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28 results on '"Hugon, Perrine"'

1. Retraction Note: Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

Author

Million, Matthieu, Alou, Maryam Tidjani, Khelaifia, Saber, Bachar, Dipankar, Lagier, Jean-Christophe, Dione, Niokhor, Brah, Souleymane, Hugon, Perrine, Lombard, Vincent, Armougom, Fabrice, Fromonot, Julien, Robert, Catherine, Michelle, Caroline, Diallo, Aldiouma, Fabre, Alexandre, Guieu, Régis, Sokhna, Cheikh, Henrissat, Bernard, Parola, Philippe, and Raoult, Didier

Published
2023
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3. Culturomics and pyrosequencing evidence of the reduction in gut microbiota diversity in patients with broad-spectrum antibiotics

Author

Dubourg, Grégory, Lagier, Jean Christophe, Robert, Catherine, Armougom, Fabrice, Hugon, Perrine, Metidji, Sarah, Dione, Niokhor, Dangui, Nicole Prisca Makaya, Pfleiderer, Anne, Abrahao, Joñatas, Musso, Didier, Papazian, Laurent, Brouqui, Philippe, Bibi, Fehmida, Yasir, Muhammad, Vialettes, Bernard, and Raoult, Didier

Published
2014
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4. RETRACTED ARTICLE: Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

Author

Million, Matthieu, Tidjani Alou, Maryam, Khelaifia, Saber, Bachar, Dipankar, Lagier, Jean-Christophe, Dione, Niokhor, Brah, Souleymane, Hugon, Perrine, Lombard, Vincent, Armougom, Fabrice, Fromonot, Julien, Robert, Catherine, Michelle, Caroline, Diallo, Aldiouma, Fabre, Alexandre, Guieu, Régis, Sokhna, Cheikh, Henrissat, Bernard, Parola, Philippe, and Raoult, Didier

Published
2016
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5. Impact of oral amoxicillin and amoxicillin/clavulanic acid treatment on bacterial diversity and β-lactam resistance in the canine faecal microbiota

Author

Espinosa-Gongora, Carmen, primary, Jessen, Lisbeth Rem, additional, Kieler, Ida Nordang, additional, Damborg, Peter, additional, Bjørnvad, Charlotte Reinhard, additional, Gudeta, Dereje Dadi, additional, Pires dos Santos, Teresa, additional, Sablier-Gallis, Frédérique, additional, Sayah-Jeanne, Sakina, additional, Corbel, Tanguy, additional, Nevière, Agathe, additional, Hugon, Perrine, additional, Saint-Lu, Nathalie, additional, de Gunzburg, Jean, additional, and Guardabassi, Luca, additional

Published
2019
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6. Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection

Author

Burdet, Charles, primary, Sayah-Jeanne, Sakina, additional, Nguyen, Thu Thuy, additional, Hugon, Perrine, additional, Sablier-Gallis, Frédérique, additional, Saint-Lu, Nathalie, additional, Corbel, Tanguy, additional, Ferreira, Stéphanie, additional, Pulse, Mark, additional, Weiss, William, additional, Andremont, Antoine, additional, Mentré, France, additional, and de Gunzburg, Jean, additional

Published
2018
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7. Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans

Author

Zhukova, Anna, Fernandes, Luis Guilherme, Hugon, Perrine, Pappas, Christopher J., Sismeiro, Odile, Coppée, Jean-Yves, Becavin, Christophe, Malabat, Christophe, Eshghi, Azad, Zhang, Jun-Jie, Yang, Frank X., Picardeau, Mathieu, Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Biologie des Spirochètes / Biology of Spirochetes, Institut Pasteur [Paris], Pasteur International Bioresources network (PIBNet), Manhattanville College [New York], Transcriptome et Epigénome (PF2), Indiana University School of Medicine, Indiana University System, This work was funded by the Institut Pasteur and FUI 14 (Fonds Unique Interministériel) COVALEPT and BPIFrance. PH was funded by Pasteur International Bioresources Network (PIBnet). CP was supported by National Science Foundation grant IIA-1159099. LF (from Dr. Ana Lucia Tabet Oller do Nascimento's lab at the Instituto Butantan, Sao Paulo, Brasil) is a doctoral recipient fellow from FAPESP. The Transcriptome and EpiGenome Platform is a member of the France Génomique consortium (ANR10-NBS-09-08)., ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris] (IP)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, promoter, transcription factors, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], leptospirosis, RNA, spirochetes, bacterial infections and mycoses, Microbiology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
Abstract

International audience; Leptospira are emerging zoonotic pathogens transmitted from animals to humans typically through contaminated environmental sources of water and soil. Regulatory pathways of pathogenic Leptospira spp. underlying the adaptive response to different hosts and environmental conditions remains elusive. In this study, we provide the first global Transcriptional Start Site (TSS) map of a Leptospira species. RNA was obtained from the pathogen Leptospira interrogans grown at 30°C (optimal in vitro temperature) and 37°C (host temperature) and selectively enriched for 5' ends of native transcripts. A total of 2865 and 2866 primary TSS (pTSS) were predicted in the genome of L. interrogans at 30 and 37°C, respectively. The majority of the pTSSs were located between 0 and 10 nucleotides from the translational start site, suggesting that leaderless transcripts are a common feature of the leptospiral translational landscape. Comparative differential RNA-sequencing (dRNA-seq) analysis revealed conservation of most pTSS at 30 and 37°C. Promoter prediction algorithms allow the identification of the binding sites of the alternative sigma factor sigma 54. However, other motifs were not identified indicating that Leptospira consensus promoter sequences are inherently different from the Escherichia coli model. RNA sequencing also identified 277 and 226 putative small regulatory RNAs (sRNAs) at 30 and 37°C, respectively, including eight validated sRNAs by Northern blots. These results provide the first global view of TSS and the repertoire of sRNAs in L. interrogans. These data will establish a foundation for future experimental work on gene regulation under various environmental conditions including those in the host.

Published
2017

8. Impact of oral amoxicillin and amoxicillin/clavulanic acid treatment on bacterial diversity and β-lactam resistance in the canine faecal microbiota.

Author

Espinosa-Gongora, Carmen, Jessen, Lisbeth Rem, Kieler, Ida Nordang, Damborg, Peter, Bjørnvad, Charlotte Reinhard, Gudeta, Dereje Dadi, Santos, Teresa Pires dos, Sablier-Gallis, Frédérique, Sayah-Jeanne, Sakina, Corbel, Tanguy, Nevière, Agathe, Hugon, Perrine, Saint-Lu, Nathalie, Gunzburg, Jean de, Guardabassi, Luca, Pires Dos Santos, Teresa, and de Gunzburg, Jean

Subjects
CLAVULANIC acid, BACTERIAL diversity, AMOXICILLIN, RIBOSOMAL RNA, TERMINATION of treatment, DRUG resistance in microorganisms, BETA lactam antibiotics, FOSFOMYCIN, RESEARCH, ANIMAL experimentation, RESEARCH methodology, RNA, MEDICAL cooperation, EVALUATION research, HYDROLASES, FECES, COMPARATIVE studies, ENZYME inhibitors, DOGS, MICROBIAL sensitivity tests, ANTIBIOTICS, PHARMACODYNAMICS
Abstract

Background: Aminopenicillins with or without a β-lactamase inhibitor are widely used in both human and veterinary medicine. However, little is known about their differential impact on the gut microbiota and development of antimicrobial resistance.Objectives: To investigate changes in the faecal microbiota of dogs treated with amoxicillin or amoxicillin/clavulanic acid.Methods: Faeces collected from 42 dogs (21 per treatment group) immediately before, during and 1 week after termination of oral treatment with amoxicillin or amoxicillin/clavulanic acid were analysed by culture and 16S rRNA gene sequence analysis.Results: In both groups, bacterial counts on ampicillin selective agar revealed an increase in the proportion of ampicillin-resistant Escherichia coli during treatment, and an increased occurrence and proportion of ampicillin-resistant enterococci during and after treatment. 16S rRNA gene analysis showed reductions in microbial richness and diversity during treatment followed by a return to pre-treatment conditions approximately 1 week after cessation of amoxicillin or amoxicillin/clavulanic acid treatment. While no significant differences were observed between the effects of amoxicillin and amoxicillin/clavulanic acid on microbial richness and diversity, treatment with amoxicillin/clavulanic acid reduced the abundance of taxa that are considered part of the beneficial microbiota (such as Roseburia, Dialister and Lachnospiraceae) and enriched Escherichia, although the latter result was not corroborated by phenotypic counts.Conclusions: Our results suggest a limited effect of clavulanic acid on selection of antimicrobial resistance and microbial richness when administered orally in combination with amoxicillin. However, combination with this β-lactamase inhibitor appears to broaden the spectrum of amoxicillin, with potential negative consequences on gut health. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Antibiotic-induced dysbiosis predicts mortality in an animal model ofClostridium difficileinfection

Author

Burdet, Charles, primary, Sayah-Jeanne, Sakina, additional, Nguyen, Thu Thuy, additional, Hugon, Perrine, additional, Sablier-Gallis, Frédérique, additional, Saint-Lu, Nathalie, additional, Corbel, Tanguy, additional, Ferreira, Stéphanie, additional, Pulse, Mark, additional, Weiss, William, additional, Andremont, Antoine, additional, Mentré, France, additional, and Gunzburg, Jean de, additional

Published
2018
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11. Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

Author

Perrin, Amandine, primary, Larsonneur, Elise, additional, Nicholson, Ainsley C., additional, Edwards, David J., additional, Gundlach, Kristin M., additional, Whitney, Anne M., additional, Gulvik, Christopher A., additional, Bell, Melissa E., additional, Rendueles, Olaya, additional, Cury, Jean, additional, Hugon, Perrine, additional, Clermont, Dominique, additional, Enouf, Vincent, additional, Loparev, Vladimir, additional, Juieng, Phalasy, additional, Monson, Timothy, additional, Warshauer, David, additional, Elbadawi, Lina I., additional, Walters, Maroya Spalding, additional, Crist, Matthew B., additional, Noble-Wang, Judith, additional, Borlaug, Gwen, additional, Rocha, Eduardo P. C., additional, Criscuolo, Alexis, additional, Touchon, Marie, additional, Davis, Jeffrey P., additional, Holt, Kathryn E., additional, McQuiston, John R., additional, and Brisse, Sylvain, additional

Published
2017
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12. Change in Bacterial Diversity of Fecal Microbiota Drives Mortality in a Hamster Model of Antibiotic-induced Clostridium difficile Colitis

Author

Burdet, Charles, primary, Nguyen, Thu Thuy, additional, Saint-Lu, Nathalie, additional, Sayah-Jeanne, Sakina, additional, Hugon, Perrine, additional, Sablier-Gallis, Frédérique, additional, Ferreira, Stéphanie, additional, Andremont, Antoine, additional, Mentré, France, additional, and Gunzburg, Jean De, additional

Published
2017
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13. Culture of previously uncultured members of the human gut microbiota by culturomics

Author

Lagier, Jean-Christophe, primary, Khelaifia, Saber, additional, Alou, Maryam Tidjani, additional, Ndongo, Sokhna, additional, Dione, Niokhor, additional, Hugon, Perrine, additional, Caputo, Aurelia, additional, Cadoret, Frédéric, additional, Traore, Sory Ibrahima, additional, Seck, El Hadji, additional, Dubourg, Gregory, additional, Durand, Guillaume, additional, Mourembou, Gaël, additional, Guilhot, Elodie, additional, Togo, Amadou, additional, Bellali, Sara, additional, Bachar, Dipankar, additional, Cassir, Nadim, additional, Bittar, Fadi, additional, Delerce, Jérémy, additional, Mailhe, Morgane, additional, Ricaboni, Davide, additional, Bilen, Melhem, additional, Dangui Nieko, Nicole Prisca Makaya, additional, Dia Badiane, Ndeye Mery, additional, Valles, Camille, additional, Mouelhi, Donia, additional, Diop, Khoudia, additional, Million, Matthieu, additional, Musso, Didier, additional, Abrahão, Jônatas, additional, Azhar, Esam Ibraheem, additional, Bibi, Fehmida, additional, Yasir, Muhammad, additional, Diallo, Aldiouma, additional, Sokhna, Cheikh, additional, Djossou, Felix, additional, Vitton, Véronique, additional, Robert, Catherine, additional, Rolain, Jean Marc, additional, La Scola, Bernard, additional, Fournier, Pierre-Edouard, additional, Levasseur, Anthony, additional, and Raoult, Didier, additional

Published
2016
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14. Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

Author

Million, Matthieu, primary, Tidjani Alou, Maryam, additional, Khelaifia, Saber, additional, Bachar, Dipankar, additional, Lagier, Jean-Christophe, additional, Dione, Niokhor, additional, Brah, Souleymane, additional, Hugon, Perrine, additional, Lombard, Vincent, additional, Armougom, Fabrice, additional, Fromonot, Julien, additional, Robert, Catherine, additional, Michelle, Caroline, additional, Diallo, Aldiouma, additional, Fabre, Alexandre, additional, Guieu, Régis, additional, Sokhna, Cheikh, additional, Henrissat, Bernard, additional, Parola, Philippe, additional, and Raoult, Didier, additional

Published
2016
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28. Non contiguous-finished genome sequence and description of Peptoniphilus grossensis sp. nov.

Author

Mishra, Ajay Kumar, Hugon, Perrine, Robert, Catherine, Raoult, Didier, and Fournier, Pierre-Edouard

Subjects
*BACTERIAL genomes, *GRAM-positive bacteria, *PLASMID genetics, *MORBID obesity, *NUTRITION disorders
Abstract

Peptoniphilus grossensis strain ph5T sp. nov., is the type strain of Peptoniphilus grossensis sp. nov., a new species within the Peptoniphilus genus. This strain, whose genome is described here, was isolated from the fecal flora of a 26-year-old woman suffering from morbid obesity. P. grossensis strain ph5 is a Gram-positive obligate anaerobic coccus. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 2,101,866-bp long genome (1 chromosome but no plasmid) exhibits a G+C content of 33.9% and contains 2,041 protein-coding and 29 RNA genes, including 3 rRNA genes. [ABSTRACT FROM AUTHOR]

Published
2012
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