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The article examines the efficacy of daratumumab in treating relapsed acute myeloid leukemia (AML) after allogeneic stem cell transplantation (alloHSCT), focusing on its limited effectiveness, particularly in patients with Fms-like tyrosine kinase 3 (FLT-3) mutations. Topics discussed include treatment outcomes, safety profiles, and the potential role of daratumumab in bridging to further therapy in AML management post-alloHSCT.

This study aims to evaluate the clinical benefit of salvage allogeneic hematopoietic stem cell transplantation (allo-HSCT) in combination with enhanced myeloablative preconditioning in the treatment of refractory liver and spleen T-cell lymphomas. A retrospective analysis was performed on three patients (with refractory liver and spleen T-cell lymphomas) who have been treated with salvage allo-HSCT combined with enhanced myeloablative preconditioning. One of three patients had a liver biopsy; the other two underwent bone marrow analysis using morphology, immunology, cytogenetics, and molecular biology. All three patients were resistant to chemotherapy and with a high tumor load, so a new total body irradiation/splenic region irradiation/GEM/CLAG/ATG preconditioning regimen was conducted and followed with salvage HSCT. Two patients received haploidentical-donor hematopoietic stem cell transplants, and one received an unrelated full-donor hematopoietic stem cell transplant. The three patients survived disease-free until May 2021. Clinically, hepatosplenic T-cell lymphoma (HSTCL) is rare, with a poor prognosis and chemotherapy response. Based on the present study's encouraging clinical results, salvage allo-HSCT in conjunction with an enhanced myeloablative preconditioning regiment may be an effective and safe treatment for HSTCL. [ABSTRACT FROM AUTHOR]

Bone marrow aspiration suggested relapse of AML, and the patient achieved I AML1/ETO i negative status after four cycles of chemotherapy (details unknown). Donor lymphocyte infusion (DLI) is the main immunotherapy given for relapse post-HSCT, and although ~60% of relapsed AML patients achieve complete remission after chemotherapy plus DLI, only ~33% achieve long-term leukemia-free survival [[8]]. Acute myeloid leukemia (AML) encompasses a clinically and genetically diverse set of blood cancers caused by abnormally rapid expansion of myeloid progenitor cells in the bone marrow and extramedullary sites leading to disrupted hematopoiesis [[1]]. To our knowledge, this is the first report of avapritinib use for treating relapsed AML post allo-HSCT, and the outcome in this patient supports further investigation of avapritinib therapy for AML. [Extracted from the article]

Leukemia is a complex disease in which mutations and other genomic and epigenomic abnormalities play a role in both its initiation and progression. Acute lymphoid leukemia (ALL) patients with loss of heterozygosity (LOH) in the HLA region before transplantation have been described rarely. In this report, we described two ALL cases with LOH encompassing the HLA, wholly or partly. HLA molecular typing was performed on peripheral blood (PB) and somatic cell. Simultaneously, we performed whole‐exome sequencing. Typing results on PB samples collected during blast crisis demonstrated complete or partial homozygosity at the ‐A, ‐B, ‐C, ‐DR, and ‐DQ loci. Two somatic samples demonstrated heterozygosity at all loci. LOH at the HLA gene locus may significantly influence the donor search, resulting in misidentification of homozygous donors. We recommend confirming the patients' HLA typing with hematological malignancies when homozygosity is detected at any locus by using somatic samples or alternatively from PB when remission is achieved. [ABSTRACT FROM AUTHOR]

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials. [ABSTRACT FROM AUTHOR]

Background: An increasing number of interventions have focused on leadership development for healthcare managers, among which coaching is a common strategy. The purpose of the present systematic review is to synthesize evidence on the effect of coaching in developing leadership of healthcare managers. Methods and analysis: A literature search will be conducted in six English databases (MEDLINE (Ovid), CINAHL, Embase, Cochrane library, Nursing & Allied Health Premium, and Scopus) and four Chinese databases (Wanfang, CNKI, SinoMed, and VIP) from inception to April 1st, 2022. The titles, abstracts, and full texts of the studies will be screened by two independent researchers to determine their eligibility. The RoB 2, ROBINS-I, CASP, and MMAT will be applied to assess the quality of randomized trials, non-randomized studies, qualitative studies, and mixed-method studies, respectively. We will then extract the study characteristics, participant characteristics, and study outcomes of the reviewed papers. The Aims, Ingredients, Mechanism, and Delivery framework will be used to extract the components of coaching strategies. For quantitative data, a meta-analysis will be performed if sufficient data are available; otherwise, we will conduct a narrative synthesis. Thematic synthesis methods will be used for qualitative data analysis. Discussion: By conducting this systematic review, we expect to synthesize evidence regarding the components of coaching for leadership development among healthcare managers; the influence of coaching on leadership development among managers at the individual, unit-wide, or organizational level; and how managers view coaching as a leadership development strategy. Trial registration: PROSPERO registration number: CRD42020194290. [ABSTRACT FROM AUTHOR]

In summary, this case suggests that T-ALL patients with I BRCA 1/2 i mutation or other "BRCAness" phenotype may benefit from PARPi treatment. Although I BRCA i mutations in hematological tumors are uncommon, identification of the BRCAness phenotype may allow more leukemia patients to benefit from PARPi treatment [[15]]. Here, we report the use of PARPi olaparib combined with chemotherapy for the successful treatment of a T-ALL patient carrying a I BRCA1 i mutation who experienced a salvage treatment failure after the recurrence of umbilical cord blood transplantation (UCBT). [Extracted from the article]

A novel surface treatment method, potassium ferrate (K 2 FeO 4 ) treatment, was developed to induce surface modification of plastics and facilitate separation of polycarbonate (PC) and polystyrene (PS) waste plastics by froth flotation. Contact angle measurements suggest the decrease in the floatability of PC is attributed to the increase of surface wettability. FT-IR and XPS analysis confirm that hydrophilic oxygen-containing groups are introduced on PC surface. SEM measurements indicate that the surface roughness of PC is also enhanced obviously. Evaluation of reusing of treatment effluent and flotation effluent was also investigated. Concerning on flotation separation of PC and PS, optimum conditions of potassium are ferrate concentration 10 mM/L, treatment time 20 min, temperature 60 °C, stirring rate 200 rpm, frother concentration 15.8 mg/L, flotation time 1 min and airflow rate 7.2 mL/L. Under optimum conditions, plastic mixtures of PC and PS with different mixing ratios can be separated efficiently. The purity of PC and PC reaches 100% and 99.54%; the recovery of PC and PS reaches 99.78% and 100% respectively. Reusing of treatment effluent and flotation effluent is feasible, indicating this method is cheap and environmentally friendly. [ABSTRACT FROM AUTHOR]

This work develops a simple and practical process for separation of acrylonitrile–butadienestyrene (ABS) and polystyrene (PS) waste plastics by froth flotation after surface modification using potassium ferrate. ABS plastics containing brominated flame retardants (BFRs) can release hazardous emissions during the process of disposal. Moreover, ABS and PS are typical styrene plastics with similar properties, posing severe restrictions on their separation for recycling. Thus, potassium ferrate modification was investigated and found to decrease selectively the floatability of ABS, providing available process for separation of ABS and PS. Contact angle measurements, FT-IR, XPS and SEM characterization analysis confirmed that potassium ferrate modification can induce the desired changes in the surface properties of ABS. With consideration to separation of ABS and PS, the optimum conditions are potassium ferrate concentration 0.15 M/L, modification time 15 min, temperature 60 °C, stirring rate 200 rpm, frother concentration 14.50 mg/L and flotation time 2 min. Under optimum conditions, separation of ABS and PS with different mixing ratios was accomplished with a recovery and purity of 98.60% and 98.62% respectively. Moreover, reusing of potassium ferrate solution is feasible, further eliminating emissions and cost of this process. Consequently, surface modification using potassium ferrate can be applied for facilitating flotation separation of ABS and PS waste plastics. [ABSTRACT FROM AUTHOR]

• The whole transcriptome profiling analysis revealed the intrinsic responses of K. mikimotoi to S. costatum allelopathy. • The allelopathic stress of S. costatum on K. mikimotoi was investigated, mainly intracellular energy storage and distribution, cell membrane structure and function were affected. • The death of K. mikimotoi under allelopathic stress was mainly necrosis caused by ion accumulation, rather than apoptosis in previous studies. • Algal cells activated the defense system as a survival strategy instead of promoting cell division to ensure the coexists of algae in low stress level of allelopathy. The roles of allelopathy for succession of marine phytoplankton communities remain controversial, especially for the development of blooms. Physiological parameters measurement (Fv/Fm value, MDA content, SOD activity, Na+/K+, Ca2+/ Mg2+-ATPase activity, cell size, chlorophyll content, apoptosis and cell cycle) and whole transcriptome profiling analysis were used to investigate allelopathy effect of Skeletonema costatum on Karenia mikimotoi. Filtrate and extracts from S. costatum culture inhibited the growth of K. mikimotoi. Allelopathic effects were dose-dependent for filtrate culture and extract culture. K. mikimotoi scavenged excessive ROS and adapted to the stress fastly and easily, so oxidative damage was not the main cause of the growth inhibition. Allelochemicals of S. costatum were found to influence the structure and function of cell membrane of K. mikimotoi by damaging membrane structure till to cell necrosis, which caused high mortality. Coupled with the sensitivity of algal cells to environmental stress and restricted cell cycle, allelopathy was suggested to be deeply detrimental to the development of competition algal population. [ABSTRACT FROM AUTHOR]