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The precipitation hotspot of the orographically locked convection highly depends on the interactions among physical processes governing local energetics and cloud dynamics. Accurately estimating the future change of these hotspots will require a model with sufficient spatial resolution as well as an appropriate representation of the critical physical processes. In this study, ensembles of TaiwanVVM large-eddy simulations (Δ x = 500 m) were designed to capture the summertime diurnal convection in Taiwan when local circulation dominates. The precipitation hotspots identified by long-term observations are well represented by the present-day ensemble simulations with appropriate environment variabilities. A pseudo global warming experiment is carried out to identify changes in convective structures, which results in local rainfall changes. Under the scenario of 3 K uniform warming with conserved relative humidity, the changes in the thermodynamic environment feature an overall higher convective available potential energy and a small decrease in convective inhibition (CIN), owing to the marked increase in low-level water vapor in the marine boundary layer. The results show that mean precipitation and the occurrence of extreme convective systems (ECSs) increase, with hotspots over mountains expanding toward the foothills and plains. The response in cloud dynamics leads to more short-duration, intense rainfall events. The tracking of ECSs with maximum rainfall exceeding 100 mm h ^−1 reveals more numerous short-lived ECSs (lifetime

Objectives: Serous effusions are a common manifestation of diffuse large B-cell lymphoma (DLBCL). However, their prognostic significance is controversial. Methods: We searched for consecutive patients who had DLBCL with effusions from 1999 through 2007. Primary effusion lymphoma was excluded. The presence of tumor cells in effusions (malignant effusions) was determined by cytology supplemented by flow cytometry, cell blocks with special studies, polymerase chain reaction for clonality, or conventional cytogenetics. Results: Forty-one (18.4%) patients had effusions, with 24 (58.5%) developing at diagnosis and 17 (41.5%) during tumor course. Nineteen patients (46.0%) had malignant effusions, with six (31.6%) from local extension and 13 (68.4%) through wide dissemination. Interestingly, malignant effusion correlated with a high International Prognostic Index (IPI) score (r = 0.490, P = .002) and high tumor stage (r = 0.342, P = .031) and was a poor prognosticator (P < .001, log-rank test), even worse than stage IV disease (P = .036). In the multivariate analysis, malignant effusion (P = .056) and supportive care (P = .014) retained significance and were more powerful than IPI score and stage. Conclusions: Patients who have DLBCL with lymphomatous effusions have a poor prognosis and should be treated as having stage IV disease. The analysis of effusions for tumor cells would be a useful addition to the routine workup. [ABSTRACT FROM AUTHOR]