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637 results on '"Huang, Wen-Sheng"'

8. The impact of ZTE-based MR attenuation correction compared to CT-AC in 18F-FBPA PET before boron neutron capture therapy.

Author

Lo, Yi-Wen, Lin, Ko-Han, Lee, Chien-Ying, Li, Chia-Wei, Lin, Chien-Yuan, Chen, Yi-Wei, Wang, Ling-Wei, Wu, Yuan-Hung, and Huang, Wen-sheng

Subjects
NEUTRON capture, BORON-neutron capture therapy, MAGNETIC resonance imaging
Abstract

Tumor-to-normal ratio (T/N) measurement of 18F-FBPA is crucial for patient eligibility to receive boron neutron capture therapy. This study aims to compare the difference in standard uptake value ratios on brain tumors and normal brains using PET/MR ZTE and atlas-based attenuation correction with the current standard PET/CT attenuation correction. Regarding the normal brain uptake, the difference was not significant between PET/CT and PET/MR attenuation correction methods. The T/N ratio of PET/CT-AC, PET/MR ZTE-AC and PET/MR AB-AC were 2.34 ± 0.95, 2.29 ± 0.88, and 2.19 ± 0.80, respectively. The T/N ratio comparison showed no significance using PET/CT-AC and PET/MR ZTE-AC. As for the PET/MRI AB-AC, significantly lower T/N ratio was observed (− 5.18 ± 9.52%; p < 0.05). The T/N difference between ZTE-AC and AB-AC was also significant (4.71 ± 5.80%; p < 0.01). Our findings suggested PET/MRI imaging using ZTE-AC provided superior quantification on 18F-FBPA-PET compared to atlas-based AC. Using ZTE-AC on 18F-FBPA-PET /MRI might be crucial for BNCT pre-treatment planning. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Evaluation of Left Ventricular Ejection Fraction Obtained from 201Tl Myocardial Perfusion Scan by CZT Cardiac Camera

Author

Chiang, Hsiao-Ling, Ting, Chien-Hsin, Chang, Cheng-Pe, Yang, Bang-Hung, Leu, Jyh-Shyan, Juang, Chi-Long, Huang, Wen-Sheng, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Lin, Kang-Ping, editor, and de Carvalho, Paulo, editor

Published
2020
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21. Boron Neutron Capture Therapy Followed by Image-Guided Intensity-Modulated Radiotherapy for Locally Recurrent Head and Neck Cancer: A Prospective Phase I/II Trial

Author

Wang, Ling-Wei, primary, Liu, Yen-Wan Hsueh, additional, Chu, Pen-Yuan, additional, Liu, Hong-Ming, additional, Peir, Jinn-Jer, additional, Lin, Ko-Han, additional, Huang, Wen-Sheng, additional, Lo, Wen-Liang, additional, Lee, Jia-Cheng, additional, Lin, Tzung-Yi, additional, Liu, Yu-Ming, additional, and Yen, Sang-Hue, additional

Published
2023
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39. Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function

Author

Wuli, Wei, primary, Lin, Shinn-Zong, additional, Chen, Shee-Ping, additional, Tannous, Bakhos A., additional, Huang, Wen-Sheng, additional, Woon, Peng Yeong, additional, Wu, Yang-Chang, additional, Yang, Hsueh-Hui, additional, Chen, Yi-Cheng, additional, Fleming, Renata Lopes, additional, Rogers, Jack T., additional, Cahill, Catherine M., additional, Ho, Tsung-Jung, additional, Chiou, Tzyy-Wen, additional, and Harn, Horng-Jyh, additional

Published
2022
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44. Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI

Author

Yeh, Skye Hsin-Hsien, Kuo, Yu-Yeh, Huang, Wen-Sheng, Chiu, Chuang-Hsin, Yu, Tsung-Hsun, II, Leo Garcia Flores, Tsai, Chi-Jung, Cheng, Cheng-Yi, and Ma, Kuo-Hsing

Subjects
General Neuroscience
Abstract

Alterations to the serotonergic system due to 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) consumption have been extensively documented. However, knowledge of the reversibility of these neurotoxic effects based on in vivo evaluations of serotonin transport (SERT) availability remains limited. This study aimed to evaluate the long-term neurotoxicity of MDMA after 66 months abstinence and explored whether Dextromethorphan, a non-competitive N-methyl-D-aspartate (NMDA) receptor, could attenuate MDMA-induced neurotoxicity using 4-[18F]-ADAM, an imaging ligand that selectively targets SERT, with positron emission tomography technology (PET). Nine monkeys (Macaca cyclopis) were used in this study: control, MDMA, and DM + MDMA. Static 4-[18F]-ADAM PET was performed at 60 and 66 months after drug treatment. Serotonin transport (SERT) availability was presented as the specific uptake ratios (SURs) of 4-[18F]-ADAM in brain regions. Voxel-based region-specific SERT availability was calculated to generate 3D PET/MR images. Structural Magnetic Resonance Imaging (MRI) volumetric analysis was also conducted at 60 months. Significantly decreased 4-[18F]-ADAM SURs were observed in the striatum and thalamus of the MDMA group at 60 and 66 months compared to controls; the midbrain and frontal cortex SURs were similar at 60 and 66 months in the MDMA and control groups. All eleven brain regions showed significantly lower (∼13%) self-recovery rates over time; the occipital cortex and cingulate recovered to baseline by 66 months. DM attenuated MDMA-induced SERT deficiency on average, by ∼8 and ∼1% at 60 and 66 months, respectively; whereas significant differences were observed between the thalamus and amygdala of the MDMA and DM + MDMA groups at 66 months. Compared to controls, the MDMA group exhibited significantly increased (∼6.6%) gray matter volumes in the frontal cortex, occipital cortex, caudate nucleus, hippocampus, midbrain, and amygdala. Moreover, the gray matter volumes of the occipital cortex, hippocampus and amygdala correlated negatively with the 4-[18F]-ADAM SURs of the same regions. DM (n = 2) did not appear to affect MDMA-induced volumetric changes. The 4-[18F]-ADAM SURs, lower self-recovery rate and increased volumetric values indicate the occipital cortex, hippocampus and amygdala still exhibit MDMA-induced neurotoxicity after 66 months’ abstinence. Moreover, DM may prevent MDMA-induced serotonergic deficiency, as indicated by increased 4-[18F]-ADAM SURs and SERT availability, but not volumetric changes.

Published
2022

50. The Titrated Mannitol Improved Central [ 99m Tc] Tc TRODAT-1 Uptake in an Animal Model—A Clinically Feasible Application.

Author

Chang, Kang-Wei, Chang, Po-Ling, Tsai, Chi-Jung, Tsai, Ya-Ju, Wu, Ping-Hsiu, Lee, Hsin-Lun, Lai, Yu-Hua, Wong, Ching-Yee Oliver, and Huang, Wen-Sheng

Subjects
MANNITOL, AUTORADIOGRAPHY, ANIMAL models in research, COMPUTED tomography, PHOTON emission, SPRAGUE Dawley rats, INTRAVENOUS therapy
Abstract

[99mTc]Tc TRODAT-1 is a widely used single photon emission tomography (SPECT) radiopharmaceutical in Asian practice for early detection of central dopaminergic disorders. However, its imaging quality remains sub-optimal. To overcome this problem, mannitol, an osmotic agent was used to observe its effect on improving striatal [99mTc]Tc TRODAT-1 uptake in rat brain by titrated human dosages to investigate a clinically feasible way to improve human imaging quality. [99mTc]Tc TRODAT-1 synthesis and quality control were performed as described. Sprague–Dawley rats were used for this study. The animal in vivo nanoSPECT/CT and ex vivo autoradiography were employed to observe and verify the striatal [99mTc]Tc TRODAT-1 uptake in rat brains using clinically equivalent doses (i.e., 0, 1 and 2 mL groups, each n = 5) of mannitol (20% w/v, equivalent to 200 mg/mL) by an intravenous administration. Specific binding ratios (SBRs) were calculated to express the central striatal uptake in different experimental groups. In the NanoSPECT/CT imaging, the highest SBRs of striatal [99mTc]Tc TRODAT-1 were reached at 75–90 min post-injection. The averaged striatal SBRs were 0.85 ± 0.13 (2 mL normal saline, the control group), 0.94 ± 0.26 (1 mL mannitol group) and 1.36 ± 0.12 (2 mL mannitol group, p < 0.01 which were significantly different than the control as well as 1 mL mannitol groups (p < 0.05). The SBRs from ex vivo autoradiography also showed a comparable trend of the striatal [99mTc]Tc TRODAT-1 uptake in the 2 mL, 1 mL mannitol and the control groups (1.76 ± 0.52, 0.91 ± 0.29, and 0.21 ± 0.03, respectively, p < 0.05). No remarkable changes of vital signs were found in the mannitol groups and the controls. Pre-treated mannitol revealed a significant increase of the central striatal [99mTc]Tc TRODAT-1 uptake in a rat model which not only enabled us to perform pre-clinical studies of dopaminergic related disorders but also provided a potential way to further optimize image quality in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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