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Your search keyword '"Huang, Chao-Sheng"' showing total 21 results
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21 results on '"Huang, Chao-Sheng"'

5. Thermal performance of various cross‐sectioned rectangular minichannels with water‐based phase change nano‐suspensions.

Author

Ho, Ching‐Jenq, Huang, Chao‐Sheng, Yang, Tien‐Fu, Yan, Wei‐Mon, and Qin, Caiyan

Subjects
*PHASE change materials, *LATENT heat of fusion, *HEAT transfer, *REYNOLDS number, *HEAT flux, *MELTING points
Abstract

Summary: A numerical study is performed to investigate the influence of geometrical factors on the performance characteristics of a laminar thermally developing flow of phase change nano‐suspensions in a rectangular minichannel considering axial wall conduction effects. The phase change material dispersed in the pure water is considered N‐eicosane with the onset point of melting of 34.7°C, latent heat of fusion of 243 J/g, and particle size of 200 nm. The volume fractions of the phase change nano‐suspensions are 2% and 10%, and the Reynolds number is in the range of 200 to 1500. To evaluate the influences of geometrical parameters on the cooling performance of the minichannel heat sinks, five minichannels are investigated, with aspect ratios (ration between channel height and width) ARch of 1, 1.25, and 1.5 and bottom wall thicknesses Hbw of 0.5, 1, and 1.5. The results reveal that the axial wall conduction significantly affects the heat transfer process of a flow in a minichannel at a low Reynolds number, and this effect is more remarkable with a shallower channel and a thicker bottom wall. Five performance indicators are used to systematically evaluate the heat transfer characteristics of the minichannels, including dimensionless heat flux at the bottom wall, temperature suppression, heat transfer effective ratio, heat dissipation of the extended wall, and figure of merit. [ABSTRACT FROM AUTHOR]

Published
2020
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21. Effects of the Nootropic Drug Nefiracetam on the GABAAReceptor-channel Complex in Dorsal Root Ganglion Neurons

Author

HUANG, CHAO-SHENG, MA, JENNY YAN, MARSZALEC, W, and NARAHASHI, T

Abstract

The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 μM to lower concentrations by 10 μM nefiracetam while the maximal response was reduced by 22.84 ± 0.68%. Thus at a low concentration (10 μM) of GABA, the chloride currents were potentiated by nefiracetam in a concentration-dependent manner. With 10 μM nefiracetam, the potentiation occurred slowly and the recovery after washout was also slow. The desensitization of the GABAAreceptor at a high concentration (100 μM) of GABA was accelerated by nefiracetam. The recovery process of chloride currents from desensitization was not affected by nefiracetam. KT 5720 (0.56 μM), a specific protein kinase A (PKA) inhibitor, blocked the transient potentiation of GABA-activated currents by nefiracetam, but did not affect the acceleration of desensitization. Nefiracetam suppression of GABA-induced currents was also abolished by KT 5720 or the pertussis toxin. Thus, nefiracetam may inhibit Gi/Goproteins leading to a cascade of events that increase the intracellular cAMP level, activate the PKA system, and suppress GABA-induced currents. Nefiracetam-induced transient potentiation and acceleration of desentization of GABA-induced currents may involve other pathways. The nefiracetam modulation of the GABAAreceptor function will result in a nootropic effect on the central nervous system through modification of synaptic transmission. Copyright © 1996 Elsevier Science Ltd.

Published
1996
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