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10. Ergosterol reverses multidrug resistance in SGC7901/Adr cells.

Author

Hu X, Jiang D, Li F, Wu Z, Huang Y, Song S, and Wang Z

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1 biosynthesis, ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, Antibiotics, Antineoplastic metabolism, Cell Line, Tumor, Coloring Agents, Doxorubicin metabolism, Gene Expression Regulation, Neoplastic drug effects, Humans, Rhodamine 123, Tetrazolium Salts, Thiazoles, Drug Resistance, Multiple drug effects, Drug Resistance, Neoplasm drug effects, Ergosterol pharmacology
Abstract

Multidrug resistance (MDR) is a major obstacle in the chemotherapeutic treatment of tumors. Elevated expression of the P-glycoprotein (P-gp) transporter is associated with MDR and responsible for the resistance of tumor cells against a variety of anticancer drugs. In this study, the reversal effect of ergosterol (Erg) on SGC7901/Adr cells was investigated. At concentrations of 1 microM and 5 microM, Erg could reverse the resistance of SGC7901/Adr to adriamycin up to 4.84 and 3.92 folds, respectively. Mechanistically, Erg could increase the intracellular accumulation of adriamycin and Rh123 in SGC7901/Adr cells through inhibiting the transcription of MDR1 gene and down-regulating the expression of P-gp. In conclusion, Erg could reverse the MDR of SGC7901/Adr cells via its influence on P-gp expression and thus be a promising lead compound for future studies.

Published
2014

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