Search

Your search keyword '"Huang, Qiutong"' showing total 23 results
Start Over Author "Huang, Qiutong"
23 results on '"Huang, Qiutong"'

3. Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Author

Jacquelot, Nicolas, Seillet, Cyril, Wang, Minyu, Pizzolla, Angela, Liao, Yang, Hediyeh-zadeh, Soroor, Grisaru-Tal, Sharon, Louis, Cynthia, Huang, Qiutong, Schreuder, Jaring, Souza-Fonseca-Guimaraes, Fernando, de Graaf, Carolyn A., Thia, Kevin, Macdonald, Sean, Camilleri, Mary, Luong, Kylie, Zhang, Shengbo, Chopin, Michael, Molden-Hauer, Tristan, Nutt, Stephen L., Umansky, Viktor, Ciric, Bogoljub, Groom, Joanna R., Foster, Paul S., Hansbro, Philip M., McKenzie, Andrew N. J., Gray, Daniel H. D., Behren, Andreas, Cebon, Jonathan, Vivier, Eric, Wicks, Ian P., Trapani, Joseph A., Munitz, Ariel, Davis, Melissa J., Shi, Wei, Neeson, Paul J., and Belz, Gabrielle T.

Published
2021
Full Text
View/download PDF

4. GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs.

Author

Huang, Qiutong, H. J. Cao, Wang, Curio, Sophie, Yu, Huiyang, Denman, Renae, Chen, Evelyn, Schreuder, Jaring, Dight, James, Chaudhry, Zeeshan, Jacquelot, Nicolas, Wimmer, Verena C., Seillet, Cyril, Möröy, Tarik, and Belz, Gabrielle T.

Subjects
INNATE lymphoid cells, LUNGS, PROGENITOR cells, LUNG development, BONE marrow
Abstract

Tissue-resident innate lymphoid cells (ILCs) play a vital role in the frontline defense of various tissues, including the lung. The development of type 2 ILCs (ILC2s) depends on transcription factors such as GATA3, RORα, GFI1, and Bcl11b; however, the factors regulating lung-resident ILC2s remain unclear. Through fate mapping analysis of the paralog transcription factors GFI1 and GFI1B, we show that GFI1 is consistently expressed during the transition from progenitor to mature ILC2s. In contrast, GFI1B expression is limited to specific subsets of bone marrow progenitors and lung-resident ILC progenitors. We found that GFI1B+ lung ILC progenitors represent a multi-lineage subset with tissue-resident characteristics and the potential to form lung-derived ILC subsets and liver-resident ILC1s. Loss of GFI1B in bone marrow progenitors led to the selective loss of lung-resident IL-18R+ ILCs and mature ILC2, subsequently preventing the emergence of effector ILCs that could protect the lung against inflammatory or tumor challenge. Editor's summary: Most innate lymphoid cells (ILCs) develop from lineage-restricted ILC progenitors in the bone marrow, but certain tissues such as the lungs are believed to harbor local ILC progenitor populations. How these local ILC progenitor pools are maintained remains unclear. Using dual reporter mice, Huang et al. mapped expression of the paralog transcription factors GFI1 and GFI1B in ILCs and their progenitors. GFI1B expression alone identified bone marrow and lung ILC progenitors that retained potential to differentiate into multiple ILC lineages. Loss of GFI1B-dependent ILCs impaired type 2 ILC development in the lungs, leading to reduced papain-induced inflammation but impaired protection against establishment of lung tumors. Together, these findings identify GFI1B expression as hallmark of lung-resident ILCs that retain multilineage developmental potential. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers.

Author

Seo, Hobin, Verma, Amisha, Kinzel, Megan, Huang, Qiutong, Mahoney, Douglas J., and Jacquelot, Nicolas

Subjects
INNATE lymphoid cells, TUMOR-infiltrating immune cells, PROGRAMMED cell death 1 receptors, IMMUNE response, IMMUNE checkpoint proteins, T cells
Abstract

Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma. While initially thought to solely strengthen adaptive T lymphocyte anti-tumor activity, recent investigations suggest that other immune cell subsets, particularly tissue-resident innate lymphoid cells (ILCs), may benefit from immunotherapy treatment. Here, we describe the recent findings showing immune checkpoint expression on tissue-resident and tumor-infiltrating ILCs and how their effector function is modulated by checkpoint blockade-based therapies in cancer. We discuss the therapeutic potential of ILCs beyond the classical PD-1 and CTLA-4 regulatory molecules, exploring other possibilities to manipulate ILC effector function to further impede tumor growth and quench disease progression. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

9. Transcriptional regulation of ILC development and function

Author

Huang, Qiutong and Huang, Qiutong

Abstract

Innate lymphoid cells (ILCs) are a specialized arm of the innate immune system responsible for protecting the mucosal barrier and defending against infection. ILC activation and cytokine production occurs in response to stimuli in the local environment making them an important initiators of the early immune response. However, they also contribute to inflammatory diseases and thus must be tightly regulated. The development and function of ILCs is dependent on the tight regulation of transcription factors. Two transcription factors GFI1 and GFI1B are involved in this differentiation but have been poorly studied and thus how they shape differentiation is not clear. GFI1 and GFI1B was differentially expressed throughout ILC development. GFI1B expression was limited to the early progenitors whereas GFI1 was expressed in both early progenitors and in all mature ILC subsets in the peripheral organs. GFI1B expression identified the early progenitors in the bone marrow with the capacity to give rise to all ILC subsets. GFI1B expression is also required for the development of progenitors in the bone marrow and lung ILC2. This impacted the lung inflammatory response induced in mice treated with papain as the eosinophil recruitment by ILC2s was impaired. In contrast, GFI1 was highly expressed in mature NK cells and was vital for development and maintenance of these cells. GFI1 regulated multiple NK cell pathways, including proliferation, homing to peripheral organs and effector functions. Defects in these functions impaired the protection mediated by NK cells against metastatic melanoma cells. Together, GFI1 and GFI1B are both key regulators of ILC development, although they regulate different stages of ILC development and function. ILCs are enriched at the mucosal barrier, particularly at the gastrointestinal tract. They play an important role in protecting against infections but also have the capacity to promote inflammation when dysregulated. Their role in the development of

Published
2021

10. Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival

Author

Huang, Qiutong, primary, Jacquelot, Nicolas, additional, Preaudet, Adele, additional, Hediyeh-zadeh, Soroor, additional, Souza-Fonseca-Guimaraes, Fernando, additional, McKenzie, Andrew N. J., additional, Hansbro, Philip M., additional, Davis, Melissa J., additional, Mielke, Lisa A., additional, Putoczki, Tracy L., additional, and Belz, Gabrielle T., additional

Published
2021
Full Text
View/download PDF

13. TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis

Author

Mielke, Lisa A., primary, Liao, Yang, additional, Clemens, Ella Bridie, additional, Firth, Matthew A., additional, Duckworth, Brigette, additional, Huang, Qiutong, additional, Almeida, Francisca F., additional, Chopin, Michael, additional, Koay, Hui-Fern, additional, Bell, Carolyn A., additional, Hediyeh-Zadeh, Soroor, additional, Park, Simone L., additional, Raghu, Dinesh, additional, Choi, Jarny, additional, Putoczki, Tracy L., additional, Hodgkin, Philip D., additional, Franks, Ashley E., additional, Mackay, Laura K., additional, Godfrey, Dale I., additional, Davis, Melissa J., additional, Xue, Hai-Hui, additional, Bryant, Vanessa L., additional, Kedzierska, Katherine, additional, Shi, Wei, additional, and Belz, Gabrielle T., additional

Published
2019
Full Text
View/download PDF

14. T cell factor-1 is a Critical Factor in Determining Natural Killer and Group 1 Innate Lymphoid Cell Fate Decisions

Author

Mielke, Lisa A., Huang, Qiutong, Firth, Matthew A., Almeida, Francisca F., Abdulla, Hesham, Rautela, Jai, Pang, Swee Heng Milon, Abeysekera, Waruni, Xue, Hai-Hui, Huntington, Nicholas D., Smyth, Gordon K., Garnham, Alexandra L., Mccormack, Matthew P., Eric Vivier, Seillet, Cyril, Belz, Gabrielle Belz T., Dou Goarin, Carine, The Walter & Eliza Hall Institute of Medical Research, University of Melbourne, Iowa State University (ISU), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, health care facilities, manpower, and services, education, [SDV.IMM]Life Sciences [q-bio]/Immunology, health care economics and organizations
Abstract

5th Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Int Cytokine & Interferon Soc, Kanazawa, JAPAN, OCT 29-NOV 02, 2017; International audience

Published
2017

20. Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

Author

Shields, Benjamin J., primary, Jackson, Jacob T., additional, Metcalf, Donald, additional, Shi, Wei, additional, Huang, Qiutong, additional, Garnham, Alexandra L., additional, Glaser, Stefan P., additional, Beck, Dominik, additional, Pimanda, John E., additional, Bogue, Clifford W., additional, Smyth, Gordon K., additional, Alexander, Warren S., additional, and McCormack, Matthew P., additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results