857 results on '"Hubbuch, Jürgen"'
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2. An HPLC-SEC-based rapid quantification method for vesicular stomatitis virus particles to facilitate process development
3. Predicting multimodal chromatography of therapeutic antibodies using multiscale modeling
4. Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements
5. Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors
6. Antibody sequence-based prediction of pH gradient elution in multimodal chromatography
7. Modeling of biopharmaceutical UF/DF from laboratory to manufacturing scale
8. Connected mechanistic process modeling to predict a commercial biopharmaceutical downstream process
9. Spectroscopic insights into multi-phase protein crystallization in complex lysate using Raman spectroscopy and a particle-free bypass
10. Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
11. Bio-based material formulation for extrusion printing by dityrosine crosslinking of unmodified casein
12. Automated and dynamic extrusion pressure adjustment based on real-time flow rate measurements for precise ink dispensing in 3D bioprinting
13. Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps
14. Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes
15. Modeling the Gibbs–Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model
16. Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification.
17. Generative data augmentation and automated optimization of convolutional neural networks for process monitoring
18. Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates
19. Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
20. Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach
21. High throughput screening of fiber-based adsorbents for material and process development
22. Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids
23. The Effect of Gelatin Source on the Synthesis of Gelatin-Methacryloyl and the Production of Hydrogel Microparticles
24. Image analysis as PAT-Tool for use in extrusion-based bioprinting
25. Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination
26. On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions
27. Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design
28. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation
29. Time-Dependent Multi-Light-Source Image Classification Combined With Automated Multidimensional Protein Phase Diagram Construction for Protein Phase Behavior Analysis
30. Kinetic reaction modeling for antibody-drug conjugate process development
31. Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography
32. Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants
33. A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
34. Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange
35. Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging
36. A phase diagram-based toolbox to assess the impact of freeze/thaw ramps on the phase behavior of proteins
37. Prediction uncertainty assessment of chromatography models using Bayesian inference
38. Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment
39. Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy
40. 3D bioprinting – Flow cytometry as analytical strategy for 3D cell structures
41. Application of Empirical Phase Diagrams for Multidimensional Data Visualization of High-Throughput Microbatch Crystallization Experiments
42. Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.
43. Corrigendum: Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions
44. Size-selective downstream processing of virus particles and non-enveloped virus-like particles
45. An adaptive soft‐sensor for advanced real‐time monitoring of an antibody‐drug conjugation reaction
46. Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates
47. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography
48. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography
49. Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression
50. An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
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