1. Adeno-associated virus type 2 in US children with acute severe hepatitis
- Author
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Servellita, Venice, Sotomayor Gonzalez, Alicia, Lamson, Daryl M, Foresythe, Abiodun, Huh, Hee Jae, Bazinet, Adam L, Bergman, Nicholas H, Bull, Robert L, Garcia, Karla Y, Goodrich, Jennifer S, Lovett, Sean P, Parker, Kisha, Radune, Diana, Hatada, April, Pan, Chao-Yang, Rizzo, Kyle, Bertumen, J Bradford, Morales, Christina, Oluniyi, Paul E, Nguyen, Jenny, Tan, Jessica, Stryke, Doug, Jaber, Rayah, Leslie, Matthew T, Lyons, Zin, Hedman, Hayden D, Parashar, Umesh, Sullivan, Maureen, Wroblewski, Kelly, Oberste, M Steven, Tate, Jacqueline E, Baker, Julia M, Sugerman, David, Potts, Caelin, Lu, Xiaoyan, Chhabra, Preeti, Ingram, L Amanda, Shiau, Henry, Britt, William, Gutierrez Sanchez, Luz Helena, Ciric, Caroline, Rostad, Christina A, Vinjé, Jan, Kirking, Hannah L, Wadford, Debra A, Raborn, R Taylor, St. George, Kirsten, and Chiu, Charles Y
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Hepatitis ,Infectious Diseases ,Genetics ,Clinical Research ,Liver Disease ,Digestive Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Good Health and Well Being ,Child ,Humans ,Acute Disease ,Adenovirus Infections ,Human ,Coinfection ,Dependovirus ,Epstein-Barr Virus Infections ,Herpesvirus 4 ,Human ,Herpesvirus 6 ,Human ,Enterovirus A ,Human ,Helper Viruses ,Pediatric Hepatitis of Unknown Etiology Working Group ,General Science & Technology - Abstract
As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P
- Published
- 2023