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112 results on '"Huang, Xuezhen"'

7. Multiple Origins and Genomic Basis of Complex Traits in Sighthounds

Author

Li, Wu Lue, Liu, Yan Hu, Li, Jin Xiu, Ding, Meng Ting, Adeola, Adeniyi C., Isakova, Jainagul, Aldashev, Almaz A., Peng, Min Sheng, Huang, Xuezhen, Xie, Guoli, Chen, Xi, Yang, Wei Kang, Zhou, Wei Wei, Ghanatsaman, Zeinab Amiri, Olaogun, Sunday C., Sanke, Oscar J., Dawuda, Philip M., Hytönen, Marjo K., Lohi, Hannes, Esmailizadeh, Ali, Poyarkov, Andrey D., Savolainen, Peter, Wang, Guo Dong, Zhang, Ya Ping, Li, Wu Lue, Liu, Yan Hu, Li, Jin Xiu, Ding, Meng Ting, Adeola, Adeniyi C., Isakova, Jainagul, Aldashev, Almaz A., Peng, Min Sheng, Huang, Xuezhen, Xie, Guoli, Chen, Xi, Yang, Wei Kang, Zhou, Wei Wei, Ghanatsaman, Zeinab Amiri, Olaogun, Sunday C., Sanke, Oscar J., Dawuda, Philip M., Hytönen, Marjo K., Lohi, Hannes, Esmailizadeh, Ali, Poyarkov, Andrey D., Savolainen, Peter, Wang, Guo Dong, and Zhang, Ya Ping

Abstract

Sighthounds, a distinctive group of hounds comprising numerous breeds, have their origins rooted in ancient artificial selection of dogs. In this study, we performed genome sequencing for 123 sighthounds, including one breed from Africa, six breeds from Europe, two breeds from Russia, and four breeds and 12 village dogs from the Middle East. We gathered public genome data of five sighthounds and 98 other dogs as well as 31 gray wolves to pinpoint the origin and genes influencing the morphology of the sighthound genome. Population genomic analysis suggested that sighthounds originated from native dogs independently and were comprehensively admixed among breeds, supporting the multiple origins hypothesis of sighthounds. An additional 67 published ancient wolf genomes were added for gene flow detection. Results showed dramatic admixture of ancient wolves in African sighthounds, even more than with modern wolves. Whole-genome scan analysis identified 17 positively selected genes (PSGs) in the African population, 27 PSGs in the European population, and 54 PSGs in the Middle Eastern population. None of the PSGs overlapped in the three populations. Pooled PSGs of the three populations were significantly enriched in "regulation of release of sequestered calcium ion into cytosol"(gene ontology: 0051279), which is related to blood circulation and heart contraction. In addition, ESR1, JAK2, ADRB1, PRKCE, and CAMK2D were under positive selection in all three selected groups. This suggests that different PSGs in the same pathway contributed to the similar phenotype of sighthounds. We identified an ESR1 mutation (chr1: g.42,177,149-T > C) in the transcription factor (TF) binding site of Stat5a and a JAK2 mutation (chr1: g.93,277,007-T > A) in the TF binding site of Sox5. Functional experiments confirmed that the ESR1 and JAK2 mutation reduced their expression. Our results provide new insights into the domestication history and genomic basis of sighthounds., QC 20230905

Published
2023
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8. A Privacy-Aware Access Model on Anonymized Data

Author

Huang, Xuezhen, Liu, Jiqiang, Han, Zhen, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Yung, Moti, editor, Zhu, Liehuang, editor, and Yang, Yanjiang, editor

Published
2015
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10. Multiple Origins and Genomic Basis of Complex Traits in Sighthounds.

Author

Li, Wu-Lue, Liu, Yan-Hu, Li, Jin-Xiu, Ding, Meng-Ting, Adeola, Adeniyi C, Isakova, Jainagul, Aldashev, Almaz A, Peng, Min-Sheng, Huang, Xuezhen, Xie, Guoli, Chen, Xi, Yang, Wei-Kang, Zhou, Wei-Wei, Ghanatsaman, Zeinab Amiri, Olaogun, Sunday C, Sanke, Oscar J, Dawuda, Philip M, Hytönen, Marjo K, Lohi, Hannes, and Esmailizadeh, Ali

Subjects
WOLVES, CALCIUM ions, CARDIAC contraction, CORONARY circulation, GENOMICS, BREEDING, BLOOD circulation, GENE flow
Abstract

Sighthounds, a distinctive group of hounds comprising numerous breeds, have their origins rooted in ancient artificial selection of dogs. In this study, we performed genome sequencing for 123 sighthounds, including one breed from Africa, six breeds from Europe, two breeds from Russia, and four breeds and 12 village dogs from the Middle East. We gathered public genome data of five sighthounds and 98 other dogs as well as 31 gray wolves to pinpoint the origin and genes influencing the morphology of the sighthound genome. Population genomic analysis suggested that sighthounds originated from native dogs independently and were comprehensively admixed among breeds, supporting the multiple origins hypothesis of sighthounds. An additional 67 published ancient wolf genomes were added for gene flow detection. Results showed dramatic admixture of ancient wolves in African sighthounds, even more than with modern wolves. Whole-genome scan analysis identified 17 positively selected genes (PSGs) in the African population, 27 PSGs in the European population, and 54 PSGs in the Middle Eastern population. None of the PSGs overlapped in the three populations. Pooled PSGs of the three populations were significantly enriched in "regulation of release of sequestered calcium ion into cytosol" (gene ontology: 0051279), which is related to blood circulation and heart contraction. In addition, ESR1 , JAK2 , ADRB1 , PRKCE , and CAMK2D were under positive selection in all three selected groups. This suggests that different PSGs in the same pathway contributed to the similar phenotype of sighthounds. We identified an ESR1 mutation (chr1: g.42,177,149 T > C) in the transcription factor (TF) binding site of Stat5a and a JAK2 mutation (chr1: g.93,277,007 T > A) in the TF binding site of Sox5. Functional experiments confirmed that the ESR1 and JAK2 mutation reduced their expression. Our results provide new insights into the domestication history and genomic basis of sighthounds. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Photo responsive silver nanoparticles incorporated liquid crystalline elastomer nanocomposites based on surface plasmon resonance

Author

Zhao Lina, Wang Jun, Niu Hongyan, Huang Xuezhen, Zhang Jindi, Yang Wenlong, Wang Binsong, LI Yuxin, Bi Meng, Gao Ya-Chen, LI Chensha, and Wang Yu-chang

Subjects
Materials science, Nanocomposite, Doping, Energy conversion efficiency, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Elastomer, 01 natural sciences, Silver nanoparticle, 0104 chemical sciences, Chemical engineering, Irradiation, Surface plasmon resonance, 0210 nano-technology, Mass fraction
Abstract

We reported a nano-Ag/liquid crystalline elastomer(LCE) nanocomposite by incorporating silver nanoparticles into a monodomain polysiloxane-based LCE matrix via a novel experimental protocol. The photo-thermo-mechanical actuation of the LCE matrix was realized via the surface plasmon resonance of silver nanoparticles while converting light into heat. The photoresponsive properties of nano-Ag/LCE nanocomposites were investigated with varying illumination intensities and silver nanoparticle doping concentrations(0.04% to 0.2%, mass fraction). The nano-Ag/LCE nanocomposites show sensitive deformation under irradiation due to their excellent photo-thermal conversion efficiency, and this photostimulated muscle-like actuation is fully reversible via the on-off behavior of light. Incorporating silver nanoparticles into the LCE matrix also improves the mechanical properties and enhances the load-actuation capability of the material.

Published
2017

22. NiC2O4nanorods embellished NiCo layered double hydroxide nanoflowers with enhanced electrochemical performances for hybrid supercapacitor

Author

Zhang, Zhe, Gao, Xinglong, Zhang, Xuetao, Zhang, Yue, Huang, Xuezhen, Shang, Zhihui, Liu, Zhaochuan, Wei, Mingzhi, Lu, Qifang, Guo, Enyan, Si, Conghui, and Han, Xiujun

Abstract

Designing and constructing a high performance and multi-component nickel-based material is preferable for efficient energy storage devices. In this study, we reasonably designed a composite material, NiC2O4/NiCo layered double hydroxide (LDH), composed of 1D NiC2O4nanorods and 3D NiCo-LDH nanoflowers self-assembled from nanosheets via a hydrothermal method. This causes NiCo-LDH nanoflowers to stretch out, increasing the specific surface area (up to 47 m2g−1), improving contact with the electrolyte and providing abundant active sites, speeding up the transfer of protons. The excellent double redox reactions of NiC2O4and NiCo-LDH expedite the reaction kinetics and boost electrochemical activities, resulting in high energy densities of 37.6 Wh kg−1and high power densities of 809.8 W kg−1for the NiC2O4/NiCo-LDH||AC hybrid supercapacitor devices. Furthermore, DFT calculations indicate NiC2O4/NiCo-LDH enhance the adsorption ability of OH−. And the improved electrochemical performance of NiC2O4/NiCo-LDH is due to partial electrons transfer through the interface.

Published
2024
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50. Erbium-Doped Mixed OxideNanowires of Zinc and Germanium:Role of Host Structure on Near Infrared Emission.

Author

Huang, Xuezhen and Coffer, Jeffery L.

Subjects
*ERBIUM compounds, *OXIDES, *NANOWIRES, *ZINC compounds, *GERMANIUM compounds, *MICROSTRUCTURE
Abstract

This work describes the fabrication of Er-doped oxidenanowirescontaining both zinc and germanium through selected sol–gelreactions in concert with electrospinning and thermal removal of polymertemplates. These nanowires exhibit strong Er3鷦IRphotoluminescence at 1.54 μm after annealing; it is found thatthe mechanism of this emission can be mediated through the selectionof appropriate composition and annealing temperature. Relatively highEr concentrations (up to 3 at. %, excluding oxygen) can be incorporatedinto these structures, with retention of Er3穨겲⨧due presumably to an absence of erbium self-quenching and associatednonradiative pathways. [ABSTRACT FROM AUTHOR]

Published
2012
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