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137 results on '"Huang, Shi-Ting"'

15. Substrate Characterization for Hydrolysis of Multiple Types of Aromatic Esters by Promiscuous Aminopeptidases

Author

Ning, Hang, Liu, Wen-long, Li, Qing-yun, Liu, You-yan, Huang, Shi-ting, Liu, Hai-bo, and Tang, Ai-xing

Abstract

Synthetic aromatic esters, widely employed in agriculture, food, and chemical industries, have become emerging environmental pollutants due to their strong hydrophobicity and poor bioavailability. This study attempted to address this issue by extracellularly expressing the promiscuous aminopeptidase (Aps) from Pseudomonas aeruginosaGF31 in B. subtilis, achieving an impressive enzyme activity of 13.7 U/mg. Notably, we have demonstrated, for the first time, the Aps-mediated degradation of diverse aromatic esters, including but not limited to pyrethroids, phthalates, and parabens. A biochemical characterization of Aps reveals its esterase properties and a broader spectrum of substrate profiles. The degradation rates of p-nitrobenzene esters (p-NB) with different side chain structures vary under the action of Aps, showing a preference for substrates with relatively longer alkyl side chains. The structure-dependent degradability aligns well with the binding energies between Aps and p-NB. Molecular docking and enzyme–substrate interaction elucidate that hydrogen bonding, hydrophobic interactions, and π–π stacking collectively stabilize the enzyme–substrate conformation, promoting substrate hydrolysis. These findings provide new insights into the enzymatic degradation of aromatic ester pollutants, laying a foundation for the further development and modification of promiscuous enzymes.

Published
2024
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27. Efficacy and Safety of Radiotherapy Plus Anti-PD1 Versus Transcatheter Arterial Chemoembolization Plus Sorafenib For Advanced Hepatocellular Carcinoma: a Real-World Study

Author

Li, Jian-Xu, primary, Deng, Wen-Xiang, additional, Huang, Shi-Ting, additional, Lin, Xiao-Feng, additional, Long, Mei-Ying, additional, Zhang, Jie, additional, Su, Ting-Shi, additional, Li, Li-Qing, additional, Pang, Ya-Dan, additional, Liang, Chun-Feng, additional, Zhou, Hong-Mei, additional, Lu, Hai-Yan, additional, Liang, Shi-Xiong, additional, and Xiang, Bang-De, additional

Published
2021
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30. Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma

Author

Pan,Xin-Bin, Huang,Shi-Ting, and Zhu,Xiao-Dong

Subjects
stage II, Cancer Management and Research, neutrophil-to-lymphocyte ratio, nasopharyngeal carcinoma, fungi, NPC, Original Research, NLR
Abstract

Xin-Bin Pan, Shi-Ting Huang, Xiao-Dong Zhu Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of ChinaCorrespondence: Xiao-Dong ZhuDepartment of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Qingxiu District, Nanning, Guangxi 530021, People’s Republic of ChinaTel +86 1 347 117 1468Fax +86 0 771 531 2000Email zhuxiaodonggx@163.comPurpose: To assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in stage II nasopharyngeal carcinoma (NPC).Methods: Stage II (2010 UICC/AJCC staging system) NPC patients treated between January 2007 and December 2014 were retrospectively analyzed. The NLR was calculated from peripheral blood cell counts before treatment. The optimal cut-off value of NLR was determined by receiver operating characteristic curve analysis. Survival rates were compared according to the NLR value. Multivariable Cox regression analyses were performed to assess the association between the NLR and overall survival (OS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS).Results: Two hundred and fifty-one stage II NPC patients were included in this study. The NLR was correlated with T stage (r=0.158, p=0.012). An NLR ≥2.92 was associated with poor 5-year OS (84.3% vs 97.4%, p=0.001) and LRFS (91.4% vs 98.4%, p=0.003). An NLR ≥2.82 was associated with poor 5-year DMFS (92.6% vs 98.2%, p=0.033). The multivariate Cox regression analysis showed that an NLR ≥2.92 was an independent prognostic biomarker in stage II NPC.Conclusion: The NLR is an independent prognostic factor in stage II NPC.Keywords: nasopharyngeal carcinoma, NPC, stage II, neutrophil-to-lymphocyte ratio, NLR

Published
2019

35. Rapid Development and Critical Issues of Secondary Lithium-air Batteries

Author

Zhao Ning, Huang Shi-Ting, Li Hong, Cui Zhonghui, LI Chi-Lin, Fan Wu-Gang, and Guo Xiangxin

Subjects
Inorganic Chemistry, Specific energy density, Materials science, Risk analysis (engineering), Energy density, Forensic engineering, General Materials Science
Abstract

Rechargeable lithium-air batteries have been the focus in recent years, owing to their great potential for achieving super-high specific energy density. Many researchers have carried out investigations on crucial issues such as reaction mechanism, cycle life, overpotential, rate capability, and significant progresses have been made. Based on these efforts, in combination with our own experience, this paper summarizes recent development of secondary lithium-air batteries, and our opinions on the critical scientific issues which are urgently required to solve in view of real application.

Published
2014

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