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220 results on '"Huang, Lisu"'

6. X-shape Feature Expansion Network for Salient Object Detection in Optical Remote Sensing Images

Author

Huang, Lisu, Sun, Minghui, Liang, Yanhua, Qin, Guihe, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Iliadis, Lazaros, editor, Papaleonidas, Antonios, editor, Angelov, Plamen, editor, and Jayne, Chrisina, editor

Published
2023
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11. Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial

Author

Zhao, Yuanhan, Lin, Ke, Zhang, Haocheng, Yuan, Guanmin, Zhang, Yanliang, Pan, Jingye, Hong, Liang, Huang, Yan, Ye, Ying, Huang, Lisu, Chen, Xiaohua, Liu, Jun, Li, Xiang, He, Xiaoju, Yue, Qiaoyan, Zhang, Hong, Zhou, Aiming, Zhuang, Yangyang, Chen, Jie, Wu, Caixia, Zhou, Wei, Cai, Fujing, Zhang, Shengguo, Li, Liang, Li, Shaling, Bian, Tingting, Li, Jiabin, Yin, Jun, Ruan, Zhengshang, Xu, Shanshan, Zhang, Yan, Chen, Jie, Zhang, Ying, Han, Jun, Su, Tingting, Tu, Fan, Jiang, Lijing, Lei, Chen, Du, Qiu, Ai, Jingwen, and Zhang, Wenhong

Published
2022
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12. Prognostic value of poly-microorganisms detected by droplet digital PCR and pathogen load kinetics in sepsis patients: a multi-center prospective cohort study

Author

Zhao, Yuanhan, primary, Lin, Ke, additional, Zhang, Haocheng, additional, Zhang, Yanliang, additional, Li, Shaling, additional, Zhang, Shengguo, additional, Zhang, Wei, additional, Zhou, Aiming, additional, Zhuang, Yangyang, additional, Chen, Jie, additional, Wu, Caixia, additional, Zhou, Wei, additional, He, Xiaoju, additional, Yue, Qiaoyan, additional, Zhang, Meng, additional, Huang, Yan, additional, Li, Liang, additional, Hong, Liang, additional, Cai, Fujing, additional, Huang, Lisu, additional, Ruan, Zhengshang, additional, Xu, Shanshan, additional, Zhang, Yan, additional, Chen, Xiaohua, additional, Ye, Ying, additional, Bian, Tingting, additional, Li, Jiabin, additional, Yin, Jun, additional, Li, Xiang, additional, Jiang, Lijing, additional, Lei, Chen, additional, Liu, Jun, additional, Zhang, Ying, additional, Jin, Jialin, additional, Ai, Jingwen, additional, Pan, Jingye, additional, and Zhang, Wenhong, additional

Published
2024
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14. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Author

Guo, Yu, Huang, Lisu, Zhang, Guangshun, Yao, Yanfeng, Zhou, He, Shen, Shu, Shen, Bingqing, Li, Bo, Li, Xin, Zhang, Qian, Chen, Mingjie, Chen, Da, Wu, Jia, Fu, Dan, Zeng, Xinxin, Feng, Mingfang, Pi, Chunjiang, Wang, Yuan, Zhou, Xingdong, Lu, Minmin, Li, Yarong, Fang, Yaohui, Lu, Yun-Yueh, Hu, Xue, Wang, Shanshan, Zhang, Wanju, Gao, Ge, Adrian, Francisco, Wang, Qisheng, Yu, Feng, Peng, Yun, Gabibov, Alexander G., Min, Juan, Wang, Yuhui, Huang, Heyu, Stepanov, Alexey, Zhang, Wei, Cai, Yan, Liu, Junwei, Yuan, Zhiming, Zhang, Chen, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Shan, Chao, Schweizer, Liang, Sun, Kun, and Rao, Zihe

Published
2021
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15. A Multicenter Epidemiological and Pathogenic Characteristics Study of Community-Acquired Bacterial Meningitis Children in China: Results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019–2020

Author

Wang, Caiyun, primary, Xu, Hongmei, additional, Liu, Gang, additional, Liu, Jing, additional, Yu, Hui, additional, Chen, Biquan, additional, Zheng, Guo, additional, Shu, Min, additional, Du, Lijun, additional, Xu, Zhiwei, additional, Huang, Lisu, additional, Li, Haibo, additional, Shu, Sainan, additional, and Chen, Yinghu, additional

Published
2023
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24. Heparin-Binding Protein: A Prognostic Biomarker Associated with Severe or Complicated Community-Acquired Pneumonia in Children

Author

Li,Shuang, Xu,Yanwen, Wu,Yuhang, Huang,Heyu, Sun,Chen, Xu,Shanshan, Li,Huajun, Zhang,Xi, Zhao,Shiyong, Huang,Lisu, Li,Shuang, Xu,Yanwen, Wu,Yuhang, Huang,Heyu, Sun,Chen, Xu,Shanshan, Li,Huajun, Zhang,Xi, Zhao,Shiyong, and Huang,Lisu

Abstract

Shuang Li,1,2,* Yanwen Xu,2,* Yuhang Wu,2,* Heyu Huang,2 Chen Sun,2 Shanshan Xu,2 Huajun Li,2 Xi Zhang,3 Shiyong Zhao,4 Lisu Huang1,2 1Department of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Infectious Diseases, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Clinical Research Unit, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Department of Infectious Diseases, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lisu Huang, Department of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Hangzhou, Zhejiang Province, 310052, People’s Republic of China, Email lisuhuang@zju.edu.cn Shiyong Zhao, Department of Infectious Diseases, Hangzhou Children’s Hospital, 195 Wenhui Road, Hangzhou, Zhejiang Provinve, 310005, People’s Republic of China, Email jhzsyhj@163.comPurpose: Heparin-binding protein (HBP) is a novel biomarker for inflammatory diseases. This study aimed to investigate the role of serum HBP in community-acquired pneumonia (CAP) in children and the association of HBP with the severity and prognosis.Patients and Methods: A total of 125 children with CAP admitted to the hospital were enrolled in this retrospective study. We analyzed the differences in clinical characteristics and examination findings between patients with different levels of HBP. The severe or complicated CAP was defined as having severe radiographic findings and/or systemic manifestations. Receiver operator characteristic (ROC) curves detected the performance of biomarkers in identif

Published
2023

25. A Multicenter Epidemiological and Pathogenic Characteristics Study of Community-Acquired Bacterial Meningitis Children in China: Results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019–2020

Author

Wang,Caiyun, Xu,Hongmei, Liu,Gang, Liu,Jing, Yu,Hui, Chen,Biquan, Zheng,Guo, Shu,Min, Du,Lijun, Xu,Zhiwei, Huang,Lisu, Li,Haibo, Shu,Sainan, Chen,Yinghu, Wang,Caiyun, Xu,Hongmei, Liu,Gang, Liu,Jing, Yu,Hui, Chen,Biquan, Zheng,Guo, Shu,Min, Du,Lijun, Xu,Zhiwei, Huang,Lisu, Li,Haibo, Shu,Sainan, and Chen,Yinghu

Abstract

Caiyun Wang,1 Hongmei Xu,2 Gang Liu,3,4 Jing Liu,5 Hui Yu,6 Biquan Chen,7 Guo Zheng,8 Min Shu,9 Lijun Du,10 Zhiwei Xu,11 Lisu Huang,1,12 Haibo Li,13 Sainan Shu,14 Yinghu Chen,1 Corporate Authors of Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) Study Group:Dong Wang, Huiling Deng, Songting Bai, Qingwen Shan, Chunhui Zhu, Jianmei Tian, Jianhua Hao, Aiwei Lin, Daojiong Lin, Jinzhun Wu, Xinhua Zhang, Qing Cao, Zhongbin Tao, Yuan Chen, Guolong Zhu, Ping Xue, Zhengzhen Tang, Xuewen Su, Zhenghai Qu, Shiyong Zhao, Lin Pang On behalf of The CPBMS Study Group1Department of Infectious Disease, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Infectious Disease, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China; 4Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 5Department of Infectious Disease, Hunan Children’s Hospital, Changsha, Hunan, People’s Republic of China; 6Department of Infectious Disease, The Children’s Hospital of Fudan University, Shanghai, People’s Republic of China; 7Department of Infection, Anhui Province Children’s Hospital, Hefei, Anhui, People’s Republic of China; 8Department of Neurology, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 9Department of Pediatrics, West China Second University Hospital, Sichuan University/ West China Women’s and Children’s Hospital, Chengdu, Sichuang, People’s Republic of China; 10Department of Neurology, Child

Published
2023

31. Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China

Author

Zheng, Hang, Zeng, Xinxin, Xie, Qiuling, Wu, Yuhang, Liu, Quanhua, Chen, Qian, Huang, Lisu, and Zhang, Weixi

Subjects
China, Public Health, Environmental and Occupational Health, Infant, Allergens, Asthma, Dermatitis, Atopic, Anti-Bacterial Agents, Pregnancy, Child, Preschool, Humans, Female, Prospective Studies, Food Hypersensitivity, Biological Monitoring
Abstract

BackgroundGlobally, the prevalence of allergic diseases remains high, as does the level of environmental antibiotics. It has been found that clinical antibiotic application may increase preschool allergy risk. However, few biomonitoring studies have been conducted about the association between early life environmental trace dose antibiotic exposure and preschool allergy.ObjectiveTo analyze the association between prenatal environmental antibiotic levels and allergic diseases using logistic regression models.MethodsA total of 743 pregnant women and their offspring from the Shanghai Allergy Birth Cohort completed five years follow-up, and 251 mother-infant pairs were finally included. Maternal urine samples were collected for 15 antibiotic quantitative measurements using liquid chromatography-tandem mass spectrometry. The high-antibiotic group was defined as having at least half of antibiotics exceeding the median concentration. Allergic diseases were assessed by clinicians through clinical history, standardized questionnaires, and annual physical examinations until the age of five. Skin-prick-test (SPT) was performed at 5 years old.ResultsThe incidence of allergic diseases was generally higher in the high-antibiotic than that in the low-antibiotic group. Compared to the low-comprehensive antibiotic group, children in the high-antibiotic group were weakly associated with allergic diseases but had a 6-fold increased risk of food allergens sensitivity (OR: 7.09, 95% CI: 1.59, 31.74). Association of above-median single prenatal antibiotic concentration exposure and allergic diseases was also observed (azithromycin and asthma, OR: 2.72, 95% CI: 1.15, 6.42; enrofloxacin and wheeze, OR: 2.22, 95% CI: 1.22, 4.05; trimethoprim and atopic dermatitis, OR: 2.00, 95% CI: 1.08, 3.71). Moreover, children with higher prenatal norfloxacin levels were more sensitive to food allergens (OR: 5.52, 95%CI: 1.54, 19.71).ConclusionEarly-life environmental antibiotic exposure may be correlated with an increased risk of asthma, wheeze, atopic dermatitis, and SPT positivity for food allergens in 5-year-old children.

Published
2022

48. Association between high-birth-weight and dental caries in 4–5-year-old children

Author

Wang, Huning, Zhang, Hao, Zeng, Xiaoli, Yu, Jin, Jiang, Yiwei, Huang, Lisu, Zeng, Xinxin, Chen, Qian, Da, Dongxin, and Zhang, Ying

Abstract

The worldwide issue of early childhood caries has grown significantly over time. Numerous researches have explored the link between low birth weight and early childhood caries, however, studies concentrating on high birth weight are comparatively few. The purpose of this study is to evaluate the effect of high birth weight on the occurrence and intensity of dental caries in children aged 4–5 years.

Published
2024
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49. Additional file 1 of A risk score based on pediatric sequential organ failure assessment predicts 90-day mortality in children with Klebsiella pneumoniae bloodstream infection

Author

Li, Shuang, Jingxian Liu, Chen, Feng, Cai, Kang, Jintong Tan, Xie, Wei, Qian, Rong, Xiaoqin Liu, Wenhong Zhang, Huimin Du, Liu, Ying, and Huang, Lisu

Abstract

Additional file 1: Table S1. Antimicrobial therapy and 90-day mortality in 71 patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae. In patients with CR-Kp bloodstream infection, there was no significant association between the types of definitive antimicrobial therapy and mortality according to Cox proportional hazards model. Table S2. Predictive performance of the single predictors and the combined models for predicting 90-day mortality. The SOFA score achieved the best predictive performance among single predictors. Any combination of SOFA with risk factors (prior hospitalization, intra-abdominal source of infection, levels C-reactive protein, and albumin) improved the predictive performance. Table S3. The added prognostic value of the predictive models as determined by the integrated discrimination improvement index. The combinations of other predictors had no additional prognostic value over the final model: SOFA + prior hospitalization + intra-abdominal source of infection. Figure S1. Receiver operating characteristic curves of the original SOFA score and the Kp-specific SOFA score for predicting 30-day mortality. Figure S2. Thirty-day survival probabilities at three risk categories (score ≤ 8, 9–11 and ≥ 12) after the onset of Klebsiella pneumoniae bloodstream infection in children estimated by the Kaplan-Meier analysis (log-rank test, P

Published
2020
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