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High-precision indoor positioning is essential for various applications, such as the Internet of Things, robotics, and smart manufacturing, requiring accuracy better than 1 m. Conventional indoor positioning methods, like Wi-Fi or Bluetooth fingerprinting, typically provide low accuracy within a range of several meters, while techniques such as laser or visual odometry often require fusion with absolute positioning methods. Ultra-wideband (UWB) and Wi-Fi Round-Trip Time (RTT) are emerging radio positioning technologies supported by industry leaders like Apple and Google, respectively, both capable of achieving high-precision indoor positioning. This paper offers a comprehensive survey of UWB and Wi-Fi positioning, beginning with an overview of UWB and Wi-Fi RTT ranging, followed by an explanation of the fundamental principles of UWB and Wi-Fi RTT-based geometric positioning. Additionally, it compares the strengths and limitations of UWB and Wi-Fi RTT technologies and reviews advanced studies that address practical challenges in UWB and Wi-Fi RTT positioning, such as accuracy, reliability, continuity, and base station coordinate calibration issues. These challenges are primarily addressed through a multi-sensor fusion approach that integrates relative and absolute positioning. Finally, this paper highlights future directions for the development of UWB- and Wi-Fi RTT-based indoor positioning technologies. [ABSTRACT FROM AUTHOR]

Kimura's disease (KD) is a chronic inflammatory disease characterized by painless subcutaneous head and neck swelling, eosinophilia, and elevated serum immunoglobulin (Ig) E levels. There are various therapies, including surgery, radiation, systemic steroids, and immune suppressants, but their efficacy remains moderate due to the high recurrence rate. Biologics, like monoclonal antibodies, have shown tremendous effectiveness for chronic inflammatory diseases. Omalizumab is a monoclonal antibody against IgE and has not been approved for KD so far. We describe two refractory KD cases that responded to a small dose of steroids plus omalizumab. Additionally, we reviewed another 13 KD cases that were treated with biologics, including omalizumab, rituximab, dupilumab, and mepolizumab. The results indicate that biologics provide an alternative treatment strategy for KD. [ABSTRACT FROM AUTHOR]

High temperature and humidity affect the tribological performance of nitrile butadiene rubber (NBR) seals, which affects the precise positioning of cylinder systems. Therefore, it is crucial to study the effect of hydrothermal aging on the tribological performance of the NBR seals. In this study, the changes in the tribological performance of the NBR seals under hydrothermal aging conditions were investigated. The results show that the volatilization of additives and the increase in crosslink density of the NBR seals occurs in the hydrothermal aging environment, leading to the deterioration of their surface quality, elastic deformability, and tribological performance. The formation of surface micropores due to additive volatilization is the main factor in the degradation of tribological performance. [ABSTRACT FROM AUTHOR]

The global navigation satellite system (GNSS)-based multi-antenna attitude determination method has the advantages of a simple algorithm and no error accumulation with time in long endurance operation. However, it is sometimes difficult to simultaneous obtain the fixed solutions of all antennas in vehicle attitude determination. If float or incorrect fixed solutions are used, precision and reliability of attitude cannot be guaranteed. Given this fact, a baseline-constrained ambiguity function method (BCAFM) based on a self-built four GNSS antennas hardware platform is proposed. The coordinates obtained by BCAFM can replace the unreliable real-time kinematic (RTK) float or incorrect fixed solutions, so as to assist the direct method for attitude determination. In the proposed BCAFM, the baseline constraint is applied to improve search efficiency (searching time), and the ambiguity function value (AFV) formula is optimized to enhance the discrimination of true peak. The correctness of the proposed method is verified by vehicle attitude determination results and baseline length difference. Experimental results demonstrate that the function values of error peaks are reduced, and the only true peak can be identified accurately. The valid epoch proportion increases by 14.95% after true peak coordinates are used to replace the GNSS-RTK float or incorrect fixed solutions. The precision of the three attitude angles is 0.54°, 1.46°, and 1.15°, respectively. Meanwhile, the RMS of baseline length difference is 3.8 mm. [ABSTRACT FROM AUTHOR]

The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication of advanced scaffolds and the use of newly discovered functional drugs. As the creation of new drugs and their clinical approval often cost a long time and billions of U.S. dollars, producing scaffolds loaded with repositioned conventional drugs whose biosafety has been verified clinically to treat critical-sized bone defect has gained increasing attention. Carfilzomib (CFZ), an approved clinical proteasome inhibitor with a much fewer side effects, is used to replace bortezomib to treat multiple myeloma. It is also reported that CFZ could enhance the activity of alkaline phosphatase and increase the expression of osteogenic transcription factors. With the above consideration, in this study, a porous CFZ/β-tricalcium phosphate/poly lactic-co-glycolic acid scaffold (designated as "cytidine triphosphate [CTP]") was produced through cryogenic three-dimensional (3D) printing. The hierarchically porous CTP scaffolds were mechanically similar to human cancellous bone and can provide a sustained CFZ release. The implantation of CTP scaffolds into critical-sized rabbit radius bone defects improved the growth of new blood vessels and significantly promoted new bone formation. To the best of our knowledge, this is the first work that shows that CFZ-loaded scaffolds could treat nonunion of bone defect by promoting osteogenesis and angiogenesis while inhibiting osteoclastogenesis, through the activation of the Wnt/β-catenin signaling. Our results suggest that the loading of repositioned drugs with effective osteogenesis capability in advanced bone tissue engineering scaffold is a promising way to treat critical-sized defects of a long bone., Competing Interests: The authors have no conflict of interest to declare., (Copyright: © 2021 Li, et al.)