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An easy-to-read publication defining 100 key circus terms translated in nine languages. The 2015 edition has been re-created in a smaller "pocket" version, 44 pages in length and weighing 63 grams per book. Additional images have been added to illustrate terms and each book is sold complete with a beautiful circus envelope that can be used for gift-giving or mailing. The full color Guide is categorized by aerial acts, acrobatics, balancing, juggling, daredevil and specialty acts, clowning and performing animals. Terms are illustrated by photographs supplied by circuses and participants in the Federation’s annual World Circus Photo Contest. Perfect for circuses and organisations to give to visiting media, special guests, school groups or politicians. Edited by R. Huey, Ph.D.

Alzheimer’s disease is a neurodegenerative disorder featuring both the aggregation of extraneuronal amyloid plaques and intraneuronal neurofibrillary tangles. The deposition of Aβ peptides in the brain plays a key role in the onset and progression of this disease, and β-secretase (BACE-1) is critical in this process. Thus, the inhibition of this enzyme is an attractive approach to anti-Alzheimer therapy. So far, the rational design of new BACE-1 inhibitors has been hampered by the intrinsic flexibility displayed by the enzyme which is not included in standard molecular modeling methods. Here, we incorporated protein flexibility into Virtual Screening (VS) in order to discover new BACE-1 inhibitors in two ways. First, we used an ensemble of static Xray BACE-1 structures representing the receptor flexibility in a VS of the NCI database. Also, the different conformations of BACE-1 were combined to generate a unified description of the protein motion. To do this, a set of map...

Nocturnal Gekkonidae forage in the open at a body temperature (BT) lower and often more variable than those of diurnal species BTs. Their thermal physiology is of interest because some species maintain relatively high BTs during daytime., Asociación Herpetológica Argentina (AHA)

An easy-to-read publication defining 100 key circus terms translated in nine languages. The 24-page full color Guide (A4 size) is categorized by aerial acts, acrobatics, balancing, juggling, daredevil and specialty acts, clowning and performing animals. Terms are illustrated by photographs supplied by circuses and participants in the Federation’s annual World Circus Photo Contest. Perfect for circuses and organisations to give to visiting media. Edited by R. Huey, Ph.D.

Ultrasound ranging devices have been widely used in unmanned vehicles or autonomous mobile robots because of their cost-effectiveness and reliability. They have been widely used for detecting obstacles for collision avoidance, and path planning. However, due to the properties of the ultrasound devices, they suffer a few important drawbacks for these applications. First, they detect only objects whose surface is normal with respect to the travelling direction of the sound beam generated, i.e., they do not “see” obstacles whose surfaces are oriented more than ± 12% off normal. Second, they do not provide any information on the size of the obstacle even when the surface is normal with respect to the sound beam. In this paper, we describe a technique by which a system can estimate the size of objects of different orientations. This technique utilizes a pair of Polaroid ultrasonic ranging units mounted on a rotating shaft to scan the surrounding environment. The data are then fed into an IBM-PC/XT and processed by a novel algorithm. Experimental results show that the system can estimate the size of an object at different orientations. It can detect an obstacle and determine if the obstacle is moving or stationary. With this property, the system can plot its environmental setting, and the perimeter of an object, which is essential information for any unmanned or autonomous vehicles. The algorithm is first simulated on the IBM-PC/XT using the raw data collected with the dual ultrasound device based system. The algorithm is then verified experimentally with the “real-world” environment.