, Z., Mori, W. B., Lu, W., Malka, V., and Joshi, C.
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Physics - Accelerator Physics - Abstract
Ultra-intense lasers produce and manipulate plasmas, allowing to locally generate extremely high static and electromagnetic fields. This Letter presents a concept of an ultra-intense optical tweezer, where two counter-propagating circularly polarized intense lasers of different frequencies collide on a nano-foil. Interfering inside the foil, lasers produce a beat wave, which traps and moves plasma electrons as a thin sheet with an optically controlled velocity. The electron displacement creates a plasma micro-capacitor with an extremely strong electrostatic field, that efficiently generates narrow-energy-spread ion beams from the multi-species targets, e.g. protons from the hydrocarbon foils. The proposed ion accelerator concept is explored theoretically and demonstrated numerically with the multi-dimensional particle-in-cell simulations.
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- 2017
18. Capturing relativistic wake eld structures in plasmas using ultrashort high-energy electrons as a probe
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Zhang, C. J., Hua, J. F., Xu, X. L., Li, F., Pai, C. -H., Wan, Y., Wu, Y. P., Gu, Y. Q., Mori, W. B., Joshi, C., and Lu, W.
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Physics - Plasma Physics - Abstract
A new method capable of capturing coherent electric field structures propagating at nearly the speed of light in plasma with a time resolution as small as a few femtoseconds is proposed. This method uses a few femtoseconds long relativistic electron bunch to probe the wake produced in a plasma by an intense laser pulse or an ultra-short relativistic charged particle beam. As the probe bunch traverses the wake, its momentum is modulated by the electric field of the wake, leading to a density variation of the probe after free-space propagation. This variation of probe density produces a snapshot of the wake that can directly give many useful information of the wake structure and its evolution. Furthermore, this snapshot allows detailed mapping of the longitudinal and transverse components of the wakefield. We develop a theoretical model for field reconstruction and verify it using 3-dimensional particle-in-cell (PIC) simulations. This model can accurately reconstruct the wakefield structure in the linear regime, and it can also qualitatively map the major features of nonlinear wakes. The capturing of the injection in a nonlinear wake is demonstrated through 3D PIC simulations as an example of the applications of this new method., Comment: 9 pages, 6 figures
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- 2016
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19. Femtosecond probing of light-speed plasma wakefields by using a relativistic electron bunch
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Zhang, C. J., Hua, J. F., Wan, Y., Guo, B., Wu, Y. P., Pai, C. -H., Li, F., Chu, H. -H., Gu, Y. Q., Xu, X. L., Mori, W. B., Joshi, C., Wang, J., and Lu, W.
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Physics - Plasma Physics - Abstract
Relativistic wakes produced by intense laser or particle beams propagating through plasmas are being considered as accelerators for next generation of colliders and coherent light sources. Such wakes have been shown to accelerate electrons and positrons to several gigaelectronvolts (GeV), with a few percent energy spread and a high wake-to-beam energy transfer efficiency. However, complete mapping of electric field structure of the wakes has proven elusive. Here we show that a high-energy electron bunch can be used to probe the fields of such light-speed wakes with femtosecond resolution. The highly transient, microscopic wakefield is reconstructed from the density modulated ultra-short probe bunch after it has traversed the wake. This technique enables visualization of linear wakefields in low-density plasmas that can accelerate electrons and positrons beams. It also allows characterization of wakes in plasma density ramps critical for maintaining the beam emittance, improving the energy transfer efficiency and producing high brightness beams from plasma accelerators., Comment: 15 pages, 3 figures
- Published
- 2016
20. A 3,5-Connected 3D Nickel-Mixed Ligands Coordination Polymer with Selective Adsorption of Carbon Dioxide
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Hua, J. A., Duan, Z. P., Gao, C. K., Xie, X. H., Qiao, Z. P., Feng, T. Q., and Ma, X.
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- 2021
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21. Physical mechanism of the transverse instability in radiation pressure ion acceleration
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Wan, Y., Pai, C. -H., Zhang, C. J., Li, F., Wu, Y. P., Hua, J. F., Lu, W., Gu, Y. Q., Silva, L. O., Joshi, C., and Mori, W. B.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
The transverse stability of the target is crucial for obtaining high quality ion beams using the laser radiation pressure acceleration (RPA) mechanism. In this letter, a theoretical model and supporting two-dimensional (2D) Particle-in-Cell (PIC) simulations are presented to clarify the physical mechanism of the transverse instability observed in the RPA process. It is shown that the density ripples of the target foil are mainly induced by the coupling between the transverse oscillating electrons and the quasi-static ions, a mechanism similar to the transverse two stream instability in the inertial confinement fusion (ICF) research. The predictions of the mode structure and the growth rates from the theory agree well with the results obtained from the PIC simulations in various regimes, indicating the model contains the essence of the underlying physics of the transverse break-up of the target.
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- 2016
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22. Temporal characterization of ultrashort linearly chirped electron bunches generated from a laser wakefield accelerator
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Zhang, C. J., Hua, J. F., Wan, Y., Guo, B., Pai, C. -H., Wu, Y. P., Li, F., Chu, H. -H., Gu, Y. Q., Mori, W. B., Joshi, C., Wang, J., and Lu, W.
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Physics - Plasma Physics - Abstract
A new method for diagnosing the temporal characteristics of ultrashort electron bunches with linear energy chirp generated from a laser wakefield accelerator is described. When the ionization-injected bunch interacts with the back of the drive laser, it is deflected and stretched along the direction of the electric field of the laser. Upon exiting the plasma, if the bunch goes through a narrow slit in front of the dipole magnet that disperses the electrons in the plane of the laser polarization, it can form a series of bunchlets that have different energies but are separated by half a laser wavelength. Since only the electrons that are undeflected by the laser go through the slit, the energy spectrum of the bunch is modulated. By analyzing the modulated energy spectrum, the shots where the bunch has a linear energy chirp can be recognized. Consequently, the energy chirp and beam current profile of those bunches can be reconstructed. This method is demonstrated through particle-in-cell simulations and experiment., Comment: 7 pages, 6 figures
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- 2016
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23. Nano-scale electron bunching in laser-triggered ionization injection in plasma accelerators
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Xu, X. L., Zhang, C. J., Li, F., Wan, Y., Wu, Y. P., Hua, J. F., Pai, C. -H., Lu, W., An, W., Yu, P., Mori, W. B., and Joshi, C.
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Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
Ionization injection is attractive as a controllable injection scheme for generating high quality electron beams using plasma-based wakefield acceleration. Due to the phase dependent tunneling ionization rate and the trapping dynamics within a nonlinear wake, the discrete injection of electrons within the wake is nonlinearly mapped to discrete final phase space structure of the beam at the location where the electrons are trapped. This phenomenon is theoretically analyzed and examined by three-dimensional particle-in-cell simulations which show that three dimensional effects limit the wave number of the modulation to between $> 2k_0$ and about $5k_0$, where $k_0$ is the wavenumber of the injection laser. Such a nano-scale bunched beam can be diagnosed through coherent transition radiation upon its exit from the plasma and may find use in generating high-power ultraviolet radiation upon passage through a resonant undulator., Comment: 5 pages, 4 figures
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- 2015
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24. Colliding ionization injection in a beam driven plasma accelerator
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Wan, Y., Zhang, C. J., Li, F., Wu, Y. P., Hua, J. F., Pai, C. -H., Lu, W., Joshi, C., Mori, W. B., and Gu, Y. Q.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
The proposal of generating high quality electron bunches via ionization injection triggered by an counter propagating laser pulse inside a beam driven plasma wake is examined via two-dimensional particle-in-cell simulations. It is shown that electron bunches obtained using this technique can have extremely small slice energy spread, because each slice is mainly composed of electrons ionized at the same time. Another remarkable advantage is that the injection distance is changeable. A bunch with normalized emittance of 3.3 nm, slice energy spread of 15 keV and brightness of $7.2\times 10^{18}$ A m$^{-2}$ rad$^{-2}$ is obtained with an optimal injection length which is achieved by adjusting the launch time of the drive beam or by changing the laser focal position. This makes the scheme a promising approach to generate high quality electron bunches for the fifth generation light source., Comment: 10 pages, 5 figures
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- 2015
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25. Generation of Low Absolute Energy Spread Electron Beams in Laser Wakefield Acceleration Using Tightly Focused Laser through Near-Ionization-Threshold Injection
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Li, F., Zhang, C. J., Wan, Y., Wu, Y. P., Hua, J. F., Pai, C. H., Lu, W., Mori, W. B., and Joshi, C.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
An enhanced ionization injection scheme using a tightly focused laser pulse with intensity near the ionization potential to trigger the injection process in a mismatched pre-plasma channel has been proposed and examined via multi-dimensional particle-in-cell simulations. The core idea of the proposed scheme is to lower the energy spread of trapped beams by shortening the injection distance. We have established theory to precisely predict the injection distance, as well as the ionization degree of injection atoms/ions, electron yield and ionized charge. We have found relation between injection distance and laser and plasma parameters, giving a strategy to control injection distance hence optimizing beam's energy spread. In the presented simulation example, we have investigated the whole injection and acceleration in detail and found some unique features of the injection scheme, like multi-bunch injection, unique longitudinal phase-space distribution, etc. Ultimate electron beam has a relative energy spread (rms) down to 1.4% with its peak energy 190 MeV and charge 1.7 pC. The changing trend of beam energy spread indicates that longer acceleration may further lower the energy spread down to less than 1%, which may have potential in applications related to future coherent light source driven by laser-plasma accelerators.
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- 2015
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26. Nucleon electromagnetic form factors in two-flavour QCD
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Capitani, S., Della Morte, M., Djukanovic, D., von Hippel, G., Hua, J., Jäger, B., Knippschild, B., Meyer, H. B., Rae, T. D., and Wittig, H.
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
We present results for the nucleon electromagnetic form factors, including the momentum transfer dependence and derived quantities (charge radii and magnetic moment). The analysis is performed using O(a) improved Wilson fermions in Nf=2 QCD measured on the CLS ensembles. Particular focus is placed on a systematic evaluation of the influence of excited states in three-point correlation functions, which lead to a biased evaluation, if not accounted for correctly. We argue that the use of summed operator insertions and fit ans\"atze including excited states allow us to suppress and control this effect. We employ a novel method to perform joint chiral and continuum extrapolations, by fitting the form factors directly to the expressions of covariant baryonic chiral effective field theory. The final results for the charge radii and magnetic moment from our lattice calculations include, for the first time, a full error budget. We find that our estimates are compatible with experimental results within their overall uncertainties., Comment: 22 pages, 10 figures, citations modified
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- 2015
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27. Nucleon axial form factors from two-flavour Lattice QCD
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Junnarkar, P. M., Capitani, S., Djukanovic, D., von Hippel, G., Hua, J., Jäger, B., Meyer, H. B., Rae, T. D., and Wittig, H.
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High Energy Physics - Lattice - Abstract
We present preliminary results on the axial form factor $G_A(Q^2)$ and the induced pseudoscalar form factor $G_P(Q^2)$ of the nucleon. A systematic analysis of the excited-state contributions to form factors is performed on the CLS ensemble `N6' with $m_\pi = 340 \ \text{MeV}$ and lattice spacing $a \sim 0.05 \ \text{fm}$. The relevant three-point functions were computed with source-sink separations ranging from $t_s \sim 0.6 \ \text{fm}$ to $t_s \sim \ 1.4 \ \text{fm}$. We observe that the form factors suffer from non-trivial excited-state contributions at the source-sink separations available to us. It is noted that naive plateau fits underestimate the excited-state contributions and that the method of summed operator insertions correctly accounts for these effects., Comment: 7 pages, 12 figures; talk presented at Lattice 2014 -- 32nd International Symposium on Lattice Field Theory, 23-28 June, 2014, Columbia University New York, NY
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- 2014
28. Suppression of excited-state effects in lattice determination of nucleon electromagnetic form factors
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von Hippel, G. M., Capitani, S., Djukanovic, D., Hua, J., Jäger, B., Junnarkar, P., Meyer, H. B., Rae, T. D., and Wittig, H.
- Subjects
High Energy Physics - Lattice - Abstract
We study the ability of a variety of fitting techniques to extract the ground state matrix elements of the vector current from ratios of nucleon three- and two-point functions that contain contaminations from excited states. Extending our high-statistics study of nucleon form factors, we are able to demonstrate that the treatment of excited-state contributions in conjunction with approaching the physical pion mass has a significant impact on the $Q^2$-dependence of the form factors., Comment: 7 pages, 5 pdf figures; talk presented at Lattice 2014 -- 32nd International Symposium on Lattice Field Theory, 23-28 June, 2014, Columbia University New York, NY
- Published
- 2014
29. Exact phase space matching for staging plasma and traditional accelerator components using longitudinally tailored plasma profiles
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Xu, X. L., Wu, Y. P., Zhang, C. J., Li, F., Wan, Y., Hua, J. F., Pai, C. -H., Lu, W., Yu, P., An, W., Mori, W. B., Hogan, M. J., and Joshi, C.
- Subjects
Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Phase space matching between two plasma-accelerator (PA) stages and between a PA and a traditional accelerator component is a critical issue for emittance preservation of beams accelerated by PAs. The drastic differences of the transverse focusing strengths as the beam propagates between different stages and components may lead to a catastrophic emittance growth in the presence of both finite energy spread and lack of proper matching. We propose using the linear focusing forces from nonlinear wakes in longitudinally tailored plasma density profiles to provide exact phase space matching to properly transport the electron beam through two such stages with negligible emittance growth. Theoretical analysis and particle-in-cell simulations show how these structures may work in four different scenarios. Good agreement between theory and simulation is obtained., Comment: 5 pages, 3 figures
- Published
- 2014
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30. Cu2Zn(Si,Ge)Se4 quaternary semiconductors as potential photovoltaic materials
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Jibran, M., Sun, X., Hua, J., Wang, B., Yamauchi, Y., Da, B., and Ding, Z.J.
- Published
- 2020
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31. Characterization testing of the Northrop Grumman MiniCoolerPlus (MCP).
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Rich, N, Amouzegar, L, Petach, M, Colbert, R, Dair, E, Russo, J, Durand, D, and Hua, J
- Published
- 2024
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32. The Geoheritage of Mount Olympus: Ancient Mythology and Modern Geology
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Rassios, Anne Ewing, Krikeli, A., Dilek, Y., Ghikas, C., Batsi, A., Koutsovitis, P., and Hua, J.
- Published
- 2022
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33. Prevention of Acute Exacerbation in Subjects with Moderate-to-very Severe COPD by Modulating Lower Respiratory Microbiome: Protocol of a Prospective, Multicenter, Randomized Controlled Trial
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Hua J, Hu W, Zuo Y, and Zhang J
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chronic obstructive pulmonary disease ,probiotics ,amikacin ,vaccination ,Diseases of the respiratory system ,RC705-779 - Abstract
Jian-lan Hua, Wei-ping Hu, Yi-hui Zuo, Jing Zhang Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Jing ZhangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai 200032, People’s Republic of ChinaEmail jingatlas@hotmail.comBackground: COPD is a global respiratory disease that has produced a worldwide health care burden. Acute exacerbation of COPD (AECOPD) is the leading cause of death in patients with COPD and accounts for the majority of expenditure of COPD management. The colonization of potential pathogenic bacteria in the lower respiratory tract is an important cause of the acute exacerbation especially in patients with moderate and severe COPD. Some clinical studies have shown the potential of oral probiotics, aerosol-inhaled amikacin and combined vaccination to prevent AECOPD.Methods and Analysis: We hypothesize that patients with stable COPD will benefit from aerosol-inhaled amikacin, oral probiotics or combined vaccination in terms of preventing acute exacerbation of COPD, slowing the progression of the disease and improving their quality of life. The trial aimsto investigate the efficacy and safety of the above interventions to decolonize bacteria in the lower respiratory tract and prevent acute exacerbation of COPD. In the study, 144 patients with stable phase of moderate-to-very severe COPD will be recruited and randomized into aerosol-inhaled amikacin group, oral probiotics group, combined vaccination group and the control group at a 1:1:1:1 ratio. The primary outcome is time to the first COPD exacerbation. Other endpoints include colonization of potential pathogenic bacteria in induced sputum, microbiome in induced sputum, pulmonary function and symptoms of patients, inflammation level and adverse events, serious adverse events, and death.Keywords: chronic obstructive pulmonary disease, probiotics, amikacin, vaccination
- Published
- 2020
34. Functional Genetic Variation in the 3′-UTRNTRK2 is Associated with Risk of Ischemic Stroke
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Shi J, Sun Y, and Hua J
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bioinformatics ,ntrk2 ,ischemic stroke ,homocysteine ,mirna ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Jiajia Shi,1,* Ying Sun,1,* Jiajia Hua2 1Department of Rehabilitation Medicine, Kunshan Rehabilitation Hospital, Suzhou, Jiangsu, People’s Republic of China; 2Department of Rehabilitation Medicine, The Sixth People’s Hospital of Nantong, Nantong, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiajia HuaThe Sixth People’s Hospital of Nantong, Nantong, Jiangsu, People’s Republic of ChinaTel +86-25-68137102Fax +86-513-80886666Email huajiajia1@yeah.netBackground: Stroke is a leading cause of death and disability worldwide. It remains difficult to treat brain injury and improve functional rehabilitation after cerebral ischemia. Brain-derived neurotrophic factor (BDNF) is involved in ischemic stroke (IS) through interactions in the CREB1-BDNF-NTRk2 pathway. In this study, we aimed to determine the association of NTRK2 gene polymorphisms and the effects of intergenetic interactions in the Chinese population.Materials and Methods: A total of 400 patients diagnosed with IS and 400 healthy controls were enrolled for genotyping. Detailed sequence-based analysis was predicted through bioinformatical investigation. Polymorphisms associated with miRNA were analyzed by a dual-luciferase reporter assay system.Results: Analysis of clinical characteristics revealed that IS was highly associated with exposure to cigarette smoking, alcohol intake, as well as metabolic diseases, such as diabetes, hypertension, and higher serum triglyceride concentration. Three polymorphisms in NTRK2 located in the 3ʹ-untranslated region (3ʹ-UTR) were genotyped. Logistic regression analysis showed that IS patients with rs11140793, rs7047042, and rs1221 polymorphisms had a higher risk of stroke and indicated a worse short-term recovery. The mRNA level of NTRK2 was suppressed in a mutant genotype compared with wild genotype. The suppression of NTRK2 was induced by the gain-of-binding ability of certain miRNAs through the direct binding of 3ʹ-UTR.Conclusion: Our research indicated that, by influencing the expression of NTRK2, the SNPs rs11140793, rs7047042, and rs1221 in the 3′UTR of NTRK2 can be used as risk factors for IS patients.Keywords: bioinformatics, NTRK2, ischemic stroke, homocysteine, miRNA
- Published
- 2020
35. Development of Experimental Mouse Models for Intra-Oral Implants Osteointegration and Alveolar Bone Response Study in the Context of Oro-Dental Rare Developmental Diseases
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Strub, M., primary, Kuchler-Bopp, S., additional, Hua, J., additional, Fioretti, F., additional, Bornert, F., additional, Manière, M-C., additional, Huck, O., additional, Benkirane-Jessel, N., additional, and Clauss, F., additional
- Published
- 2021
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36. STCF conceptual design report (Volume 1): Physics & detector
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Achasov, M., primary, Ai, X. C., additional, An, L. P., additional, Aliberti, R., additional, An, Q., additional, Bai, X. Z., additional, Bai, Y., additional, Bakina, O., additional, Barnyakov, A., additional, Blinov, V., additional, Bobrovnikov, V., additional, Bodrov, D., additional, Bogomyagkov, A., additional, Bondar, A., additional, Boyko, I., additional, Bu, Z. H., additional, Cai, F. M., additional, Cai, H., additional, Cao, J. J., additional, Cao, Q. H., additional, Cao, X., additional, Cao, Z., additional, Chang, Q., additional, Chao, K. T., additional, Chen, D. Y., additional, Chen, H., additional, Chen, H. X., additional, Chen, J. F., additional, Chen, K., additional, Chen, L. L., additional, Chen, P., additional, Chen, S. L., additional, Chen, S. M., additional, Chen, S., additional, Chen, S. P., additional, Chen, W., additional, Chen, X., additional, Chen, X. F., additional, Chen, X. R., additional, Chen, Y., additional, Chen, Y. Q., additional, Cheng, H. Y., additional, Cheng, J., additional, Cheng, S., additional, Cheng, T. G., additional, Dai, J. P., additional, Dai, L. Y., additional, Dai, X. C., additional, Dedovich, D., additional, Denig, A., additional, Denisenko, I., additional, Dias, J. M., additional, Ding, D. Z., additional, Dong, L. Y., additional, Dong, W. H., additional, Druzhinin, V., additional, Du, D. S., additional, Du, Y. J., additional, Du, Z. G., additional, Duan, L. M., additional, Epifanov, D., additional, Fan, Y. L., additional, Fang, S. S., additional, Fang, Z. J., additional, Fedotovich, G., additional, Feng, C. Q., additional, Feng, X., additional, Feng, Y. T., additional, Fu, J. L., additional, Gao, J., additional, Gao, Y. N., additional, Ge, P. S., additional, Geng, C. Q., additional, Geng, L. S., additional, Gilman, A., additional, Gong, L., additional, Gong, T., additional, Gou, B., additional, Gradl, W., additional, Gu, J. L., additional, Guevara, A., additional, Gui, L. C., additional, Guo, A. Q., additional, Guo, F. K., additional, Guo, J. C., additional, Guo, J., additional, Guo, Y. P., additional, Guo, Z. H., additional, Guskov, A., additional, Han, K. L., additional, Han, L., additional, Han, M., additional, Hao, X. Q., additional, He, J. B., additional, He, S. Q., additional, He, X. G., additional, He, Y. L., additional, He, Z. B., additional, Heng, Z. X., additional, Hou, B. L., additional, Hou, T. J., additional, Hou, Y. R., additional, Hu, C. Y., additional, Hu, H. M., additional, Hu, K., additional, Hu, R. J., additional, Hu, W. H., additional, Hu, X. H., additional, Hu, Y. C., additional, Hua, J., additional, Huang, G. S., additional, Huang, J. S., additional, Huang, M., additional, Huang, Q. Y., additional, Huang, W. Q., additional, Huang, X. T., additional, Huang, X. J., additional, Huang, Y. B., additional, Huang, Y. S., additional, Hüsken, N., additional, Ivanov, V., additional, Ji, Q. P., additional, Jia, J. J., additional, Jia, S., additional, Jia, Z. K., additional, Jiang, H. B., additional, Jiang, J., additional, Jiang, S. Z., additional, Jiao, J. B., additional, Jiao, Z., additional, Jing, H. J., additional, Kang, X. L., additional, Kang, X. S., additional, Ke, B. C., additional, Kenzie, M., additional, Khoukaz, A., additional, Koop, I., additional, Kravchenko, E., additional, Kuzmin, A., additional, Lei, Y., additional, Levichev, E., additional, Li, C. H., additional, Li, C., additional, Li, D. Y., additional, Li, F., additional, Li, G., additional, Li, H. B., additional, Li, H., additional, Li, H. N., additional, Li, H. J., additional, Li, H. L., additional, Li, J. M., additional, Li, J., additional, Li, L., additional, Li, L. Y., additional, Li, N., additional, Li, P. R., additional, Li, R. H., additional, Li, S., additional, Li, T., additional, Li, W. J., additional, Li, X., additional, Li, X. H., additional, Li, X. Q., additional, Li, Y., additional, Li, Y. Y., additional, Li, Z. J., additional, Liang, H., additional, Liang, J. H., additional, Liang, Y. T., additional, Liao, G. R., additional, Liao, L. Z., additional, Liao, Y., additional, Lin, C. X., additional, Lin, D. X., additional, Lin, X. S., additional, Liu, B. J., additional, Liu, C. W., additional, Liu, D., additional, Liu, F., additional, Liu, G. M., additional, Liu, H. B., additional, Liu, J., additional, Liu, J. J., additional, Liu, J. B., additional, Liu, K., additional, Liu, K. Y., additional, Liu, L., additional, Liu, Q., additional, Liu, S. B., additional, Liu, T., additional, Liu, X., additional, Liu, Y. W., additional, Liu, Y., additional, Liu, Y. L., additional, Liu, Z. Q., additional, Liu, Z. Y., additional, Liu, Z. W., additional, Logashenko, I., additional, Long, Y., additional, Lu, C. G., additional, Lu, J. X., additional, Lu, N., additional, Lü, Q. F., additional, Lu, Y., additional, Lu, Z., additional, Lukin, P., additional, Luo, F. J., additional, Luo, T., additional, Luo, X. F., additional, Lyu, H. J., additional, Lyu, X. R., additional, Ma, J. P., additional, Ma, P., additional, Ma, Y., additional, Ma, Y. M., additional, Maas, F., additional, Malde, S., additional, Matvienko, D., additional, Meng, Z. X., additional, Mitchell, R., additional, Nefediev, A., additional, Nefedov, Y., additional, Olsen, S. L., additional, Ouyang, Q., additional, Pakhlov, P., additional, Pakhlova, G., additional, Pan, X., additional, Pan, Y., additional, Passemar, E., additional, Pei, Y. P., additional, Peng, H. P., additional, Peng, L., additional, Peng, X. Y., additional, Peng, X. J., additional, Peters, K., additional, Pivovarov, S., additional, Pyata, E., additional, Qi, B. B., additional, Qi, Y. Q., additional, Qian, W. B., additional, Qian, Y., additional, Qiao, C. F., additional, Qin, J. J., additional, Qin, L. Q., additional, Qin, X. S., additional, Qiu, T. L., additional, Rademacker, J., additional, Redmer, C. F., additional, Sang, H. Y., additional, Saur, M., additional, Shan, W., additional, Shan, X. Y., additional, Shang, L. L., additional, Shao, M., additional, Shekhtman, L., additional, Shen, C. P., additional, Shen, J. M., additional, Shen, Z. T., additional, Shi, H. C., additional, Shi, X. D., additional, Shwartz, B., additional, Sokolov, A., additional, Song, J. J., additional, Song, W. M., additional, Song, Y., additional, Song, Y. X., additional, Sukharev, A., additional, Sun, J. F., additional, Sun, L., additional, Sun, X. M., additional, Sun, Y. J., additional, Sun, Z. P., additional, Tang, J., additional, Tang, S. S., additional, Tang, Z. B., additional, Tian, C. H., additional, Tian, J. S., additional, Tian, Y., additional, Tikhonov, Y., additional, Todyshev, K., additional, Uglov, T., additional, Vorobyev, V., additional, Wan, B. D., additional, Wang, B. L., additional, Wang, B., additional, Wang, D. Y., additional, Wang, G. Y., additional, Wang, G. L., additional, Wang, H. L., additional, Wang, J., additional, Wang, J. H., additional, Wang, J. C., additional, Wang, M. L., additional, Wang, R., additional, Wang, S. B., additional, Wang, W., additional, Wang, W. P., additional, Wang, X. C., additional, Wang, X. D., additional, Wang, X. L., additional, Wang, X. P., additional, Wang, X. F., additional, Wang, Y. D., additional, Wang, Y. P., additional, Wang, Y. Q., additional, Wang, Y. L., additional, Wang, Y. G., additional, Wang, Z. Y., additional, Wang, Z. L., additional, Wang, Z. G., additional, Wei, D. H., additional, Wei, X. L., additional, Wei, X. M., additional, Wen, Q. G., additional, Wen, X. J., additional, Wilkinson, G., additional, Wu, B., additional, Wu, J. J., additional, Wu, L., additional, Wu, P., additional, Wu, T. W., additional, Wu, Y. S., additional, Xia, L., additional, Xiang, T., additional, Xiao, C. W., additional, Xiao, D., additional, Xiao, M., additional, Xie, K. P., additional, Xie, Y. H., additional, Xing, Y., additional, Xing, Z. Z., additional, Xiong, X. N., additional, Xu, F. R., additional, Xu, J., additional, Xu, L. L., additional, Xu, Q. N., additional, Xu, X. C., additional, Xu, X. P., additional, Xu, Y. C., additional, Xu, Y. P., additional, Xu, Y., additional, Xu, Z. Z., additional, Xuan, D. W., additional, Xue, F. F., additional, Yan, L., additional, Yan, M. J., additional, Yan, W. B., additional, Yan, W. C., additional, Yan, X. S., additional, Yang, B. F., additional, Yang, C., additional, Yang, H. J., additional, Yang, H. R., additional, Yang, H. T., additional, Yang, J. F., additional, Yang, S. L., additional, Yang, Y. D., additional, Yang, Y. H., additional, Yang, Y. S., additional, Yang, Y. L., additional, Yang, Z. W., additional, Yang, Z. Y., additional, Yao, D. L., additional, Yin, H., additional, Yin, X. H., additional, Yokozaki, N., additional, You, S. Y., additional, You, Z. Y., additional, Yu, C. X., additional, Yu, F. S., additional, Yu, G. L., additional, Yu, H. L., additional, Yu, J. S., additional, Yu, J. Q., additional, Yuan, L., additional, Yuan, X. B., additional, Yuan, Z. Y., additional, Yue, Y. F., additional, Zeng, M., additional, Zeng, S., additional, Zhang, A. L., additional, Zhang, B. W., additional, Zhang, G. Y., additional, Zhang, G. Q., additional, Zhang, H. J., additional, Zhang, H. B., additional, Zhang, J. Y., additional, Zhang, J. L., additional, Zhang, J., additional, Zhang, L., additional, Zhang, L. M., additional, Zhang, Q. A., additional, Zhang, R., additional, Zhang, S. L., additional, Zhang, T., additional, Zhang, X., additional, Zhang, Y., additional, Zhang, Y. J., additional, Zhang, Y. X., additional, Zhang, Y. T., additional, Zhang, Y. F., additional, Zhang, Y. C., additional, Zhang, Y. M., additional, Zhang, Y. L., additional, Zhang, Z. H., additional, Zhang, Z. Y., additional, Zhao, H. Y., additional, Zhao, J., additional, Zhao, L., additional, Zhao, M. G., additional, Zhao, Q., additional, Zhao, R. G., additional, Zhao, R. P., additional, Zhao, Y. X., additional, Zhao, Z. G., additional, Zhao, Z. X., additional, Zhemchugov, A., additional, Zheng, B., additional, Zheng, L., additional, Zheng, Q. B., additional, Zheng, R., additional, Zheng, Y. H., additional, Zhong, X. H., additional, Zhou, H. J., additional, Zhou, H. Q., additional, Zhou, H., additional, Zhou, S. H., additional, Zhou, X., additional, Zhou, X. K., additional, Zhou, X. P., additional, Zhou, X. R., additional, Zhou, Y. L., additional, Zhou, Y., additional, Zhou, Y. X., additional, Zhou, Z. Y., additional, Zhu, J. Y., additional, Zhu, K., additional, Zhu, R. D., additional, Zhu, R. L., additional, Zhu, S. H., additional, Zhu, Y. C., additional, Zhu, Z. A., additional, Zhukova, V., additional, Zhulanov, V., additional, Zou, B. S., additional, and Zuo, Y. B., additional
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- 2023
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37. Generating 10~40MeV high quality monoenergetic electron beams using a 5TW 60fs laser at Tsinghua University
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Hua, J. F., Yan, L. X., Pai, C. H., Zhang, C. J., Li, F., Wan, Y., Wu, Y. P., Xu, X. L., Du, Y. C., Huang, W. H., Chen, H. B., Tang, C. X., and Lu, W.
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Physics - Accelerator Physics - Abstract
A unique facility for laser plasma physics and advanced accelerator research has been built recently at Tsinghua Universtiy. This system is based on Tsinghua Thomson scattering X-ray source (TTX), which combining an ultrafast TW laser with a synchronized 45MeV high brightness linac. In our recent laser wakefield acceleration experiments, we have obtained 10~40MeV high quality monoenergetic electron beams by running the laser at 5TW peak power. Under certain conditions, very low relative energy spread of a few percent can be achieved. Absolute charge calibration for three different scintillating screens has also been performed using the linac system.
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- 2014
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38. Low emittance electron beam generation from a laser wakefield accelerator using two laser pulses with different wavelengths
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Xu, X. L., Wu, Y. P., Zhang, C. J., Li, F., Wan, Y., Hua, J. F., Pai, C. -H., Lu, W., Yu, P., Joshi, C., and Mori, W. B.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Ionization injection triggered by short wavelength laser pulses inside a nonlinear wakefield driven by a longer wavelength laser is examined via multi-dimensional particle-in-cell simulations. We find that very bright electron beams can be generated through this two-color scheme in either collinear propagating or transverse colliding geometry. For a fixed laser intensity $I$, lasers with longer/shorter wavelength $\lambda$ have larger/smaller ponderomotive potential ($\propto I \lambda^2$). The two color scheme utilizes this property to separate the injection process from the wakefield excitation process. Very strong wakes can be generated at relatively low laser intensities by using a longer wavelength laser driver (e.g. a $10 \micro\meter$ CO$_2$ laser) due to its very large ponderomotive potential. On the other hand, short wavelength laser can produce electrons with very small residual momenta ($p_\perp\sim a_0\sim \sqrt{I}\lambda$) inside the wake, leading to electron beams with very small normalized emittances (tens of $\nano\meter$). Using particle-in-cell simulations we show that a $\sim10 \femto\second$ electron beam with $\sim4 \pico\coulomb$ of charge and a normalized emittance of $\sim 50 \nano\meter$ can be generated by combining a 10 $\micro\meter $ driving laser with a 400 $\nano\meter$ injection laser, which is an improvement of more than one order of magnitude compared to the typical results obtained when a single wavelength laser used for both the wake formation and ionization injection., Comment: 18 pages (one column), 7 figures
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- 2014
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39. Sequential Infusion of Anti-CD22 and Anti-CD19 Chimeric Antigen Receptor T Cells for a Pediatric Ph-Like B-ALL Patient That Relapsed After CART-Cell and Haplo-HSCT Therapy: A Case Report and Review of Literature
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Hua J, Qian W, Wu X, Zhou L, Yu L, Chen S, Zhang J, and Qiu H
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philadelphia-chromosome-like ,acute lymphoblastic leukemia ,chimeric antigen receptor ,cd19 ,cd22 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Jingsheng Hua,1,2 Weiqing Qian,3 Xiaoxia Wu,1 Lili Zhou,1 Lei Yu,4 Suning Chen,1 Jian Zhang,1 Huiying Qiu1 1Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, People’s Republic of China; 2Department of Hematology, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang, People’s Republic of China; 3Suzhou Vocational Health College, Suzhou, Jiangsu, People’s Republic of China; 4College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, People’s Republic of ChinaCorrespondence: Huiying Qiu Tel +8613912792913Fax +8651267781850Email qiuhuiying8303@suda.edu.cnAbstract: Pediatric Philadelphia chromosome-like (Ph-like) acute B-lymphoblastic leukemia (B-ALL), a high-risk subset of B-ALL characterized by a gene expression profile similar to that of Ph-positive ALL, has extremely poor outcome after a relapse following autologous chimeric antigen receptor (CAR)-T and haploidentical (haplo) hematopoietic stem cell transplantation(HSCT)therapy. with very limited treatment options. Donor-derived CAR T-cell therapy, the most vital advanced anticancer technology, may be a promising salvage strategy for patients with Ph-like B-ALL. Here, we presented a relapsed and refractory case of a child with Ph-like B-ALL after autologous anti-CD19 CAR T-cell therapy followed by haplo-HSCT. She successfully achieved the fourth complete remission (CR4) and maintained CR for five months after the sequential infusion of donor-derived anti-CD22 and anti-CD19 CAR T cells, with mild CRS side effects and no obvious graft-versus-host disease. A donor-derived anti-CD22 and -CD19 CAR T-cell therapy combined with a sequential infusion strategy may provide a promising alternative treatment strategy as effective and safe salvage therapy for children with recurrent and refractory Ph-like B-ALL after autologous CD19-directed CAR T-cell therapy followed by haplo-HSCT.Keywords: Philadelphia-chromosome-like, acute lymphoblastic leukemia, chimeric antigen receptor, CD19, CD22
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- 2020
40. Variable Effects Of LDL Subclasses Of Cholesterol On Endothelial Nitric Oxide/Peroxynitrite Balance – The Risks And Clinical Implications For Cardiovascular Disease
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Hua J and Malinski T
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low density lipoprotein ,nitric oxide ,endothelium ,peroxynitrite ,cell adhesion ,Medicine (General) ,R5-920 - Abstract
Jiangzhou Hua , Tadeusz Malinski Nanomedical Research Laboratory, Ohio University, Athens, OH, USACorrespondence: Tadeusz MalinskiNanomedical Research Laboratory, Biochemistry Research Facility, Ohio University, 350 West State Street, Athens, OH 45701, USATel/fax +1 740 597 1247Email malinski@ohio.eduBackground: Elevated levels of low density lipoprotein (LDL), “bad cholesterol”, is not an accurate indicator of coronary disease. About 75% of patients with heart attacks have cholesterol levels that do not indicate a high risk for a cardiovascular event. LDL is comprised of three subclasses, with particles of different size and density. We used nanomedical systems to elucidate the noxious effects of LDL subclasses on endothelium.Experimental: Nanosensors were employed to measure the concentrations of nitric oxide (NO) and peroxynitrite (ONOO−) stimulated by LDL subclasses in HUVECs. N-LDL and ox-LDL (subclass A: 1.016–1.019 g/mL, subclass I: 1.024–1.029 g/mL, and subclass B: 1.034–1.053 g/mL) stimulated NO and ONOO− release. The concentrations ratio of (NO)/(ONOO−) was used to evaluate the noxious effects of the subclasses on endothelium.Results: In HUVECs, the (NO)/(ONOO−) ratio for normal endothelium is about 5, but shifts to 2.7±0.4, 0.5±0.1, and 0.9±0.1 for subclasses A, B, and I, respectively. Ratios below 1.0 indicate an imbalance between NO and ONOO−, affecting endothelial function. LDL of 50% B and 50% I produced the most severe imbalance (0.45±0.04), whereas LDL of 60% A, 20% B, and 20% I had the most favorable balance of 5.66±0.69. Subclass B significantly elevated the adhesion of molecules and monocytes. The noxious effect was significantly higher for ox-LDL than n-LDL.Conclusion: Subclass B of “bad cholesterol” is the most damaging to endothelial function and can contribute to the development of atherosclerosis. Contrary to the current national guidelines, this study suggests that it’s not the total LDL, rather it is the concentration of subclass B in relation to subclasses A and/or I, that should be used for diagnosis of atherosclerosis and the risk of heart attack. By utilizing specific pharmacological therapy to address the concentration of subclass B, there is a potential to significantly reduce the risk of heart attack and atherosclerosis.Keywords: low density lipoprotein, nitric oxide, endothelium, peroxynitrite, cell adhesion
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- 2019
41. Water flow and nitrate transport through a lakeshore with different revetment materials
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Li, Y, Šimůnek, J, Zhang, Z, Huang, M, Ni, L, Zhu, L, Hua, J, and Chen, Y
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Lakeshore ,Groundwater ,Flow regime ,Nitrate ,Slope revetment material ,Hydrus-2D ,Environmental Engineering - Abstract
As an important part of a transition zone surrounding a lake, lakeshore plays a critical role in connecting hydrology and biochemistry between surface water and groundwater. The shape, slope, subsurface features, and seepage face of a lakeside slope have been reported to affect water and nutrient exchange and consequently the water quality of near-shore lake water. Soil tank experiments and Hydrus-2D model simulations were conducted to improve our understanding of the influence of slope revetment materials (SRMs) on water flow and solute transport in a lakeshore zone. The low hydraulic conductivity of SRMs affected flow patterns in the lakeshore zone and resulted in a local increase of the groundwater table near the slope face. Water and solute flux distributions on the slope face under bare-slope conditions followed an exponential function. Fluxes were concentrated within a narrow portion of the slope surface near the intersection point between the lake water level and the slope face. Surface pollutants (for example from fishponds and paddy fields surrounding a lake) were transported into the lake along shallow groundwater through both unsaturated and saturated zones. The SRMs on the slope face affected the ratio of water and solute fluxes in the unsaturated zone, increasing along with the decline of the hydraulic conductivity of SRMs. Furthermore, as the hydraulic conductivity of SRMs decreased, the retention time and the potential for oxygen reduction correspondingly increased, which affected the nitrogen transport and transformations in the lakeshore zone. Simulated and experimental results indicate that if concrete along the shoreline of Lake Taihu is replaced with a relatively high-conductivity lime or the slope is left bare, water fluxes will increase less than solute fluxes, which will rise significantly, in particular in the unsaturated zone and along the seepage face. On the other hand, the largest water and solute fluxes along the shoreline for the bare and lime-slope conditions will be located higher at the slope than for the concrete-slope conditions. Hydrus-2D provided a good description of complicated hydrodynamic and solute transport/transformation conditions in the lakeshore zone.
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- 2015
42. Phase Space Dynamics of Ionization Injection in Plasma Based Accelerators
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Xu, X. L., Hua, J. F., Li, F., Zhang, C. J., Yan, L. X., Du, Y. C., Huang, W. H., Chen, H. B., Tang, C. X., Lu, W., Yu, P., An, W., Mori, W. B., and Joshi, C.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
The evolution of beam phase space in ionization-induced injection into plasma wakefields is studied using theory and particle-in-cell (PIC) simulations. The injection process causes special longitudinal and transverse phase mixing leading initially to a rapid emittance growth followed by oscillation, decay, and eventual slow growth to saturation. An analytic theory for this evolution is presented that includes the effects of injection distance (time), acceleration distance, wakefield structure, and nonlinear space charge forces. Formulas for the emittance in the low and high space charge regimes are presented. The theory is verified through PIC simulations and a good agreement is obtained. This work shows how ultra-low emittance beams can be produced using ionization-induced injection., Comment: 5 pages, 4 figures
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- 2013
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43. Generation of High Brightness Electron Beams via Ionization Induced Injection by Transverse Colliding Lasers in a Beam-Driven Plasma Wakefield Accelerator
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Li, F., Hua, J. F., Xu, X. L., Zhang, C. J., Yan, L. X., Du, Y. C., Huang, W. H., Cheng, H. B., Tang, C. X., Lu, W., Joshi, C., Mori, W. B., and Gu, Y. Q.
- Subjects
Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
The production of ultra-bright electron bunches using ionization injection triggered by two transversely colliding laser pulses inside a beam-driven plasma wake is examined via three-dimensional (3D) particle-in-cell (PIC) simulations. The relatively low intensity lasers are polarized along the wake axis and overlap with the wake for a very short time. The result is that the residual momentum of the ionized electrons in the transverse plane of the wake is much reduced and the injection is localized along the propagation axis of the wake. This minimizes both the initial 'thermal' emittance and the emittance growth due to transverse phase mixing. 3D PIC simulations show that ultra-short (around 8 fs) high-current (0.4 kA) electron bunches with a normalized emittance of 8.5 and 6 nm in the two planes respectively and a brightness greater than 1.7*10e19 A rad-2 m-2 can be obtained for realistic parameters.
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- 2013
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44. London penetration depth in Ba(Fe$_{1-x}$T$_x$)$_2$As$_2$ (T=Co, Ni) superconductors irradiated with heavy ions
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Kim, H., Gordon, R. T., Tanatar, M. A., Hua, J., Welp, U., Kwok, W. K., Ni, N., Bud'ko, S. L., Canfield, P. C., Vorontsov, A. B., and Prozorov, R.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
Irradiation with Pb ions was used to study the effect of disorder on the in-plane London penetration depth, $\lambda(T)$, in single crystals of Ba(Fe$_{1-x}$T$_x$)$_2$As$_2$ (T=Co, Ni). An increase of the irradiation dose results in a monotonic decrease of the superconducting transition temperature, $T_c$, without affecting much the transition width. In both Co and Ni doped systems we find a power-law behavior, $\Delta\lambda(T) \propto T^n$, with the exponent $n$ systematically decreasing with the increase of disorder. This observation, supported by the theoretical analysis, conclusively points to a nodeless $s^\pm$ state with pairbreaking impurity scattering (interband) with strength being intermediate between Born and unitary limits., Comment: new version includes theoretical model
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- 2010
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45. Magneto-optical study of Ba(Fe$_{1-x}$T$_{x}$)$_2$As$_2$ (T=Co, Ni) single crystals irradiated with heavy-ions
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Prozorov, R., Tanatar, M. A., Roy, B., Ni, N., Bud'ko, S. L., Canfield, P. C., Hua, J., Welp, U., and Kwok, W. K.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
Optimally doped single crystals of Ba(Fe$_{1-x}$T$_x$)$_2$As$_2$ (T=Co, Ni) were irradiated with 1.4 GeV $^{208}$Pb$^{56+}$ ions at fluences corresponding to matching fields of $B_{\phi}=0.1, 0.5, 1$ and 2 T. Magneto-optical imaging has been used to map the distribution of the magnetic induction in the irradiated samples. The imaging is complemented by the magnetization measurements. The results show a substantial enhancement of the apparent critical current densities as revealed by the much larger Bean penetration fields and an increase of the hysteretic magnetization. However, the effect depends on the compound, temperature and applied magnetic field. In \FeCo crystals, at 15 K and low fields, the enhancement appears to scale with the irradiation dose at a rate of about 0.27 MA$\cdot$cm$^{-2}$T$^{-1}$, whereas in \FeNi crystals, higher irradiation doses are less effective. Our results suggest that moderate irradiation with heavy ions is a an effective way to \emph{homogeneously} enhance the current-currying capabilities of pnictide superconductors.
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- 2010
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46. Magnetoresistance Oscillations in Granular Superconducting Niobium Nitride Nanowires
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Patel, U., Xiao, Z. L., Gurevich, A., Avci, S., Hua, J., Divan, R., Welp, U., and Kwok, W. K.
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Condensed Matter - Superconductivity - Abstract
We report on magnetoresistance oscillations in superconducting NbNx nanowires synthesized through ammonia gas annealing of NbSe3 precursor nanostructures. Even though the transverse dimensions of the nanowires are much larger than the superconducting coherence length, the voltage-current characteristics of these nanowires at low temperatures are reminiscent of one-dimensional superconductors where quantum phase slips are associated with the origin of dissipation. We show that both the magnetoresistance oscillations and voltage-current characteristics observed in this work result from the granular structure of our nanowires., Comment: Published in Phys. Rev. B
- Published
- 2009
47. Growth and Superconductivity of FeSex Crystals
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Patel, U., Hua, J., Yu, S. H., Avci, S., Xiao, Z. L., Claus, H., Schlueter, J., Vlasko-Vlasov, V. V., Welp, U., and Kwok, W. K.
- Subjects
Condensed Matter - Superconductivity - Abstract
Iron selenide (FeSex) crystals with lateral dimensions up to millimeters were grown via a vapor self-transport method. The crystals consist of the dominant alpha - phase with trace amounts of beta- phase as identified by powder x-ray diffraction. With four-probe resistance measurements we obtained a zero-resistance critical temperature of 7.5 K and a superconducting onset transition temperature of up to 11.8 K in zero magnetic field as well as an anisotropy of 1.5 +- 0.1 for the critical field. Magnetization measurements on individual crystals reveal the co-existence of superconductivity and ferromagnetism., Comment: To appear in Applied Physics Letters
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- 2009
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48. Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis
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Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, and Gan J
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butorphanol ,etomidate ,myoclonus ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Jun Hua,1 Shuai Miao,2 Mengzhu Shi,2 Qing Tu,3 Xiuli Wang,2 Su Liu,2 Guanglei Wang,2 Jianhui Gan31Department of Anesthesiology, The 101 Hospital of Chinese People’s Libration Army, Wuxi, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, The Affiliated Hospital of XuZhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 3Department of Anesthesiology, Tangshan People‘s Hospital, North China University of Science and Technology, Tangshan, Hebei, People’s Republic of ChinaObjective: To evaluate the effect of butorphanol on the prevention of myoclonus induced by etomidate.Materials and methods: We searched the PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases to collect relevant randomized controlled trials (RCTs) evaluating the effect of butorphanol on etomidate-induced myoclonus in January 2019 without any language restrictions. The primary outcome was the incidence of etomidate-induced myoclonus. Secondary outcomes included the incidence of myoclonus at various degrees and the incidence of adverse effects. Risk ratios (RRs) were calculated for binary outcomes. All statistical analysis were performed by using RevMan 5.3 software.Results: We identified 6 RCTs involving a total of 608 patients who reported the incidence of etomidate-induced myoclonus. In pooled analyses, the incidence of etomidate-induced myoclonus in the butorphanol group was significantly lower than that in the control group (RR =0.15, 95% CI [0.10, 0.22], P
- Published
- 2019
49. A Silicon-Based Micro Gas Turbine Engine for Power Generation
- Author
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Shan, X. -C., Wang, Z. -F., Maeda, R., Sun, Y. F., Wu, M., and Hua, J. S.
- Subjects
Computer Science - Other Computer Science - Abstract
This paper reports on our research in developing a micro power generation system based on gas turbine engine and piezoelectric converter. The micro gas turbine engine consists of a micro combustor, a turbine and a centrifugal compressor. Comprehensive simulation has been implemented to optimal the component design. We have successfully demonstrated a silicon-based micro combustor, which consists of seven layers of silicon structures. A hairpin-shaped design is applied to the fuel/air recirculation channel. The micro combustor can sustain a stable combustion with an exit temperature as high as 1600 K. We have also successfully developed a micro turbine device, which is equipped with enhanced micro air-bearings and driven by compressed air. A rotation speed of 15,000 rpm has been demonstrated during lab test. In this paper, we will introduce our research results major in the development of micro combustor and micro turbine test device., Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)
- Published
- 2007
50. Resistance Anomaly in Disordered Superconducting Films
- Author
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Hua, J., Xiao, Z. L., Rosenmann, D., Beloborodov, I. S., Welp, U., Kwok, W. K., and Crabtree, G. W.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science - Abstract
We report on a resistance anomaly in disordered superconducting films containing arrays of irregularly distributed nanoscale holes. At high driving currents, peaks appear in the resistance as a function of temperature, with peak values up to 2% above the classic normal-state resistance. We attribute the observed resistance anomaly to dissipation-induced granularity which enhances the contributions from fluctuation-induced reduction of the density of states of the quasiparticles. The granular feature of a disordered superconducting film originates from the inhomogeneous temperature distribution caused by the variation of the local dissipation and/or heat transfer., Comment: 14 pages, 3 figures, accepted for publication in Applied Physics Letters
- Published
- 2007
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