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20. The α-synuclein gene is not a major risk factor in familial Parkinson disease

Author

Scott, W. K., Yamaoka, L. H., Stajich, J. M., Scott, B. L., Vance, J. M., Roses, A. D., Pericak-Vance, M. A., Watts, R. L., Nance, M., Hubble, J., Koller, W., Stern, M. B., Colcher, A., Allen Jr, F. H., Hiner, B. C., Jankovic, J., Ondo, W., Laing, N. G., Mastaglia, F., Goetz, C., Pappert, E., Small, G. W., Masterman, D., Haines, J. L., Davies, T. L., and Roses, A. D.

Published
1999
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21. Closed-loop glycaemic control using an implantable artificial pancreas in diabetic domestic pig

Author

Taylor, M. Joan, Gregory, R., Tomlins, P., Jacob, D., Hubble, J., and Sahota, T. S.

Subjects
implantable, glucose-sensitive, artificial pancreas, Diabetes, Insulin, closed loop, smart material
Abstract

INsmart in the DMU Pharmacy department in association with University Hospitals Leicester, Bath University, National Physical Laboratory and Renfrew International Group Leicester The performance of a completely implantable peritoneal artificial pancreas (AP) has been demonstrated in principle in a live diabetic domestic pig. The device consists of a smart glucose-sensitive gel that forms a gateway to an insulin reservoir and is designed to both sense glucose and deliver insulin in the peritoneal cavity. It can be refilled with insulin via subcutaneous ports and surgery was developed to insert the AP. Diabetes was induced with streptozotocin (STZ), the device filled with insulin (Humulin1 R U-500) in situ and the animal observed for several weeks, during which time there was normal access to food and water and several oral glucose challenges. Blood glucose (BG) levels were brought down from >30 mmol/L (540 mg/dL) to non-fasted values between 7 and 13 mmol/L (126–234 mg/dL) about five days after filling the device. Glucose challenge responses improved ultimately so that, starting at 10 mmol/L (180 mg/dL), the BG peak was 18 mmol/L (324 mg/dL) and fell to 7 mmol/L (126 mg/dL) after 30 min, contrasting with intravenous attempts. The reservoir solution was removed after 8 days of blood glucose levels during which they had been increasingly better controlled. A rapid return to diabetic BG levels (30 mmol/L) occurred only after a further 24 days implying some insulin had remained in the device after removal of the reservoir solution. Thus, the closed loop system appeared to have particular influence on the basal and bolus needs for the 8 days in which the reservoir solution was in place and substantial impact for a further 3 weeks. No additional insulin manual adjustment was given during this period.

Published
2015
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24. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

Author

Nalls, M.A. Pankratz, N. Lill, C.M. Do, C.B. Hernandez, D.G. Saad, M. Destefano, A.L. Kara, E. Bras, J. Sharma, M. Schulte, C. Keller, M.F. Arepalli, S. Letson, C. Edsall, C. Stefansson, H. Liu, X. Pliner, H. Lee, J.H. Cheng, R. Ikram, M.A. Ioannidis, J.P.A. Hadjigeorgiou, G.M. Bis, J.C. Martinez, M. Perlmutter, J.S. Goate, A. Marder, K. Fiske, B. Sutherland, M. Xiromerisiou, G. Myers, R.H. Clark, L.N. Stefansson, K. Hardy, J.A. Heutink, P. Chen, H. Wood, N.W. Houlden, H. Payami, H. Brice, A. Scott, W.K. Gasser, T. Bertram, L. Eriksson, N. Foroud, T. Singleton, A.B. Plagnol, V. Sheerin, U.-M. Simón-Sánchez, J. Lesage, S. Sveinbjörnsdóttir, S. Barker, R. Ben-Shlomo, Y. Berendse, H.W. Berg, D. Bhatia, K. de Bie, R.M.A. Biffi, A. Bloem, B. Bochdanovits, Z. Bonin, M. Bras, J.M. Brockmann, K. Brooks, J. Burn, D.J. Charlesworth, G. Chinnery, P.F. Chong, S. Clarke, C.E. Cookson, M.R. Cooper, J.M. Corvol, J.C. Counsell, C. Damier, P. Dartigues, J.-F. Deloukas, P. Deuschl, G. Dexter, D.T. van Dijk, K.D. Dillman, A. Durif, F. Dürr, A. Edkins, S. Evans, J.R. Foltynie, T. Dong, J. Gardner, M. Gibbs, J.R. Gray, E. Guerreiro, R. Harris, C. van Hilten, J.J. Hofman, A. Hollenbeck, A. Holton, J. Hu, M. Huang, X. Wurster, I. Mätzler, W. Hudson, G. Hunt, S.E. Huttenlocher, J. Illig, T. Jónsson, P.V. Lambert, J.-C. Langford, C. Lees, A. Lichtner, P. Limousin, P. Lopez, G. Lorenz, D. McNeill, A. Moorby, C. Moore, M. Morris, H.R. Morrison, K.E. Mudanohwo, E. O’sullivan, S.S. Pearson, J. Pétursson, H. Pollak, P. Post, B. Potter, S. Ravina, B. Revesz, T. Riess, O. Rivadeneira, F. Rizzu, P. Ryten, M. Sawcer, S. Schapira, A. Scheffer, H. Shaw, K. Shoulson, I. Sidransky, E. Smith, C. Spencer, C.C.A. Stefánsson, H. Bettella, F. Stockton, J.D. Strange, A. Talbot, K. Tanner, C.M. Tashakkori-Ghanbaria, A. Tison, F. Trabzuni, D. Traynor, B.J. Uitterlinden, A.G. Velseboer, D. Vidailhet, M. Walker, R. van de Warrenburg, B. Wickremaratchi, M. Williams, N. Williams-Gray, C.H. Winder-Rhodes, S. Stefánsson, K. Hardy, J. Factor, S. Higgins, D. Evans, S. Shill, H. Stacy, M. Danielson, J. Marlor, L. Williamson, K. Jankovic, J. Hunter, C. Simon, D. Ryan, P. Scollins, L. Saunders-Pullman, R. Boyar, K. Costan-Toth, C. Ohmann, E. Sudarsky, L. Joubert, C. Friedman, J. Chou, K. Fernandez, H. Lannon, M. Galvez-Jimenez, N. Podichetty, A. Thompson, K. Lewitt, P. Deangelis, M. O'brien, C. Seeberger, L. Dingmann, C. Judd, D. Marder, K. Fraser, J. Harris, J. Bertoni, J. Peterson, C. Rezak, M. Medalle, G. Chouinard, S. Panisset, M. Hall, J. Poiffaut, H. Calabrese, V. Roberge, P. Wojcieszek, J. Belden, J. Jennings, D. Marek, K. Mendick, S. Reich, S. Dunlop, B. Jog, M. Horn, C. Uitti, R. Turk, M. Ajax, T. Mannetter, J. Sethi, K. Carpenter, J. Dill, B. Hatch, L. Ligon, K. Narayan, S. Blindauer, K. Abou-Samra, K. Petit, J. Elmer, L. Aiken, E. Davis, K. Schell, C. Wilson, S. Velickovic, M. Koller, W. Phipps, S. Feigin, A. Gordon, M. Hamann, J. Licari, E. Marotta-Kollarus, M. Shannon, B. Winnick, R. Simuni, T. Videnovic, A. Kaczmarek, A. Williams, K. Wolff, M. Rao, J. Cook, M. Fernandez, M. Kostyk, S. Hubble, J. Campbell, A. Reider, C. Seward, A. Camicioli, R. Carter, J. Nutt, J. Andrews, P. Morehouse, S. Stone, C. Mendis, T. Grimes, D. Alcorn-Costa, C. Gray, P. Haas, K. Vendette, J. Sutton, J. Hutchinson, B. Young, J. Rajput, A. Klassen, L. Shirley, T. Manyam, B. Simpson, P. Whetteckey, J. Wulbrecht, B. Truong, D. Pathak, M. Frei, K. Luong, N. Tra, T. Tran, A. Vo, J. Lang, A. Kleiner-Fisman, G. Nieves, A. Johnston, L. So, J. Podskalny, G. Giffin, L. Atchison, P. Allen, C. Martin, W. Wieler, M. Suchowersky, O. Furtado, S. Klimek, M. Hermanowicz, N. Niswonger, S. Shults, C. Fontaine, D. Aminoff, M. Christine, C. Diminno, M. Hevezi, J. Dalvi, A. Kang, U. Richman, J. Uy, S. Sahay, A. Gartner, M. Schwieterman, D. Hall, D. Leehey, M. Culver, S. Derian, T. Demarcaida, T. Thurlow, S. Rodnitzky, R. Dobson, J. Lyons, K. Pahwa, R. Gales, T. Thomas, S. Shulman, L. Weiner, W. Dustin, K. Singer, C. Zelaya, L. Tuite, P. Hagen, V. Rolandelli, S. Schacherer, R. Kosowicz, J. Gordon, P. Werner, J. Serrano, C. Roque, S. Kurlan, R. Berry, D. Gardiner, I. Hauser, R. Sanchez-Ramos, J. Zesiewicz, T. Delgado, H. Price, K. Rodriguez, P. Wolfrath, S. Pfeiffer, R. Davis, L. Pfeiffer, B. Dewey, R. Hayward, B. Johnson, A. Meacham, M. Estes, B. Walker, F. Hunt, V. O'neill, C. Racette, B. Swisher, L. Dijamco, C. Conley, E.D. Dorfman, E. Tung, J.Y. Hinds, D.A. Mountain, J.L. Wojcicki, A. Lew, M. Klein, C. Golbe, L. Growdon, J. Wooten, G.F. Watts, R. Guttman, M. Goldwurm, S. Saint-Hilaire, M.H. Baker, K. Litvan, I. Nicholson, G. Nance, M. Drasby, E. Isaacson, S. Burn, D. Pramstaller, P. Al-Hinti, J. Moller, A. Sherman, S. Roxburgh, R. Slevin, J. Perlmutter, J. Mark, M.H. Huggins, N. Pezzoli, G. Massood, T. Itin, I. Corbett, A. Chinnery, P. Ostergaard, K. Snow, B. Cambi, F. Kay, D. Samii, A. Agarwal, P. Roberts, J.W. Higgins, D.S. Molho, E. Rosen, A. Montimurro, J. Martinez, E. Griffith, A. Kusel, V. Yearout, D. Factor, S. Zabetian, C. Clark, L.N. Liu, X. Lee, J.H. Cheng Taub, R. Louis, E.D. Cote, L.J. Waters, C. Ford, B. Fahn, S. Vance, J.M. Beecham, G.W. Martin, E.R. Nuytemans, K. Pericak-Vance, M.A. Haines, J.L. Destefano, A. Seshadri, S. Choi, S.H. Frank, S. Bis, J.C. Psaty, B.M. Rice, K. Longstreth, W.T., Jr. Ton, T.G.N. Jain, S. van Duijn, C.M. Uitterlinden, A.G. Verlinden, V.J. Koudstaal, P.J. Singleton, A. Cookson, M. Gibbs, J.R. Hernandez, D. Nalls, M. Zonderman, A. Ferrucci, L. Johnson, R. Longo, D. O'brien, R. Traynor, B. Troncoso, J. van der Brug, M. Zielke, R. Weale, M. Ramasamy, A. Dardiotis, E. Tsimourtou, V. Spanaki, C. Plaitakis, A. Bozi, M. Stefanis, L. Vassilatis, D. Koutsis, G. Panas, M. Hadjigeorgiou, G.M. Lunnon, K. Lupton, M. Powell, J. Parkkinen, L. Ansorge, O. International Parkinson's Disease Genomics Consortium (IPDGC) Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI) 23andMe GenePD NeuroGenetics Research Consortium (NGRC) Hussman Institute of Human Genomics (HIHG) The Ashkenazi Jewish Dataset Investigator Cohorts for Health Aging Research in Genetic Epidemiology (CHARGE) North American Brain Expression Consortium (NABEC) United Kingdom Brain Expression Consortium (UKBEC) Greek Parkinson's Disease Consortium Alzheimer Genetic Analysis Group

Abstract

We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55-4.30; P = 2 × 10-16). We also show six risk loci associated with proximal gene expression or DNA methylation. © 2014 Nature America, Inc. All rights reserved.

Published
2014

29. Changing focus of practice for community health nurses: Advancing the practice role

Author

Munns, Ailsa, Downie, Jill, Wynaden, Dianne, Hubble, J., Munns, Ailsa, Downie, Jill, Wynaden, Dianne, and Hubble, J.

Abstract

Many parents lack support in their parenting role that was once provided through extended families and community structures. Thus, some new parents experience high levels of stress and low self-esteem associated with the challenges of parentig. The lack of support also results in family discord and breakdown with the family environment having the potential to adversely impact children's mental and physical wellbeing and development. The Community Mothers Program (CMP) was initially development in England and offers support to families during the first year of parenting. The program aims to provide parents with the support once experienced from within the extended family. It also aims to enrich community development by building the capacity of community members living in local communties to support parents. This paper describes the impact of the CMP when implemented in Western Australia, as well as the changes to the professional practice role of community child health nurses involved in the program. The Community Mothers Program has proved to be very successful. The success is attributed to the partnership model established between community members, parents and community child health nurses.

Published
2004

33. TB database: an integrated platform for tuberculosis research

Author

Reddy, T. B. K., primary, Riley, R., additional, Wymore, F., additional, Montgomery, P., additional, DeCaprio, D., additional, Engels, R., additional, Gellesch, M., additional, Hubble, J., additional, Jen, D., additional, Jin, H., additional, Koehrsen, M., additional, Larson, L., additional, Mao, M., additional, Nitzberg, M., additional, Sisk, P., additional, Stolte, C., additional, Weiner, B., additional, White, J., additional, Zachariah, Z. K., additional, Sherlock, G., additional, Galagan, J. E., additional, Ball, C. A., additional, and Schoolnik, G. K., additional

Published
2009
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38. The α-synuclein gene is not a major risk factor in familial Parkinson disease

Author

Scott, W.K., Yamaoka, L.H., Stajich, J.M., Scott, B.L., Vance, J.M., Roses, A.D., Pericak-Vance, M.A., Watts, R.L., Nance, M., Hubble, J., Koller, W., Stern, M.B., Colcher, A., Allen Jr., F.H., Hiner, B.C., Jankovic, J., Ondo, W., Laing, N.G., Mastaglia, F., Goetz, C., Pappert, E., Small, G.W., Masterman, D., Haines, J.L., Davies, T.L., Scott, W.K., Yamaoka, L.H., Stajich, J.M., Scott, B.L., Vance, J.M., Roses, A.D., Pericak-Vance, M.A., Watts, R.L., Nance, M., Hubble, J., Koller, W., Stern, M.B., Colcher, A., Allen Jr., F.H., Hiner, B.C., Jankovic, J., Ondo, W., Laing, N.G., Mastaglia, F., Goetz, C., Pappert, E., Small, G.W., Masterman, D., Haines, J.L., and Davies, T.L.

Abstract

Letter to the Editor

Published
1999

41. Apolipoprotein E controls the risk and age at onset of Parkinson disease

Author

Li, Y. J., primary, Hauser, M. A., additional, Scott, W. K., additional, Martin, E. R., additional, Booze, M. W., additional, Qin, X. J., additional, Walter, J. W., additional, Nance, M. A., additional, Hubble, J. P., additional, Koller, W. C., additional, Pahwa, R., additional, Stern, M. B., additional, Hiner, B. C., additional, Jankovic, J., additional, Goetz, C. G., additional, Small, G. W., additional, Mastaglia, F., additional, Haines, J. L., additional, Pericak-Vance, M. A., additional, and Vance, J. M., additional

Published
2004
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43. Vagus nerve stimulation for essential tremor

Author

Handforth, A., primary, Ondo, W. G., additional, Tatter, S., additional, Mathern, G. W., additional, Simpson, R. K., additional, Walker, F., additional, Sutton, J. P., additional, Hubble, J. P., additional, and Jankovic, J., additional

Published
2003
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44. Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease

Author

van der Walt, J. M., primary, Martin, E.R., additional, Scott, W. K., additional, Zhang, F., additional, Nance, M.A., additional, Watts, R. L., additional, Hubble, J. P., additional, Haines, J. L., additional, Koller, W. C., additional, Lyons, K., additional, Pahwa, R., additional, Stern, M. B., additional, Colcher, A., additional, Hiner, B. C., additional, Jankovic, J., additional, Ondo, W. G., additional, Allen, F. H., additional, Goetz, C. G., additional, Small, G. W., additional, Mastaglia, F., additional, Roses, A. D., additional, Stajich, J. M., additional, Booze, M.W., additional, Fujiwara, K., additional, Gibson, R. A., additional, Middleton, L. T., additional, Scott, B. L., additional, Pericak-Vance, M. A., additional, and Vance, J. M., additional

Published
2003
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47. Epidemiologic study of 203 sibling pairs with Parkinson’s disease

Author

Maher, N. E., primary, Golbe, L. I., additional, Lazzarini, A. M., additional, Mark, M. H., additional, Currie, L. J., additional, Wooten, G. F., additional, Saint-Hilaire, M., additional, Wilk, J. B., additional, Volcjak, J., additional, Maher, J. E., additional, Feldman, R. G., additional, Guttman, M., additional, Lew, M., additional, Schuman, S., additional, Suchowersky, O., additional, Lafontaine, A. L., additional, Labelle, N., additional, Vieregge, P., additional, Pramstaller, P. P., additional, Klein, C., additional, Hubble, J., additional, Reider, C., additional, Growdon, J., additional, Watts, R., additional, Montgomery, E., additional, Baker, K., additional, Singer, C., additional, Stacy, M., additional, and Myers, R.H., additional

Published
2002
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49. Genome-wide scan for Parkinson's disease: The Gene PD Study

Author

DeStefano, A. L., primary, Golbe, L. I., additional, Mark, M. H., additional, Lazzarini, A. M., additional, Maher, N. E., additional, Saint-Hilaire, M., additional, Feldman, R. G., additional, Guttman, M., additional, Watts, R. L., additional, Suchowersky, O., additional, Lafontaine, A. L., additional, Labelle, N., additional, Lew, M. F., additional, Waters, C. H., additional, Growdon, J. H., additional, Singer, C., additional, Currie, L. J., additional, Wooten, G. F., additional, Vieregge, P., additional, Pramstaller, P. P., additional, Klein, C., additional, Hubble, J. P., additional, Stacy, M., additional, Montgomery, E., additional, MacDonald, M. E., additional, Gusella, J. F., additional, and Myers, R. H., additional

Published
2001
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