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Abstract This study aims to observe the clinical efficacy and safety of rigid gas permeable corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced keratoconus eyes. Twenty-five patients (27 eyes) fitted with RGP-CLs after FL-MILK were enrolled, and 22 grading-matched keratoconus patients (23 eyes) as a control group. Corneal morphological data, diopter, best corrected vision, corneal endothelium, non-invasive tear film rupture time (NIBUT), corneal perception and comfort questionnaire were analysed before and after wearing RGP-CLs. In the FL-MILK group, the flat K, steep K and Kmax of the corneal anterior surface were decreased by 3.05D, 3.48D and 7.17D respectively after surgery (P = 0.011, 0.004 and 0.007). The central corneal thickness increased by 175.29 μm (P

Abstract Background This study aims to evaluate the clinical outcomes and efficacy of a modified tectonic corneoscleral graft (TCG) in patients suffering from devastating corneoscleral infections. Methods Thirty-eight eyes from 38 patients who underwent the modified TCG were included in this study. The outcomes measured were recurrence rates, best-corrected visual acuity (BCVA), ocular surface stability, postoperative complications, and graft survival. Results Among the 38 patients, 23 had fungal infections, 9 had bacterial infections and 6 had Pythium insidiosum infections. At the final follow-up, with an average duration of 25.1 ± 8.6 months, the rate of monocular blindness decreased from 100 to 58%. Significant improvements in LogMAR BCVA were observed from preoperative to postoperative measurements (P

Highlights Polysaccharide-based microneedles are novel and emerging tools for ocular drug delivery and the research on the diagnosis and treatment of eye diseases is advancing at a fast pace. Microneedle devices constructed from polysaccharide molecules derived from ocular tissue have the potential to significantly enhance the efficiency of clinical treatments and improve patient compliance with therapeutic regimens. Guided by our vast clinical experience, this is the first review collates the cutting-edge scientific findings from the interdisciplinary field combining natural macromolecules and ophthalmology.

AIM: To describe the surgical procedure of fusiform penetrating keratoplasty (FPK) using multiple trephines of different sizes for treating patients with severe infectious keratitis. METHODS: Fourteen eyes underwent FPK, and 15 eyes received conventional penetrating keratoplasty (PK) were included in the study. The best-corrected visual acuity (BCVA), refractive outcomes, endothelial cell density, and postoperative complications were recorded. RESULTS: The FPK group was followed for an average of 15.3±2.1mo, whereas the PK group was followed for 16.1±1.9mo. The corneal ulcers were elliptical-shaped in all 14 eyes in the FPK group. The mean BCVA (logMAR, 0.26±0.13) showed no statistically significant differences from that in the PK group (logMAR, 0.21±0.12, P>0.05) at 1y after surgery. But the mean curvature, mean astigmatism, and mean spherical equivalent in the FPK group were lower than those in the PK group (P

Abstract Osteoarthritis (OA) is a chronic disease due to the deterioration of cartilage structure and function, involving the progressive degradation of the cartilage extracellular matrix. Cathepsins, lysosomal cysteine proteases, play pivotal roles in various biological and pathological processes, particularly in protein degradation. Excess cathepsins levels are reported to contribute to the development of OA. However, the causal relationship between the cathepsin family and knee and hip OA remains uncertain. Therefore, this study utilized bidirectional Mendelian Randomization (MR) analyses to explore this causal association. Our results indicated that elevated serum levels of cathepsin O increase the overall risk of knee OA, while increased serum levels of cathepsin H enhance the risk of hip OA. Conversely, the reverse MR analyses did not reveal a reverse causal relationship between them. In summary, OA in different anatomical locations may genetically result from pathological elevations in different serum cathepsin isoforms, which could be utilized as diagnostic and therapeutic targets in clinical practice.

Abstract An air spring (AS) for ships must have the structural strength of its bellows enhanced considerably to ensure its reliability under high internal pressure and strong impact. In this case, the stiffness of the bellows gradually dominates the overall stiffness of the AS. Nevertheless, the parameterization calculation of stiffness for an AS mainly focuses on its pneumatic stiffness. The bellows stiffness is normally analyzed by virtue of equivalent simplification or numeric simulation. There is not an effective parameterization calculation model for the stiffness of the bellows, making it difficult to achieve the structural optimization design of the bellows. In this paper, the shell theory was borrowed to build a mechanical model for the bellows. Subsequently, the state vector of the bellows was solved by precision integration and boundary condition. Iteration was conducted to identify the complex coupling relationship between the vector of the bellows and other parameters. On this basis, the parameterization calculation method was introduced for the stiffness of the bellows to obtain the vertical and horizontal stiffness of the AS. After that, a dual-membrane low-stiffness structure was designed to analyze the dominating factors affecting the strength and stiffness of the AS, which highlighted the way to the low-stiffness optimization design of high-strength ASs. In the end, three prototypes and one optimized prototype were tested to verify the correctness of the parameterization design model for stiffness as well as the effectiveness of the structural optimization design.

Summary: IscBs, as hypercompact ancestry proteins of Cas9 nuclease, are suitable for in vivo gene editing via single adeno-associated virus (AAV) delivery. Due to the low activity of natural IscBs in eukaryotic cells, recent studies have been focusing on improving OgeuIscB’s gene editing efficiency via protein engineering. However, in vivo gene editing efficacy of IscBs for disease correction remained to be demonstrated. Here, we showed effective gene knockout and base editing in mouse embryos. To further improve IscB activity, we performed systematic engineering of IscB-associated ωRNA and identified a variant, ωRNA∗-v2, with enhanced gene editing efficiency. Furthermore, our study demonstrated the efficacy of an engineered IscB-ωRNA system for robust gene knockout and base editing in vivo. Single AAV delivery of IscB-derived cytosine and adenine base editors achieved disease correction in a mouse model of tyrosinemia. Therefore, our results indicated the great potential of miniature IscBs for developing single-AAV-based gene editing therapeutics.

Abstract Media bias widely exists in the articles published by news media, influencing their readers’ perceptions, and bringing prejudice or injustice to society. However, current analysis methods usually rely on human efforts or only focus on a specific type of bias, which cannot capture the varying magnitudes, connections, and dynamics of multiple biases, thus remaining insufficient to provide a deep insight into media bias. Inspired by the Cognitive Miser and Semantic Differential theories in psychology, and leveraging embedding techniques in the field of natural language processing, this study proposes a general media bias analysis framework that can uncover biased information in the semantic embedding space on a large scale and objectively quantify it on diverse topics. More than 8 million event records and 1.2 million news articles are collected to conduct this study. The findings indicate that media bias is highly regional and sensitive to popular events at the time, such as the Russia-Ukraine conflict. Furthermore, the results reveal some notable phenomena of media bias among multiple U.S. news outlets. While they exhibit diverse biases on different topics, some stereotypes are common, such as gender bias. This framework will be instrumental in helping people have a clearer insight into media bias and then fight against it to create a more fair and objective news environment.

Abstract Purpose To compare the outcomes of big-bubble deep anterior lamellar keratoplasty (BB-DALK) and penetrating keratoplasty (PKP) in the management of medically unresponsive Acanthamoeba keratitis (AK). Methods This retrospective study included 27 eyes of BB-DALK and 24 eyes of PKP from a tertiary ophthalmology care centre. Glucocorticoid eye drops were subsequently added to the treatment plan 2 months postoperatively based on the evaluation using confocal laser scanning microscopy. The clinical presentations, best-corrected visual acuity (BCVA), postoperative refractive outcomes, graft survival, and Acanthamoeba recurrence were analyzed. Results The AK patients included in the study were in stage 2 or stage 3, and the percentage of patients in stage 3 was higher in the PKP group (P = 0.003). Clinical presentations were mainly corneal ulcers and ring infiltrates, and endothelial plaques, hypopyon, uveitis and glaucoma were more common in the PKP group (P = 0.007). The BCVA and the graft survival rate showed no statistically significant differences between the two groups at 1 year after surgery. However, 3 years postoperatively, the BCVA of 0.71 ± 0.64 logMAR, the graft survival rate of 89.5%, and the endothelial cell density of 1899 ± 125 cells per square millimeter in the BB-DALK group were significantly better than those of the PKP group (P = 0.010, 0.046, and 0.032, respectively). 3 eyes (11.1%) in the BB-DALK group and 2 eyes (8.3%) in the PKP group experienced Acanthamoeba recurrence, but the rates showed no statistically significant difference between the two groups (P = 1.000). In the PKP group, immune rejection and elevated intraocular pressure were observed in 5 and 6 eyes, respectively. Conclusion Corneal transplantation is recommended for AK patients unresponsive to antiamoebic agents. The visual acuity and graft survival can be maintained after BB-DALK surgery. Acanthamoeba recurrence is not related to the surgical approach performed, whereas complete dissection of the infected corneal stroma and delayed prescribing of glucocorticoid eye drops were important to prevent recurrence.

Purpose: To evaluate regional changes in the posterior corneal elevation after three laser refractive surgeries for correction of myopia of different degrees. Settings and Design: Retrospective, comparative, and non-randomized study. Methods: Two hundred patients (200 eyes) who underwent laser epithelial keratoplasty (LASEK), femtosecond-assisted laser in-situ keratomileusis (FS-LASIK), and small-incision lenticule extraction (SMILE) were included in this study. According to preoperative spherical equivalent (SE), each surgical group was divided into two refractive subgroups: low-to-moderate myopia (LM group) and high myopia (H group). The posterior corneal elevation from Pentacam Scheimpflug tomography was analyzed preoperatively and at 1 month, 3 months, 6 months, and 12 months postoperatively. Three subregions of the posterior cornea were divided in this study as the central, paracentral, and peripheral regions. Statistical Analysis Used: Generalized Estimating Equations (GEE). Results: For all three surgical groups, similar changing trends were seen in the two refractive subgroups. H group presented a larger changing magnitude than the LM group in FS-LASIK over time (P < 0.05), whereas no significant difference was noted in the two refractive subgroups of LASEK or SMILE (P > 0.05). At 12 months postoperatively, the central posterior corneal elevation returned to the preoperative level in LASEK (P > 0.05) but shifted forward significantly in FS-LASIK and SMILE (P < 0.05). Conclusion: Different posterior corneal regions respond differently to corneal refractive surgeries. LASEK, FS-LASIK, and SMILE demonstrate different trends in the regional changes in posterior corneal elevation. The corneal shape seems more stable in LASEK than in FS-LASIK and SMILE.

Abstract Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted ‘reduction, replacement and refinement’ principle, which has been highly considered by regulatory agencies from different countries. We used NF-κB, a central signalling molecule mediating inflammatory responses, as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence signal. Here, we show that this test can quantitatively and sensitively detect endotoxin (lipopolysaccharide from different strains) and nonendotoxin (lipoteichoic acid, zymosan, peptidoglycan, lectin and glucan), has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals (group A & C meningococcal polysaccharide vaccine; basiliximab; rabies vaccine (Vero cells) for human use, freeze-dried; Japanese encephalitis vaccine (Vero cells), inactivated; insulin aspart injection; human albumin; recombinant human erythropoietin injection (CHO Cell)). The within-laboratory reproducibility of the test in three independent laboratories was 85%, 80% and 80% and the interlaboratory reproducibility among laboratories was 83.3%, 95.6% and 86.7%. The sensitivity (true positive rate) and specificity (true negative rate) of the test were 89.9% and 90.9%, respectively. In summary, the test provides a novel alternative for pyrogen detection.

Abstract Background Postnatal period is a critical transitional phase in the lives of mothers and newborn babies. In recent years the importance on promoting a positive experience of care following childbirth is increasingly emphasized. Yet published evidence of the methodological and psychometric quality of instruments to evaluate women’s experience of comprehensive postnatal care is still lacking. Objective This study aimed to develop and validate a unique scale (the Chinese version of the Postnatal Care Experience Scale, PCES) to measure women’s overall experience of care during postnatal periods. Methods The PCES instrument was developed and validated over three phases, including item development, scale development, and scale evaluation. The item pool of the PCES was generated through existing literature and in-depth semi-structured interviews, followed by assessment of content validity and rating of importance and feasibility of items through two-round Delphi surveys. Psychometric properties were examined in a convenience sample of 736 postpartum women. Both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to assess the construct validity of the developed PCES. The relationship between the total PCES score and the global item construct was estimated using Pearson product-moment coefficient. Reliability was assessed using Cronbach’s alpha and Spearman Brown coefficients. Results The content validity index of the Chinese version PCES was 0.867. Following item reduction analysis, this instrument consisted of 30 five-point Likert items. The Kaiser-Meyer-Olkin statistic was 0.964 and the chi-square value of the Bartlett spherical test was 11665.399 (P

Solar-driven photoreduction of CO2 to value-added fuels such as CO, CH4, and CH3OH is a promising approach for alleviating the greenhouse effect. Transition-metal-complex molecular catalysts exhibit high catalytic performance for CO2 reduction owing to their tunable structures. In this study, we developed an efficient, inexpensive, and noble-metal-free photocatalytic CO2 reduction system containing an organic photosensitizer proflavine, a cobalt molecular catalyst, and an organic electron transfer relay emodin in DMF/H2O (DMF: N,N-dimethylformamide) solvent. In the presence of water, a turnover number (TON) of 1333 was achieved for CO2-to-CO conversion under ambient conditions and visible light irradiation, which is a 1.7-fold improvement over the system without emodin. In addition, a high selectivity of 90% was obtained for CO production. Absorption spectroscopy and cyclic voltammetry confirmed the crucial role of emodin in facilitating electron transfer between the photosensitizer and catalyst. We expect that our system will promote the development of an effective homogenous photocatalytic solar-fuel production technology.

ObjectiveTo analyze the epidemiological characteristics and wound healing conditions of common unintentional skin lacerations in children.MethodsA retrospective analysis was conducted on data from 1,107 children, aged 0–12 years, with skin lacerations who received emergency treatment at Qilu Hospital of Shandong University from January 1, 2019, to December 30, 2022. Data on age, injury site, time from injury to suturing, and wound healing conditions were statistically analyzed.ResultsAmong the 1,107 cases, 714 (64.5%) were male and 393 (35.5%) were female, with a male-to-female ratio of 1.8:1; median age was 5 years (IQR, 3–7). Infants and toddlers (0–3 years old) constituted the highest proportion, accounting for 36.3% (402 cases). The number of children aged over 3 years gradually decreased with increasing age. In younger children, the most common injuries were to the forehead, scalp, and lower jaw; in school-aged children, the proportion of limb and trunk injuries significantly increased. Age (OR, 1.34; 95% CI, 1.23–1.46), outdoor injuries (OR, 2.21; 95% CI, 1.18–4.16), lower limb injuries (OR, 5.35; 95% CI, 2.86–10.00), and wound length greater than 3 cm (OR, 10.65; 95% CI, 5.02–22.60) were significant risk factors for poor wound healing. The risk of poor wound healing increased by 34% for each additional year of age.ConclusionIn children, the common sites of unintentional skin lacerations show distinct age and gender distribution characteristics. Older age, outdoor injuries, longer wound lengths, and lower limb injuries are independent risk factors for poor wound healing.

Active mobility, such as cycling and walking, is assuming a growing significance in the daily lives of urban residents in China due to its positive impact on health and the environment. The impact of the COVID-19 epidemic has elicited significant changes in behaviors, perceptions, and intellectual viewpoints in this domain, potentially altering residents’ physical activities in the long-term. This scoping review seeks to delve into the multi-dimensional influence of the epidemic on active mobility in urban China. A thorough investigation of English and Chinese studies up to January 2024 was conducted, drawing from articles in Web of Science and the Chinese National Knowledge Infrastructure. Only empirical studies providing knowledge into this subject were selected in the review, which comprised 20 studies in total. This review indicates that the influence of COVID-19 on active urban mobility in China has exhibited contradictory outcomes in terms of behavior. Besides, the experiences during the epidemic have significantly shaped citizens’ attitudes and understanding of active mobility. The repercussions of the epidemic and the ensuing restrictions exacerbate the existing challenges faced by women, particularly those who are married, the older adult, and individuals with low incomes. The results exhibit both resemblances and idiosyncrasies when juxtaposed with prior research conducted in different nations. This analysis also offers valuable insights for improving active mobility across individual, organizational, and socio-political realms. The current state of empirical understanding in this field underscores the need for further research endeavors employing diverse methodological approaches and increased emphasis on the transformations anticipated in the post-epidemic era.

Summary: The accumulation of omics and biobank resources allows for a genome-wide understanding of the shared pathologic mechanisms between diseases and for strategies to identify drugs that could be repurposed as novel treatments. Here, we present a computational protocol, implemented as a Snakemake workflow, to identify shared transcriptional processes and screen compounds that could result in mutual benefit. This protocol also includes a description of a pharmacovigilance study designed to validate the effect of compounds using electronic health records.For complete details on the use and execution of this protocol, please refer to Gao et al.1 and Baylis et al.2 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Abstract Keratoconus is a progressive, ectatic and blinding disorder of the cornea, characterized by thinning of corneal stroma. As a highly prevalent among adolescents, keratoconus has been a leading indication for corneal transplantation worldwide. However, the severe shortage of donor corneas is a global issue, and the traditional corneal transplantation surgeries may superinduce multiple complications, necessitating efforts to develop more effective strategies for keratoconus treatment. In this review, we summarized several strategies to promote corneal stromal regeneration or improve corneal stromal thickness, including cell-based therapies, biosynthetic alternatives for inducing corneal regeneration, minimally invasive intrastromal implantation and bioengineered tissues for implantation. These strategies provided more accessible but safer alternatives from various perspectives for keratoconus treatment, paving the way for arresting the keratoconus progression in its earlier stage. For the treatments of corneal ectatic diseases beyond keratoconus, these approaches will provide important references and widen the therapy options in a donor tissue-independent manner.

Abstract Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo visualization of cells bearing mtDNA mutations is important for resolving the complexity of these diseases, which remains challenging. Here we develop an integrated nano Cas12a sensor (InCasor) and show its utility for efficient imaging of mtDNA mutations in live cells and tumor-bearing mouse models. We co-deliver Cas12a/crRNA, fluorophore-quencher reporters and Mg2+ into mitochondria. This process enables the activation of Cas12a’s trans-cleavage by targeting mtDNA, which efficiently cleave reporters to generate fluorescent signals for robustly sensing and reporting single-nucleotide variations (SNVs) in cells. Since engineered crRNA significantly increase Cas12a’s sensitivity to mismatches in mtDNA, we can identify tumor tissue and metastases by visualizing cells with mutant mtDNAs in vivo using InCasor. This CRISPR imaging nanoprobe holds potential for applications in mtDNA mutation-related basic research, diagnostics and gene therapies.

Abstract Cannulated screw fixation is essential in treating femoral neck fractures, and the widely used freehand technique has several limitations. Therefore, we designed a new laser-positioning and navigation system and compared its efficacy with that of the traditional freehand technique in the cannulated screw fixation of femoral neck fractures. This randomized controlled single-blind trial recruited patients with femoral neck fracture, who were treated using either the newly designed laser-navigation device or the freehand technique. In in-vitro experiments, using the femoral neck model, the laser group was better than the freehand group in terms of operation time (P = 0.0153) and radiation exposure time (P

In this study, we investigated whether rutaecarpine could aggravate acetaminophen-induced acute liver damage in vivo and in vitro. CCK-8 and apoptosis assays were performed to verify the cytotoxicity of acetaminophen to L02 cells with or without rutaecarpine. The expression levels of the target proteins and genes were determined using Western blotting and qRT-PCR. The liver pathological changes were evaluated with hematoxylin and eosin staining, while the aspartate aminotransferase (AST) and alanine aminotransferase (AST) levels in plasma were measured to assess the liver damage. Our results revealed that pretreatment of the cell and mice with rutaecarpine significantly aggravated the acetaminophen-induced liver damage. Mechanistically, rutaecarpine induces the CYP1A2 protein, which accelerates the metabolism of acetaminophen to produce a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), leading to severe liver inflammation. Rutaecarpine exacerbated the liver damage by upregulating CYP1A2 and proinflammatory factors. These findings highlight the importance of carefully considering the dosage of rutaecarpine when combined with acetaminophen in drug design and preclinical trials.

This study addresses the challenges in plant pest and disease prediction within the context of smart agriculture, highlighting the need for efficient data processing techniques. In response to the limitations of existing models, which are characterized by slow training speeds and a low prediction accuracy, we introduce an innovative prediction method that integrates gene expression programming (GEP) with support vector machines (SVM). Our approach, the gene expression programming—support vector machine (GEP-SVM) model, begins with encoding and fitness function determination, progressing through cycles of selection, crossover, mutation, and the application of a convergence criterion. This method uniquely employs individual gene values as parameters for SVM, optimizing them through a grid search technique to refine genetic parameters. We tested this model using historical data on wheat blossom midges in Shaanxi Province, spanning from 1933 to 2010, and compared its performance against traditional methods, such as GEP, SVM, naive Bayes, K-nearest neighbor, and BP neural networks. Our findings reveal that the GEP-SVM model achieves a leading back-generation accuracy rate of 90.83%, demonstrating superior generalization and fitting capabilities. These results not only enhance the computational efficiency of pest and disease prediction in agriculture but also provide a scientific foundation for future predictive endeavors, contributing significantly to the optimization of agricultural production strategies.

To better assess the practical value and avoid potential risks of the traditionally medicinal and edible basidiomycete Schizophyllum commune, which may arise from undescribed metabolites, a combination of elicitors was introduced for the first time to discover products from cryptic and low-expressed gene clusters under laboratory cultivation. Treating S. commune NJFU21 with the combination of five elicitors led to the upregulated production of a class of unusual linear diterpene-derived variants, including eleven new ones (1–11), along with three known ones (12–14). The structures and stereochemistry were determined by 1D and 2D NMR, HRESIMS, ECD, OR and VCD calculations. Notably, the elongation terminus of all the diterpenes was decorated by an unusual butenedioic acid moiety. Compound 1 was a rare monocyclic diterpene, while 2–6 possessed a tetrahydrofuran moiety. The truncated metabolites 4, 5 and 13 belong to the trinorditerpenes. All the diterpenes displayed approximately 70% scavenging of hydroxyl radicals at 50 μM and null cytotoxic activity at 10 μM. In addition, compound 1 exhibited potent antifungal activity against the plant pathogenic fungi Colletotrichum camelliae, with MIC values of 8 μg/mL. Our findings indicated that this class of diterpenes could provide valuable protectants for cosmetic ingredients and the lead compounds for agricultural fungicide development.

Abstract Particle migration dynamics in viscoelastic fluids in spiral channels have attracted interest in recent years due to potential applications in the 3D focusing and label-free sorting of particles and cells. Despite a number of recent studies, the underlying mechanism of Dean-coupled elasto-inertial migration in spiral microchannels is not fully understood. In this work, for the first time, we experimentally demonstrate the evolution of particle focusing behavior along a channel downstream length at a high blockage ratio. We found that flow rate, device curvature, and medium viscosity play important roles in particle lateral migration. Our results illustrate the full focusing pattern along the downstream channel length, with side-view imaging yielding observations on the vertical migration of focused streams. Ultimately, we anticipate that these results will offer a useful guide for elasto-inertial microfluidics device design to improve the efficiency of 3D focusing in cell sorting and cytometry applications.

It is not straightforward to physically interpret the apparent morphology of galaxies. Recent observations by the James Webb Space Telescope (JWST) revealed a dominant galaxy population at high redshifts ( z > 2) that were visually classified as disks for their flattened shapes and/or exponential light profiles. The extensively accepted interpretation is that they are dynamically cold disks supported by bulk rotation. However, it is long known that flattened shapes and exponential profiles are not exclusive for rotating disk structure. To break degeneracy and assess the rotational support of typical high- z galaxies in the JWST samples, those with active star formation and stellar masses $\mathrm{lg}({{ \mathcal M }}_{\star }/{{ \mathcal M }}_{\odot })\sim 9$ , we study the kinematics of their equal-mass counterparts at z = 0. While these local star-forming low-mass galaxies are photometrically similar to real dynamically cold disks, they are not supported by ordered rotation but primarily by random motion, and their flattened shapes result largely from tangential orbital anisotropy. Given the empirical and theoretical evidence that young galaxies are dynamically hotter at higher redshifts, our results suggest that the high- z JWST galaxies may not be cold disks but are dynamically warm/hot galaxies with flattened shapes driven by anisotropy. While both have low rotational support, local low-mass galaxies possess oblate shapes, contrasting the prolate shapes (i.e., cigar like) of low-mass systems at high redshifts. Such shape transition (prolate ⇒ oblate) indicates an associated change in orbital anisotropy (radial ⇒ tangential), with roots likely in the assembly of their host dark matter halos.

IntroductionThe parent–child attachment has a significant impact on adolescents’ mental health. However, the influence of psychological quality and coping styles on this connection remains unknown. This study examined the relationship between parent–child attachment and adolescent mental health, by exploring the mediating role of psychological quality and the moderating role of coping styles.MethodsA total of 633 young adolescents participated in this study after signing informed consent. They anonymously completed questionnaires including the Parent and Peer Attachment Scale (Parent Attachment Section), the Coping Styles Inventory for Middle School Students, the Brief Version of the Psychological Quality Inventory for Middle School Students, and the Chinese Middle School Students’Psychological Quality Inventory. After controlling for gender, grade, left-behind category, only-child status, and family structure.ResultsThe moderated mediation model yielded the following findings: (a) parent–child attachment significantly and positively predicted adolescents’mental health; (b) psychological quality partially mediated the relationship between parent–child attachment and adolescents’ mental health; (c) the association between psychological quality and mental health was moderated by task-focused coping.DiscussionThis moderation effect was more substantial for students with low task-focused coping behaviors, which aligns with the “exclusionary hypothesis” model. Therefore, our results indicate that parent–child attachment indirectly impacts mental health, influenced by internal and external factors. These findings carry significant implications for safeguarding and promoting adolescents’ mental well-being.

Abstract Immune rejection and side effects of long‐term administration of immunosuppressants are the two major obstacles to allograft acceptance and tolerance. The immunosuppressive extracellular vesicles (EVs)‐based approach has been proven to be effective in treating autoimmune/inflammatory disorders. Herein, the anti‐rejection advantage of exosomes (Rapa‐Exo) from rapamycin‐conditioned myeloid‐derived suppressor cells (MDSCs) over exosomes (Exo‐Nor) from the untreated MDSCs is shown. The exosomal small RNA sequencing and loss‐of‐function assays reveal that the anti‐rejection effect of Rapa‐Exo functionally relies on miR‐181d‐5p. Through target prediction and double‐luciferase reporter assay, Kruppel‐like factor (KLF) 6 is identified as a direct target of miR‐181d‐5p. Finally, KLF6 knockdown markedly resolves inflammation and prolongs the survival of corneal allografts. Taken together, these findings support that Rapa‐Exo executes an anti‐rejection effect, highlighting the immunosuppressive EVs‐based treatment as a promising approach in organ transplantation.

Antiplatelet therapy is the foundational treatment for the prevention and treatment of coronary and cerebrovascular ischemic events in patients with coronary heart disease, ischemic stroke, and transient ischemic attack (TIA). However, with more and more studies reporting an increased risk of thrombosis in some patients due to poor response to therapeutic agents, the selection of appropriate P2Y12 inhibitors has become a major challenge that needs to be addressed urgently. Currently, commonly used oral P2Y12 inhibitors include clopidogrel, ticagrelor, and prasugrel. Assessing patients' risk factors before the development of treatment regimens by effectively predicting the risk of high platelet reactivity with specific P2Y12 inhibitors in advance to avert the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) is the key point to the problem. Up to now, methods available for predicting platelet reactivity include genetic testing, platelet function testing, and risk scores. This review provides a summarization of the existent available identification methods and analyzes the advantages and drawbacks of different methods in specific clinical settings, intending to guide the rational clinical application of P2Y12 receptor inhibitors.

The goal of person re-identification (ReID) is to recognize the same person across cameras. Classification loss is one of the most widely used objective functions in person ReID tasks based on deep learning. However, the features, which are learned with the classification loss, are not sufficiently discriminative enough when they are close to the origin. In this study, we propose a feature enhancement loss to move features of person images away from the origin. During training, our proposed method adds a regularization item to avoid the feature vector near the origin point. Our method was evaluated on two benchmark person ReID benchmark datasets, Market1501 and DukeMTMC-reID. Results show that the proposed method outperforms the state-of-the-art method by 0.9% and 1.2% on rank-1 accuracy and mean average precision (mAP) index on Market-1501, 1.0% and 1.4% on rank-1 accuracy and mAP index on DukeMTMC-reID. This means that when learning features with a classification loss, making the features far away from the origin point is meaningful.

Abstract Fungal keratitis is challenging to diagnose and treat and remains a significant cause of blindness worldwide. The easiest and most common method of drug delivery for patients with fungal keratitis is eye drop administration. However, the therapeutic effect of traditional eye drops is unsatisfactory, largely due to the intrinsic nature of the ocular barriers, which limit drug absorption; the rapid decrease in the drug concentration caused by tears; and the side effects induced by the uncontrolled release of ocular drugs. Oxidative stress and inflammation are the main causes of corneal tissue necrosis in fungal keratitis, and reducing reactive oxygen species (ROS) and the inflammatory response are important goals in developing drugs for fungal keratitis. In the current study, we developed a ROS-responsive and controllable nanocarrier (GC-EB) that efficiently delivered a clinically used antifungal drug, voriconazole (VOR), to treat fungal keratitis. In vitro and in vivo results demonstrated that the developed GC-EB-VOR exhibited high penetration through corneal barriers, good retention in the cornea and controllable drug release under low concentrations of ROS. As a result, ROS were effectively depleted and the inflammatory response was inhibited; thus, GC-EB-VOR shows promising antifungal efficacy. This work may provide a new strategy for developing nanodrugs to improve the therapeutic effect of eye drop instillation on fungal keratitis and reduce the risk of blindness.

We proposed and verified a scheme of chaos synchronization for integrated five-section semiconductor lasers with matching parameters. The simulation results demonstrated that the integrated five-section semiconductor laser could generate a chaotic signal within a large parameter range of the driving currents of five sections. Subsequently, chaos synchronization between two integrated five-section semiconductor lasers with matched parameters was realized by using a common noise signal as a driver. Moreover, it was found that the synchronization was sensitive to the current mismatch in all five sections, indicating that the driving currents of the five sections could be used as keys of chaotic optical communication. Therefore, this synchronization scheme provides a candidate to increase the dimension of key space and enhances the security of the system.

Accurate and efficient flower identification holds significant importance not only for the general public—who may use this information for educational, recreational, or conservation purposes—but also for professionals in fields such as botany, agriculture, and environmental science, where precise flower recognition can assist in biodiversity assessments, crop management, and ecological monitoring. In this study, we propose a novel flower recognition method utilizing a masked autoencoder, which leverages the power of self-supervised learning to enhance the model’s feature extraction capabilities, resulting in improved classification performance with an accuracy of 99.6% on the Oxford 102 Flowers dataset. Consequently, we have developed a large-scale masked autoencoder pre-training model specifically tailored for flower identification. This approach allows the model to learn robust and discriminative features from a vast amount of unlabeled flower images, thereby enhancing its generalization ability for flower classification tasks. Our method has been applied successfully to flower target detection, achieving a Mean Average Precision (mAP) of 71.3%. This result underscores the versatility and effectiveness of our approach across various flower-related tasks, including both detection and recognition. Simultaneously, we have developed a straightforward, user-friendly flower recognition and classification software application, which offers convenient and reliable references for flower education, teaching, dataset annotation, and other uses.

The two-dimensional distribution method based on the laser spectrum is widely used in the reconstruction of two-dimensional temperature fields or concentration fields. However, the existing methods are all based on small-scale measurements. In large-scale spatial detection of farmland, the detection accuracy cannot reach the expected result due to the long optical path and the noise of various frequencies brought by environmental factors such as vibration, temperature, and other interfering gases. Aiming at the above-mentioned problems, this paper proposes a method to reduce open optical path noise interference in two-dimensional gas detection of farmland to improve detection accuracy. The signal denoising approach combines variational modal decomposition with the SG filtering algorithm to decompose, smooth out, and rebuild the detection signal. In addition, we built a two-dimensional detection system based on an open optical path. Throughout experimental validation, the proposed method outperformed the traditional method by 24% and 19%, respectively, in terms of the fitting degree and fitting effect of the gas absorption curve.

Abstract We derive the ALOS‐2 coseismic interferograms, pixel‐offsets and Sentinel‐2 sub‐pixel offsets of the 2023 Mw7.8 and Mw7.7 Kahramanmaras, Turkey earthquake sequence. Offset maps show that the sequence ruptured ∼300 km along the East Anatolian Fault (EAF) and ∼180 km along the secondary Cardak and Dogansehir faults. We infer the coseismic slip distribution and interseismic fault motion by inverting the co‐ and inter‐seismic observations. Inversion results show that the coseismic slip (∼8.0 m) and interseismic strike‐slip rate (∼4.6 mm/yr) on the main rupture of the Mw7.8 event are basically consistent with the ∼8.4 m and ∼3.9 mm/yr of the Mw7.7 event. Most coseismic slips of the Mw7.8 and Mw7.7 events occur within 10 and 12 km at depth, respectively, in keeping with the interseismic locking depth of 10.4 ± 3.3 km and 11.1 ± 3.1 km. This implies that the coseismic rupture kinematics correlate with the interseismic strain accumulation. Moreover, static stress changes show that the Mw7.7 event is likely promoted by ∼2 bar stress increase from the Mw7.8 event on the central section of its main rupture.

Summary: Cancer and cardiovascular disease (CVD) are the leading causes of death worldwide. Numerous overlapping pathophysiologic mechanisms have been hypothesized to drive the development of both diseases. Further investigation of these common pathways could allow for the identification of mutually detrimental processes and therapeutic targeting to derive mutual benefit. In this study, we intersect transcriptomic datasets correlated with disease severity or patient outcomes for both cancer and atherosclerotic CVD. These analyses confirmed numerous pathways known to underlie both diseases, such as inflammation and hypoxia, but also identified several novel shared pathways. We used these to explore common translational targets by applying the drug prediction software, OCTAD, to identify compounds that simultaneously reverse the gene expression signature for both diseases. These analyses suggest that certain tumor-specific therapeutic approaches may be implemented so that they avoid cardiovascular consequences, and in some cases may even be used to simultaneously target co-prevalent cancer and atherosclerosis.

The direct ink writing (DIW) technology of slurry is a 3D printing technology based on slurry extrusion. It has the advantages of low energy consumption, low cost, fast printing speed and no structural design restrictions. On the basis of summarizing the advantages of the application of DIW technology to ceramic-based diamond tools, key steps in the application process, such as the raw material selection, the slurry preparation, the printing suitability, the degreasing and the sintering process, are discussed and the powder agglomeration problem that needs to be given attention to in the slurry preparation process is pointed out. At the same time, some research examples of DIW manufacturing process are analyzed. Finally, it points out the key problems that should be solved in DIW manufacturing ceramic-based diamond tools.

Abstract The bellows structure in an air spring can be constantly reinforced to cope with the complicated work environment, but it exerts a stronger and stronger effect on the stiffness characteristics of the air spring. However, there is not any effective way for the parameterized solution of the bellows stiffness of the air spring. With the precise transfer matrix method, the bellows stiffness characteristics of a cord-reinforced air spring with winding formation under preload conditions were analyzed in this paper. The thin-shell theory was used to solve the bellows pre-stress of the air spring under preload conditions. The pre-stress was introduced into the equilibrium equation for the bellows. Based on the geometrical and physical equations for the bellows with the complex cord winding characteristics, the precise integration method was borrowed to construct a transfer matrix for the bellows of the air spring under preload conditions. The state vector of the bellows in the air spring was solved through boundary conditions. The iteration method was adopted to develop the expression for the bellows stiffness characteristics, and combined with the theoretical model of pneumatic stiffness to solve the stiffness characteristics of the air spring. The comparison with the prototype test results verified the validity and correctness of the theoretical model. On this basis, we explored the influence of preload conditions, geometrical structure, and material characteristics on the stiffness characteristics of the air spring. The research findings will provide significant guidance for the structural design and material selection of cord-reinforced air springs with winding formation.

Abstract Background: To compare the 6-month changes in aberration and biomechanics after femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for high astigmatism. Methods: In this retrospective case control study, 47 eyes with high astigmatism (≥ 2.5 D, HA group) and 47 eyes with low astigmatism (≤ 1.0 D, LA group) underwent FS-LASIK. Preoperative and follow-up examinations included visual outcomes, higher order aberrations (HOAs) and biomechanics. Biomechanical parameters include a deformation amplitude ratio of 2 mm (DA ratio 2 mm), integrated inverse radius (IIR), stiffness parameter at first applanation (SP-A1), and ambrosio relational thickness through the horizontal meridian (ARTh). Results: Six months postoperatively, there was no significant difference in the efficacy and safety index (both P > 0.05) between the two groups, but the cylinder was higher in the HA group. The HOAs increased significantly after surgery in both groups (all P 0.05). Significant decreases in SP-A1 and ARTh and significant increases in the IIR and DA ratio of 2 mm (all P

Abstract Background To investigate the effects of rigid gas permeable contact lens (RGP-CL) wear on contrast visual acuity in patients after penetrating keratoplasty. Methods Nineteen patients (19 eyes), aged 30.45 ± 5.83 years, who had received penetrating keratoplasty and were successfully fitted with RGP-CLs at our hospital from July 2017 to June 2018 were included. Contrast visual acuities at 100%, 25%, and 10% with spectacles and RGP-CLs were analyzed using the Chi-square test. The wavefront aberrations at the anterior surface of the cornea before and 1 month after RGP-CL wear were compared using the matched sample t-test. Results The mean best spectacle-corrected visual acuities were 0.390 ± 0.135 logMAR, 0.706 ± 0.182 logMAR, and 0.952 ± 0.223 logMAR at the 100%, 25%, and 10% contrast levels, respectively, which were significantly lower than the RGP-CL-corrected visions at the three levels (0.255 ± 0.133 logMAR, 0.488 ± 0.168 logMAR, and 0.737 ± 0.159 logMAR; all P

Corneal neovascularization is a serious corneal pathological change caused by various factors. The drug delivery system is of great significance for the effective treatment of corneal neovascularization. Herein, we developed and characterized a monolith/hydrogel composite as the triamcinolone acetonide (TA) carrier for curing corneal neovascularization. The composite was prepared by photo-initiated free radical polymerization of multi-methacrylate substituted dodecamine organic molecular cage and post-modified by the sequential photo-initiated free radical polymerization of acrylated gelatin. The globular morphology and structural property of as-prepared composites were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy and solid-state cross polarization magic angle spinning carbon-13 nuclear magnetic resonance. Then swelling ratio and the TA loading capacity were investigated then. Compared with gelatin hydrogel, the composites exhibited a decreased swelling ratio and an improved loading capacity. With good biocompatibility, the composite can sustainedly release TA for up to 28 days, and effectively inhibit corneal neovascularization with an alkali burn-induced corneal neovascularization model. Additionally, tandem mass tags-labeled quantitative proteomics were performed to identify differentially expressed proteins between vascularized and devascularized corneas. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that the inhibition process could be primarily linked to the fibrinolytic system. These results demonstrated the potential of monolith/hydrogel composites as delivery systems in the therapy for biomedical diseases.

Abstract Background Intramedullary nail (IMN) is one of the key essential minimally invasive “weapons” in orthopaedic trauma, while the distal locking is still challenging for surgeons. Although there are various inventions and technologies to improve the locking procedure, there are still problems such as inaccurate positioning, excessive radiation exposure, low first success rate and long learning curve. Therefore, a new laser guiding navigation device was designed and compared with the traditional freehand (FH) technique in the distal locking of femoral IMN. Methods This randomized controlled single-blind trial recruited patients with femoral diaphyseal fracture. The self-designed laser navigation device (laser group) and freehand technique (FH group) were used in the distal locking of the IMNs. The patients enrolled were randomized into FH group and laser group, all operations were performed by two surgeons of the same level. The differences between the two groups were compared in terms of radiation exposure time, operative time, first success rate, blood loss, visual analogue score (VAS), Harris score and healing time. Results 32 patients ended the study period and 16 patients in each group. The results showed that the laser group was better than the FH group in terms of distal locking time (10(9/11) vs 19.5 (17.25/21) min, Z = 4.83, P

We realize a tunable narrowband and broadband coexisting absorber based on a simple step-shaped all-metal grating structure. The absorber presents an ultra-narrow absorption band of 1.5 nm and a relatively broad absorption band of 29.8 nm, both with nearly 100% absorption in the infrared region. The mechanism underlying the dual-band perfect absorption is the interaction between two diffraction coupled surface plasmon polariton (SPP) modes with one of them modulated by a cavity resonance. Influences of structure parameters on the absorption performance are numerically investigated. It is found that the positions of the two perfect absorption peaks can be easily tuned both independently and together by changing the structural parameters. In addition, the designed grating structure presents excellent sensing performance with sensitivity and figure of merit as high as 2,514 nm/RIU and 1,600 RIU−1, respectively. The excellent sensing performance, flexible tenability and simple structure design endow this grating absorber with great potential in high-precision biochemical sensing applications.

Myopia has significantly risen in East and Southeast Asia, and the pathological outcomes of this condition, such as myopic maculopathy and optic neuropathy linked to high myopia, have emerged as leading causes of irreversible vision loss. Addressing this issue requires strategies to reduce myopia prevalence and prevent progression to high myopia. Encouraging outdoor activities for schoolchildren and reducing near-work and screen time can effectively prevent myopia development, offering a safe intervention that promotes healthier habits. Several clinical approaches can be employed to decelerate myopia progression, such as administering low-dose atropine eye drops (0.05%), utilizing orthokeratology lenses, implementing soft contact lenses equipped with myopia control features, and incorporating spectacle lenses with aspherical lenslets. When choosing an appropriate strategy, factors such as age, ethnicity, and the rate of myopia progression should be considered. However, some treatments may encounter obstacles such as adverse side effects, high costs, complex procedures, or limited effectiveness. Presently, low-dose atropine (0.05%), soft contact lenses with myopia control features, and orthokeratology lenses appear as promising options for managing myopia. The measures mentioned above are not necessarily mutually exclusive, and researchers are increasingly exploring their combined effects. By advocating for a personalized approach based on individual risk factors and the unique needs of each child, this review aims to contribute to the development of targeted and effective myopia prevention strategies, thereby minimizing the impact of myopia and its related complications among school-aged children in affected regions.

The pathology of depression involves various factors including the interaction between genes and the environment. The deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine. However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain. We observed that CUMS-induced depression-like behaviors were ameliorated by krill oil supplementation in mice. The metabolism of glycerophospholipids and sphingolipids was disrupted by CUMS treatment, which were ameliorated after krill oil supplementation. Further analysis found that differently expressed genes after krill oil supplementation were mainly enriched in the membrane structures and neuroactive ligand–receptor interaction pathway, which may be responsible for the amelioration of CUMS-induced depression-like behaviors. Altogether, our results uncovered the relationship between lipid metabolism and CUMS, and provided new strategies for the prevention and treatment of depression.

We present extensive observations of the Type II supernova (SN II) SN 2023ufx, which is likely the most metal-poor SN II observed to date. It exploded in the outskirts of a low-metallicity ( Z _host ∼ 0.1 Z _⊙ ) dwarf ( M _g = −13.39 ± 0.16 mag, r _proj ∼ 1 kpc) galaxy. The explosion is luminous, peaking at M _g ≈ −18.5 mag, and shows rapid evolution. The r -band (pseudobolometric) light curve has a shock-cooling phase lasting 20 (17) days followed by a 19 (23) day plateau. The entire optically thick phase lasts only ≈55 days following explosion, indicating that the red supergiant progenitor had a thinned H envelope prior to explosion. The early spectra obtained during the shock-cooling phase show no evidence for narrow emission features and limit the preexplosion mass-loss rate to $\dot{M}\lesssim {10}^{-3}$ M _⊙ yr ^−1 . The photospheric-phase spectra are devoid of prominent metal absorption features, indicating a progenitor metallicity of ≲0.1 Z _⊙ . The seminebular (∼60–130 days) spectra reveal weak Fe ii , but other metal species typically observed at these phases (Ti ii , Sc ii , and Ba ii ) are conspicuously absent. The late-phase optical and near-infrared spectra also reveal broad (≈10 ^4 km s ^−1 ) double-peaked H α , P β , and P γ emission profiles suggestive of a fast outflow launched during the explosion. Outflows are typically attributed to rapidly rotating progenitors, which also prefer metal-poor environments. This is only the second SN II with ≲0.1 Z _⊙ and both exhibit peculiar evolution, suggesting a sizable fraction of metal-poor SNe II have distinct properties compared to nearby metal-enriched SNe II. These observations lay the groundwork for modeling the metal-poor SNe II expected in the early Universe.

We perform a thorough analysis of the projected shapes of nearby galaxies in both observations and cosmological simulations. We implement a forward-modeling approach to overcome the limitations in previous studies, which hinder accurate comparisons between observations and simulations. We measure axis ratios of z = 0 (snapshot 99) TNG50 galaxies from their synthetic Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) images and compare them with those obtained from real HSC-SSP images of a matched galaxy sample. Remarkably, the comparison shows excellent agreement between the observations and the TNG50 simulation, challenging previous claims that ΛCDM models underproduced the abundance of thin galaxies. Specifically, for galaxies with stellar masses $10\leqslant \mathrm{log}({M}_{\star }/{M}_{\odot })\leqslant 11.5$ , we find ≲0.1 σ tensions between the observations and the simulation, a stark contrast to the previously reported ≳10 σ tensions. We reveal that low-mass galaxies $({M}_{\star }\lesssim {10}^{9.5}\,{M}_{\odot })$ in TNG50 are thicker than their observed counterparts in HSC-SSP and attribute this to the spurious dynamical heating effects that artificially puff up galaxies. We also find that, despite the overall broad agreement, TNG50 galaxies are more concentrated than the HSC-SSP ones at the low- and high-mass end of the stellar mass range of $9.0\leqslant \mathrm{log}({M}_{\star }/{M}_{\odot })\leqslant 11.2$ and are less concentrated at intermediate stellar masses. But we argue that the higher concentrations of the low-mass TNG50 galaxies are not likely the cause of their thicker/rounder appearances. Our study underscores the critical importance of conducting mock observations of simulations and applying consistent measurement methodologies to facilitate proper comparison with observations.

We present the photometric and spectroscopic evolution of SN 2022oqm, a nearby multipeaked hydrogen- and helium-weak calcium-rich transient (CaRT). SN 2022oqm was detected 13.1 kpc from its host galaxy, the face-on spiral galaxy NGC 5875. Extensive spectroscopic coverage reveals an early hot ( T ≥ 40,000 K) continuum and carbon features observed ∼1 day after discovery, SN Ic-like photospheric-phase spectra, and strong forbidden calcium emission starting 38 days after discovery. SN 2022oqm has a relatively high peak luminosity ( M _B = −17 mag) for CaRTs, making it an outlier in the population. We determine that three power sources are necessary to explain the light curve (LC), with each corresponding to a distinct peak. The first peak is powered by an expanding blackbody with a power-law luminosity, suggesting shock cooling by circumstellar material (CSM). Subsequent LC evolution is powered by a double radioactive decay model, consistent with two sources of photons diffusing through optically thick ejecta. From the LC, we derive an ejecta mass and ^56 Ni mass of ∼0.6 M _⊙ and ∼0.09 M _⊙ . Spectroscopic modeling ∼0.6 M _⊙ of ejecta, and with well-mixed Fe-peak elements throughout. We discuss several physical origins for SN 2022oqm and find either a surprisingly massive white dwarf progenitor or a peculiar stripped envelope model could explain SN 2022oqm. A stripped envelope explosion inside a dense, hydrogen- and helium-poor CSM, akin to SNe Icn, but with a large 56Ni mass and small CSM mass could explain SN 2022oqm. Alternatively, helium detonation on an unexpectedly massive white dwarf could also explain SN 2022oqm.

The nearby type II supernova, SN 2023ixf in M101 exhibits signatures of early time interaction with circumstellar material in the first week postexplosion. This material may be the consequence of prior mass loss suffered by the progenitor, which possibly manifested in the form of a detectable presupernova outburst. We present an analysis of long-baseline preexplosion photometric data in the g , w , r , i , z , and y filters from Pan-STARRS as part of the Young Supernova Experiment, spanning ∼5000 days. We find no significant detections in the Pan-STARRS preexplosion light curves. We train a multilayer perceptron neural network to classify presupernova outbursts. We find no evidence of eruptive presupernova activity to a limiting absolute magnitude of −7 mag. The limiting magnitudes from the full set of gwrizy (average absolute magnitude ≈ −8 mag) data are consistent with previous preexplosion studies. We use deep photometry from the literature to constrain the progenitor of SN 2023ixf, finding that these data are consistent with a dusty red supergiant progenitor with luminosity $\mathrm{log}\left(L/{L}_{\odot }\right)$ ≈ 5.12 and temperature ≈ 3950 K, corresponding to a mass of 14–20 M _⊙ .

We present high-cadence ultraviolet through near-infrared observations of the Type Ia supernova (SN Ia) 2023bee at D = 32 ± 3 Mpc, finding excess flux in the first days after explosion, particularly in our 10 minutes cadence TESS light curve and Swift UV data. Compared to a few other normal SNe Ia with early excess flux, the excess flux in SN 2023bee is redder in the UV and less luminous. We present optical spectra of SN 2023bee, including two spectra during the period where the flux excess is dominant. At this time, the spectra are similar to those of other SNe Ia but with weaker Si ii , C ii, and Ca ii absorption lines, perhaps because the excess flux creates a stronger continuum. We compare the data to several theoretical models on the origin of early excess flux in SNe Ia. Interaction with either the companion star or close-in circumstellar material is expected to produce a faster evolution than observed. Radioactive material in the outer layers of the ejecta, either from double detonation explosion or from a ^56 Ni clump near the surface, cannot fully reproduce the evolution either, likely due to the sensitivity of early UV observable to the treatment of the outer part of ejecta in simulation. We conclude that no current model can adequately explain the full set of observations. We find that a relatively large fraction of nearby, bright SNe Ia with high-cadence observations have some amount of excess flux within a few days of explosion. Considering potential asymmetric emission, the physical cause of this excess flux may be ubiquitous in normal SNe Ia.

The No.4 tailings pond of the Dexing Copper Mine is the second largest in Asia. The tailing pond is a dangerous source of man-made debris flow with high potential energy. In view of the lack of effective and low-cost global safety monitoring means in this region, in this paper, the time-series InSAR technology is innovatively introduced to monitor the deformation of tailings dam and significant key findings are obtained. First, the surface deformation information of the tailings pond and its surrounding areas was extracted by using SBAS-InSAR technology and Sentinel-1A data. Second, the cause of deformation is explored by analyzing the deformation rate, deformation accumulation, and three typical deformation rate profiles of the representative observation points on the dam body. Finally, the power function model is used to predict the typical deformation observation points. The results of this paper indicated that: (1) the surface deformation of the tailings dam can be categorized into two directions: the upper portion of the dam moving away from the satellite along the Line of Sight (LOS) at a rate of −40 mm/yr, whereas the bottom portion approaching the satellite along the LOS at a rate of 8 mm/yr; (2) the deformation of the dam body is mainly affected by the inventory deposits and the construction materials of the dam body; (3) according to the current trend, deformation of two typical observation points in the LOS direction will reach the cumulative deformation of 80 mm and −360 mm respectively. The research results can provide data support for safety management of No.4 tailings dam in the Dexing Copper Mine, and provide a method reference for monitoring other similar tailings dams.