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321 results on '"Huang, Zhi-Guang"'

18. Nucleolar protein interacting with the FHA domain of MKI67 may be an important factor in promoting the development of colorectal cancer: a comprehensive study integrating bulk RNA-seq, scRNA-seq, protein immunohistochemistry and CRISPR

Author

Li, Hui, primary, Tang, Yu-Xing, additional, Chen, Yi, additional, Huang, Wan-Ying, additional, He, Rong-Quan, additional, Huang, Zhi-Guang, additional, Zeng, Da-Tong, additional, Xia, Zhi-Yuan, additional, Song, Rui, additional, Zhang, Han Jie, additional, Chen, Yu-Zhen, additional, Zhao, Bin-Hui, additional, Qin, Si-Ru, additional, Luo, Jia-Yuan, additional, and Chen, Gang, additional

Published
2024
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19. TM9SF1 promotes bladder cancer cell growth and infiltration

Author

Wei, Long, primary, Wang, Shi-Shuo, additional, Huang, Zhi-Guang, additional, He, Rong-Quan, additional, Luo, Jia-Yuan, additional, Li, Bin, additional, Cheng, Ji-Wen, additional, Wu, Kun-Jun, additional, Zhou, Yu-Hong, additional, Liu, Shi, additional, Li, Sheng-Hua, additional, and Chen, Gang, additional

Published
2024
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36. MMP12 serves as an immune cell–related marker of disease status and prognosis in lung squamous cell carcinoma

Author

Zhang, Wei, primary, Li, Guo-Sheng, additional, Gan, Xiang-Yu, additional, Huang, Zhi-Guang, additional, He, Rong-Quan, additional, Huang, Hong, additional, Li, Dong-Ming, additional, Tang, Yu-Lu, additional, Tang, Deng, additional, Zou, Wen, additional, Liu, Jun, additional, Dang, Yi-Wu, additional, Chen, Gang, additional, Zhou, Hua-Fu, additional, Kong, Jin-Liang, additional, and Lu, Hui-ping, additional

Published
2023
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42. High expression of centromere protein A and its molecular mechanism and clinical significance in prostate cancer: A study based on data mining and immunohistochemistry.

Author

Jiang, Fang‐Cheng, Zhai, Gao‐Qiang, Liu, Jia‐Lin, Wang, Rui‐Gong, Yang, Yuan‐Ping, Murugesan, Harivignesh, Yu, Xiao‐Xiang, Du, Xiu‐Fang, He, Juan, Feng, Zhen‐Bo, Pan, Shang Ling, Chen, Gang, Li, Sheng‐Hua, and Huang, Zhi‐Guang

Subjects
ANDROGEN receptors, PROSTATE cancer, DATA mining, CENTROMERE, GENE expression, CANCER stem cells, PROTEIN expression
Abstract

The progression of prostate cancer (PCa) leads to poor prognosis. However, the molecular mechanism of PCa is still not completely clear. This study aimed to elucidate the important role of centromere protein A (CENPA) in PCa. Large numbers of bulk RNA sequencing (RNA‐seq) data and in‐house immunohistochemistry data were used in analysing the expression level of CENPA in PCa and metastatic PCa (MPCa). Single‐cell RNA‐seq data was used to explore the expression status of CENPA in different prostate subpopulations. Enrichment analysis was employed to detect the function of CENPA in PCa. Clinicopathological parameters analysis was utilised in analysing the clinical value of CENPA. The results showed that CENPA was upregulated in PCa (standardised mean difference [SMD] = 0.83, p = 0.001) and MPCa (SMD = 0.61, p = 0.029). CENPA was overexpressed in prostate cancer stem cells (CSCs) with androgen receptor (AR) negative compared to epithelial cells with AR positive. CENPA may influence the development of PCa through affecting cell cycle. Patients with nodal metastasis had higher expression level of CENPA. And patients with high CENPA expression had poor disease‐free survival. Taken together, Overexpression of CENPA may influence the development of PCa by regulating cell cycle and promoting metastasis. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Clinicopathological and prognostic significance of XPO1 in solid tumors: meta-analysis and TCGA analysis

Author

Tan, Yang, Chen, Gang, He, Rong-Quan, Huang, Zhi-Guang, Dang, Yi-Wu, Luo, Jia-Yuan, Huang, Wan-Ying, Huang, Su-Ning, Liu, Run, and Feng, Zhen-Bo

Abstract

Exportin 1 (XPO1) is overexpressed in several solid tumors, and is associated with poor prognosis. Here, we aimed to evaluate the implication of XPO1 expression in solid tumors through a meta-analysis. PubMed, Web of Science, and Embase databases were searched for articles published until February 2023. Statistical data of the patients, odds ratios and hazard ratios (HRs), together with their corresponding 95% confidence intervals (CIs) were pooled to assess clinicopathological features and survival outcomes. Besides, the Cancer Genome Atlas (TCGA) was used to explore the prognostic significance of XPO1 in solid tumors. A total of 22 works, comprising 2595 patients were included in this study. The results suggested that increased XPO1 expression was associated with a higher tumor grade, more lymph node metastasis, advanced tumor stage, and progressively worse total clinical stage. Additionally, high XPO1 expression was associated with worse overall survival (OS) (HR = 1.43, 95% CI = 1.12–1.81, P = 0.004) and shorter progression-free survival (HR = 1.40, 95% CI = 1.07–1.84, P = 0.01). An analysis using the TCGA dataset showed that high XPO1 expression was associated with poor OS and disease-free survival. XPO1 is a promising prognostic biomarker and may constitute a therapeutic target for solid tumors. PROSPERO registration number: CRD42023399159

Published
2023
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