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[This corrects the article DOI: 10.3389/fonc.2022.940162.].

BackgroundBreast cancer is the most common cancer among women in the U.S. and the leading cause of cancer death among Hispanics/Latinas (H/L). H/L are less likely than Non-H/L White (NHW) women to be diagnosed in the early stages of this disease. Approximately 5-10% of breast cancer can be attributed to inherited genetic mutations in high penetrance genes such as BRCA1/2. Women with pathogenic variants in these genes have a 40-80% lifetime risk of breast cancer. Past studies have shown that genetic counseling can help women and their families make informed decisions about genetic testing and early cancer detection or risk-reduction strategies. However, H/L are 3.9-4.8 times less likely to undergo genetic testing than NHW women. We developed a program to outreach and educate the H/L community about hereditary breast cancer, targeting monolingual Spanish-speaking individuals in California. Through this program, we have assessed cancer screening behavior and identified women who might benefit from genetic counseling in a population that is usually excluded from cancer research and care.Materials and methodsThe "Tu Historia Cuenta" program is a promotores-based virtual outreach and education program including the cities of San Francisco, Sacramento, and Los Angeles. Participants responded to three surveys: a demographic survey, a breast cancer family history survey, and a feedback survey. Survey responses were described for participants and compared by area where the program took place using chi-square, Fisher exact tests, and t tests. Multinomial logistic regression models were used for multivariate analyses.Results and conclusionWe enrolled 1042 women, 892 completed the cancer family history survey and 62 (7%) provided responses compatible with referral to genetic counseling. We identified 272 women (42.8% ages 40 to 74 years) who were due for mammograms, 250 women (24.7% ages 25 to 65 years) due for Papanicolaou test, and 189 women (71.6% ages 50+) due for colorectal cancer screening. These results highlight the need of additional support for programs that spread awareness about cancer risk and facilitate access to resources, specifically within the H/L community.

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.

InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.

Breast cancer is the most common cancer in women in the United States (U.S.) and the leading cause of cancer related death among U.S. Hispanics/Latinas (H/Ls). H/Ls have lower rates of screening and longer time to follow up after an abnormal mammogram. We developed a comprehensive community health educator (promotores)‐led education and risk identification program for Spanish‐speaking H/Ls in California to increase mammography screening, genetic testing, and the understanding of the impact of family history on cancer risk. Due to COVID‐19, we adapted the program to a virtual platform. The experience of transforming the program to a virtual platform provided unique opportunities for collaboration between researchers, community partners, and participants. Promotores are major partners in community based participatory research and in the provision of health care services, but their voices are often excluded from scientific reports. This commentary is an effort to provide a platform for promotores to share their experiences and for the readers to understand their approach in bridging the gap between health care services and communities. [ABSTRACT FROM AUTHOR]

For triple-frequency radar, the attenuation attributed to atmospheric gases and stratiform clouds is diverse due to different snowfall microphysical properties, particularly in regions far from the radar. When using triple-frequency ground-based radar measurements, evaluating the attenuation of the three radars at different heights is common to derive attenuation-corrected effective reflectivity. Therefore, this study proposes a novel quality-controlled approach to identify radar attenuation due to gases and stratiform clouds that can be neglected due to varying snowfall microphysical properties and assess attenuation along the radar observation path. The key issue lies in the lack of information about vertical hydrometeor and cloud distribution. Therefore, European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis data are employed. The Self-Similar-Rayleigh-Gans Approximation (SSRGA) for the nonspherical scattering model in the Passive and Active Microwave TRAnsfer model 2 (PAMTRA2) is compared and analyzed against other scattering models to obtain the optimal triple-frequency radar attenuation correction strategies for stratiform cloud meteorological conditions with varying snowfall microphysical properties. This methodology paves the way for understanding differential attenuation attributed to gas and stratiform clouds with snowfall microphysical properties. Simultaneously, the bin-by-bin approximation method is used to perform the attenuation correction. The two-way attenuation correction increased up to 4.71 dB for heights above 6 km, remaining minimal for regions with heights below 6 km. These values, attributable to gases and stratiform clouds' two-way attenuation, are nonnegligible, especially at distances far from the W-band radar at heights above 6 km. Both values are relatively small for the X- and Ka-band radars and can be neglected for the varying snowfall microphysical properties. The attenuation correction of triple-frequency radar reflectivity is validated using the cross-calibration and dual-frequency reflectivity ratios. The results show that the method is valid and feasible. [ABSTRACT FROM AUTHOR]