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Your search keyword '"Hui, Ho-Wah"' showing total 30 results
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30 results on '"Hui, Ho-Wah"'

1. Contributors

Author

Ajithdoss, D.K., primary, Al-Humadi, Nabil, additional, Amuzie, C.J., additional, Attar, Mayssa, additional, Aulbach, Adam D., additional, Boersen, Nathan, additional, Bolger, Gordon, additional, Brown, Jennifer G., additional, Chang, T.T.A., additional, Chanut, Franck Jacques-Antoine, additional, Cheng, Z., additional, Colagiovanni, Dorothy B., additional, Colerangle, John B., additional, Collins, Roger, additional, Cristofori, Patrizia, additional, Denny, Kevin H., additional, Dill-Okubo, J., additional, Ennulat, Daniela, additional, Faqi, Ali S., additional, Farmer, John T., additional, Frantz, Stephen, additional, Freshwater, Les, additional, Gauvin, David V., additional, Goud, N.S., additional, Green, M.D., additional, Henry, Scott P., additional, Hoberman, Alan, additional, Hui, Ho-Wah, additional, Hui, Julia Y., additional, Ji, A.Y., additional, Johnson, Colleen, additional, Kile, J.W., additional, Kim, Tae-Won, additional, Koch, Elisabeth, additional, Kornbrust, Douglas, additional, Kulshreshtha, V., additional, Learn, D.B., additional, LeBaron, Mathew J., additional, Levin, Arthur A., additional, Lewis, Elise, additional, Licollari, Albert, additional, Li, X.P., additional, Loo, Deryk, additional, Luhrs, Keith A., additional, Martini, Austin, additional, McCormick, D.L., additional, Meyer-Tamaki, K.B., additional, Nicolette, John, additional, O'Carroll, Andrew, additional, Oh, Hyesun Helena, additional, Oyejide, L., additional, Peraza, Marjorie A., additional, Plassmann, Stephanie, additional, Qiao, H.W., additional, Ramos, Meg Ferrell, additional, Rehagen, D., additional, Resendez, J.C., additional, Schultze, A. Eric, additional, Seals, Jennifer R., additional, Settivari, Raja S., additional, Slauter, Ric, additional, Stahl, Kurt, additional, Stump, Donald, additional, Surapaneni, Sekhar, additional, Templin, Michael, additional, Toltin, Abigail, additional, Vidmar, Tom, additional, Vrbanac, Jim, additional, Wang, Z.J., additional, Whiteley, Laurence O., additional, Wijeyesakere, Sanjeeva, additional, Wrzesinski, Claudia, additional, Xu, Jie, additional, Yang, Ping, additional, Yoder, Lisa, additional, Younis, Husam S., additional, Zhang, Y.M., additional, and Zimmermann, Zachary J., additional

Published
2024
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15. Contributors

Author

Abdi, Mohamoud M., primary, Al-Humadi, Nabil Hussain, additional, Attar, Mayssa, additional, Baird, Theodore J., additional, Behrens, Jeff, additional, Boersen, Nathan, additional, Brassard, Jacqueline A., additional, Beck, Melissa J., additional, Brown, Jennifer G., additional, Carney, Edward W., additional, Chang, Ting-Tung A., additional, Chen, Mingli, additional, Colagiovanni, Dorothy B., additional, Colerangle, John B., additional, Collins, Roger, additional, Dabora, Rebecca, additional, Dalton, Jill A., additional, Denny, Kevin H., additional, Dietert, Rodney R., additional, Donald, Forbes P., additional, Duncan, J. Neil, additional, Farmer, John T., additional, Faqi, Ali S., additional, Frantz, Stephen, additional, Freshwater, Les, additional, Fuchs, Tobias C., additional, Gauvin, David V., additional, Green, Martin David, additional, Guo, Lining, additional, Henry, Scott P., additional, Hewitt, Philip G., additional, Hoberman, Alan, additional, Hui, Ho-Wah, additional, Hui, Julia Y., additional, Johnson, Colleen, additional, Kille, John W., additional, Kim, Andrea S., additional, Kim, Tae-Won, additional, Kirby, Neil, additional, Kornbrust, Douglas, additional, Learn, Douglas B., additional, Lee, Thomas, additional, Lewis, Elise, additional, Matsumoto, Steven, additional, McCormick, David L., additional, Meyer-Tamaki, Kathleen B., additional, Mendes, Odete R., additional, Milburn, Michael V., additional, Mikaelian, Igor, additional, Morford, LaRonda L., additional, Nicolette, John, additional, Nugent, Paul, additional, Oh, Hyesun H., additional, Oyejide, Lekan, additional, Ramos, Meg, additional, Regal, Kelly A., additional, Rehagen, David, additional, Resendez, John Cody, additional, Ryals, John A., additional, Sambuco, Christopher P., additional, Schrag, Michael, additional, Serota, David G., additional, Settivari, Raja, additional, Slauter, Richard, additional, Stewart, Christopher W., additional, Stump, Donald, additional, Surapaneni, Sekhar, additional, Templin, Michael, additional, Thorsrud, Bjorn A., additional, Truisi, Germaine L., additional, Vangyi, Chang, additional, Vidmar, Tom, additional, Vrbanac, Jim, additional, Wang, Qingli, additional, Wang, Zheng J., additional, Whitely, Lawrence O., additional, Yan, James S., additional, York, Malcolm J., additional, and Younis, Husam S., additional

Published
2013
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23. A preliminary assessment of the impact of hot-melt extrusion on the physico-mechanical properties of a tablet.

Author

Boersen, Nathan, Lee, Thomas Wai-Yip, Shen, Xiaole (George), and Hui, Ho-Wah

Subjects
COMPRESSIBILITY, TEMPERATURE, MANNITOL, DRUG tablets, AMORPHOUS substances, EXTRUSION process, THERAPEUTICS
Abstract

Objectives: This research aimed at investigating the difference between the powders prior to and after hot melt extrusion. A preliminary assessment was also conducted to gain a better mechanistic understanding of the impact of hot melt extrusion on tabletability. Materials and methods: Kollidon® VA 64 and mannitol were sieved into different particles sizes and used as is or after drying for 24 h. Hot melt extrusion was used to manufacture an amorphous solid dispersion of Kollidon® VA 64 and mannitol. The extrudates were milled and sieved into different particles sizes. Tablets were manufactured from the different powders and their tabletability, compressibility and compactibility determined. Results and discussions: It was shown that the as received tablets gave higher tabletability compared with the tablets manufactured from the dried or hot melt extruded ( HME) powder. Differences in the tabletability between the as received. dried and HME material could be related back to changes in the bonding area and bonding strength as a result of the hot melt extrusion process and/or a loss of moisture because of the high processing temperature. Conclusions: The reduced tabletability of the HME tablets appeared to be a function of multiple factors. Both the hot melt extrusion process and the moisture content may play significant roles in determining this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2014
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24. Evaluation of different screening methods to understand the dissolution behaviors of amorphous solid dispersions.

Author

Lee, Thomas Wai-Yip, Boersen, Nathan A., Yang, Gang, and Hui, Ho-Wah

Subjects
AMORPHOUS substances, DRUG analysis, PRECIPITATION (Chemistry), PHARMACEUTICAL powders, PHARMACEUTICAL encapsulation, DRUG solubility, DRUG formularies
Abstract

Objective: The objectives of the current study were to understand the dissolution behaviors of amorphous solid dispersions (ASD) using different screening methods and their correlation to the dissolution of formulated products. Materials and methods: A poorly soluble compound, compound E, was used as a model compound. ASDs were prepared with HPMC, Kollidon VA64 and Eudragit EPO using hot-melt extrusion. Different techniques including precipitation, powder, capsule and compact dissolution and the dissolution of formulated products were conducted in USP simulated gastric fluid using a USP II dissolution apparatus. Results and discussions: It was found that a precipitation study could generally predict powder, capsule and compact dissolution. Yet, it was recommended to run the dissolution at a higher paddle speed or for a longer duration to improve the predictability. It was also recommended to run powder, capsule and compact dissolution at both slow and high speeds to gain insights into wetting, dispersion and the dissolution of a system. Sometimes, capsule or compact dissolution could not be predicted by precipitation or powder dissolution due to plug formation. In this case, properly designed dosage forms were needed to break up this plug to optimize the dissolution profiles. On the contrary, formulations and dissolution conditions would have minimal effects on the dissolution profiles of a fast-dissolving solid dispersion. Conclusions: Different techniques are available to select the right polymers to optimize dissolution behaviors. However, it is important to understand the merits and limitations of each technique in order to optimize the formulations for amorphous solid dispersions. [ABSTRACT FROM AUTHOR]

Published
2014
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29. Effect of Particle Dissolution Rate on Ocular Drug Bioavailability

Author

Hui, Ho-Wah and Robinson, Joseph R.

Abstract

Aqueous ophthalmic drug solutions typically exhibit low bioavailability due to various loss processes such as drainage, tear turnover, nonproductive absorption, and protein binding. Suspensions may improve bioavailability, but because of a short residence time and a low corneal permeability rate constant, the dissolution rate of the drug and its intrinsic solubility must be considered. The relationship between the various parameters affecting the relative dissolution rate have not heretofore been examined with respect to the eye. In the present study, a kinetic model that predicts ocular tissue drug levels for suspensions has been developed and tested using a steroid, fluorometholone, as the test drug suspension. The proposed model is able to predict the effects of particle size, concentration, and changes in drainage rate such that a reasonable a priori prediction of drug levels can be made.

Published
1986
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