168 results on '"Huarong Zhang"'
Search Results
2. Life history traits associated with high fecundity help offset the worst genetic impacts of targeted poaching in Aquilaria sinensis
- Author
-
Wan-hin Kwok, Huarong Zhang, Feng Yang, Stephan W. Gale, Gunter A. Fischer, and Richard M.K. Saunders
- Subjects
Life history traits ,Onset of flowering ,Fecundity ,Incense tree ,Genetic diversity ,Agarwood ,Ecology ,QH540-549.5 - Abstract
Poaching is a global issue that threatens many species. However, little research attention has been paid to key life history traits that might help offset some of the worst genetic and demographic impacts of poaching. We investigate the onset of flowering and fecundity in Aquilaria sinensis, an agarwood-producing tree species that faces a constant threat of poaching throughout its native range in southern China. We hypothesise that certain life history traits in this species could buffer genetic erosion associated with selective poaching of larger individuals. We genotyped 1464 individuals using 15 microsatellite markers and examined the difference in genetic diversity between seedlings and adults, as well as that between individuals either side of the threshold diameter at breast height (DBH) size class targeted by poachers. Our study reveals that flowering commences at a DBH of 2.50 cm and that even trees at a DBH of about 6.9 cm invest heavily in seed-set, but that poachers tend to target individuals with a DBH of 15.25 cm or greater. No significant difference in genetic diversity was detected among individuals belonging to seedling and adult life-history stages, or between targeted and non-targeted size classes. The lack of such difference could be explained by certain life history traits which offset some of the most adverse impacts of poaching in Aquilaria sinensis, with important implications for the management and conservation of other species that are threatened by poaching.
- Published
- 2024
- Full Text
- View/download PDF
3. Impact of Free Trade (Pilot) Zone Establishment on Urban Land Use Efficiency—Empirical Evidence from Cities in China
- Author
-
Siwen Xia, Jiaying Han, Anglu Li, Penghao Ye, and Huarong Zhang
- Subjects
free trade (pilot) zone ,urban land use efficiency ,multi-period difference-in-differences ,heterogeneity analysis ,spatial spillover effect ,Agriculture - Abstract
The establishment of the Free Trade (Pilot) Zone (FTZ) is a new attempt by China to embark on modern sustainable urban planning and governmental territorial management at the development stage of a high-quality economy. As urban lands serve as the limited resource foundation for civic production and livelihoods, enhancing land use efficiency becomes a key measure to facilitate metropolitan economies of high quality. Utilizing panel data from prefecture-level cities spanning from 2005 to 2021, this study constructs a multi-period difference-in-differences model to explore the impact of FTZs on urban land use efficiency (ULUE). The results indicate that FTZs can significantly enhance urban land use efficiency, with a more pronounced policy effect observed in central cities, inland cities, and cities with higher urbanization rates. Furthermore, the FTZs also demonstrate spatial spillover effects on urban land use efficiency. This study holds great significance for relevant government departments in formulating policies to optimize land resource allocation, promote FTZ development, and foster high-quality urban planning and territorial management.
- Published
- 2024
- Full Text
- View/download PDF
4. Preparation of Polyoxymethylene/Exfoliated Molybdenum Disulfide Nanocomposite through Solid-State Shear Milling
- Author
-
Shuo Feng, Xinwen Zhou, Sen Yang, Jiayu Tan, Meiqiong Chen, Yinghong Chen, Huarong Zhang, Xu Zhu, Shulong Wu, and Haidong Gu
- Subjects
molybdenum disulfide ,polyoxymethylene ,solid-state shear milling ,exfoliation ,dispersion ,Organic chemistry ,QD241-441 - Abstract
In this paper, the solid-state shear milling (S3M) strategy featuring a very strong three-dimensional shear stress field was adopted to prepare the high-performance polyoxymethylene (POM)/molybdenum disulfide (MoS2) functional nanocomposite. The transmission electron microscope and Raman measurement results confirmed that the bulk MoS2 particle was successfully exfoliated into few-layer MoS2 nanoplatelets by the above simple S3M physical method. The polarized optical microscope (PLM) observation indicated the pan-milled nanoscale MoS2 particles presented a better dispersion performance in the POM matrix. The results of the tribological test indicated that the incorporation of MoS2 could substantially improve the wear resistance performance of POM. Moreover, the pan-milled exfoliated MoS2 nanosheets could further substantially decrease the friction coefficient of POM. Scanning electron microscope observations on the worn scar revealed the tribological mechanism of the POM/MoS2 nanocomposite prepared by solid-state shear milling. The tensile test results showed that the pan-milled POM/MoS2 nanocomposite has much higher elongation at break than the conventionally melt-compounded material. The solid-state shear milling strategy shows a promising prospect in the preparation of functional nanocomposite with excellent comprehensive performance at a large scale.
- Published
- 2024
- Full Text
- View/download PDF
5. Identification reproducible microbiota biomarkers for the diagnosis of cirrhosis and hepatocellular carcinoma
- Author
-
Huarong Zhang, Junling Wu, Yijuan Liu, Yongbin Zeng, Zhiyu Jiang, Haidan Yan, Jie Lin, Weixin Zhou, Qishui Ou, and Lu Ao
- Subjects
Diagnostic biomarkers ,Gut microbiota ,Hepatocellular carcinoma ,Liver cirrhosis ,Reproducible genera ,Biotechnology ,TP248.13-248.65 ,Microbiology ,QR1-502 - Abstract
Key points Gut microbial biomarkers across Chinese population can be used as a non-invasive tool for the diagnosis of LC and HCC We constructed two RFmodels based on reproducible genera to distinguish LC or HCC from HC The efficacy of two models was greatly improved when clinical factors were added
- Published
- 2023
- Full Text
- View/download PDF
6. Lightweight Model Design and Compression of CRN for Trunk Borers’ Vibration Signals Enhancement
- Author
-
Xiaorong Zhao, Juhu Li, and Huarong Zhang
- Subjects
pest detection ,vibration signal ,denoising ,signal enhancement ,convolutional recurrent neural network ,transformer ,Plant ecology ,QK900-989 - Abstract
Trunk borers are among the most destructive forest pests. The larvae of some species living and feeding in the trunk, relying solely on the tree’s appearance to judge infestation is challenging. Currently, one of the most effective methods to detect the larvae of some trunk-boring beetles is by analyzing the vibration signals generated by the larvae while they feed inside the tree trunk. However, this method faces a problem: the field environment is filled with various noises that get collected alongside the vibration signals, thus affecting the accuracy of pest detection. To address this issue, vibration signal enhancement is necessary. Moreover, deploying sophisticated technology in the wild is restricted due to limited hardware resources. In this study, a lightweight vibration signal enhancement was developed using EAB (Emerald Ash Borer) and SCM (Small Carpenter Moth) as insect example. Our model combines CRN (Convolutional Recurrent Network) and Transformer. We use a multi-head mechanism instead of RNN (Recurrent Neural Network) for intra-block processing and retain inter-block RNN. Furthermore, we utilize a dynamic pruning algorithm based on sparsity to further compress the model. As a result, our model achieves excellent enhancement with just 0.34M parameters. We significantly improve the accuracy rate by utilizing the vibration signals enhanced by our model for pest detection. Our results demonstrate that our method achieves superior enhancement performance using fewer computing and storage resources, facilitating more effective use of vibration signals for pest detection.
- Published
- 2023
- Full Text
- View/download PDF
7. Multi-Channel Time-Domain Boring-Vibration-Enhancement Method Using RNN Networks
- Author
-
Xiaolin Xu, Juhu Li, and Huarong Zhang
- Subjects
beamforming ,multi-channel ,boring vibration signal ,self-attention mechanism ,denoising ,Science - Abstract
The larvae of certain wood-boring beetles typically inhabit the interior of trees and feed on the wood, leaving almost no external traces during the early stages of infestation. Acoustic techniques are commonly employed to detect the vibrations produced by these larvae while they feed on wood, significantly increasing detection efficiency compared to traditional methods. However, this method’s accuracy is greatly affected by environmental noise interference. To address the impact of environmental noise, this paper introduces a signal separation system based on a multi-channel attention mechanism. The system utilizes multiple sensors to receive wood-boring vibration signals and employs the attention mechanism to adjust the weights of relevant channels. By utilizing beamforming techniques, the system successfully removes noise from the wood-boring vibration signals and separates the clean wood-boring vibration signals from the noisy ones. The data used in this study were collected from both field and laboratory environments, ensuring the authenticity of the dataset. Experimental results demonstrate that this system can efficiently separate the wood-boring vibration signals from the mixed noisy signals.
- Published
- 2023
- Full Text
- View/download PDF
8. A CNN-Based Method for Enhancing Boring Vibration with Time-Domain Convolution-Augmented Transformer
- Author
-
Huarong Zhang, Juhu Li, Gaoyuan Cai, Zhibo Chen, and Haiyan Zhang
- Subjects
boring vibration ,pest management ,deep learning ,neural network ,attention mechanism ,Science - Abstract
Recording vibration signals induced by larvae activity in the trunk has proven to be an efficient method for detecting trunk-boring insects. However, the accuracy of the detection is often limited because the signals collected in real-world environments are heavily disrupted by environmental noises. To deal with this problem, we propose a deep-learning-based model that enhances trunk-boring vibration signals, incorporating an attention mechanism to optimize its performance. The training data utilized in this research consist of the boring vibrations of Agrilus planipennis larvae recorded within trunk sections, as well as various environmental noises that are typical of the natural habitats of trees. We mixed them at different signal-to-noise ratios (SNRs) to simulate the realistically collected sounds. The SNR of the enhanced boring vibrations can reach up to 17.84 dB after being enhanced by our model, and this model can restore the details of the vibration signals remarkably. Consequently, our model’s enhancement procedure led to a significant increase in accuracy for VGG16, a commonly used classification model. All results demonstrate the effectiveness of our approach for enhancing the detection of larvae using boring vibration signals.
- Published
- 2023
- Full Text
- View/download PDF
9. Effects of Initial Turbulence on the Explosion Limit and Flame Propagation Behaviors of Premixed Syngas–Air Mixtures
- Author
-
Huarong Zhang, Yingxin Tan, Shuo Zhang, Yabei Xu, Yuxin Zhao, Jiaxin Guo, and Weiguo Cao
- Subjects
Chemistry ,QD1-999 - Published
- 2021
- Full Text
- View/download PDF
10. Microbiome analysis reveals universal diagnostic biomarkers for colorectal cancer across populations and technologies
- Author
-
Huarong Zhang, Junling Wu, Daihan Ji, Yijuan Liu, Shuting Lu, Zeman Lin, Ting Chen, and Lu Ao
- Subjects
microbial dysbiosis ,Porphyromonas ,Parvimonas ,Peptostreptococcus ,non-invasive diagnosis ,colorectal cancer ,Microbiology ,QR1-502 - Abstract
The gut microbial dysbiosis is a risk of colorectal cancer (CRC) and some bacteria have been reported as potential markers for CRC diagnosis. However, heterogeneity among studies with different populations and technologies lead to inconsistent results. Here, we investigated six metagenomic profiles of stool samples from healthy controls (HC), colorectal adenoma (CA) and CRC, and six and four genera were consistently altered between CRC and HC or CA across populations, respectively. In FengQ cohort, which composed with 61 HC, 47 CA, and 46 CRC samples, a random forest (RF) model composed of the six genera, denoted as signature-HC, distinguished CRC from HC with an area under the curve (AUC) of 0.84. Similarly, another RF model composed of the four universal genera, denoted as signature-CA, discriminated CRC from CA with an AUC of 0.73. These signatures were further validated in five metagenomic sequencing cohorts and six independent 16S rRNA gene sequencing cohorts. Interestingly, three genera overlapped in the two models (Porphyromonas, Parvimonas and Peptostreptococcus) were with very low abundance in HC and CA, but sharply increased in CRC. A concise RF model on the three genera distinguished CRC from HC or CA with AUC of 0.87 and 0.67, respectively. Functional gene family analysis revealed that Kyoto Encyclopedia of Genes and Genomes Orthogroups categories which were significantly correlated with markers in signature-HC and signature-CA were mapped into pathways related to lipopolysaccharide and sulfur metabolism, which might be vital risk factors of CRC development. Conclusively, our study identified universal bacterial markers across populations and technologies as potential aids in non-invasive diagnosis of CRC.
- Published
- 2022
- Full Text
- View/download PDF
11. Neutrophil infiltration and myocarditis in patients with severe COVID-19: A post-mortem study
- Author
-
Quanyu Zhang, Huarong Zhang, Xiaowei Yan, Sicong Ma, Xiaohong Yao, Yu Shi, Yifang Ping, Mianfu Cao, Chengfei Peng, Shuai Wang, Min Luo, Chenghui Yan, Shuyang Zhang, Yaling Han, and Xiuwu Bian
- Subjects
COVID-19 ,autopsy ,heart ,myocarditis ,neutrophil infiltration ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
AimsTo investigate cardiac pathology in critically ill patients with coronavirus disease 2019 (COVID-19) and identify associations between pathological changes and clinical characteristics.MethodsThe present autopsy cohort study included hearts from 26 deceased patients hospitalized in intensive care units due to COVID-19, and was conducted at four sites in Wuhan, China. Cases were divided into a neutrophil infiltration group and a no-neutrophil group based on the presence or absence of histopathologically identified neutrophilic infiltrates.ResultsAmong the 26 patients, histopathological examination identified active myocarditis in four patients. All patients with myocarditis exhibited extensive accompanying neutrophil infiltration, and all patients without myocarditis did not. The neutrophil infiltration group exhibited significantly higher rates of detection of interleukin-6 (100 vs. 4.6%) and tumor necrosis factor-alpha (100 vs. 31.8%) than the no-neutrophil group (both p < 0.05). On admission, four patients with neutrophil infiltration in myocardium had significantly higher baseline levels of aspartate aminotransferase, D dimer, and high-sensitivity C reactive protein than the other 22 patients (all p < 0.05). During hospitalization, patients with neutrophil infiltration had significantly higher maximum creatine kinase-MB (median 280.0 IU/L vs. 38.7 IU/L, p = 0.04) and higher troponin I (median 1.112 ng/ml vs. 0.220 ng/ml, p = 0.56) than patients without neutrophil infiltration.ConclusionActive myocarditis was frequently associated with neutrophil infiltration in the hearts of deceased patients with severe COVID-19. Patients with neutrophil-infiltrated myocarditis had a series of severely abnormal laboratory test results on admission, and high maximum creatine kinase-MB during hospitalization. The role of neutrophils in severe heart injury and systemic conditions in patients with COVID-19 should be emphasized.
- Published
- 2022
- Full Text
- View/download PDF
12. Two thirds of species in a global shark fin trade hub are threatened with extinction: Conservation potential of international trade regulations for coastal sharks
- Author
-
Diego Cardeñosa, Stanley K. Shea, Huarong Zhang, Gunter A. Fischer, Colin A. Simpfendorfer, and Demian D. Chapman
- Subjects
CITES ,governance ,Hong Kong ,international shark trade ,management ,shark conservation ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Abstract One third of chondrichthyan species (sharks, rays, and chimeras) are threatened with extinction, mainly due to unsustainable fishing. Large accessible international markets for meat and luxury products like dried fins can help drive overfishing by encouraging targeted capture or retention of high‐value export species. If this is common, then species in international trade could have heightened extinction risk. Here, we examined the species composition of the Hong Kong shark fin market from 2014 to 2018, finding that traded species disproportionately occur in threatened categories (70.9%) and all premium value species are threatened. A small number of cosmopolitan species dominate the trade, but noncosmopolitan coastal species are still traded at concerning levels given their limited distribution. These coastal species are not generally subject to retention prohibitions, fisheries management, or international trade regulations and without management many could become extinct. The conservation potential of international trade regulations alone for coastal chondrichthyans depends on the extent to which overfishing is driven by export markets; socioeconomic studies of coastal fishing communities are needed to make this determination. Nonetheless, adding international trade regulations for more coastal shark species that are in the fin trade could prompt broad engagement with overfishing in nations lacking effective management.
- Published
- 2022
- Full Text
- View/download PDF
13. The impact of FDI quality characteristics on carbon emission intensity: Evidence from China
- Author
-
Wenjing Ma, Kai Liu, Yunlong Li, and Huarong Zhang
- Subjects
FDI ,quality characteristics ,CO2 emission intensity ,technique effect ,composition effect ,Environmental sciences ,GE1-350 - Abstract
Using data from 30 provincial-level in China during 2005–2019, this paper investigates the impact of foreign direct investment (FDI) quality characteristics on carbon emission intensity. Based on the Copeland-Taylor model, the mechanism of the impact of FDI quality characteristics on carbon emission intensity is also investigated. The key findings demonstrate that FDI quality traits considerably lower regional carbon intensity, and the result is still robust after considering the spatial correlation and using IV-2sls in consideration of endogeneity. The FDI quality characteristics mainly reduce carbon emission intensity through green technology improvement, industrial structure, and factor endowment structure optimization. Moreover, further evidence shows that there are heterogeneous effects with regard to regional and FDI quality characteristics. From the standpoint of FDI quality characteristics, this study adds to the literature on FDI and environmental pollution. Policy recommendations for China are also discussed in this paper, which can serve as a guide for other emerging nations.
- Published
- 2022
- Full Text
- View/download PDF
14. Can Pollution Regulations Enable Key Industries to Reduce CO2 Emissions?—Empirical Evidence from China, Based on Green Innovative Technology Patents and Energy Efficiency Perspectives
- Author
-
Jin Li and Huarong Zhang
- Subjects
environmental regulation ,technological innovation ,carbon trading rights ,energy efficiency ,carbon peaking ,carbon neutrality policies ,Meteorology. Climatology ,QC851-999 - Abstract
Under the influence of the dual policies of sustainable economic development and the national dual-carbon target, the establishment of an environmental protection department for the treatment of heavily polluting industries is imminent, and the country has launched pollution control policies and regulations to restrict the emission rights of heavily polluting industries. Therefore, this paper focuses on whether the restriction of emission rights in key industries has reduced carbon emissions. To achieve this, this paper uses panel data of prefecture-level cities in China from 2006 to 2019 and adopts a two-way fixed-effects DID model to systematically analyze the impact of the key pollution industry governance policies launched by the Ministry of Environmental Protection on CO2 emissions in 2017. And further analyze the role of variables such as green technology innovation patents and energy efficiency using this model, while parallel trend tests and placebo tests, and related policies are used to ensure the robustness of the regression results. This paper reveals that: (1) The heavy pollution industry governance policy implemented in 2017 can effectively reduce CO2 emissions in the cities of the treated group, and the effect is more significant in the year of policy implementation; (2) Green utility patents and energy-use efficiency are the effective mediating mechanisms to reduce CO2 emissions; (3) Over time, the effect of heavy pollution industry governance policy on CO2 emissions gradually decreases; (4) The reliability of the baseline regression results of this paper is proved by the use of parallel trend tests, placebo tests, and tests excluding the influence factors such as relevant policies in the same period. Therefore, the key polluting industries treatment policy launched by China’s Ministry of Environmental Protection in 2017 under the recent dual-carbon policy development goals formulated by China, can effectively reduce carbon emissions; however, in the future economic development process, the government should give more consideration to the continuity of the policy impact and its coherence on economic development when implementing the policy.
- Published
- 2022
- Full Text
- View/download PDF
15. Metabolism-Related Gene Pairs to Predict the Clinical Outcome and Molecular Characteristics of Early Hepatocellular Carcinoma
- Author
-
Junling Wu, Zeman Lin, Daihan Ji, Zhenli Li, Huarong Zhang, Shuting Lu, Shenglin Wang, Xiaolong Liu, and Lu Ao
- Subjects
metabolism-related genes ,hepatocellular carcinoma ,risk stratification model ,prognosis ,molecular characteristics ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Recurrence is the main factor affecting the prognosis of early hepatocellular carcinoma (HCC), which is not accurately evaluated by clinical indicators. The metabolic heterogeneity of HCC hints at the possibility of constructing a stratification model to predict the clinical outcome. On the basis of the relative expression orderings of 2939 metabolism-related genes, an individualized signature with 10 metabolism-related gene pairs (10-GPS) was developed from 250 early HCC samples in the discovery datasets, which stratified HCC patients into the high- and low-risk subgroups with significantly different survival rates. The 10-GPS was validated in 311 public transcriptomic samples from two independent validation datasets. A nomogram that included the 10-GPS, age, gender, and stage was constructed for eventual clinical evaluation. The low-risk group was characterized by lower proliferation, higher metabolism, increased activated immune microenvironment, and lower TIDE scores, suggesting a better response to immunotherapy. The high-risk group displayed hypomethylation, higher copy number alterations, mutations, and more overexpression of immune-checkpoint genes, which might jointly lead to poor outcomes. The prognostic accuracy of the 10-GPS was further validated in 47 institutional transcriptomic samples and 101 public proteomic samples. In conclusion, the 10-GPS is a robust predictor of the clinical outcome for early HCC patients and could help evaluate prognosis and characterize molecular heterogeneity.
- Published
- 2022
- Full Text
- View/download PDF
16. A Knowledge Map Study of an Application of a Smart Land Planning Free-Trade Zone and China’s Contribution
- Author
-
Penghao Ye, Huarong Zhang, Siyi Ma, Fang Yang, and Yanan Li
- Subjects
smart land-use planning ,free-trade zone ,China ,knowledge map ,CiteSpace ,Agriculture - Abstract
The use of a free-trade zone (FTZ) has emerged as a smart land tool in increasing trading, attracting foreign investment, attempting financial openness and conducting other pilot economic reforms, which adds higher requirements for smart spatial planning, smart industry planning and smart management planning. However, no systematic analysis has been performed, making it difficult to provide deeper insights into FTZs. Thus, this study conducted bibliometric and visual analysis to identify the research status, new theories or practices, and potential future directions of FTZs based on 953 publications from the Web of Science Core Collection. The results show that there is a marked rise in the number of FTZ studies since 2013, which is the same year China authorized the first FTZ in Shanghai. China and the United States of America have played a leading role in FTZ research. Finally, the increasing trend in FTZ utilization will remain sizeable during its deepening development. The findings may contribute to a better understanding of FTZs and make some references to smart land-use planning experience and practices around the globe.
- Published
- 2022
- Full Text
- View/download PDF
17. Impact of Collaborative Agglomeration of Manufacturing and Producer Services on Air Quality: Evidence from the Emission Reduction of PM2.5, NOx and SO2 in China
- Author
-
Penghao Ye, Jin Li, Wenjing Ma, and Huarong Zhang
- Subjects
atmospheric environment ,manufacturing ,producer services ,industrial agglomeration ,full generalized least squares (FGLS) ,Meteorology. Climatology ,QC851-999 - Abstract
Industrial agglomeration is a major source of regional economic development and the main pattern enterprises employ after having developed to a certain stage. Industrial agglomeration also affects the emissions of air pollutants in production. Based on provincial panel data for China from 2006 to 2019, this paper introduces the full generalized least squares (FGLS) panel econometrics model. By considering spatial correlation, the potential endogenous problem has been controlled using the instrumental variable and the effects of the co-agglomeration of manufacturing and producer services on three major air pollutants, i.e., SO2, PM2.5, and NOx, have been empirically estimated. The empirical results show that: (1) The agglomeration of manufacturing increases the emission of PM2.5 in the air, while the agglomeration of producer services and the co-agglomeration of manufacturing and producer services reduce it. Moran correlation index test showed that SO2 and NOx had no significant spatial correlation. (2) The agglomeration of manufacturing, the agglomeration of producer services, and co-agglomeration exert the most significant effects on PM2.5 in the air in central and western China. This is probably because of the availability of basic natural resources in these areas. (3) The energy consumption structure mediates the effect of the agglomeration of manufacturing on PM2.5, and human capital mediates the effect of the agglomeration of producer services on PM2.5 emissions. Based on the results, policy suggestions to improve the atmospheric environment during the process of industrial agglomeration are proposed.
- Published
- 2022
- Full Text
- View/download PDF
18. A Qualitative Transcriptional Signature for Predicting Recurrence Risk of Stage I–III Bladder Cancer Patients After Surgical Resection
- Author
-
Yawei Li, Huarong Zhang, You Guo, Hao Cai, Xiangyu Li, Jun He, Hung-Ming Lai, Qingzhou Guan, Xianlong Wang, and Zheng Guo
- Subjects
bladder cancer ,micro-metastasis ,qualitative transcriptional signature ,differentially expressed genes ,differentially methylated genes ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Previously reported transcriptional signatures for predicting the prognosis of stage I-III bladder cancer (BLCA) patients after surgical resection are commonly based on risk scores summarized from quantitative measurements of gene expression levels, which are highly sensitive to the measurement variation and sample quality and thus hardly applicable under clinical settings. It is necessary to develop a signature which can robustly predict recurrence risk of BLCA patients after surgical resection.Methods: The signature is developed based on the within-sample relative expression orderings (REOs) of genes, which are qualitative transcriptional characteristics of the samples.Results: A signature consisting of 12 gene pairs (12-GPS) was identified in training data with 158 samples. In the first validation dataset with 114 samples, the low-risk group of 54 patients had a significantly better overall survival than the high-risk group of 60 patients (HR = 3.59, 95% CI: 1.34~9.62, p = 6.61 × 10−03). The signature was also validated in the second validation dataset with 57 samples (HR = 2.75 × 1008, 95% CI: 0~Inf, p = 0.05). Comparison analysis showed that the transcriptional differences between the low- and high-risk groups were highly reproducible and significantly concordant with DNA methylation differences between the two groups.Conclusions: The 12-GPS signature can robustly predict the recurrence risk of stage I-III BLCA patients after surgical resection. It can also aid the identification of reproducible transcriptional and epigenomic features characterizing BLCA metastasis.
- Published
- 2019
- Full Text
- View/download PDF
19. Molecular tracing of confiscated pangolin scales for conservation and illegal trade monitoring in Southeast Asia
- Author
-
Huarong Zhang, Mark P. Miller, Feng Yang, Hon Ki Chan, Philippe Gaubert, Gary Ades, and Gunter A. Fischer
- Subjects
Wildlife trade ,DNA forensics ,Pangolin scales ,Pangolin confiscation ,Haplotype richness ,Southeast Asia ,Ecology ,QH540-549.5 - Abstract
Despite being protected by both international and national regulations, pangolins are threatened by illegal trade. Here we report mitochondrial DNA identification and haplotype richness estimation, using 239 pangolin scale samples from two confiscations in Hong Kong. We found a total of 13 genetically distinct cytochrome c oxidase I (COI) haplotypes in two confiscations (13 and ten haplotypes respectively, with ten shared haplotypes between confiscations). These haplotypes clustered in two distinct clades with one clade representing the Sunda pangolin (Manisjavanica). The other clade did not match with any known Asian pangolin sequences, and likely represented a cryptic pangolin lineage in Asia. By fitting sample coverage and rarefaction/regression models to our sample data, we predicted that the total number of COI haplotypes in two confiscations were 14.86 and 11.06 respectively, suggesting that our sampling caught the majority of haplotypes and that we had adequately characterized each confiscation. We detected substantial sequence divergence among the seized scales, likely evidencing that the Sunda pangolins were harvested over wide geographical areas across Southeast Asia. Our study illustrates the value of applying DNA forensics for illegal wildlife trade monitoring.
- Published
- 2015
- Full Text
- View/download PDF
20. The 'Generator' of Int-Soft Filters on Residuated Lattices
- Author
-
Huarong Zhang and Minxia Luo
- Subjects
residuated lattice ,soft set ,filter ,t-filter ,t-int-soft filter ,Mathematics ,QA1-939 - Abstract
In this paper, we give the “generator” of int-soft filters and propose the notion of t-int-soft filters on residuated lattices. We study the properties of t-int-soft filters and obtain some commonalities (e.g., the extension property, quotient characteristics, and a triple of equivalent characteristics). We also use involution-int-soft filters as an example and show some basic properties of involution-int-soft filters. Finally, we investigate the relations among t-int-soft filters and give a simple method for judging their relations.
- Published
- 2019
- Full Text
- View/download PDF
21. sizzled function and secreted factor network dynamics
- Author
-
Jianli Shi, Huarong Zhang, Robin D. Dowell, and Michael W. Klymkowsky
- Subjects
sizzled ,Secreted signaling antagonists ,WNT ,BMP ,Neural crest induction ,Signaling networks ,Science ,Biology (General) ,QH301-705.5 - Abstract
Summary Studies on the role of the E-box binding transcription factor Snail2 (Slug) in the induction of neural crest by mesoderm (Shi et al., 2011) revealed an unexpected increase in the level of sizzled RNA in the dorsolateral mesodermal zone (DMLZ) of morphant Xenopus embryos. sizzled encodes a secreted protein with both Wnt and BMP inhibitor activities. Morpholino-mediated down-regulation of sizzled expression in one cell of two cell embryos or the C2/C3 blastomeres of 32-cell embryos, which give rise to the DLMZ, revealed decreased expression of the mesodermal marker brachyury and subsequent defects in neural crest induction, pronephros formation, and muscle patterning. Loss of sizzled expression led to decreases in RNAs encoding the secreted Wnt inhibitor SFRP2 and the secreted BMP inhibitor Noggin; the sizzled morphant phenotype could be rescued by co-injection of RNAs encoding Noggin and either SFRP2 or Dickkopf (a mechanistically distinct Wnt inhibitor). Together, these observations reveal that sizzled, in addition to its established role in dorsal-ventral patterning, is also part of a dynamic BMP and Wnt signaling network involved in both mesodermal patterning and neural crest induction.
- Published
- 2012
- Full Text
- View/download PDF
22. The Relations among Fuzzy t-Filters on Residuated Lattices
- Author
-
Huarong Zhang and Qingguo Li
- Subjects
Technology ,Medicine ,Science - Abstract
We give the simple general principle of studying the relations among fuzzy t-filters on residuated lattices. Using the general principle, we can easily determine the relations among fuzzy t-filters on different logical algebras.
- Published
- 2014
- Full Text
- View/download PDF
23. Fabrication and Photocatalytic Property of One-Dimensional SrTiO3/TiO2-xNx Nanostructures
- Author
-
Huarong Zhang, Miao Guashuai, Ma Xingping, and Wang Bei
- Subjects
Renewable energy sources ,TJ807-830 - Abstract
One-dimensional SrTiO3/TiO2−xNx nanostructures were prepared by the hydrothermal method and investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS) measurements. The photocatalytic activities of the prepared samples were evaluated by photodegrading the methylene blue (MB) solution. According to the characterizations, the intermediate product of SrTiO3/titanate nanotubes was presented after hydrothermal processing of the TiO2−xNx nanoparticles with the mixed solution of NaOH and Sr(NO3)2. The final product of SrTiO3/TiO2−xNx nanorods was obtained after calcining the intermediate. As compared to the TiO2−xNx nanoparticles, the absorption performance of SrTiO3/titanate nanotubes or SrTiO3/TiO2−xNx nanorods was depressed, instead of improving it. The mechanisms of the absorption property changes were discussed. The SrTiO3/TiO2−xNx nanorods presented better photocatalytic activity than the TiO2−xNx nanoparticles or nanorods. However, due to overmuch adsorption, the SrTiO3/titanate nanotubes gave ordinary photocatalytic performances.
- Published
- 2013
- Full Text
- View/download PDF
24. Environmental regulation, innovation capability, and green total factor productivity of the logistics industry.
- Author
-
Dongfang Wang, Arthur Tarasov, and Huarong Zhang
- Published
- 2023
- Full Text
- View/download PDF
25. The sheaf representation of residuated lattices.
- Author
-
Huarong Zhang and Dongsheng Zhao
- Published
- 2022
- Full Text
- View/download PDF
26. Value of susceptibility-weighted imaging in differentiating benign from malignant portal vein thrombosis
- Author
-
Chengling Huang, Xixi Xiao, Man Guo, Xianling Hu, Chen Liu, Jian Wang, Huarong Zhang, Xiaoming Li, and Ping Cai
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2023
27. Intuitionistic fuzzy filter theory on residuated lattices.
- Author
-
Huarong Zhang and Qingguo Li
- Published
- 2019
- Full Text
- View/download PDF
28. Spectrum of prime L-fuzzy ideals of an ordered semigroup.
- Author
-
Huanrong Wu, Xiangnan Zhou, Qingguo Li, and Huarong Zhang
- Published
- 2019
- Full Text
- View/download PDF
29. Multi-criteria decision making method based on the single valued neutrosophic sets.
- Author
-
Minxia Luo, Lixian Wu, Kaiyan Zhou, and Huarong Zhang
- Published
- 2019
- Full Text
- View/download PDF
30. The generalized Bosbach states on EQ-algebras.
- Author
-
Huarong Zhang and Minxia Luo
- Published
- 2018
- Full Text
- View/download PDF
31. Environmental regulation, innovation capability, and green total factor productivity of the logistics industry
- Author
-
Dongfang Wang, Arthur Tarasov, and Huarong Zhang
- Subjects
Control and Systems Engineering ,Computer Science (miscellaneous) ,Engineering (miscellaneous) ,Social Sciences (miscellaneous) ,Theoretical Computer Science - Abstract
PurposeThe purpose of this paper is to test the relationship between environmental regulations and green total factor productivity (GTFP) of China's logistics industry. The high-factor input, high-energy consumption, and high-pollution emissions model of the logistics industry developed within China faces challenges from severe resource and environmental constraints. It is generally believed that environmental regulations effectively restrain pollution emissions and help protect the environment.Design/methodology/approachThe authors employ the undesirable slack-based Malmquist Luenberger model to calculate the GTFP across the provincial logistics industry and use the mediation effect model and threshold effect model to explore the effects and mechanics of environmental transmission regulations on the GTFP.FindingsThe main results show significant regional differences in the GTFP of logistics industry across China. In the transmission path of the impact of environmental regulations on the GTFP, regional innovation capabilities have mediation effects. Regional innovation capacities have a masking effect on the transmission path of environmental regulations on accumulated technical efficiency changes (AEC) and accumulated technical changes (ATC). The threshold effect test results show a dual-threshold effect between environmental regulations and the GTFP, with environmental regulations as threshold variable. Furthermore, the impact of regional innovation capability on the GTFP has a dual-threshold effect, with environmental regulation as threshold variable.Practical implicationsFirst, it is advisable to plan the environmental regulation policy system thoroughly and add supporting measures to ensure the efficiency and smooth implementation of the nation's environmental policies. Second, it is important to further understand the critical role of innovation capability in improving the GTFP. Third, there is an urgent need to standardize the operating behavior and market order of the leading players in the logistics market and to improve the operational efficiency of logistics enterprises.Originality/valueSo far, a systematical study researched on effect of environmental regulation on the GTFP in logistics industry was not published. This study can provide experience for the high-quality development of the logistics industry.
- Published
- 2022
32. Experimental and numerical study of the influence of initial temperature on explosion limits and explosion process of syngas-air mixtures
- Author
-
Fengyuan Jiao, Huarong Zhang, Wenjuan Li, Yuxin Zhao, Jiaxin Guo, Xin Zhang, Weiguo Cao, and Yun Zhang
- Subjects
Fuel Technology ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Condensed Matter Physics - Published
- 2022
33. Macrotrabecular-Massive Hepatocellular Carcinoma: What Should We Know?
- Author
-
Xiaoming Li, Qiandong Yao, Chen Liu, Jian Wang, Huarong Zhang, Shiguang Li, and Ping Cai
- Abstract
Hepatocellular carcinoma is one of the most common malignancies globally. Recently, a newly identified histological subtype, designated as "macrotrabecular-massive hepatocellular carcinoma" (MTM-HCC), has been associated with an aggressive phenotype and has received extensive attention. MTM-HCC was a strong independent prognostic predictor of early and overall recurrence because it is closely related to tumor molecular subclass, gene mutation, carcinogenesis pathways, and immunohistochemical markers. In addition, preoperative imaging examination can potentially provide an essential clue for diagnosing MTM-HCC, intratumor necrosis or ischemia is an independent predictor for MTM-HCC on Gd-EOB-DTPA enhanced MRI or CT. Early diagnosis and appropriate treatment of MTM-HCC could prove beneficial for preventing early recurrence and could improve outcomes.
- Published
- 2022
34. Expression of Insulin-Like Growth Factor Type 1 Receptor Is Linked to Inflammation in Adamantinomatous Craniopharyngioma
- Author
-
Lang, Yang, Kai, Li, Weizhao, Li, Chaohu, Wang, Yi, Liu, Huarong, Zhang, Jun, Pan, Songtao, Qi, and Junxiang, Peng
- Subjects
Inflammation ,body regions ,Craniopharyngioma ,Cellular and Molecular Neuroscience ,Endocrinology ,Endocrine and Autonomic Systems ,Pituitary Gland ,Endocrinology, Diabetes and Metabolism ,Humans ,Pituitary Neoplasms ,Receptor, IGF Type 1 - Abstract
Introduction: Insulin-like growth factor type 1 receptor (IGF1R) is overexpressed in various malignant tumors, which relates to their transformation and recurrence. Craniopharyngioma is a benign tumor with malignant results, often accompanied by a severe inflammatory reaction. However, the relationship between IGF1R expression and the inflammatory response of craniopharyngioma is unclear. Methods: We enrolled 85 patients with adamantinomatous craniopharyngioma (ACP) in a study to explore the relationship between IGF1R expression and clinical features of this disease. Results: Patients in the IGF1R high-expression group had a significantly higher incidence of hypopituitarism, higher recurrence rate, and lower progression-free survival. β-Catenin can further regulate expression of the stem cell marker, CD44, by regulating IGF1R. Using immunofluorescence, we found that tumor stem cell-like cells did not express phosphorylated (p)-ERK, although p-ERK activation was evident in the surrounding cells. Picropodophyllin, a specific inhibitor of IGF1R, increased the expression of p-ERK protein and decreased the transcription level of interleukin-6. Conclusions: High expression of IGF1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor stem cell-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. IGF1R plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation.
- Published
- 2021
35. Effects of Initial Turbulence on the Explosion Limit and Flame Propagation Behaviors of Premixed Syngas–Air Mixtures
- Author
-
Yuxin Zhao, Huarong Zhang, Yingxin Tan, Shuo Zhang, Weiguo Cao, Yabei Xu, and Jiaxin Guo
- Subjects
Materials science ,Explosive material ,Turbulence ,General Chemical Engineering ,General Chemistry ,Mechanics ,Combustion ,Article ,Pressure vessel ,Chemistry ,Limit (music) ,Turbulence kinetic energy ,QD1-999 ,Flammability ,Syngas - Abstract
Syngas with important industrial applications has explosive hazards because of its flammability. It is necessary and valuable to study the combustion and explosion characteristics of syngas under actual working conditions. To explore the effects of initial turbulence on the explosion limits and the flame propagation behavior of the syngas–air mixtures, the explosion limits were tested by the explosive limit instrument, and the flame propagation process in the spherical pressure vessel was recorded by a high-speed camera. By adjusting the rotating speed of the stirrer to obtain turbulence of different intensities, the explosion limit and flame propagation behavior of syngas under different turbulent conditions were analyzed. The explosion limit of syngas in the macro-static state was 9.5–76.1%, and its flame front was relatively smooth. However, with the increase in turbulence intensity, both the upper and lower explosion limits of syngas decreased. The disturbance of turbulence made the flame shape change. The flame front was wrinkled, and the flame boundary was blurred, which became more and more obvious with the increase in turbulence intensity. The maximum velocity and duration of flame propagation increased with the increase in turbulence intensity. Under the same turbulence intensity, the flame propagation velocity generally augmented first and then lessened.
- Published
- 2021
36. Inhibition of integrated stress response protects against lipid-induced senescence in hypothalamic neural stem cells in adamantinomatous craniopharyngioma
- Author
-
Chaohu Wang, Huarong Zhang, Jun Fan, Qing Li, Rongrong Guo, Jun Pan, Yawei Liu, Junxiang Peng, Qianchao Zhu, Yiwen Feng, Chengdong Wu, Peng Luo, Xiaoyu Qiu, Jin Shi, Yingying Deng, Songtao Qi, and Yi Liu
- Subjects
Cancer Research ,Oncology ,Neurology (clinical) - Abstract
Background Adamantinomatous craniopharyngioma (ACP) is a benign tumor with malignant clinical manifestations. ACP adjacent to the hypothalamus often presents with more severe symptoms and higher incidence of hypothalamic dysfunction. However, the mechanism underlying hypothalamic dysfunction remains unclear. Methods Immunostaining was performed to determine the nerve damage to the floor of the third ventricle (3VF) adjacent to ACP and to examine the recruitment and senescence of hypothalamic neural stem cells (htNSCs). The accumulation of lipid droplets (LDs) in htNSCs was evaluated via BODIPY staining, oil red O staining, and transmission electron microscopy. In vitro and in vivo assays were used to evaluate the effect of cystic fluid or oxidized low-density lipoprotein and that of oxytocin (OXT) on htNSC senescence and the hypothalamic function. The protein expression levels were analyzed using western blotting. Results htNSCs with massive LD accumulation were recruited to the damaged 3VF adjacent to ACP. The LDs in htNSCs induced senescence and reduced neuronal differentiation; however, htNSC senescence was effectively prevented by inhibiting either CD36 or integrated stress response (ISR) signaling. Furthermore, OXT pretreatment reduced lipotoxicity via the inhibition of ISR signaling and the repair of the blood–brain barrier. Conclusions Reduced LD aggregation or ISR signaling inhibition prevented senescence in htNSCs and identified molecular pathways and potential therapeutic targets that may improve hypothalamic dysfunction in ACP patients.
- Published
- 2022
37. (∈ , ∈ ∨ q)-fuzzy t-filters on residuated lattices.
- Author
-
Huarong Zhang and Qingguo Li
- Published
- 2015
- Full Text
- View/download PDF
38. Preoperative Assessment of Abdominal Adipose Tissue to Predict Microvascular Invasion in Small Hepatocellular Carcinoma
- Author
-
Jie Cheng, Kuansheng Ma, Zongqian Wu, Liang Tan, Huarong Zhang, Xiaofei Hu, Xiaoming Li, Chen Liu, Qiao Xie, Ping Cai, and Hong Lu
- Subjects
Pathology ,medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,business.industry ,Adipose tissue ,Computed tomography ,medicine.disease ,Hepatocellular carcinoma ,Medicine ,In patient ,Subcutaneous adipose tissue ,business ,After treatment - Abstract
Microvascular invasion (MVI) affects recurrence after treatment of small hepatocellular carcinoma (sHCC) of ≤3 cm in size. The present study aimed to investigate whether abdominal subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and intermuscular adipose tissue (IMAT) are associated with MVI in patients with sHCC.A total of 124 patients with pathologically-confirmed sHCC diagnosed on surgical resection at the First Hospital Affiliated to Army Military University were recruited and divided into two groups according to MVI classification criteria (i.e., MVI-positive or MVI-negative). The SAT, VAT, and IMAT areas at the lumbar 3 vertebral level were imaged with abdominal computed tomography and measured using ImageJ software. Their association with MVI in sHCC was analyzed.Of the 124 patients with sHCC, 67 were MVI-positive and 57 were MVI-negative. Univariate analysis revealed a significant difference in the abdominal VAT and SAT between the MVI-positive and MVI-negative groups (The results of this study suggest that the areas of abdominal SAT and VAT are of significant clinical value because they can effectively predict the MVI status in patients with sHCC.
- Published
- 2021
39. Tumor-selective blockade of CD47 signaling with CD47 antibody for enhanced anti-tumor activity in malignant meningioma
- Author
-
Yi Liu, Xiaotong Liu, Huarong Zhang, Chaohu Wang, Zhiyong Li, Qianchao Zhu, Yiwen Feng, Jun Fan, Songtao Qi, and Zhiyong Wu
- Subjects
Pharmacology ,Psychiatry and Mental health ,Neurology ,Pharmacology (medical) ,Neurology (clinical) ,General Medicine - Abstract
Background: Patients with WHO grade III meningioma have a poor prognosis with a median survival of less than two years and a high risk of recurrence. However, traditional treatment options have failed to improve prognosis. Therefore, development of novel immunotherapy targets is urgently needed. CD47 acting as a “don't eat me” signal to macrophages can trigger tumor immune escape. However, the role of CD47 in malignant meningioma is not well understood. Methods: We collected 190 clinical meningioma samples and detected the expression of CD47 and immune infiltration in WHO grade I-III by immunohistochemistry, western blot, qPCR. We also ex- amined the functional effects of anti-CD47 on cell proliferation, migration and invasion, macrophage- mediated phagocytosis and tumorigenicity both in vitro and in vivo. Results: We found that the expression of CD47 was increased in malignant meningioma along with a decreased number of T cells and an increase in CD68+ macrophages. Blocking CD47 with anti-CD47 antibody (B6H12) suppressed tumor cell growth, motility and promoted macrophage-mediated phagocytosis in IOMM-Lee cells in vitro. In vivo experiments showed that anti-CD47 antibody (B6H12 or MIAP301) significantly inhibited the tumor growth and this effect was partly blocked by the depletion of macrophages. Finally, p-ERK and EGFR showed higher expression in malignant meningioma with high expression of CD47, which was verified by western blot. Conclusion: Our results demonstrated that CD47 maybe involved in the meningioma progression andprognosis and offered a novel therapeutic option by targeting CD47 in malignant meningioma.
- Published
- 2022
40. The Application Practices of the Double-zone ESP in Coal-fired Power Plant
- Author
-
Huarong, Zhang, Liu, Meng, Rongfa, Zhang, Jun, Guo, and Yan, Keping, editor
- Published
- 2009
- Full Text
- View/download PDF
41. Determination of phytic acid in wheat products by complete methyl esterification and liquid chromatography‐mass spectrometry analysis
- Author
-
Yan Wang, Huarong Zhang, Chunqi Sheng, Zhiwei Chen, Kezhi Jiang, and Saisai Yu
- Subjects
Phytic Acid ,Metal ions in aqueous solution ,Filtration and Separation ,02 engineering and technology ,Mass spectrometry ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Tandem Mass Spectrometry ,Liquid chromatography–mass spectrometry ,Derivatization ,Ion-exchange resin ,Chromatography, High Pressure Liquid ,Triticum ,Phytic acid ,Chromatography ,Esterification ,Diazomethane ,Solid Phase Extraction ,010401 analytical chemistry ,food and beverages ,Phosphorus ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Standard curve ,chemistry ,0210 nano-technology ,Chromatography, Liquid - Abstract
Phytic acid, the principal storage form of phosphorus in wheat, plays both beneficial and anti-nutrient functions for human-being, and its analytical method still needs further development. In this work, we have developed a new method for the determination of phytic acid in wheat products based on derivatization with (trimethylsilyl)diazomethane in combination with liquid chromatography-mass spectrometry analysis. Methyl esterification greatly decreased the polarity and the acidity of phytic acid, and thus the corresponding derivative can be easily analyzed by liquid chromatography-mass spectrometry under common conditions. Furthermore, treatment with cation exchange resin removed the polyvalent metal ions in the solutions, and thus derivatization of phytic acid can be achieved efficiently and completely. The standard curve for phytic acid has been well established in the linear range of 0.5∼100 ng/mL with squared correlation coefficient more than 0.999, and the quantification limit of 0.25 ng/mL. The phytic acid content varies very greatly in different wheat products, ranging from 153.5 to 17299.0 μg/g. This article is protected by copyright. All rights reserved.
- Published
- 2021
42. Autocatalytic decomposition properties and thermal decomposition of benzoyl peroxide
- Author
-
Yun Zhang, Weiguo Cao, Yingxin Tan, Chi-Min Shu, Huarong Zhang, Jingwen Luo, and Yabei Xu
- Subjects
Thermogravimetric analysis ,Materials science ,Enthalpy ,Thermal decomposition ,Thermodynamics ,02 engineering and technology ,Benzoyl peroxide ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Decomposition ,Isothermal process ,010406 physical chemistry ,0104 chemical sciences ,Autocatalysis ,Differential scanning calorimetry ,medicine ,Physical and Theoretical Chemistry ,0210 nano-technology ,medicine.drug - Abstract
Differential scanning calorimetry (DSC) and thermogravimetric analyzer (TGA) were used to examine the thermal decomposition of benzoyl peroxide (BPO). The interruption rescanning method was adopted to examine the effect of thermal history on the autocatalysis and thermal decomposition of BPO. Autocatalysis of BPO was verified through isothermal experiments. According to the DSC linear temperature rise data of BPO, mathematical methods were used to decouple and divide the peaks. Kinetic analysis using both the Kissinger and Friedman methods was performed. The initial decomposition temperature of the decoupled BPO ranged between 101.4 and 104.6 °C. The peak temperature was 110.9–126.2 °C, and the decomposition enthalpy was 229.7–524.2 J g–1. The apparent activation energy was higher in the coupling state than after decoupling one. The thermal history and isothermal experiments demonstrated that BPO possessed autocatalytic properties. Results revealed that initial decomposition temperature tended to decrease with the increase in interruption temperature. In addition, the apparent activation energy of BPO decreased following the thermal history analysis because of the formation of intermediate products from BPO in the thermal history experiments, which further promoted BPO’s thermal decomposition. This effect led to a decrease in BPO’s initial decomposition temperature.
- Published
- 2021
43. A Fuzzy Evaluation Approach for Scientific Research Projects with 2-Tuple Linguistic Preference Relations
- Author
-
Huarong Zhang and Xiangqian Feng
- Abstract
Science and technology project evaluation is an important means of science and technology management. Whether the evaluation of science and technology projects is fair or not directly affects the development of national economy and the allocation of science and technology resources. Due to the complexity of the project and the fuzziness of human thinking, the expert information is often difficult to quantify in the process of project evaluation. Generally, the better choice is to express it in qualitative language. In this paper, the 2-tuple linguistic preference relation is proposed to evaluate scientific research projects. The reasonableness of the concept of complete consistency for the 2-tuple linguistic preference relation is discussed. Priority of 2-tuple linguistic preference relation is set up based on the 2-tuple weighted geometric averaging operator. Finally, combined with Science and technology project evaluation problem, the effectiveness and feasibility of the method are verified.
- Published
- 2021
44. C-H Fluoroalkylsulfinylation/Intramolecular Rearrangement for Precise Synthesis of Fluoroalkyl Sulfoxides
- Author
-
Shuya Xing, Yu-Yi Zhu, Wen Liu, Yong Liu, Jing Zhang, Huarong Zhang, Yan Wang, Shao-Fei Ni, and Xinxin Shao
- Subjects
Organic Chemistry ,Physical and Theoretical Chemistry ,Biochemistry - Abstract
An efficient methodology to access various fluoroalkyl sulfoxides bearing
- Published
- 2022
45. A qualitative transcriptional signature of recurrence risk for stages II–III gastric cancer patients after surgical resection
- Author
-
Lu Ao, Lishuang Qi, Yawei Li, Haiyan Huang, Junling Wu, Ting Chen, Xiangyu Li, Shanshan Wang, Huarong Zhang, Jiahui Zhang, Jie Xia, and Meifeng Li
- Subjects
Oncology ,Surgical resection ,medicine.medical_specialty ,Disease-Free Survival ,Recurrence risk ,Metastasis ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Epigenetics ,Gene ,Lymph node ,Pathological ,Hepatology ,business.industry ,Gastroenterology ,Cancer ,Genomics ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business - Abstract
Background and aim Metastasis is the leading cause of recurrence in gastric cancer. However, the imaging techniques and pathological examinations for tumor metastasis have a high false-positive rate or a high false-negative rate, and many proposed that metastasis-related molecular biomarkers can hardly be validated in independent datasets. Methods We propose to use significantly stable gene pairs with reversal relative expression orderings (REOs) between non-metastasis and metastasis gastric cancer samples as the metastasis-related gene pairs. Based on the REOs of these gene pairs, we developed a qualitative transcriptional signature for predicting the recurrence risk of stages II-III gastric cancer patients after surgical resection. Results A REOs-based signature, consisting of 19 gene pairs (19-GPS), was selected from 77 stages II-III gastric cancer patients and validated in two independent datasets. Samples in the high-risk group had shorter disease-free survival time and overall survival time than those in the low-risk group. Differentially expressed genes (DEGs) between the high- and low-risk groups classified by 19-GPS were highly reproducible comparing with those between lymph node metastasis and lymph node non-metastasis groups. Functional enrichment analysis showed that these DEGs were significantly enriched in metastasis-related pathways, such as PI3K-Akt and Rap1 signaling pathways. The multi-omics analyses suggested that the epigenetic and genomic features might cause transcriptional differences between two subgroups, which help to characterize the mechanism of gastric cancer metastasis. Conclusions The signature could robustly identify patients at high recurrence risk after resection surgery, and the multi-omics analyses might aid in revealing the metastasis-related characteristics of gastric cancer.
- Published
- 2021
46. Study of SO2 measurement based on a dual optical path Fabry-Perot correlation spectroscopy
- Author
-
Yinsheng Lv, Pinhua Xie, Jin Xu, Ang Li, Zhaokun Hu, Youtao Li, Huarong Zhang, Zhidong Zhang, Xin Tian, Feng Hu, Jiangyi Zheng, and Yingjie Ye
- Subjects
Atomic and Molecular Physics, and Optics - Abstract
This paper investigates a method for measuring SO2 concentration using Fabry–Perot interferometer correlation spectroscopy. In this method, the experimental system is designed as a separated beam, with the beam entering the F–P cavity at two incidence angles simultaneously to match the peak and valley positions of the SO2 absorption cross-section. The system achieves a 2σ detection limit of 28.2 ppm·m(15 cm) at a sampling frequency of 10 Hz. An outfield comparison experiment with the differential optical absorption spectroscopy method shows good agreement for the simultaneous measurement of SO2 concentration from sulfur combustion, with a correlation coefficient of R2 = 0.93. This study introduces a non-dispersive, highly accurate, and fast gas detection technique.
- Published
- 2023
47. Qualitative diagnostic signature for pancreatic ductal adenocarcinoma based on the within‐sample relative expression orderings
- Author
-
Jie Xia, Haiyan Huang, Huarong Zhang, Qingzhou Guan, Meifeng Li, Shanshan Wang, Jiajing Xie, Yawei Li, Haidan Yan, and Ting Chen
- Subjects
Pathology ,medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,endocrine system diseases ,Biopsy ,Datasets as Topic ,Specimen Handling ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Pancreatic cancer ,Humans ,Medicine ,Sampling (medicine) ,Survival rate ,Pathological ,Training set ,Hepatology ,medicine.diagnostic_test ,business.industry ,Gene Expression Profiling ,Gastroenterology ,medicine.disease ,digestive system diseases ,Pancreatic Neoplasms ,Diagnostic Techniques, Digestive System ,030220 oncology & carcinogenesis ,Pancreatitis ,030211 gastroenterology & hepatology ,Transcriptome ,business ,Carcinoma, Pancreatic Ductal - Abstract
Background Pancreatic ductal adenocarcinoma (PDAC) accounts for about 90% of pancreatic cancer, which is one of the most aggressive malignant neoplasms with a 9.3% five-year survival rate. The pathological biopsy is the current golden standard for confirming suspicious lesions of PDAC, but it is not entirely reliable because of the insufficient sampling amount and inaccurate sampling location. Therefore, developing a robust signature to aid the accurate diagnosis of PDAC is critical. Methods Based on the within-sample relative expression orderings of gene pairs, we identified a qualitative signature to discriminate both PDAC and adjacent samples from both chronic pancreatitis and normal samples in the training datasets and validated it in other independent datasets produced by different laboratories with different measuring platforms. Results A six-gene-pair signature was identified in the training data and validated in eight independent datasets. For surgical samples, 96.63% of 356 PDAC tissues, 100% of 11 pancreatitis tissues of non-cancer patients, and 23 of 24 normal pancreatic tissues were correctly classified. Especially, 59 of 60 cancer-adjacent normal tissues of PDAC patients were correctly identified as PDAC. For biopsy samples, all of 11 PDAC biopsy tissues were correctly classified as PDAC. Conclusion The signature can distinguish both PDAC and PDAC-adjacent normal tissues from both chronic pancreatitis and normal tissues of non-cancer patients even when the sampling locations are inaccurate, which can aid the diagnosis of PDAC.
- Published
- 2020
48. Neutrophil Infiltration Induces Myocardial Injury In COVID-19 Post-Mortem Cases
- Author
-
Yaling Han, Quanyu Zhang, Huarong Zhang, Xiaowei Yan, Sicong Ma, Xiaohong Yao, Yu Shi, Yifang Ping, Mianfu Cao, Chengfei Peng, Shuai Wang, Min Luo, Chenghui Yan, Shuyang Zhang, and Xiuwu Bian
- Abstract
Objectives: The pathological features of severe cardiac injury induced by COVID-19 and relevant clinical features is unknown.Methods: This autopsy cohort study, including hearts from 26 deceased patients hospitalized in intensive care unit due to COVID-19, was conducted at four sites in Wuhan, China. Cases were divided into neutrophil-infiltration group and no-neutrophil group according to histopathological identification of neutrophilic infiltrates or not.Results: Among 26 cases, four cases had active myocarditis with histopathological examination. All cases with myocarditis accompanied with extensive neutrophil infiltration, while cases without myocarditis did not. Detection rates of interleukin-6 (100% vs 4.6%) and tumor necrosis factor-a (100% vs 31.8%) in neutrophil-infiltration group were significantly higher compared to no-neutrophil group (pConclusions: In hearts from deceased patients with severe COVID-19, active myocarditis was commonly infiltrated with neutrophils. Cases with neutrophil-infiltrated myocarditis had a series of severe abnormal laboratory tests at admission, and a high maximum of CK-MB during hospitalization. Role of neutrophil on severe heart injury and even systemic condition in COVID-19 should be emphasized.
- Published
- 2022
49. Neutrophil Infiltration Induces Myocardial Injury in COVID-19 Post-Mortem Cases
- Author
-
Quanyu Zhang, Huarong Zhang, Xiaowei Yan, Sicong Ma, Xiaohong Yao, Yu Shi, Yifang Ping, Mianfu Cao, Chengfei Peng, Shuai Wang, Min Luo, Chenghui Yan, Shuyang Zhang, Yaling Han, and Xiuwu Bian
- Abstract
Background: The pathological features of severe cardiac injury induced by COVID-19 and relevant clinical features is unknown. This post-mortem study intended to determine the pathological findings of hearts from critically ill COVID-19 cases and explore the association of pathological changes and clinical characteristics.Methods: This autopsy cohort study, including hearts from 26 deceased COVID-19 patients admitted in intensive care unit, was conducted at four sites in Wuhan, China. Pathological changes were evaluated using hematoxylin and eosin, and immunohistochemical staining. Cases were divided into neutrophil-infiltration group and no-neutrophil group according to histopathological identification of neutrophilic infiltrates or not. Results: Among 26 cases, four cases had active myocarditis with histopathological examination. All cases with myocarditis accompanied with extensive neutrophil infiltration, while cases without myocarditis did not. Detection rates of interleukin-6 and tumor necrosis factor-α in neutrophil-infiltration group were significantly higher compared to no-neutrophil group. At admission, patients with neutrophil infiltration in myocardium had significantly higher baseline values of aspartate aminotransferase, D dimer and high-sensitivity C reactive protein compared to other 22 patients (PConclusions: In hearts from deceased patients with severe COVID-19, active myocarditis was commonly infiltrated with neutrophils. Cases with neutrophil-infiltrated myocarditis had severe abnormal laboratory tests involving multiple organs at admission, and a high peak value of CK-MB during hospitalization. Role of neutrophil on severe heart injury and even systemic condition in COVID-19 should be emphasized.
- Published
- 2022
50. A qualitative transcriptional prognostic signature for patients with stage I-II pancreatic ductal adenocarcinoma
- Author
-
Yawei Li, Haiyan Huang, Zheng Guo, Yi Zou, Lu Ao, Huarong Zhang, Huaqin Sun, Xiang Li, and Xusheng Deng
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Transcription, Genetic ,Datasets as Topic ,TNM staging system ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Carcinoma ,medicine ,Humans ,MAPK10 ,Stage (cooking) ,Survival analysis ,Aged ,Neoplasm Staging ,Epigenomics ,Aged, 80 and over ,Proportional hazards model ,business.industry ,Gene Expression Profiling ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Pancreatic Neoplasms ,Gene expression profiling ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,business ,Carcinoma, Pancreatic Ductal - Abstract
Accurately prognostic evaluation of patients with stage I-II pancreatic ductal adenocarcinoma (PDAC) is of importance to treatment decision and patient management. Most previously reported prognostic signatures were based on risk scores summarized from quantitative expression measurements of signature genes, which are susceptible to experimental batch effects and impractical for clinical applications. Based on the within-sample relative expression orderings of genes, we developed a robust qualitative transcriptional prognostic signature, consisting of 64 gene pairs (64-GPS), to predict the overall survival (OS) of 161 stage I-II PDAC patients in the training dataset who were treated with surgery only. Samples were classified into the high-risk group when at least 25 of 64 gene pairs suggested it was at high risk. The signature was successfully validated in 324 samples from 6 independent datasets produced by different laboratories. All samples in the low-risk group had significantly better OS than samples in the high-risk group. Multivariate Cox regression analyses showed that the 64-GPS remained significantly associated with the OS of patients after adjusting available clinical factors. Transcriptomic analysis of the 2 prognostic subgroups showed that the differential expression signals were highly reproducible in all datasets, whereas the differences between samples grouped by the TNM staging system were weak and irreproducible. The epigenomic analysis showed that the epigenetic alternations may cause consistently transcriptional changes between the 2 different prognostic groups. The genomic analysis revealed that mutation‑induced disturbances in several key genes, such as LRMDA, MAPK10, and CREBBP, might lead to poor prognosis for PDAC patients. Conclusively, the 64-GPS can robustly predict the prognosis of patients with stage I-II PDAC, which provides theoretical basis for clinical individualized treatment.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.