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8. West Nile Virus Vaccination Protects against Usutu Virus Disease in Mice

Author

Salgado, Rebecca, Hawks, Seth A., Frere, Francesca, Vázquez, Ana, Huang, Claire Y.-H., and Duggal, Nisha K.

Subjects
animal diseases, viruses, virus diseases, nervous system diseases
Abstract

West Nile virus (WNV) and Usutu virus (USUV) are mosquito-borne flaviviruses that can cause neuroinvasive disease in humans. WNV and USUV circulate in both Africa and Europe and are closely related. Due to antigenic similarity, WNV-specific antibodies and USUV-specific antibodies have the potential to bind heterologous viruses; however, it is unclear whether this interaction may offer protection against infection. To investigate how prior WNV exposure would influence USUV infection, we used an attenuated WNV vaccine that contains the surface proteins of WNV in the backbone of a dengue virus 2 vaccine strain and protects against WNV disease. We hypothesized that vaccination with this attenuated WNV vaccine would protect against USUV infection. Neutralizing responses against WNV and USUV were measured in vitro using sera following vaccination. Sera from vaccinated CD-1 and Ifnar1−/− mice cross-neutralized with WNV and USUV. All mice were then subsequently challenged with an African or European USUV strain. In CD-1 mice, there was no difference in USUV titers between vaccinated and mock-vaccinated mice. However, in the Ifnar1−/− model, vaccinated mice had significantly higher survival rates and significantly lower USUV viremia compared to mock-vaccinated mice. Our results indicate that exposure to an attenuated form of WNV protects against severe USUV disease in mice and elicits a neutralizing response to both WNV and USUV. Future studies will investigate the immune mechanisms responsible for the protection against USUV infection induced by WNV vaccination, providing critical insight that will be essential for USUV and WNV vaccine development. Published version

Published
2021

9. Exposures Before Issuance of Stay-at-Home Orders Among Persons with Laboratory-Confirmed COVID-19 — Colorado, March 2020

Author

Marshall, Kristen, Vahey, Grace M., McDonald, Emily, Tate, Jacqueline E., Herlihy, Rachel, Midgley, Claire M., Kawasaki, Breanna, Killerby, Marie E., Alden, Nisha B., Staples, J. Erin, Basile, Alison J., Beck, Alyssa R., Boroughs, Karen L., Burns, Paul L., Buschmeier, Cathy L., Byers, Nathaniel M., Calvert, Amanda E., Chambers, Trudy V., Dennis, David T., Fernandez, Mary Ellen, Ficalora, Katherine T., Fitzpatrick, Kelly A., Fleck-Derderian, Shannon, Foster, Erik S., Goodman, Christin H., Heck, Garrett, Huang, Claire Y-H., Lambert, Amy J., Lehane, Aine, Lehman, Jennifer A., Lindell, Kristine, Lindsey, Nicole P., Maes, Sarah E., Nawrocki, Courtney, Nay, Nancy H., Orloski, Kathleen A., Osikowicz, Lynn, Parise, Christina, Perinet, Lara C., Pilgard, Mark A., Powers, Jordan A., Rizzo, María F., Russell, Brandy J., Semcer, Tracey M., Skinner, Benjamin, and Spillane, Melanie

Subjects
Adult, Male, medicine.medical_specialty, Colorado, Health (social science), Electronic data capture, Coronavirus disease 2019 (COVID-19), Epidemiology, Health, Toxicology and Mutagenesis, Pneumonia, Viral, Population, 01 natural sciences, Proxy (climate), 03 medical and health sciences, 0302 clinical medicine, Health Information Management, medicine, Humans, Full Report, 030212 general & internal medicine, 0101 mathematics, education, Pandemics, Disease surveillance, education.field_of_study, Data collection, business.industry, Public health, 010102 general mathematics, COVID-19, Environmental Exposure, General Medicine, Environmental exposure, Middle Aged, Social Isolation, Family medicine, Female, Public Health, Coronavirus Infections, Laboratories, business
Abstract

On March 26, 2020, Colorado instituted stay-at-home orders to reduce community transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). To inform public health messaging and measures that could be used after reopening, persons with laboratory-confirmed COVID-19 during March 9-26 from nine Colorado counties comprising approximately 80% of the state's population† (Adams, Arapahoe, Boulder, Denver, Douglas, El Paso, Jefferson, Larimer, and Weld) were asked about possible exposures to SARS-CoV-2 before implementation of stay-at-home orders. Among 1,738 persons meeting the inclusion criteria§ in the Colorado Electronic Disease Surveillance System, 600 were randomly selected and interviewed using a standardized questionnaire by telephone. Data collection during April 10-30 included information about demographic characteristics, occupations, and selected activities in the 2 weeks preceding symptom onset. During the period examined, SARS-CoV-2 molecular testing was widely available in Colorado; community transmission was documented before implementation of the stay-at-home order. At least three attempts were made to contact all selected patients or their proxy (for deceased patients, minors, and persons unable to be interviewed [e.g., those with dementia]) on at least 2 separate days, at different times of day. Data were entered into a Research Electronic Data Capture (version 9.5.13; Vanderbilt University) database, and descriptive analyses used R statistical software (version 3.6.3; The R Foundation).

Published
2020

10. The Specificity of the Persistent IgM Neutralizing Antibody Response in Zika Virus Infections among Individuals with Prior Dengue Virus Exposure

Author

Calvert, Amanda E., primary, Horiuchi, Kalanthe, additional, Boroughs, Karen L., additional, Ong, Yee T., additional, Anderson, Kimberly M., additional, Biggerstaff, Brad J., additional, Stone, Mars, additional, Simmons, Graham, additional, Busch, Michael P., additional, and Huang, Claire Y.-H., additional

Published
2021
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15. N-linked glycosylation of the West Nile virus envelope protein is not a requisite for avian virulence or vector competence

Author

Maharaj, Payal D., primary, Langevin, Stanley A., additional, Bolling, Bethany G., additional, Andrade, Christy C., additional, Engle, Xavier A., additional, Ramey, Wanichaya N., additional, Bosco-Lauth, Angela, additional, Bowen, Richard A., additional, Sanders, Todd A., additional, Huang, Claire Y.-H., additional, Reisen, William K., additional, and Brault, Aaron C., additional

Published
2019
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23. Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, phase 1 study

Author

Osorio, Jorge E, primary, Velez, Ivan D, additional, Thomson, Cynthia, additional, Lopez, Liliana, additional, Jimenez, Alejandra, additional, Haller, Aurelia A, additional, Silengo, Shawn, additional, Scott, Jaclyn, additional, Boroughs, Karen L, additional, Stovall, Janae L, additional, Luy, Betty E, additional, Arguello, John, additional, Beatty, Mark E, additional, Santangelo, Joseph, additional, Gordon, Gilad S, additional, Huang, Claire Y-H, additional, and Stinchcomb, Dan T, additional

Published
2014
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24. A Rapid Immunization Strategy with a Live-Attenuated Tetravalent Dengue Vaccine Elicits Protective Neutralizing Antibody Responses in Non-Human Primates

Author

Ambuel, Yuping, primary, Young, Ginger, additional, Brewoo, Joseph N., additional, Paykel, Joanna, additional, Weisgrau, Kim L., additional, Rakasz, Eva G., additional, Haller, Aurelia A., additional, Royals, Michael, additional, Huang, Claire Y.-H., additional, Capuano, Saverio, additional, Stinchcomb, Dan T., additional, Partidos, Charalambos D., additional, and Osorio, Jorge E., additional

Published
2014
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26. Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion

Author

Roehrig, John T., primary, Butrapet, Siritorn, additional, Liss, Nathan M., additional, Bennett, Susan L., additional, Luy, Betty E., additional, Childers, Thomas, additional, Boroughs, Karen L., additional, Stovall, Janae L., additional, Calvert, Amanda E., additional, Blair, Carol D., additional, and Huang, Claire Y.-H., additional

Published
2013
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27. Genetic and Phenotypic Characterization of Manufacturing Seeds for a Tetravalent Dengue Vaccine (DENVax)

Author

Huang, Claire Y.-H., primary, Kinney, Richard M., additional, Livengood, Jill A., additional, Bolling, Bethany, additional, Arguello, John J., additional, Luy, Betty E., additional, Silengo, Shawn J., additional, Boroughs, Karen L., additional, Stovall, Janae L., additional, Kalanidhi, Akundi P., additional, Brault, Aaron C., additional, Osorio, Jorge E., additional, and Stinchcomb, Dan T., additional

Published
2013
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29. Mutational analysis of the West Nile virus NS4B protein

Author

Wicker, Jason A., primary, Whiteman, Melissa C., additional, Beasley, David W.C., additional, Davis, C. Todd, additional, McGee, Charles E., additional, Lee, J. Ching, additional, Higgs, Stephen, additional, Kinney, Richard M., additional, Huang, Claire Y.-H., additional, and Barrett, Alan D.T., additional

Published
2012
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31. Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate

Author

Langevin, Stanley A., primary, Bowen, Richard A., additional, Ramey, Wanichaya N., additional, Sanders, Todd A., additional, Maharaj, Payal D., additional, Fang, Ying, additional, Cornelius, Jennine, additional, Barker, Christopher M., additional, Reisen, William K., additional, Beasley, David W. C., additional, Barrett, Alan D. T., additional, Kinney, Richard M., additional, Huang, Claire Y.-H., additional, and Brault, Aaron C., additional

Published
2011
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39. Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III

Author

Zhang, Shuliu, primary, Bovshik, Evgeniy I., additional, Maillard, Rodrigo, additional, Gromowski, Gregory D., additional, Volk, David E., additional, Schein, Catherine H., additional, Huang, Claire Y.-H., additional, Gorenstein, David G., additional, Lee, James C., additional, Barrett, Alan D.T., additional, and Beasley, David W.C., additional

Published
2010
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41. Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes

Author

Bryant, Juliet E., primary, Calvert, Amanda E., additional, Mesesan, Kyeen, additional, Crabtree, Mary B., additional, Volpe, Katharine E., additional, Silengo, Shawn, additional, Kinney, Richard M., additional, Huang, Claire Y.-H., additional, Miller, Barry R., additional, and Roehrig, John T., additional

Published
2007
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