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17 results on '"Hughes, Seamus"'

1. Is distance associated with tuberculosis treatment outcomes? A retrospective cohort study in Kampala, Uganda.

Author

Robsky, Katherine O., Hughes, Seamus, Kityamuwesi, Alex, Kendall, Emily A., Kitonsa, Peter James, Dowdy, David W., and Katamba, Achilles

Subjects
*DIRECTLY observed therapy, *TREATMENT effectiveness, *HEALTH facilities, *TUBERCULOSIS, *COHORT analysis, *POISSON regression
Abstract

Background: Challenges accessing nearby health facilities may be a barrier to initiating and completing tuberculosis (TB) treatment. We aimed to evaluate whether distance from residence to health facility chosen for treatment is associated with TB treatment outcomes.Methods: We conducted a retrospective cohort study of all patients initiating TB treatment at six health facilities in Kampala from 2014 to 2016. We investigated associations between distance to treating facility and unfavorable TB treatment outcomes (death, loss to follow up, or treatment failure) using multivariable Poisson regression.Results: Unfavorable treatment outcomes occurred in 20% (339/1691) of TB patients. The adjusted relative risk (aRR) for unfavorable treatment outcomes (compared to treatment success) was 0.87 (95% confidence interval [CI] 0.70, 1.07) for patients living ≥2 km from the facility compared to those living closer. When we separately compared each type of unfavorable treatment outcome to favorable outcomes, those living ≥2 km from the facility had increased risk of death (aRR 1.42 [95%CI 0.99, 2.03]) but decreased risk for loss to follow-up (aRR 0.57 [95%CI 0.41, 0.78]) than those living within 2 km.Conclusions: Distance from home residence to TB treatment facility is associated with increased risk of death but decreased risk of loss to follow up. Those who seek care further from home may have advanced disease, but once enrolled may be more likely to remain in treatment. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Hunter Biden Sues I.R.S., Saying Agents Violated Privacy.

Author

SCHMIDT, MICHAEL S., Hughes, Seamus, and Broadwater, Luke

Subjects
*MISDEMEANORS, *ACTIONS & defenses (Law), *FELONIES
Abstract

The article reports that Hunter Biden has been suing the Internal Revenue Service, claiming privacy violations for disclosing tax information to Congress and the public amid ongoing legal challenges, including gun and tax charges.

Published
2023

3. PANDEMIC FRAUD CLAIMED BILLIONS MEANT FOR RELIEF.

Author

FAHRENTHOLD, DAVID A. and Hughes, Seamus

Subjects
*PANDEMICS
Abstract

The article reports on the billions of U.S. government fund meant for pandemic relief that fell into fraudulent loan schemes, which are now under federal investigation. It discusses the honor system as a flaw of the pandemic-related relief money legislative packages that included expansion of employment benefit, Paycheck Protection Program and Economic Injury Disaster Loan program. Example cases of schemes to defraud government loan programs are presented.

Published
2022

4. Alone, Underage and Exploited for Labor.

Author

DREIER, HANNAH, Fischer, Andrew, Hughes, Seamus, Keller, Michael H., and Tate, Julie

Abstract

The article reveals cases of migrant children who are exploited for labor and toiling in hazardous jobs across the U.S. It presents the stories of 15-year old Carolina Yoc from Guatemala and 16-year old Cristian Lopez who both work for Hearthside Food Solutions. It reports flaws in sponsorship of migrant children, occupational hazards and accidents facing young migrant workers, and child labor violations in the supply chains of brands and retailers.

Published
2023

5. For Giuliani, 9/11 Charity Is a Financial Safety Net.

Author

FAHRENTHOLD, DAVID A., SULLIVAN, EILEEN, and Hughes, Seamus

Subjects
*CHARITY, *CHARITIES, *SEPTEMBER 11 Terrorist Attacks, 2001, NEW York City mayors
Abstract

The article reveals Rudolph W. Giuliani's reliance on a 9/11 charity as a financial lifeline amid legal troubles, highlighting his failure to disclose its support during bankruptcy proceedings.

Published
2024

6. Capitol Rioter Threatened to Assassinate Ocasio-Cortez, Officials Say.

Author

LEVENSON, MICHAEL and Hughes, Seamus

Subjects
WASHINGTON (D.C.)
Abstract

The article discusses a Trump supporter stormed the Capitol on January 6 threatened on social media to assassinate Representative Alexandria Ocasio-Cortez day and threatened the Capitol Police officer fatally shot a woman's tried to enter the Speaker's Lobby, federal prosecutors.

Published
2021

7. Veterans Fortify the Ranks of Militias That Align With Trump's Views.

Author

STEINHAUER, JENNIFER and Hughes, Seamus

Subjects
*MILITIAS, *VETERANS, *RANKING
Abstract

The article reports that militia groups emboldened by president Donald Trump's campaign have bolstered strength before Election Day by attracting military veterans and mentions role of veterans in militia groups.

Published
2020

8. South Korea's Hunt for Fugitive in 2014 Ferry Disaster Ends in U.S.

Author

CHOE SANG-HUN and HUGHES, SEAMUS

Subjects
*FUGITIVES from justice, *ARREST, *FERRIES, *DISASTERS, *EXTRADITION
Abstract

In this article the author talks about one of South Korea's most notorious fugitives named Yoo Hyuk-kee, was arrested on in the U.S this on embezzlement charges at home stemming from the 2014 sinking of a ferry that killed several people, many of them high school students.

Published
2020

9. Hunter Biden Likely to Avoid Prison in Deal: A Federal Tax and Gun Inquiry Nears an End.

Author

SCHMIDT, MICHAEL S., ENTOUS, ADAM, Hughes, Seamus, Epstein, Reid J., Broadwater, Luke, Thrush, Glenn, Kayla Guo, and Weisman, Jonathan

Subjects
*GUILTY pleas, *FIREARMS, *PRISONS, *TAXATION, *FEDERAL prosecutors
Abstract

The article reports on the possible deal between U.S. President Joe Biden's son Hunter Biden and the Justice Department, in which Hunter will plead guilty of two misdemeanor tax charges and accept terms on a gun case that would allow him to avoid prosecution. The deal is contingent on Hunter's promise to avoid drugs for 24 months and not to own firearm again. Also cited is the comment of Hunter's lawyer Christopher Clark on the case.

Published
2023

10. Federal Judge Blocks Biden Administration's Asylum Policy.

Author

JORDAN, MIRIAM, SULUVAN, EILEEN, and Hughes, Seamus

Abstract

The article focuses on a federal judge striking down a new asylum policy that the Biden administration deemed crucial to curbing illegal crossings along the U.S.-Mexico border, leading to uncertainty about how this ruling will affect migration and potential appeals.

Published
2023

11. Tugging Hearts to Raise $89 Million, but Sending A Scant 1% to the Causes.

Author

FAHRENTHOLD, DAVID A., FEHR, TIFF, SMART, CHARLIE, Baker, Camille, Tate, Julie, and Hughes, Seamus

Subjects
*HEART, *SMARTPHONES
Abstract

The article reports on the operations of five linked nonprofit organizations including the American Police Officers Alliance, particularly on how they raised 89 million dollars in their fundraising activities, but just 1% of the amount were used to their intended purposes. Based on an investigation by "The New York Times," the group also paid 2.8 million dollars to three Republican political consultants from Wisconsin.

Published
2023

12. Flynn Family Is Getting Rich On Trump Ties.

Author

FAHRENTHOLD, DAVID A., BERZON, ALEXANDRA, Yourish, Karen, Hughes, Seamus, and Noyes, Kirsten

Subjects
*FAMILIES, *NONPROFIT organizations, *WORKING hours
Abstract

The article discusses the pocketing of at least 2.2 million dollars by retired General Michael T. Flynn and family members from the small charity America's Future where he is chairman as of 2024. Topics covered include his ties to former President Donald Trump, his progressive drawing of payments to himself and his relatives, and their sale of far-right conspiracy theories and lies embraced by QAnon followers. Also noted is Flynn's use of his popularity to collect money from supporters.

Published
2024

13. Retired General Under Scrutiny Over Lobbying.

Author

MAZZETTI, MARK, KIRKPATRICK, DAVID D., and Hughes, Seamus

Subjects
*RETIRED military personnel, *LOBBYING
Abstract

The article discusses court documents which showed that retired Marine General John R. Allen secretly lobbied for the government of Qatar, lied to investigators about his role and tried to withhold evidence sought by a federal subpoena. Topics include statement from a spokesman for General Allen, Beau Phillips, impact of General Allen's time at Central Command on establishing relations with senior Qatari leaders, and an email by General Allen to make amends.

Published
2022

14. Military Bases Turn Into Small Cities as Afghans Wait for U.S. Homes.

Author

JORDAN, MIRIAM, STEINHAUER, JENNIFER, and Hughes, Seamus

Abstract

The article reports that more than a month later to evacuation of Afghans, the remote base some 170 miles from Milwaukee is home to 12,600 Afghan evacuees, almost half of them children, now bigger than any city in western Wisconsin's Monroe County.

Published
2021

15. CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML.

Author

Maxson, Julia E., Ries, Rhonda E., Yi-Cheng Wang, Gerbing, Robert B., Kolb, E. Anders, Thompson, Sarah L., Guidry Auvil, Jaime M., Marra, Marco A., Yussanne Ma, Zusheng Zong, Mungall, Andrew J., Moore, Richard, Long, William, Gesuwan, Patee, Davidsen, Tanja M., Hermida, Leandro C., Hughes, Seamus B., Farrar, Jason E., Radich, Jerald P., and Smith, Malcolm A.

Subjects
*COLONY-stimulating factors (Physiology), *ACUTE myeloid leukemia, *RUNX proteins, *ONCOLOGY, *TREATMENT effectiveness
Abstract

The article presents a study which identified the oncogenic colony-stimulating factor 3 receptor (CSF3R) mutations in pediatric acute myeloid leukemia (AML). Also cited are the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program by the Children's Oncology Group (COG) and the U.S.' National Institutes of Health National Cancer Institute, and the common genetic alteration in patients with CSF3R like the core binding factor (CBF) abnormalities.

Published
2016
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16. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.

Author

Maxson, Julia E., Abel, Melissa L., Wang, Jinhua, Deng, Xianming, Reckel, Sina, Luty, Samuel B., Huahang Sun, Gorenstein, Julie, Hughes, Seamus B., Bottomly, Daniel, Wilmot, Beth, McWeeney, Shannon K., Radich, Jerald, Hantschel, Oliver, Middleton, Richard E., Gray, Nathanael S., Druker, Brian J., and Tyner, Jeffrey W.

Subjects
*LEUKEMIA diagnosis, *PROTEIN-tyrosine kinases, *GENETIC mutation, *DASATINIB, *DISEASE progression
Abstract

The amount of genomic information about leukemia cells currently far exceeds our overall understanding of the precise genetic events that ultimately drive disease development and progression. Effective implementation of personalized medicine will require tools to distinguish actionable genetic alterations within the complex genetic landscape of leukemia. In this study, we performed kinase inhibitor screens to predict functional gene targets in primary specimens from patients with acute myeloid leukemia and chronic myelomonocytic leukemia. Deep sequencing of the same patient specimens identified genetic alterations that were then integrated with the functionally important targets using the HitWalker algorithm to prioritize the mutant genes that most likely explain the observed drug sensitivity patterns. Through this process, we identified tyrosine kinase nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity. Importantly, the integration of functional and genomic data using HitWalker allowed for prioritization of rare oncogenic mutations that may have been missed through genomic analysis alone. These mutations were sensitive to the multikinase inhibitor dasatinib, which antagonizes TNK2 kinase activity, as well as novel TNK2 inhibitors, XMD8-87 and XMD16-5, with greater target specificity. We also identified activating truncation mutations in other tumor types that were sensitive to XMD8-87 and XMD16-5, exemplifying the potential utility of these compounds across tumor types dependent on TNK2. Collectively, our findings highlight a more sensitive approach for identifying actionable genomic lesions that may be infrequently mutated or overlooked and provide a new method for the prioritization of candidate genetic mutations. [ABSTRACT FROM AUTHOR]

Published
2016
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17. Two F.B.I. Agents Are Killed and Three Injured in Shootout in South Florida.

Author

Mazzei, Patricia, Goldman, Adam, Diaz, Johnny, Morales, Christina, Benner, Katie, Hughes, Seamus, Cramer, Maria, Bogel-Burroughs, Nicholas, Dance, Gabriel J. X., Keller, Michael H., and Majchrowicz, Michael

Subjects
FLORIDA
Abstract

The article reports that group of Federal Bureau of Investigation (FBI) agents were assigned to investigate criminals who were on prey for children online and mentions that several agents were injured and died in gun shooting.

Published
2021

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