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1. SALIRI‐based (raltitrexed plus irinotecan) therapy as a second‐line treatment for patients with metastatic colorectal cancer (SALLY): A prospective, multicenter, non‐interventional, registry study

Author: Shuqui Qin, Jin Li, Aiping Zhou, Yanqiao Zhang, Xianglin Yuan, Liangjun Zhu, Baoli Qin, Shan Zeng, Lin Shen, Ying Yuan, Weibo Wang, Jun Liang, Xianwen Zhang, Feng Ye, Ping Chen, Huaizhang Wang, Zhenyan Yu, Lu Yue, Yong Fang, Jianping Xiong, Jianwei Yang, Yiye Wan, Xianli Yin, Wenling Wang, Nong Xu, Xiaohong Wang, Zemin Xiao, Huafang Su, Ying Wang, Kangsheng Gu, Shuiping Tu, Zishu Wang, Bo Liu, Xiaohua Hu, Weixian Liu, and Xiaofeng Li
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2024
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2. CircRNA_101491 regulated the radiation sensitivity of esophageal squamous cell carcinomas via sponging miR-125a-5p

Author: Chen Lin, Xianfeng Huang, Yuchen Qian, Jiayi Li, Youdi He, and Huafang Su
Subjects: CircRNA_101491, miR-125a-5p, EMT, ESCC, Radiosensitivity, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background At present, it has been found that many patients have acquired resistance to radiotherapy, which greatly reduces the effect of radiotherapy and further affects the prognosis. CircRNAs is involved in the regulation of radiosensitivity of many kinds of tumor cells. Therefore, the main purpose of this study is to explore the regulatory effect of CircRNA_101491 on radiosensitivity of ESCC and its related mechanism. Methods We established ESCC radiation-resistant cell line (KYSE150R cell) by gradient dose method, and tested the difference of KYSE150 between KYSE150R cell and parent cell in vitro. Then, after knocking down the expression of CircRNA_101491, a series of in vitro experiments were conducted to verify the effects of CircRNA_101491 on the phenotype and radiosensitivity of KYSE150R cells, and further analyzed the related regulatory mechanism. In addition, we also used the model of transplanted tumor in nude mice to investigate the effect of CircRNA_101491 on the radiosensitivity of ESCC in vivo. Results According to a series of in vitro experiments, we confirmed that KYSE150R cells lost the epithelial phenotype and obtained interstitial cell-like phenotype, and found that CircRNA_101491 was highly expressed in KYSE150R cells. In addition, we found that knocking down the expression of CircRNA_101491 will lift the inhibition of miR-125a-5p, and then reverse the process of EMT, accelerate the process of apoptosis, thus play a role in radiosensitization. The in vivo experiment of transplanted tumor in nude mice also showed that knocking down the expression of CircRNA_101491 could enhance the radiosensitivity of ESCC. Conclusion In conclusion, we confirmed that interfering with the expression of CircRNA_101491 can relieve the inhibition of miR-125a-5p, thus reverse the process of interstitial phenotype, accelerate the process of apoptosis, and enhance the radiosensitivity of ESCC.
Published: 2024
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3. Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification

Author: Yi Chen, Didi Chen, Qiang Wang, Yajing Xu, Xiaowei Huang, Felix Haglund, and Huafang Su
Subjects: pancreatic ductal adenocarcinoma (PDAC), immune characteristics, immune subtypes, immune index, immunotherapy, Immunologic diseases. Allergy, RC581-607
Abstract: BackgroundCancer immunotherapy has produced significant positive clinical effects in a variety of tumor types. However, pancreatic ductal adenocarcinoma (PDAC) is widely considered to be a “cold” cancer with poor immunogenicity. Our aim is to determine the detailed immune features of PDAC to seek new treatment strategies.MethodsThe immune cell abundance of PDAC patients was evaluated with the single-sample gene set enrichment analysis (ssGSEA) using 119 immune gene signatures. Based on these data, patients were classified into different immune subtypes (ISs) according to immune gene signatures. We analyzed their response patterns to immunotherapy in the datasets, then established an immune index to reflect the different degrees of immune infiltration through linear discriminant analysis (LDA). Finally, potential prognostic markers associated with the immune index were identified based on weighted correlation network analysis (WGCNA) that was functionally validated in vitro.ResultsThree ISs were identified in PDAC, of which IS3 had the best prognosis across all three cohorts. The different expressions of immune profiles among the three ISs indicated a distinct responsiveness to immunotherapies in PDAC subtypes. By calculating the immune index, we found that the IS3 represented higher immune infiltration, while IS1 represented lower immune infiltration. Among the investigated signatures, we identified ZNF185, FANCG, and CSTF2 as risk factors associated with immune index that could potentially facilitate diagnosis and could be therapeutic target markers in PDAC patients.ConclusionsOur findings identified immunologic subtypes of PDAC with distinct prognostic implications, which allowed us to establish an immune index to represent the immune infiltration in each subtype. These results show the importance of continuing investigation of immunotherapy and will allow clinical workers to personalized treatment more effectively in PDAC patients.
Published: 2022
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4. Identification and Mechanism of the PD-1/PD-L1 Genomic Signature SORL1 as Protective Factor in Bladder Cancer

Author: Yajing Xu, Didi Chen, Lanxiao Shen, Xiaowei Huang, Yi Chen, and Huafang Su
Subjects: SORL1, bladder cancer, PD-L1, M2 macrophage, EMT, TCGA, Genetics, QH426-470
Abstract: Background: Immunotherapy has recently shown remarkable efficacy for advanced bladder cancer patients. Accordingly, identifying a biomarker associated with the programmed cell death protein 1 (PD-1)/its ligand (PD-L1) genomic signature to predict patient prognosis is necessary.Methods: In this study, we used mutation data and RNA-seq data of bladder cancer samples acquired from The Cancer Genome Atlas (TCGA) database to combine PD-1/PD-L1-associated mutational signatures with PD-1/PD-L1-associated differentially expressed genes (DEGs). Then, we performed a Kaplan-Meier analysis on the corresponding clinical data of the TCGA bladder urothelial carcinoma (BLCA) cohort to identify prognostic genes, and the results were validated using the GSE48075 cohort. The online platform UCSC Xena was used to analyze the relationship between the candidate genes and clinical parameters. We utilized the Human Protein Atlas (HPA) database to validate the protein expression levels. Then, correlation analysis, cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) analysis, and gene set enrichment analysis (GSEA) were used to clarify the mechanism.Results: We identified one prognostic gene, sortilin related receptor 1 (SORL1), whose downregulation was associated with a comparatively advanced BLCA stage. While further exploring this finding, we found that SORL1 expression was negatively correlated with PD-1/PD-L1 expression and M2 macrophage levels. Furthermore, we found that the downregulation of SORL1 expression was significantly associated with a higher epithelial-mesenchymal transition (EMT) score.Conclusion: We described a novel PD-1/PD-L1-associated signature, SORL1, that predicts favorable outcomes in bladder cancer. SORL1 might reduce immune suppression and inhibit the M2 macrophage-induced EMT phenotype of tumor cells.
Published: 2021
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5. Therapeutic effect of whole brain radiotherapy on advanced NSCLC between EGFR TKI-naïve and TKI-resistant

Author: Lihao Zhao, Xiaona Cai, Didi Chen, Xuxue Ye, Mengdan Gao, Lihuai Lu, Huafang Su, Meng Su, Meng Hou, and Congying Xie
Subjects: Non-small-cell lung cancer, EGFR-TKI resistance, EGFR TKI-naïve, The treatment sequence, Whole brain radiotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose of this study is to investigate the clinical outcome with or without EGFR-TKI resistance before WBRT and the sequence between EGFT-TKIs and whole brain radiotherapy (WBRT) of EGFR-mutant NSCLC patients who developed multiple brain metastases (BMs). Patients and methods Three hundred forty-four EGFR-mutant NSCLC patients with multiple BMs were reviewed. Enrolled patients were divided into TKI-naïve group and TKI-resistant group. The intracranial progression-free survival (PFS) and overall survival (OS) were analyzed via the Kaplan-Meier method. Results For patients with multiple BMs treated by WBRT, the median intracranial PFS and OS were longer in the TKI-naïve group than those in the TKI-resistant group, but there were no statistically significant between two groups (Intracranial PFS: 7.7 vs. 5.4 months, p = 0.052; OS: 11.2 vs. 9.2 months, p = 0.106). For patients with Lung-molGPA 0–2, no significant differences in median intracranial PFS (6.2 vs. 5.2 months, p = 0.123) and OS (7.8 vs. 6.7 months, p = 0.514) between TKI-naïve and TKI-resistant groups. For patients with Lung-molGPA 2.5–4, intracranial PFS: 12.8 vs. 10.1 months; OS: 23.3 vs. 15.3 months. Conclusions Our study found that there were no difference in intracranial PFS and OS in all patients between the two groups of TKI-naïve and TKI-resistant. But for patients in subgroup of Lung-molGPA 2.5–4, there were a better intracranial PFS and OS in TKI-naïve group.
Published: 2019
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6. Preoperative Nomogram for Differentiation of Histological Subtypes in Ovarian Cancer Based on Computer Tomography Radiomics

Author: Haiyan Zhu, Yao Ai, Jindi Zhang, Ji Zhang, Juebin Jin, Congying Xie, Huafang Su, and Xiance Jin
Subjects: ovarian cancer, epithelial ovarian cancer, non-epithelial ovarian cancer, computed tomography, radiomics, nomogram, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: ObjectivesNon-invasive method to predict the histological subtypes preoperatively is essential for the overall management of ovarian cancer (OC). The feasibility of radiomics in the differentiating of epithelial ovarian cancer (EOC) and non-epithelial ovarian cancer (NEOC) based on computed tomography (CT) images was investigated.MethodsRadiomics features were extracted from preoperative CT for 101 patients with pathologically proven OC. Radiomics signature was built using the least absolute shrinkage and selection operator (LASSO) logistic regression. A nomogram was developed with the combination of radiomics features and clinical factors to differentiate EOC and NEOC.ResultsEight radiomics features were selected to build a radiomics signature with an area under curve (AUC) of 0.781 (95% confidence interval (CI), 0.666 -0.897) in the discrimination between EOC and NEOC. The AUC of the combined model integrating clinical factors and radiomics features was 0.869 (95% CI, 0.783 -0.955). The nomogram demonstrated that the combined model provides a better net benefit to predict histological subtypes compared with radiomics signature and clinical factors alone when the threshold probability is within a range from 0.43 to 0.97.ConclusionsNomogram developed with CT radiomics signature and clinical factors is feasible to predict the histological subtypes preoperative for patients with OC.
Published: 2021
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7. Prognostic Performance of Different Lymph Node Staging Systems in Patients With Small Bowel Neuroendocrine Tumors

Author: Sujing Jiang, Lihao Zhao, Congying Xie, Huafang Su, and Ye Yan
Subjects: small bowel neuroendocrine tumor, the log odds of positive lymph nodes, lymph node ratio, survival analysis, prognosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Background: The prognostic significance of the lymph node (LN) classification for small bowel neuroendocrine tumors (SBNETs) remains unknown. The aim of the present study was to evaluate and compare the prognostic assessment of different LN staging systems.Methods: Patients with SBNETs were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The X-tile program was used to determine the cutoff value of the resected lymph nodes (RLNs), negative lymph nodes (NLNs), lymph node ratio (LNR), and the log odds of positive lymph nodes (LODDS). Survival analyses were performed using Kaplan–Meier curves with log-rank test. Logistic regression analysis was used to evaluate the differences between different periods. Univariate and multivariate Cox proportional hazards models were used to assess the prognostic value of different LN staging systems on cause-specific survival (CSS). The relative discriminative abilities of the different LN staging systems were assessed using the Akaike information criterion (AIC) and the Harrell consistency index (HCI).Result: A total of 3,680 patients were diagnosed with SBNETs between 1988 and 2014 from the SEER database. A significant difference over time (1988–1999 vs. 2000–2014) was seen in age (P
Published: 2020
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8. Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damage

Author: Zhenhua Fei, Wenyue Gu, Raoying Xie, Huafang Su, and Yiyan Jiang
Subjects: Therapeutics. Pharmacology, RM1-950
Abstract: Radiotherapy plays an important therapeutic role in esophageal cancer (EC). However, acquired radioresistance impairs the efficacy of radiotherapy, often leading to treatment failure. Therefore, it is important to develop novel radiosensitizers to enhance the clinical treatment of EC. The purpose of this study was to investigate the role of artesunate (ART) on radiosensitivity of human EC cell line TE-1. We found that ART inhibited the proliferation of EC cells and enhanced the radiosensitivity of TE-1 cells (SER = 1.24). In vivo tumor growth of xenografts was inhibited markedly by irradiation (IR) combined with ART, with a tumor inhibition rate of 53.76% in IR + ART group vs. 41.13% in IR-alone group. Pretreatment with ART significantly prompted cell apoptosis and reversed the IR-induced G2/M arrest. ART treatment could aggravate DNA damage of EC cells and prolong the formation of γ-H2AX foci induced by IR. ART up-regulated P21 and down-regulated the expression of cyclin D1, RAD51, RAD54, Ku70 and Ku86 protein of irradiated TE-1 cells. These findings support that ART induce radiosensitivity of TE-1 cells in vitro and in vivo, and may prove to be a promising radiosensitizer for EC treatment. Keywords: Artesunate (ART), Radiosensitivity, Esophageal cancer, γ-H2AX
Published: 2018
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9. Induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus volumetric modulated arc therapy alone in the treatment of stage II-IVB nasopharyngeal carcinoma patients: a retrospective controlled study

Author: Linger Liu, Zhenghua Fei, Mengfeng Chen, Lihao Zhao, Huafang Su, Dianna Gu, Baochai Lin, Xiaona Cai, Lihuai Lu, Mengdan Gao, Xuxue Ye, Xiance Jin, and Congying Xie
Subjects: Nasopharyngeal carcinoma, Concurrent chemotherapy, Volumetric modulated arc therapy, Toxicity, Survival outcome, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background In the era of intensity-modulated radiotherapy (IMRT), the role of additional concurrent chemotherapy (CC) to radiotherapy (RT) after induction chemotherapy (IC) compared to IC followed by RT alone remains unclear for stage II-IVB nasopharyngeal carcinoma (NPC) patients. The aim of this study was to evaluate the efficacy and toxicities of IC/RT and IC/CCRT in the treatment of NPC with volumetric modulated arc therapy (VMAT). Methods From January 2012 to March 2016, a total of 217 NPC patients were retrospectively assessed. Of the 217 patients, 139 patients received IC followed by VMAT alone and 78 patients received IC plus CCRT. Overall survival (OS), progression-free survival (PFS) and toxicities were assessed. Results The 5-year OS, PFS rates were 57.5%, 41.8% and 47.8%, 38.4% for the IC/RT and IC/CCRT arms, respectively, without significant difference in survival between the two groups (both p > 0.05). Multivariate analysis indicated that treatment modality (IC/RT vs. IC/CCRT) was not an independent prognostic factor for OS or PFS. Grade 3–4 leukopenia/neutropenia (3.60% vs. 20.51%, p
Published: 2018
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10. Treatment outcome comparisons between exons 19 and 21 EGFR mutations for non-small-cell lung cancer patients with malignant pleural effusion after first-line and second-line tyrosine kinase inhibitors

Author: Zhen Zheng, Deyao Xie, Huafang Su, Baochai Lin, Lihao Zhao, Xia Deng, Hanbin Chen, Shaoran Fei, Xiance Jin, and Congying Xie
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Recent studies demonstrated a significantly increased frequency of epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer (NSCLC) patients with malignant pleural effusions (MPEs). The purpose of this study is to investigate the effect of first-line and second-line EGFR-tyrosine kinase inhibitors (TKIs) in the treatment of NSCLC with MPEs harboring exon 19 deletion and L858R mutation. From 2010 to 2015, 203 NSCLC patients with MPEs harboring EGFR mutation treated with EGFR-TKIs were reviewed. The efficacy were evaluated with Pearson chi-square or Fisher’s exact tests, Log-rank test and Cox proportional hazards model. The objective response rate (ORR) and disease control rate (DCR) for patients treated with first-line and second-line EGFR-TKIs were 21.9%, 91.4% and 14.7%, 85.3%, respectively. The overall median PFS and OS of enrolled NSCLC patients with MPE were 9.3 months (95% CI, 8.4–10.2 months), 20.9 months (95% CI, 18.9–22.9 months) after first-line TKIs, and 7.6 months (95% CI, 6.6–8.6 months), 15.3 months (95% CI, 13.6–15.9 months) after second-line TKIs. The exon 19 deletion arm had a longer median PFS (9.4 vs 7.1 months, p=0.003) and OS (16.8 vs 13.8 months, p=0.003) compared with the L858R mutation arm after second-line TKIs. In a conclusion, EGFR genotype was an independent predictor of PFS and OS. No significant side effects differences between the two mutation groups was observed for first or second-line EGFR-TKIs. This study demonstrated that EGFR mutations are significant predictors for advanced NSCLC patients with MPE receiving second-line EGFR-TKIs treatment.
Published: 2017
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11. figure s2 from Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing

Author: Congying Xie, Deyao Xie, Lanxiao Shen, Huanle Pan, Meng Su, Lihao Zhao, Huafang Su, Baochai Lin, Linger Liu, Xiaona Cai, Didi Chen, Shaoran Fei, Hanbin Chen, Yanfan Chen, and Xiance Jin
Abstract: expression pattern of miR-627-5p, miR-128-3p, miR-101-3p, miR-129-5p (A), miR-1246 and miR-155-5p (C) in AC and health controls or miR-150-5p, miR-4459, miR-6873-3p, miR-9-3p (B), miR-149-5p and miR-1246 (D) in SCC and health controls comparison by evaluating threshold cycle number difference (A, B) or calculating 2ÃƒÆ'Ã,Æ'Ãƒâ€šÃ,â¢ÃƒÆ'Ã,â€š-ÃƒÆ'Ã,â€šÃƒâ€šÃ,â³Ct(C, D).
Published: 2023
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12. table s1 from Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing

Author: Congying Xie, Deyao Xie, Lanxiao Shen, Huanle Pan, Meng Su, Lihao Zhao, Huafang Su, Baochai Lin, Linger Liu, Xiaona Cai, Didi Chen, Shaoran Fei, Hanbin Chen, Yanfan Chen, and Xiance Jin
Abstract: The raw miRNA-seq data
Published: 2023
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13. ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway

Author: Yi Chen, Tung-Ying Chen, Yaxuan Liu, Jiwei Gao, Shuijie Li, Wen-Kuan Huang, Chun-Nan Yeh, and Huafang Su
Subjects: Male, Carcinogenesis, Mice, Nude, RAC1, Adenocarcinoma, medicine.disease_cause, Applied Microbiology and Biotechnology, Mice, 03 medical and health sciences, PAK1, Cell Line, Tumor, Pancreatic cancer, medicine, Animals, Humans, RNA, Neoplasm, Molecular Biology, Protein kinase B, Ecology, Evolution, Behavior and Systematics, PI3K/AKT/mTOR pathway, Cell Proliferation, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Gene knockdown, Cell growth, Chemistry, TOR Serine-Threonine Kinases, Cell Cycle, GTPase-Activating Proteins, Neoplasms, Experimental, Cell Biology, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Oncogene Protein v-akt, Pancreatic Neoplasms, Cell Transformation, Neoplastic, Cancer research, Female, Glycolysis, Signal Transduction, Developmental Biology
Abstract: Increasing evidence reveals that the Rho GTPase-activating protein is a crucial negative regulator of Rho family GTPase involved in tumorigenesis. The Rho GTPase-activating protein 25 (ARHGAP25) has been shown to specifically inactivate the Rho family GTPase Rac1, which plays an important role in pancreatic adenocarcinoma (PAAD) progression. Therefore, here we aimed to clarify the expression and functional role of ARHGAP25 in PAAD. The ARHGAP25 expression was lower in PAAD tissues than that in normal pancreatic tissues based on bioinformatics analysis and immunohistochemistry staining. Overexpression of ARHGAP25 inhibited cell growth of AsPC-1 human pancreatic cancer cells in vitro, while opposite results were observed in BxPC-3 human pancreatic cancer cells with ARHGAP25 knockdown. Consistently, in vivo tumorigenicity assays also confirmed that ARHGAP25 overexpression suppressed tumor growth. Mechanically, overexpression of ARHGAP25 inactivated AKT/mTOR signaling pathway by regulating Rac1/PAK1 signaling, which was in line with the results from the Gene set enrichment analysis on The Cancer Genome Atlas dataset. Furthermore, we found that ARHGAP25 reduced HIF-1α-mediated glycolysis in PAAD cells. Treatment with PF-04691502, a dual PI3K/mTOR inhibitor, hampered the increased cell growth and glycolysis due to ARHGAP25 knockdown in PAAD cells. Altogether, these results conclude that ARHGAP25 acts as a tumor suppressor by inhibiting the AKT/mTOR signaling pathway, which might provide a therapeutic target for PAAD.
Published: 2021
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14. miR-18a increases insulin sensitivity by inhibiting PTEN

Author: Chun Chen, Ruoqi Wu, Huafang Su, Yongqiang Zhou, Kejie Li, and Raoying Xie
Subjects: Adult, Male, Genetically modified mouse, PTEN, Aging, medicine.medical_specialty, miR-18a, Phosphatase, T2DM, Down-Regulation, Adipose tissue, Mice, Transgenic, Cell Line, Mice, 3T3-L1 Cells, Internal medicine, Diabetes mellitus, medicine, insulin sensitivity, Animals, Humans, Tensin, Phosphorylation, Muscle, Skeletal, Aged, biology, Chemistry, PTEN Phosphohydrolase, Type 2 Diabetes Mellitus, Skeletal muscle, Cell Biology, Middle Aged, medicine.disease, MicroRNAs, Endocrinology, medicine.anatomical_structure, Adipose Tissue, Diabetes Mellitus, Type 2, Case-Control Studies, biology.protein, Female, Insulin Resistance, Proto-Oncogene Proteins c-akt, Research Paper
Abstract: The miR-17-92 cluster (miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a) contributes to the occurrence and development of various diseases by inhibiting multiple target genes. Here, we explored the effects of miR-18a on insulin sensitivity. Quantitative real-time PCR indicated that serum miR-18a levels were lower in type 2 diabetes mellitus patients than in healthy controls, suggesting that miR-18a may influence blood glucose levels. Global overexpression of miR-18a in transgenic mice increased their glucose tolerance and insulin sensitivity, while it reduced expression of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) in their skeletal muscle and adipose tissue. Western blotting indicated that overexpressing miR-18a in 3T3-L1 and C2C12 cells enhanced insulin-stimulated AKT phosphorylation and suppressed PTEN expression, while inhibiting miR-18a had the opposite effects. These results suggest that miR-18a improves insulin sensitivity by downregulating PTEN. This makes miR-18a a potentially useful target for the treatment of diabetes mellitus in the future.
Published: 2020
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15. Epigenetic-dysregulated lncRNAs in Prostate Cancer Based on Multi-omics Analysis

Author: Yangjing Xu, Xuexiao Xiang, Jianxiao Zheng, Xiaowei Huang, Huafang Su, and Zhipeng Xu
Subjects: Prostate cancer, Text mining, business.industry, medicine, Multi omics, Computational biology, Epigenetics, Biology, business, medicine.disease
Abstract: Background: The purpose of this study was to investigate the relationship between Long non-coding RNAs (lncRNAs) expression and epigenetic changes, and explore the prognostic value of these findings in patients with prostate cancer. Methods: In this study, we systematically compared the histone modification and methylation regions on lncRNAs promoter and enhancer elements by multiomics. We analyzed the distribution characteristics of histone modified apparent lncRNAs promoters and enhancers in the genome. Single sample Gene Set Enrichment Analysis (ssGSEA) and Kyoto Encyclopedia of Gene and Genomes (KEGG) were used to analyze the functional enrichment of epigenetic dysregulated lncRNAs. The prostate cancer associated lncRNAs were downloaded from lnc2cancer V3.0 and survival analysis was performed. Results: We found 1124 epigenetic-dysregulated lncRNAs (epi-lncRNAs) and 9734 epigenetic-dysregulated protein coding genes (epi-PCGs) in prostate cancer, and the abnormal frequency of lncRNAs was much lower than that of PCGs. H3K4me3, H3K4me1, H3K27ac and H3K27me3 abnormally modified histones accounted for a large proportion and were mainly concentrated in the promoter region. Epigenetic abnormal lncRNAs affects the biological specific molecular function of prostate cancer by changing the abnormal modification of histone. The abnormal expression of lncRNAs caused by abnormal modification of H3K36me3 may be an important factor in the occurrence of prostate cancer. Finally, based on lncRNAs analysis of the prognosis of prostate cancer samples, three lncRNAs (HAR1A, SNHG12 and SNHG17) were identified as prognostic markers of prostate cancer.Conclusions: These findings may help to better understand the abnormal epigenetic regulation of lncRNAs expression in prostate cancer.
Published: 2021
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16. Clinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer

Author: Ya Gao, Xiaona Cai, Xuxue Ye, Xiaohua Zhang, Lihao Zhao, Huafang Su, Didi Chen, Qingyu Zhou, Congying Xie, and Meng Su
Subjects: 0301 basic medicine, Oncology, Cervical cancer, Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, Retrospective cohort study, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Refractory, 030220 oncology & carcinogenesis, Internal medicine, Mucositis, medicine, Pharmacology (medical), In patient, Apatinib, business, Adverse effect
Abstract: Purpose Apatinib is effective and safe for several advanced or metastatic cancers, but its therapeutic value in cervical cancer is still unknown. The aim of the study was to assess the therapeutic value of apatinib in patients with chemo-refractory advanced cervical cancer. Patients and methods This was a retrospective study of patients with advanced cervical cancer treated with apatinib between April 2015 and December 2018 at the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Patients had to have failed at least 2 lines of chemotherapy prior to receiving apatinib. The clinical tumor response was evaluated after 4 weeks of apatinib treatment, and then every 8 weeks (two cycles). Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events were evaluated. Results Twenty-five patients were included in this study. The median PFS was 5.8 months (95% CI, 4.65-6.95), and the median OS was 12.2 months (95% CI, 8.99-15.41). ORR was 48% and DCR was 96%. Complete response was not observed. The most common adverse events in this study (all grades) were hand-foot syndrome (48%), hypertension (20%), and mouth mucositis (20%). Conclusion Apatinib monotherapy showed good therapeutic value with tolerable adverse events for patients with chemo-refractory advanced cervical cancer.
Published: 2019
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17. MicroRNA‐1275 induces radiosensitization in oesophageal cancer by regulating epithelial‐to‐mesenchymal transition via Wnt/β‐catenin pathway

Author: Huafang Su, Congying Xie, Shenlan Xiao, Youyi Wu, Zhenghua Fei, and Ya Fang
Subjects: 0301 basic medicine, Male, oesophageal cancer, Wnt/β‐catenin, Epithelial-Mesenchymal Transition, Esophageal Neoplasms, Cell, Mice, Nude, Apoptosis, Wnt1 Protein, Radiation Tolerance, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Movement, Radioresistance, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Radiosensitivity, Epithelial–mesenchymal transition, beta Catenin, Cell Proliferation, Mice, Inbred BALB C, epithelial‐mesenchymal transition, Chemistry, Wnt signaling pathway, Cell Biology, Original Articles, Xenograft Model Antitumor Assays, Hedgehog signaling pathway, radioresistance, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Catenin, embryonic structures, Cancer research, miR‐1275, Molecular Medicine, Original Article, Esophageal Squamous Cell Carcinoma
Abstract: Acquired radioresistance is one of the main obstacles for the anti‐tumour efficacy of radiotherapy in oesophageal cancer (EC). Recent studies have proposed microRNAs (miRNAs) as important participators in the development of radioresistance in various cancers. Here, we investigated the role of miR‐1275 in acquired radioresistance and epithelial‐mesenchymal transition (EMT) in EC. Firstly, a radioresistant cell line KYSE‐150R was established, with an interesting discovery was observed that miR‐1275 was down‐regulated in KYSE‐150R cells compared to the parental cells. Functionally, miR‐1275 inhibition elevated radioresistance in KYSE‐150 cells via promoting EMT, whereas enforced expression of miR‐1275 increased radiosensitivity in KYSE‐150R cells by inhibiting EMT. Mechanically, we demonstrated that miR‐1275 directly targeted WNT1 and therefore inactivated Wnt/β‐catenin signalling pathway in EC cells. Furthermore, WNT1 depletion countervailed the promoting effect of miR‐1275 suppression on KYSE‐150 cell radioresistance through hampering EMT, whereas WNT1 overexpression rescued miR‐1275 up‐regulation‐impaired EMT to reduce the sensitivity of KYSE‐150R cells to radiation. Collectively, our findings suggested that miR‐1275 suppressed EMT to encourage radiosensitivity in EC cells via targeting WNT1‐activated Wnt/β‐catenin signalling, providing a new therapeutic outlet for overcoming radioresistance of patients with EC.
Published: 2019

18. Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling

Author: Huafang Su, Zhenghua Fei, Liting Chen, Tongzhou Hu, and Raoying Xie
Subjects: Male, 0301 basic medicine, Time Factors, Mice, Nude, Apoptosis, Bone Neoplasms, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Glucosides, Downregulation and upregulation, In vivo, Cell Line, Tumor, Stilbenes, medicine, Animals, Humans, Protein kinase B, Cell Proliferation, Pharmacology, Mice, Inbred BALB C, Osteosarcoma, Antibiotics, Antineoplastic, Dose-Response Relationship, Drug, Cell growth, Chemistry, medicine.disease, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Tumor Burden, Gene Expression Regulation, Neoplastic, Blot, 030104 developmental biology, Doxorubicin, Drug Resistance, Neoplasm, Cell culture, 030220 oncology & carcinogenesis, Cancer research, RNA, Long Noncoding, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract: Background Development of doxorubicin-resistance is the main difficulty for osteosarcoma treatment. LncRNA Taurine upregulated gene 1 (TUG1) has been identified as oncogenic lncRNA in different types of carcinomas and was involved in chemoresistance. We aim to evaluate the anti-proliferative effects and the underlying molecular mechanism of Polydatin in doxorubicin-resistant osteosarcoma. Methods Doxorubicin-resistant osteosarcoma cell lines were established. MTT, colony formation, apoptosis assay, qRT-PCR and Western blotting analysis, immunohistochemistry and animal study were carried out. Results It has been showed Polydatin (50–250 μM) inhibited the cell proliferation in a dose- and time-dependent manner at 24 h, 48 h, and 72 h. Polydatin promoted the cell apoptosis significantly with the highest apoptosis rate >50%. Polydatin down-regulated TUG1 expression and TUG1/Akt signaling suppression was involved in Polydatin treated doxorubicin-resistant osteosarcoma cells. The in vivo study further confirmed the anti-cancer effect of Polydatin and related mechanisms. Conclusions Polydatin may be a novel therapeutic agent for doxorubicin-resistant osteosarcoma treatment and TUG1 would be a potential molecular target.
Published: 2019
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19. Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer

Author: Yajing Xu, Lanxiao Shen, Huafang Su, Chan Chen, Yi Chen, and Xiaowei Huang
Subjects: 0301 basic medicine, Epithelial-Mesenchymal Transition, Colorectal cancer, T cell, medicine.medical_treatment, T-Lymphocytes, Bioengineering, TPM1, Applied Microbiology and Biotechnology, survival, 03 medical and health sciences, 0302 clinical medicine, Lymphocytes, Tumor-Infiltrating, Gene expression, medicine, Biomarkers, Tumor, Humans, Gene, business.industry, Proportional hazards model, T-cells, EMT, General Medicine, Immunotherapy, immune checkpoint blockade, medicine.disease, Prognosis, Immune checkpoint, Colon cancer, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Colonic Neoplasms, Cancer research, business, Transcriptome, TP248.13-248.65, Biotechnology, Research Article, Research Paper
Abstract: EMT-related gene expression reportedly exhibits correlation with the anti-tumor immunity of T cells. In the present study, we explored the factors that might affect the efficacy of immunotherapy in colon cancer with treatment. In this regard, RNA-seq and clinical data of 469 colon cancer samples derived from the Cancer Genome Atlas (TCGA) database were used to calculate infiltrating T-cell abundance (ITA), to illustrate a pathway enrichment analysis, and to construct Cox proportional hazards (CPH) regression models. Subsequently, the RNA-seq and clinical data of 177 colon cancer samples derived from the GSE17536 cohort were used to validate the CPH regression models. We found that ITA showed correlation with EMT-related gene expression, and that it was not an independent prognostic factor for colon cancer. However, upon comparison of two groups with the same ITA, higher EMT expression helped predicted a worse prognosis, whereas a higher ITA could help predict a better prognosis upon comparison of two groups with the same EMT. Additionally, seven genes were found to be statistically related to the prognosis of patients with colon cancer. These results suggest that the balance between ITA and EMT-related gene expression is conducive to the prognosis of patients with colon cancer, and TPM1 is necessary to further explore the common target genes of immune checkpoint blockade., Graphical Abstract
Published: 2021

20. Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma

Author: Yi Chen, Huafang Su, Yanhong Su, Yifan Zhang, Yingbo Lin, and Felix Haglund
Subjects: risk model, regulation network, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RNA-binding proteins, prognosis prediction, RC254-282, Article, Ewing sarcoma
Abstract: Simple Summary Ewing sarcoma (ES) is an aggressive childhood tumor for which response to chemotherapy is central to long-term prognosis, but few prognostic markers have been identified. RNA-binding proteins (RBPs) are strong regulators of cell behavior, working, for example, through post-translational modifications of mRNA. In this study, we investigated whether patterns in the RBP levels were related to outcomes in ES patients. A total of three distinct patterns were recognized, and additional modelling suggested that 10 RPBs had predictive value, suggesting that this model could be used in a clinical setting to identify patients with a higher risk of mortality. Abstract RNA-binding proteins (RBPs) are important transcriptomic regulators and may be important in tumorigenesis. Here, we sought to investigate the clinical impact of RBPs for patients with Ewing sarcoma (ES). ES transcriptome signatures were characterized from four previously published cohorts and grouped into new training and validation cohorts. A total of three distinct subtypes were identified and compared for differences in patient prognosis and RBP signatures. Next, univariate Cox and Lasso regression models were used to identify hub prognosis-related RBPs and construct a prognostic risk model, and prediction capacity was assessed through time-dependent receiver operating characteristics (ROCs), Kaplan–Meier curves, and nomograms. Across the three RBP subtypes, 29 significant prognostic-associated RBP genes were identified, of which 10 were used to build and validate an RBP-associated prognostic risk model (RPRM) that had a stable predictive value and could be considered valuable for clinical risk-stratification of ES. A comparison with immunohistochemistry validation showed a significant association between overall survival and NSUN7 immunoreactivity, which was an independent favorable prognostic marker. The association of RBP signatures with ES clinical prognosis provides a strong rationale for further investigation into RBPs molecular mechanisms.
Published: 2021

21. Multiclavula mucida

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340430%5DMICH-F-340430, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340430/MICH-F-340430/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

22. Fistulina hepatica

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340427%5DMICH-F-340427_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340427/MICH-F-340427_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

23. Isaria farinosa

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340372%5DMICH-F-340372_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340372/MICH-F-340372_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

24. Scleroderma floridanum

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340326%5DMICH-F-340326, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340326/MICH-F-340326/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

25. Pluteus romellii

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340373%5DMICH-F-340373, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340373/MICH-F-340373/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

26. Otidea onotica

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340371%5DMICH-F-340371_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340371/MICH-F-340371_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

27. Ionomidotis irregularis

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340429%5DMICH-F-340429_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340429/MICH-F-340429_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

28. Parasola conopilea

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340431%5DMICH-F-340431_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340431/MICH-F-340431_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

29. Helvella latispora

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340428%5DMICH-F-340428, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340428/MICH-F-340428/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

30. Lycoperdon caudatum

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340432%5DMICH-F-340432, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340432/MICH-F-340432/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

31. Inocybe lilacina

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340325%5DMICH-F-340325_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340325/MICH-F-340325_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

32. Hypholoma capnoides

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340426%5DMICH-F-340426_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340426/MICH-F-340426_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

33. Clavaria acuta

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340336%5DMICH-F-340336_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340336/MICH-F-340336_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

34. Leptoporus mollis

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340341%5DMICH-F-340341, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340341/MICH-F-340341/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

35. Stropharia rugosoannulata

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340348%5DMICH-F-340348, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340348/MICH-F-340348/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

36. Leccinum snellii

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340380%5DMICH-F-340380, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340380/MICH-F-340380/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

37. Turbinellus floccosus

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340349%5DMICH-F-340349, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340349/MICH-F-340349/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

38. Fomitopsis mounceae

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340377%5DMICH-F-340377, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340377/MICH-F-340377/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

39. Xylobolus subpileatus

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340422%5DMICH-F-340422_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340422/MICH-F-340422_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

40. Thelephora multipartita

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340340%5DMICH-F-340340_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340340/MICH-F-340340_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

41. Entoloma indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340360%5DMICH-F-340360, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340360/MICH-F-340360/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

42. Lactarius indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340358%5DMICH-F-340358_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340358/MICH-F-340358_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

43. Xanthoporia radiata

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340357%5DMICH-F-340357_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340357/MICH-F-340357_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

44. Agaricus indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340359%5DMICH-F-340359, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340359/MICH-F-340359/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

45. Infundibulicybe gibba

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340378%5DMICH-F-340378, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340378/MICH-F-340378/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

46. Cortinarius indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340309%5DMICH-F-340309_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340309/MICH-F-340309_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

47. Clitocybula lacerata

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340310%5DMICH-F-340310, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340310/MICH-F-340310/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

48. Tricholoma indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340364%5DMICH-F-340364_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340364/MICH-F-340364_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

49. Singerocybe indet

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340314%5DMICH-F-340314_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340314/MICH-F-340314_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

50. Clavulina rugosa

Author: Huafang Su, Huafang Su, Huafang Su, and Huafang Su
Abstract: Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-340365%5DMICH-F-340365, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/340365/MICH-F-340365/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
Published: 2019

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