1. GSK3 as a Master Regulator of Cellular Processes.
- Author
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Lichtinghagen, Ralf and Huber, René
- Subjects
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GLYCOGEN synthase kinase , *SLEEP deprivation , *DRUG therapy , *CELL cycle , *GENE expression - Abstract
This document, published in the International Journal of Molecular Sciences, discusses the role of glycogen synthase kinase 3 (GSK3) as a master regulator of cellular processes. GSK3 is involved in various physiological functions such as gene expression, metabolism, proliferation, differentiation, apoptosis, adhesion, and migration. It is also implicated in neurological, metabolic, inflammatory diseases, and cancer. However, the development of GSK3 inhibitors for treatment has yielded disappointing results due to limited selectivity and conflicting effects. The document presents several studies that explore the regulation and diverse functions of GSK3 in different contexts, including neuroinflammation, atherosclerosis, cell cycle progression, amino acid deprivation, metabolism, and behavioral characteristics. These studies shed new light on the multifaceted roles of GSK3 and highlight its potential as a target for pharmacological interventions. [Extracted from the article]
- Published
- 2023
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