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99 results on '"Huang, Kaisong"'

1. DEX: Scalable Range Indexing on Disaggregated Memory [Extended Version]

Author

Lu, Baotong, Huang, Kaisong, Liang, Chieh-Jan Mike, Wang, Tianzheng, and Lo, Eric

Subjects
Computer Science - Databases, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Memory disaggregation can potentially allow memory-optimized range indexes such as B+-trees to scale beyond one machine while attaining high hardware utilization and low cost. Designing scalable indexes on disaggregated memory, however, is challenging due to rudimentary caching, unprincipled offloading and excessive inconsistency among servers. This paper proposes DEX, a new scalable B+-tree for memory disaggregation. DEX includes a set of techniques to reduce remote accesses, including logical partitioning, lightweight caching and cost-aware offloading. Our evaluation shows that DEX can outperform the state-of-the-art by 1.7--56.3X, and the advantage remains under various setups, such as cache size and skewness., Comment: 16 pages; To appear at VLDB 2024

Published
2024

6. Summary

Author

Huang, Kaisong, Wang, Tianzheng, Huang, Kaisong, and Wang, Tianzheng

Published
2024
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17. Evaluating Persistent Memory Range Indexes: Part Two [Extended Version]

Author

He, Yuliang, Lu, Duo, Huang, Kaisong, and Wang, Tianzheng

Subjects
Computer Science - Databases
Abstract

Scalable persistent memory (PM) has opened up new opportunities for building indexes that operate and persist data directly on the memory bus, potentially enabling instant recovery, low latency and high throughput. When real PM hardware (Intel Optane DCPMM) first became available, previous work evaluated PM indexes proposed in the pre-Optane era. Since then, newer indexes based on real PM have appeared, but it is unclear how they compare to each other and to previous proposals, and what further challenges remain. This paper addresses these issues by analyzing and experimentally evaluating state-of-the-art PM range indexes built for real PM. We find newer designs inherited past techniques with new improvements, but they do not necessarily outperform pre-Optane era proposals. Moreover, PM indexes are often also very competitive or even outperform indexes tailored for DRAM, highlighting the potential of using a unified design for both PM and DRAM. Functionalitywise, these indexes still lack good support for variable-length keys and handling NUMA effect. Based on our findings, we distill new design principles and highlight future directions.

Published
2022

18. Skeena: Efficient and Consistent Cross-Engine Transactions

Author

Zhang, Jianqiu, Huang, Kaisong, Wang, Tianzheng, and Lv, King

Subjects
Computer Science - Databases
Abstract

Database systems are becoming increasingly multi-engine. In particular, a main-memory database engine may coexist with a traditional storage-centric engine in a system to support various applications. It is desirable to allow applications to access data in both engines using cross-engine transactions. But existing systems are either only designed for single-engine accesses, or impose many restrictions by limiting cross-engine transactions to certain isolation levels and table operations. The result is inadequate cross-engine support in terms of correctness, performance and programmability. This paper describes Skeena, a holistic approach to cross-engine transactions. We propose a lightweight snapshot tracking structure and an atomic commit protocol to efficiently ensure correctness and support various isolation levels. Evaluation results show that Skeena maintains high performance for single-engine transactions and enables cross-engine transactions which can improve throughput by up to 30x by judiciously placing tables in different engines., Comment: To appear at SIGMOD 2022

Published
2021
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24. Mycobacterium tuberculosis hijacks host TRIM21-and NCOA4-dependent ferritinophagy to enhance intracellular growth

Author

Dai, Youchao, Zhu, Chuanzhi, Xiao, Wei, Huang, Kaisong, Wang, Xin, Shi, Chenyan, Lin, Dachuan, Zhang, Huihua, Liu, Xiaoqian, Peng, Bin, Gao, Yi, Liu, Cui Hua, Ge, Baoxue, Kaufmann, Stefan H.E., Feng, Carl G., Chen, Xinchun, and Cai, Yi

Subjects
Homeostasis -- Health aspects, Macrophages -- Health aspects, Mycobacterium tuberculosis -- Diagnosis -- Care and treatment, Health care industry
Abstract

Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor coactivator 4 (NCOA4) was recently identified as a cargo receptor in ferritin degradation. Here, we show that Mtb infection enhanced NCOA4-mediated ferritin degradation in macrophages, which in turn increased the bioavailability of iron to intracellular Mtb and therefore promoted bacterial growth. Of clinical relevance, the upregulation of FTH1 in macrophages was associated with tuberculosis (TB) disease progression in humans. Mechanistically, Mtb infection enhanced NCOA4-mediated ferritin degradation through p38/AKT1- and TRIM21-mediated proteasomal degradation of HERC2, an E3 ligase of NCOA4. Finally, we confirmed that NCOA4 deficiency in myeloid cells expedites the clearance of Mtb infection in a murine model. Together, our findings revealed a strategy by which Mtb hijacks host ferritin metabolism for its own intracellular survival. Therefore, this represents a potential target for host-directed therapy against tuberculosis., Introduction A variety of mechanisms have evolved in mammalian cells to control intracellular pathogens. For example, preventing intracellular pathogens from accessing iron, an essential nutrient for both host and pathogen, [...]

Published
2023
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40. Predictive value of a Five-Biomarker Signature to Diagnose Active Pulmonary Tuberculosis Patients

Author

Zeng, Jiang, primary, Yang, Qianting, additional, Xu, Dechang, additional, Chen, Qi, additional, Huang, Kaisong, additional, Cai, Yi, additional, Dai, Youchao, additional, Hai, Xie, additional, Zeng, Zhong, additional, Gong, Xiangwen, additional, Peng, Haiying, additional, Deng, Guofang, additional, Chen, Xinchun, additional, Zhang, Huihua, additional, and Liu, Hui, additional

Published
2021
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45. The SPI-19 encoded type-six secretion-systems (T6SS) of Salmonella enterica serovars Gallinarum and Dublin play different roles during infection

Author

Schroll, Casper, primary, Huang, Kaisong, additional, Ahmed, Shahana, additional, Kristensen, Bodil M., additional, Pors, Susanne Elisabeth, additional, Jelsbak, Lotte, additional, Lemire, Sebastien, additional, Thomsen, Line E., additional, Christensen, Jens Peter, additional, Jensen, Peter R., additional, and Olsen, John E., additional

Published
2019
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50. <italic>Streptococcus suis</italic> 2 Transcriptional Regulator TstS Stimulates Cytokine Production and Bacteremia to Promote Streptococcal Toxic Shock-Like Syndrome.

Author

Xu, Zhongmin, Chen, Bo, Zhang, Qiang, Liu, Liang, Zhang, Anding, Yang, Yujie, Huang, Kaisong, Yan, Shuxian, Yu, Junping, Sun, Xiaomei, and Jin, Meilin

Subjects
STREPTOCOCCUS suis, PATHOGENIC microorganisms, MICROBIAL virulence
Abstract

Two large-scale outbreaks of streptococcal toxic shock-like syndrome (STSLS) have revealed Streptococcus suis 2 to be a severe and evolving human pathogen. We investigated the mechanism by which S. suis 2 causes STSLS. The transcript abundance of the transcriptional regulator gene tstS was found to be upregulated during experimental infection. Compared with the wild-type 05ZY strain, a tstS deletion mutant (ΔtstS) elicited reduced cytokine secretion in macrophages. In a murine infection model, tstS deletion resulted in decreased virulence and bacterial load, and affected cytokine production. Moreover, TstS expression in the P1/7 strain of S. suis led to the induction of STSLS in the infected mice. This is noteworthy because, although it is virulent, the P1/7 strain does not normally induce STSLS. Through a microarray-based comparative transcriptomics analysis, we found that TstS regulates multiple metabolism-related genes and several virulence-related genes associated with immune evasion. [ABSTRACT FROM AUTHOR]

Published
2018
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