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5. Supplementary Figure 4 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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6. Supplementary Figure 2 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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7. Supplementary Video 1 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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8. Supplementary Figure 6 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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9. Supplementary Figure 5 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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10. Supplementary Table 1 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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11. Supplementary Table 2 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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12. Supplementary Table 3 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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13. Supplementary Video 2 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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14. Supplementary Figure 7 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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15. Supplementary Figure 3 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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16. Supplementary Figure 1 from Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

Author

Kubo, Takafumi, primary, Toyooka, Shinichi, primary, Tsukuda, Kazunori, primary, Sakaguchi, Masakiyo, primary, Fukazawa, Takuya, primary, Soh, Junichi, primary, Asano, Hiroaki, primary, Ueno, Tsuyoshi, primary, Muraoka, Takayuki, primary, Yamamoto, Hiromasa, primary, Nasu, Yasutomo, primary, Kishimoto, Takumi, primary, Pass, Harvey I., primary, Matsui, Hideki, primary, Huh, Nam-ho, primary, and Miyoshi, Shinichiro, primary

Published
2023
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18. DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes

Author

Sakaguchi, Masakiyo, Murata, Hitoshi, Aoyama, Yumi, Hibino, Toshihiko, Putranto, Endy Widya, Ruma, I. Made Winarsa, Inoue, Yusuke, Sakaguchi, Yoshihiko, Yamamoto, Ken-ichi, Kinoshita, Rie, Futami, Junichiro, Kataoka, Ken, Iwatsuki, Keiji, and Huh, Nam-ho

Published
2014
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19. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells

Author

Saho, Satomi, Satoh, Hiroki, Kondo, Eisaku, Inoue, Yusuke, Yamauchi, Akira, Murata, Hitoshi, Kinoshita, Rie, Yamamoto, Ken-ichi, Futami, Junichiro, Putranto, Endy Widya, Ruma, I Made Winarsa, Sumardika, I Wayan, Youyi, Chen, Suzawa, Ken, Yamamoto, Hiromasa, Soh, Junichi, Tomida, Shuta, Sakaguchi, Yoshihiko, Saito, Ken, iioka, Hidekazu, Huh, Nam-ho, Toyooka, Shinichi, and Sakaguchi, Masakiyo

Published
2016
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31. Bifurcated converging pathways for high [Ca.sup.2+]- and TGF [beta]-induced inhibition of growth of normal human keratinocytes

Author

Sakaguchi, Masakiyo, Sonegawa, Hiroyuki, Nukui, Takamasa, Sakaguchi, Yoshihiko, Miyazaki, Masahiro, Namba, Masayoshi, and Huh, Nam-ho

Subjects
Keratinocytes -- Research, Transforming growth factors -- Research, Science and technology
Abstract

Growth suppression of normal human keratinocytes by high [Ca.sup.2+] or TGF[beta] was shown to be mediated by [p21.sup.WAF1/CIP1] and Sp1 [Pardali, K., et al. (2000) J. Biol. Chem. 275, 29244-29256; Santini, M. P., Talora, C., Seki, T., Bolgan, L. & Dotto, G. P. (2001) Proc. Nat. Acad. Sci. USA 98, 9575-9580; Al-Daraji, W. I., Grant, K. R., Ryan, K., Saxton, A., & Reynolds, N. J. (2002) J. Invest. Dermatol. 118, 779-788]. We previously demonstrated that $100C/All is a key mediator for growth inhibition of normal human epidermal keratinocytes (NHK) triggered by high [Ca.sup.2+] or TGF[beta] [Sakaguchi, M., et al. (2003) J. Cell Biol. 163, 825-835; Sakaguchi, M., et al. (2004) 164, 979-984]. On exposure of NHK cells to either agent, S100C/ A11 is transferred to nuclei, where it induces [p21.sup.WAF1/CIP1] through activation of Sp1/Sp3. In the present study, we found that high [Ca.sup.2+] activated NFAT1 through calcineurin-dependent dephosphorylation. In growing NHK cells, Krueppel-like factor (KLF)16, a member of the Sp/KLF family, bound to the [p21.sup.WAF1/CIP1] promoter and, thereby, inhibited the transcription of [p21.sup.WAF1/CIP1]. Sp1 complexed with NFAT1 in high [Ca.sup.2+]-treated cells or with Smad3 in TGF[beta]1-treated cells, but not Sp1 alone, replaced KLF16 from the [p21.sup.WAF1/CIP1] promoter and transcriptionally activated the [p21.sup.WAF1/CIP1] gene. Thus, high [Ca.sup.2+] and TGF[beta]1 have a common S100C/A11-mediated pathway in addition to a unique pathway (NFAT1-mediated pathway for high [Ca.sup.2+] and Smad-mediated pathway for TGF[beta]1) for exhibiting a growth inhibitory effect on NHK cells, and both pathways were shown to be indispensable for growth inhibition. p21 | S100 | NFAT1 | Smad | Krueppel-like factor

Published
2005

42. Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin

Author

Kashiwagi, Mariko, Kuroki, Toshio, and Huh, Nam-ho

Subjects
Hair follicles -- Research, Epidermal growth factor -- Research, Mice -- Anatomy, Biological sciences
Abstract

Embryonic mouse skin undergoes a drastic morphological change from 13 to 16 gestational days, i.e., formation of rudiments of hair follicles and stratification and cornification of interfollicular epidermis. To investigate underlying molecular mechanisms of the morphogenesis, we established an organ culture system that allows skin tissues isolated from 12.5- or 13.5-days postcoitus embryos to develop in a manner that is histologically and temporally similar to the process in vivo. Expression of differentiation markers of epidermal keratinocytes including cholesterol sulfotransferase and cytokeratin K1 was induced in culture, as it occurs also in vivo. The morphogenic process was observed by time-lapse videomicrography. In this culture system, epidermal growth factor (EGF) and transforming growth factor [Alpha] specifically and completely inhibited the hair follicle formation with marginal effects on interfollicular epidermis. The inhibitory action by EGF was reversible and stage specific, i.e., at an early stage of the development of hair rudiments. Among known ligands to the EGF receptor, Schwannoma-derived growth factor and heparin-binding EGF were expressed in in vivo epidermis during the period of the initial formation of hair follicles. EGF receptor is expressed in epidermis throughout the developing period examined. Using an adenovirus vector, we demonstrated that the lacZ gene was transduced into the epidermal and dermal cell layers without appreciable toxicity. These results indicate that the present culture system provides a unique opportunity to investigate molecular mechanisms of skin morphogenesis including the role of EGF signaling under defined experimental conditions.

Published
1997

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