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This paper proposes a terahertz (THz) slow-wave scalable interconnect based on multilayered back-end-of-lines in a complementary metal-oxide-semi-conductor process. Capacitances are realized beside and below the signal line. The ground plane is slotted to significantly reduce the propagation velocity of electromagnetic waves and improve the quality factor. Compared with a conventional microstrip line, the proposed slow-wave interconnect not only realizes a slow-wave factor up to 1.96 but also achieves a quality factor higher than 20 at 0.14–0.15 THz. In addition, a one-step data processing method is proposed to directly calculate the performance metrics of interconnects by using the measured S-parameters of device-under-test and the Thru calibration kit. For millimeter-wave and THz chips, the proposed slow-wave interconnect is a promising candidate to realize on-chip passive components with increased quality factor as well as reduced footprint and loss. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the anti-ageing effect of Yisui moxibustion on regulating the klotho protein and insulin (INS)/IGF-1 signalling cascade in d-galactose mice. Sixty male Kunming mice were randomly divided into five groups after the Morries test: the normal sodium, model, moxa cone moxibustion 1 and 2, and sham groups. The treatment and model were given d-galactose injection for 70 days, while mice in the normal sodium group were injected the same dosage of normal sodium. From day 13 after the first injection, the three treatment groups were treated every day for 58 days. The INS and klotho in the cerebral tissues were measured. p-Akt, p-FoxO3a, Klotho, SOD2 expression were observed immunohistochemically. The escape latency of mice in the model and sham were significantly prolonged, and the spanning original platform times were significantly decreased compared with the normal sodium and moxa cone moxibustion 1 and 2 (p < 0.01). The content of INS and klotho in the model was significantly lower than the normal sodium, moxa cone moxibustion 1 and 2 (p < 0.01). Compared with the model and sham, p-Akt and p-FoxO3a expression in moxa cone moxibustion 1 and 2 were markedly decreased (p < 0.05), and the expressions of klotho and SOD2 were significantly increased (p < 0.05) in hippocampal CA1. Yisui moxibustion could exert the antioxidative effect on klotho protein, which negatively regulated the insulin signalling pathway and its downstream elements in cerebral tissue and hippocampal CA1, so as to enhance learning and memory capacities, delay brain ageing. [ABSTRACT FROM AUTHOR]

Consistent calibration and monitoring is a basic prerequisite for providing a reliable time series of global and regional sea-level variations from altimetry. The precisions of sea-level measurements and regional biases for six altimeter missions (Jason-1/2/3, Envisat, Saral, Sentinel-3A) are assessed in this study at 11 GNSS-controlled tide gauge stations in the German Bight (SE North Sea) for the period 2002 to 2019. The gauges are partly located at the open water, and partly at the coast close to mudflats. The altimetry is extracted at virtual stations with distances from 2 to 24 km from the gauges. The processing is optimized for the region and adjusted for the comparison with instantaneous tide gauge readings. An empirical correction is developed to account for mean height gradients and slight differences of the tidal dynamics between the gauge and altimetry, which improves the agreement between the two data sets by 15–75%. The precision of the altimeters depends on the location and mission and ranges from 1.8 to 3.7 cm if the precision of the gauges is 2 cm. The accuracy of the regional mission biases is strongly dependent on the mean sea surface heights near the stations. The most consistent biases are obtained based on the CLS2011 model with mission-dependent accuracies from 1.3 to 3.4 cm. Hence, the GNSS-controlled tide gauges operated operationally by the German Waterway and Shipping Administration (WSV) might complement the calibration and monitoring activities at dedicated CalVal stations. [ABSTRACT FROM AUTHOR]