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2. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

Author

Razavi-Shearer, Devin, Gamkrelidze, Ivane, Nguyen, Mindie H, Chen, Ding-Shinn, Van Damme, Pierre, Abbas, Zaigham, Abdulla, Maheeba, Abou Rached, Antoine, Adda, Danjuma, Aho, Inka, Akarca, Ulus, Hasan, Fuad, Al Lawati, Faryal, Al Naamani, Khalid, Al-Ashgar, Hamad Ibrahim, Alavian, Seyed M, Alawadhi, Sameer, Albillos, Agustin, Al-Busafi, Said A, Aleman, Soo, Alfaleh, Faleh Z, Aljumah, Abdulrahman A, Anand, Anil C, Anh, Nguyen Thu, Arends, Joop E, Arkkila, Perttu, Athanasakis, Kostas, Bane, Abate, Ben-Ari, Ziv, Berg, Thomas, Bizri, Abdul R, Blach, Sarah, Brandão Mello, Carlos E, Brandon, Samantha M, Bright, Bisi, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Chan, Henry L Y, Chaudhry, Asad, Chien, Rong-Nan, Choi, Moon S, Christensen, Peer B, Chuang, Wan-Long, Chulanov, Vladimir, Clausen, Mette R, Colombo, Massimo, Cornberg, Markus, Cowie, Benjamin, Craxi, Antonio, Croes, Esther A, Cuellar, Diego Alberto, Cunningham, Chris, Desalegn, Hailemichael, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve S, El-Sayed, Manal H, Estes, Chris, Falconer, Karolin, Ferraz, Maria L G, Ferreira, Paulo R, Flisiak, Robert, Frankova, Sona, Gaeta, Giovanni B, García-Samaniego, Javier, Genov, Jordan, Gerstoft, Jan, Goldis, Adrian, Gountas, Ilias, Gray, Richard, Guimarães Pessôa, Mário, Hajarizadeh, Behzad, Hatzakis, Angelos, Hézode, Christophe, Himatt, Sayed M, Hoepelman, Andy, Hrstic, Irena, Hui, Yee-Tak T, Husa, Petr, Jahis, Rohani, Janjua, Naveed Z, Jarčuška, Peter, Jaroszewicz, Jerzy, Kaymakoglu, Sabahattin, Kershenobich, David, Kondili, Loreta A, Konysbekova, Aliya, Krajden, Mel, Kristian, Pavol, Laleman, Wim, Lao, Wai-cheung C, Layden, Jen, Lazarus, Jeffrey V, Lee, Mei-Hsuan, Liakina, Valentina, Lim, Young-Suk S, Loo, Ching-kong K, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham O, Mamatkulov, Adkhamjon, Manns, Michael, Marinho, Rui T, Maticic, Mojca, Mauss, Stefan, Memon, Muhammad S, Mendes Correa, Maria C, Mendez-Sanchez, Nahum, Merat, Shahin, Metwally, Ammal M, Mohamed, Rosmawati, Mokhbat, Jacques E, Moreno, Christophe, Mossong, Joel, Mourad, Fadi H, Müllhaupt, Beat, Murphy, Kimberly, Musabaev, Erkin, Nawaz, Arif, Nde, Helen M, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Njouom, Richard, Ntagirabiri, Renovat, Nurmatov, Zuridin, Obekpa, Solomon, Ocama, Ponsiano, Oguche, Stephen, Omede, Ogu, Omuemu, Casimir, Opare-Sem, Ohene, Opio, Christopher K, Örmeci, Necati, Papatheodoridis, George, Pasini, Ken, Pimenov, Nikolay, Poustchi, Hossein, Quang, Trân D, Qureshi, Huma, Ramji, Alnoor, Razavi-Shearer, Kathryn, Redae, Berhane, Reesink, Henk W, Rios, Cielo Yaneth, Rjaskova, Gabriela, Robbins, Sarah, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Safadi, Rifaat, Sagalova, Olga, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Scott, Julia, Seguin-Devaux, Carole, Shah, Samir R, Sharara, Ala I, Sharma, Manik, Shiha, Gamal E, Shin, Tesia, Sievert, William, Sperl, Jan, Stärkel, Peter, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek S, Tanaka, Junko, Tomasiewicz, Krzysztof, Urbanek, Petr, van der Meer, Adriaan J, Van Vlierberghe, Hans, Vella, Stefano, Vince, Adriana, Waheed, Yasir, Waked, Imam, Walsh, Nicholas, Weis, Nina, Wong, Vincent W, Woodring, Joseph, Yaghi, Cesar, Yang, Hwai-I, Yang, Chung-Lin, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yusuf, Muhammed Aasim M, Zeuzem, Stefan, and Razavi, Homie

Published
2018
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3. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Author

Blach, Sarah, Zeuzem, Stefan, Manns, Michael, Altraif, Ibrahim, Duberg, Ann-Sofi, Muljono, David H, Waked, Imam, Alavian, Seyed M, Lee, Mei-Hsuan, Negro, Francesco, Abaalkhail, Faisal, Abdou, Ahmed, Abdulla, Maheeba, Rached, Antoine Abou, Aho, Inka, Akarca, Ulus, Al Ghazzawi, Imad, Al Kaabi, Saad, Al Lawati, Faryal, Al Namaani, Khalid, Al Serkal, Youssif, Al-Busafi, Said A, Al-Dabal, Layla, Aleman, Soo, Alghamdi, Abdullah S, Aljumah, Abdulrahman A, Al-Romaihi, Hamad E, Andersson, Monique I, Arendt, Vic, Arkkila, Perttu, Assiri, Abdullah M, Baatarkhuu, Oidov, Bane, Abate, Ben-Ari, Ziv, Bergin, Colm, Bessone, Fernando, Bihl, Florian, Bizri, Abdul R, Blachier, Martin, Blasco, Antonio J, Mello, Carlos E Brandão, Bruggmann, Philip, Brunton, Cheryl R, Calinas, Filipe, Chan, Henry L Y, Chaudhry, Asad, Cheinquer, Hugo, Chen, Chien-Jen, Chien, Rong-Nan, Choi, Moon Seok, Christensen, Peer B, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Clausen, Mette R, Cramp, Matthew E, Craxi, Antonio, Croes, Esther A, Dalgard, Olav, Daruich, Jorge R, de Ledinghen, Victor, Dore, Gregory J, El-Sayed, Manal H, Ergör, Gul, Esmat, Gamal, Estes, Chris, Falconer, Karolin, Farag, Elmoubashar, Ferraz, Maria L G, Ferreira, Paulo R, Flisiak, Robert, Frankova, Sona, Gamkrelidze, Ivane, Gane, Ed, García-Samaniego, Javier, Khan, Amir Ghafoor, Gountas, Ilias, Goldis, Adrian, Gottfredsson, Magnús, Grebely, Jason, Gschwantler, Michael, Pessôa, Mário Guimarães, Gunter, Jessie, Hajarizadeh, Behzad, Hajelssedig, Omer, Hamid, Saeed, Hamoudi, Waseem, Hatzakis, Angelos, Himatt, Sayed M, Hofer, Harald, Hrstic, Irena, Hui, Yee-Tak, Hunyady, Bela, Idilman, Ramazan, Jafri, Wasim, Jahis, Rohani, Janjua, Naveed Z, Jarčuška, Peter, Jeruma, Agita, Jonasson, Jón G, Kamel, Yasser, Kao, Jia-Horng, Kaymakoglu, Sabahattin, Kershenobich, David, Khamis, Jawad, Kim, Young S, Kondili, Loreta, Koutoubi, Zaher, Krajden, Mel, Krarup, Henrik, Lai, Moon-sing, Laleman, Wim, Lao, Wai-cheung, Lavanchy, Daniel, Lázaro, Pablo, Leleu, Henri, Lesi, Olufunmilayo, Lesmana, Laurentius A, Li, Michael, Liakina, Valentina, Lim, Young-Suk, Luksic, Boris, Mahomed, Adam, Maimets, Matti, Makara, Mihály, Malu, Abraham O, Marinho, Rui T, Marotta, Paul, Mauss, Stefan, Memon, Muhammad S, Correa, Maria C Mendes, Mendez-Sanchez, Nahum, Merat, Shahin, Metwally, Ammal M, Mohamed, Rosmawati, Moreno, Christophe, Mourad, Fadi H, Müllhaupt, Beat, Murphy, Kimberly, Nde, Helen, Njouom, Richard, Nonkovic, Diana, Norris, Suzanne, Obekpa, Solomon, Oguche, Stephen, Olafsson, Sigurður, Oltman, Marian, Omede, Ogu, Omuemu, Casimir, Opare-Sem, Ohene, Øvrehus, Anne L H, Owusu-Ofori, Shirley, Oyunsuren, Tsendsuren S, Papatheodoridis, George, Pasini, Ken, Peltekian, Kevork M, Phillips, Richard O, Pimenov, Nikolay, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Razavi-Shearer, Devin, Razavi-Shearer, Kathryn, Redae, Berhane, Reesink, Henk W, Ridruejo, Ezequiel, Robbins, Sarah, Roberts, Lewis R, Roberts, Stuart K, Rosenberg, William M, Roudot-Thoraval, Françoise, Ryder, Stephen D, Safadi, Rifaat, Sagalova, Olga, Salupere, Riina, Sanai, Faisal M, Avila, Juan F Sanchez, Saraswat, Vivek, Sarmento-Castro, Rui, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Seguin-Devaux, Carole, Shah, Samir R, Sharara, Ala I, Sharma, Manik, Shevaldin, Anatoly, Shiha, Gamal E, Sievert, William, Sonderup, Mark, Souliotis, Kyriakos, Speiciene, Danute, Sperl, Jan, Stärkel, Peter, Stauber, Rudolf E, Stedman, Catherine, Struck, Daniel, Su, Tung-Hung, Sypsa, Vana, Tan, Soek-Siam, Tanaka, Junko, Thompson, Alexander J, Tolmane, Ieva, Tomasiewicz, Krzysztof, Valantinas, Jonas, Van Damme, Pierre, van der Meer, Adriaan J, van Thiel, Ingo, Van Vlierberghe, Hans, Vince, Adriana, Vogel, Wolfgang, Wedemeyer, Heiner, Weis, Nina, Wong, Vincent WS, Yaghi, Cesar, Yosry, Ayman, Yuen, Man-fung, Yunihastuti, Evy, Yusuf, Aasim, Zuckerman, Eli, and Razavi, Homie

Published
2017
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4. Incidence of hepatocellular carcinoma and mortality in chronic viral hepatitis in an Asian population with and without HIV infection.

Author

Lui, Grace Chung‐Yan, Hui, Vicki Wing‐Ki, Sze, Shun‐Fung, Wong, Bonnie Chun‐Kwan, Cheung, Catherine, Lee, Man‐Po, Yip, Terry Cheuk‐Fung, Tse, Yee‐Kit, Lai, Jimmy Che‐To, Chan, Henry Lik‐Yuen, Wong, Vincent Wai‐Sun, Hui, Yee‐Tak, and Wong, Grace Lai‐Hung

Subjects
HIV infections, VIRAL hepatitis, CHRONIC active hepatitis, HEPATOCELLULAR carcinoma, ASIANS, PROPORTIONAL hazards models, HIV-positive persons
Abstract

Summary: Background: It is uncertain whether people with HIV infection have a higher incidence of hepatocellular carcinoma (HCC) than the general population. Aims: To compare the incidence of HCC between people infected with HBV and/or HCV with and without HIV Methods: We performed a retrospective population‐based cohort study, involving people with HBV and/or HCV infection from 2001 to 2018. The primary endpoint was incidence of HCC; secondary endpoint was all‐cause mortality. We performed Cox proportional hazard regression models to estimate the hazard ratios (HR) of HIV for the primary and secondary endpoints. Results: We identified 1374 people infected with HIV and 39,908 people without HIV with HBV and/or HCV infection. Among those with HIV, 654 (47.6%) had HBV, 649 (47.2%) HCV and 71 (5.2%) HBV‐HCV‐co‐infection; they were younger, and had a higher prevalence of HCV and a lower prevalence of cirrhosis. The incidence rate estimates of HCC were, respectively, 1.5 (95% CI: 0.8–2.5) and 7.6 (95% CI 7.3‐8.0) per 1000 person‐years for those with and without HIV infection. Using multivariate Cox proportional hazard regression models, among people with HBV, HIV was associated with lower risk of HCC (adjusted HR: 0.376, 95% CI: 0.201–0.704, p = 0.01) and death (adjusted HR: 0.692, 95% CI: 0.552–0.867, p = 0.007). Risks of HCC were similar for HCV and HBV‐HCV co‐infection for people with and without HIV. Conclusions: Among individuals with HBV infection, the Incidence of HCC was lower in those with HIV. For HCV infection, incidence of HCC was similar between those with and without HIV. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry

Author

Shi, Hai Yun, Chan, Francis K. L., Leung, Wai Keung, Li, Michael K. K., Leung, Chi Man, Sze, Shun Fung, Ching, Jessica Y. L., Lo, Fu Hang, Tsang, Steve W. C., Shan, Edwin H. S., Mak, Lai Yee, Lam, Belsy C. Y., Hui, Aric J., Wong, Sai Ho, Wong, Marc T. L., Hung, Ivan F. N., Hui, Yee Tak, Chan, Yiu Kay, Chan, Kam Hon, Loo, Ching Kong, Tong, Raymond W. H., Chow, Wai Hung, Ng, Carmen K. M., Lao, Wai Cheung, Harbord, Marcus, Wu, Justin C. Y., Sung, Joseph J. Y., and Ng, Siew C.

Published
2016
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11. Use of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection and severe renal impairment

Author

Yap, Desmond Y. H., primary, Liu, Kevin S. H., additional, Hsu, Yu-Chun, additional, Wong, Grace L. H., additional, Tsai, Ming-Chang, additional, Chen, Chien-Hung, additional, Hsu, Ching-Sheng, additional, Hui, Yee Tak, additional, Li, Michael K. K., additional, Liu, Chen-Hua, additional, Kan, Yee-Man, additional, Yu, Ming-Lung, additional, and Yuen, Man-Fung, additional

Published
2020
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13. AmplifEYE assisted colonoscopy versus standard colonoscopy: A randomized controlled study.

Author

Sze, Shun Fung, Cheung, Wing I, Wong, Wai Chuen, Hui, Yee Tak, and Lam, Jodis Ting Wa

Subjects
COLONOSCOPY, ADENOMA, ADENOMATOUS polyps, RANDOMIZED controlled trials
Abstract

Background and Aim: AmplifEYE is a mucosal exposure device mounted to the tip of colonoscope to improve polyp or adenoma detection. We aim to compare the adenoma detection rates (ADR) of AmplifEYE‐assisted colonoscopy (AC) with standard colonoscopy (SC). Methods: We performed a randomized controlled trial involving patients aged 50 to 79 who underwent AC or SC in two centers. Procedures were performed by five experienced colonoscopists. Results: Three hundred fifty‐five patients were recruited, with 334 patients (170 AC and 164 SC) included into analysis. The ADR was numerically higher in AC (47.1%) versus SC (40.9%), P = 0.253. The polyp detection rate (PDR) in AC was 68.2% versus 54.3% in SC, P = 0.009, and serrated polyp detection rate (SDR) in AC was 37.6% versus 20.1% in SC, P < 0.001, both statistically significant higher in the study group. The mean cecal intubation time was shorter with AmplifEYE (8.0 min in AC vs 8.9 min in SC, P = 0.030), and there was no difference in pain score (3 in AC vs 4 in SC, P = 0.121). Conclusions: AmplifEYE‐assisted colonoscopy significantly improved the PDR and SDR, while the ADR was numerically higher in AC that did not reach statistical significance. Using the device resulted in shorter cecal intubation time and did not cause more pain. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas.

Author

Siew C. Ng, Moe Htet Kyaw, Bing Yee Suen, Yee Kit Tse, Wong, Martin C. S., Hui, Aric J., Hui Yee Tak, Lau, James Y. W., Sung, Joseph J. Y., and Chan, Francis K. L.

Subjects
ADENOMATOUS polyps, FECAL occult blood tests, SIGMOIDOSCOPY, TUMORS, HEREDITARY nonpolyposis colorectal cancer, LONGITUDINAL method, CANCER, ADENOMATOUS polyposis coli
Published
2020
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15. Territory-wide population-based study of chronic hepatitis C infection and implications for hepatitis elimination in Hong Kong

Author

Hui, Yee Tak, primary, Wong, Grace L. H., additional, Fung, James Y. Y., additional, Chan, Henry L. Y., additional, Leung, Nancy W. Y., additional, Liu, Sienna D., additional, Liu, Ken, additional, Ma, Yiu Keung, additional, But, David Y. K., additional, Mak, Wing Yan, additional, Chan, Jacky M. C., additional, Lai, Kin Bon, additional, Loo, Ching Kong, additional, Ng, Annie C. Y., additional, Lai, Moon Sing, additional, Chan, Chun Wing, additional, Lau, Joulen Y. L., additional, Fan, Tina T. T., additional, Hui, Aric J., additional, Lam, Belsy C. Y., additional, Cheung, Wing I., additional, Tsang, Owen T. Y., additional, Lam, Karen, additional, Lai, Lawrence S. W., additional, Luk, Wai Fan, additional, Li, Michael K. K., additional, Lao, Wai Cheung, additional, Lam, Jodis T. W., additional, Tsang, Steven W. C., additional, Kung, Kam Ngai, additional, Chow, Wai Hung, additional, Tong, Ronald K. N., additional, Lui, Thomas K. L., additional, Shan, Edwin H. S., additional, Yuen, Man Fung, additional, and Wong, Vincent W. S., additional

Published
2018
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17. Su1925 - Risk of Cerebrovascular Accidents in 2143 Patients with Inflammatory Bowel Diseases: Results from a Population-Based Study

Author

Hsu, Ryan H., primary, Chan, Ting Ting, additional, Lau, Louis H., additional, Tang, Whitney, additional, Leung, Wai K., additional, Li, Michael K., additional, Leung, Chi Man, additional, Lao, Wai-Cheung, additional, Ng, Carmen Ka Man, additional, Lo, Fu H, additional, Sze, Shun Fung, additional, Hui, Yee-Tak, additional, Tsang, Steve, additional, Shan, Edwin HS, additional, Loo, Ching K, additional, Chan, Kam H, additional, Hui, Aric J, additional, Chow, Wai Hung, additional, Wu, Justin C., additional, Chan, Francis K., additional, Sung, Joseph J., additional, and Ng, Siew C., additional

Published
2018
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18. Real‐life efficacy and safety of paritaprevir/ritonavir, ombitasvir, and dasabuvir in chronic hepatitis C patients in Hong Kong

Author

Chan, Henry Lik‐Yuen, primary, Tsang, Owen Tak‐Yin, additional, Hui, Yee‐Tak, additional, Fung, James, additional, Lui, Grace Chung‐Yan, additional, Lai, Ching‐Lung, additional, Wong, Grace Lai‐Hung, additional, Chan, Kam‐Hon, additional, But, David Yiu‐Kuen, additional, Lai, Moon‐Sing, additional, Lao, Wai‐Cheung, additional, Chan, Carmen Ka‐Man, additional, Lam, Yip‐Shun, additional, Seto, Wai‐Kay, additional, Li, Carlton, additional, Yuen, Man‐Fung, additional, and Wong, Vincent Wai‐Sun, additional

Published
2017
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19. 5-Aminosalicylic Acid and Statin use are Associated with Reduced Risk of Cancers in Patients with Inflammatory Bowel Disease: A Population-Based Cohort Study

Author

So, Jacqueline, primary, Tang, Whitney, additional, Chan, Francis K., additional, Leung, Wai K., additional, Li, Michael K., additional, Leung, Chi Man, additional, Lao, Wai-Cheung, additional, Ng, Carmen Ka Man, additional, Lo, Fu H, additional, Sze, Shun Fung Alex, additional, Hui, Yee Tak, additional, Tsang, Steve, additional, Shan, Edwin HS, additional, Loo, Ching K, additional, Chan, Kam H, additional, Hui, Aric J, additional, Chow, Wai Hung, additional, Wu, Justin C., additional, Sung, Joseph J., additional, and Ng, Siew C., additional

Published
2017
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20. Change in treatment paradigm in people who previously injected drugs with chronic hepatitis C in the era of direct‐acting antiviral therapy.

Author

Wong, Grace Lai‐Hung, Chan, Henry Lik‐Yuen, Loo, Ching‐Kong, Hui, Yee‐Tak, Fung, James Yue‐Yan, Cheung, David, Chung, Cedric, Chim, Angel Mei‐Ling, and Wong, Vincent Wai‐Sun

Subjects
CHRONIC hepatitis C, HEPATITIS C virus, NONGOVERNMENTAL organizations, REHABILITATION centers
Abstract

Background: Chronic hepatitis C virus (HCV) infection is highly prevalent among people who inject drugs but is often undiagnosed. The treatment paradigm for HCV patients has been changing since the availability of direct‐acting antiviral (DAA) treatment. We aimed to evaluate the change in treatment paradigm of people who previously injected drugs (ex‐PWID) in Hong Kong before and after the availability of DAA. Method: Consecutive ex‐PWID referred from various nongovernmental organizations attended education talks at rehabilitation centers and received point‐of‐care rapid test for HCV antibody (anti‐HCV) at the same session. Subjects tested positive for anti‐HCV were invited to undergo further assessment. Afterwards, the patients were referred to the regional hospitals for follow‐up and/or treatment. Results: Three hundred sixty‐five ex‐PWID received HCV rapid test; 268 (73.4%) were found to be anti‐HCV positive. Among these 268 HCV‐positive ex‐PWID, 234 (87.3%) attended the assessment session (mean age 52 years, 90.2% male, 45.5% genotype 1b, 41.1% genotype 6a, and median liver stiffness 5.9 kPa); 187 (69.8%) attended follow‐up visits at regional hospitals. Seventy‐one patients received antiviral treatment for HCV; 69 first received peginterferon and ribavirin (PegIFN/RBV), whereas 10 patients (eight PegIFN/RBV‐treated patients) received DAA treatment. Fifty‐two patients achieved sustained virologic response at 12 or 24 weeks. Treatment uptake rates of PegIFN/RBV and DAA treatment in the pre‐DAA versus post‐DAA era were 22.3% versus 48.5% and 0% versus 15.6%, respectively. Conclusions: Targeted screening in ex‐PWID is effective in identifying patients with HCV infection in the community. To improve treatment uptake, further improvements in the referral system and treatment regimens are needed. [ABSTRACT FROM AUTHOR]

Published
2019
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21. Infection-related hospitalizations in the first year after inflammatory bowel disease diagnosis

Author

Ko, Michael Kwan-Lung, primary, Ng, Siew C, additional, Mak, Lung-Yi, additional, Li, Michael K, additional, Lo, Fu Hang, additional, Ng, Carmen Ka Man, additional, Lao, Wai Cheung, additional, Tsang, Steve, additional, Chan, Kam Hon, additional, Hui, Yee Tak, additional, Shan, Edwin Hok Shing, additional, Loo, Ching Kong, additional, Hui, Aric J, additional, To, Wai Pan, additional, Hung, Ivan F, additional, and Leung, Wai K, additional

Published
2016
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22. Epidemiology of Inflammatory Bowel Disease from 1981 to 2014

Author

Ng, Siew C., primary, Leung, Wai Keung, additional, Shi, Hai Yun, additional, Li, Michael K. K., additional, Leung, Chi Man, additional, Ng, Carmen K. M., additional, Lo, Fu Hang, additional, Hui, Yee Tak, additional, Tsang, Steven W. C., additional, Chan, Yiu Kay, additional, Loo, Ching Kong, additional, Chan, Kam Hon, additional, Hui, Aric J., additional, Chow, Wai Hung, additional, Harbord, Marcus, additional, Ching, Jessica Y. L., additional, Lee, Mandy, additional, Chan, Victor, additional, Tang, Whitney, additional, Hung, Ivan F. N., additional, Ho, Judy, additional, Lao, Wai Cheung, additional, Wong, Marc T. L., additional, Sze, Shun Fung, additional, Shan, Edwin H. S., additional, Lam, Belsy C. Y., additional, Tong, Raymond W. H., additional, Mak, Lai Yee, additional, Wong, Sai Ho, additional, Wu, Justin C. Y., additional, Chan, Francis K. L., additional, and Sung, Joseph J. Y., additional

Published
2016
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23. Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry

Author

Shi, Hai Yun, primary, Chan, Francis K. L., additional, Leung, Wai Keung, additional, Li, Michael K. K., additional, Leung, Chi Man, additional, Sze, Shun Fung, additional, Ching, Jessica Y. L., additional, Lo, Fu Hang, additional, Tsang, Steven W. C., additional, Shan, Edwin H. S., additional, Mak, Lai Yee, additional, Lam, Belsy C. Y., additional, Hui, Aric J., additional, Chow, Wai Hung, additional, Wong, Marc T. L., additional, Hung, Ivan F. N., additional, Hui, Yee Tak, additional, Chan, Yiu Kay, additional, Chan, Kam Hon, additional, Loo, Ching Kong, additional, Ng, Carmen K. M., additional, Lao, Wai Cheung, additional, Harbord, Marcus, additional, Wu, Justin C. Y., additional, Sung, Joseph J. Y., additional, and Ng, Siew C., additional

Published
2016
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24. 20 Cancer Risk and Predictors in 2,432 Chinese Patients With Inflammatory Bowel Disease: A Population-Based Cohort Study

Author

Ng, Siew C., primary, Lee, Tsz Wai, additional, Tang, Ching Man, additional, Wong, Cheuk Lau, additional, Lam, Tsz Yiu, additional, Lam, Vernon, additional, Lo, Harris Ho Hin, additional, Leung, Wai K., additional, Li, Michael K., additional, Leung, Chi Man, additional, Lao, Wai C., additional, Ng, Carmen Ka Man, additional, Lo, Fu H., additional, Sze, Shun Fung Alex, additional, Hui, Yee Tak, additional, Tsang, Steve, additional, Loo, Ching K., additional, Chan, Kam H, additional, Hui, Aric J, additional, Chow, Wai Hung, additional, Ching, Jessica, additional, Lee, Mandy, additional, Tang, Whitney, additional, Wong, Marc Tin Long, additional, Shan, Edwin HS, additional, Lam, Belsy C., additional, Mak, Lai Yee, additional, Wu, Justin C., additional, Chan, Francis K., additional, and Sung, Joseph, additional

Published
2016
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25. Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry

Author

Shi, Hai Yun, primary, Chan, Francis K. L., additional, Leung, Wai Keung, additional, Li, Michael K. K., additional, Leung, Chi Man, additional, Sze, Shun Fung, additional, Ching, Jessica Y. L., additional, Lo, Fu Hang, additional, Tsang, Steve W. C., additional, Shan, Edwin H. S., additional, Mak, Lai Yee, additional, Lam, Belsy C. Y., additional, Hui, Aric J., additional, Wong, Sai Ho, additional, Wong, Marc T. L., additional, Hung, Ivan F. N., additional, Hui, Yee Tak, additional, Chan, Yiu Kay, additional, Chan, Kam Hon, additional, Loo, Ching Kong, additional, Tong, Raymond W. H., additional, Chow, Wai Hung, additional, Ng, Carmen K. M., additional, Lao, Wai Cheung, additional, Harbord, Marcus, additional, Wu, Justin C. Y., additional, Sung, Joseph J. Y., additional, and Ng, Siew C., additional

Published
2015
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26. 81 Natural History of Elderly-Onset Ulcerative Colitis in Chinese: A Population-Based Cohort Study

Author

Shi, Hai Yun, primary, Ng, Siew C, additional, Leung, Wai K., additional, Li, Michael K., additional, Leung, Chi Man, additional, Sze, Shun Fung, additional, Ching, Jessica, additional, Chung, Tiffany ML, additional, Iu, Catherine YY, additional, Lo, Fu Hang, additional, Tsang, Steve, additional, Shan, Edwin Hok Shing, additional, Mak, Lai Yee, additional, Lam, Belsy Chung Yan, additional, Hui, Aric J., additional, Wong, Sai Ho, additional, Wong, Marc Tin Long, additional, Hung, Ivan Fan Ngai, additional, HUI, Yee Tak, additional, Chan, Yiu Kay, additional, Chan, Kam Hon, additional, Loo, Ching Kong, additional, Tong, Raymond Wai Hung, additional, Chow, Wai Hung, additional, Ng, Carmen Ka Man, additional, Lao, Wai Cheung, additional, Harbord, Marcus, additional, Wu, Justin C., additional, Sung, Joseph J.Y., additional, and Chan, Francis K.L., additional

Published
2015
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27. Factors Associated with Mucosal Healing in Patients with Ulcerative Colitis in Clinical Remission

Author

Shi, Hai Yun, primary, Chan, Francis K. L., additional, Tsang, Steven W. C., additional, Hui, Yee Tak, additional, Sze, Shun Fung, additional, Ching, Jessica Y. L., additional, Chung, Tiffany, additional, Iu, Catherine Y. Y., additional, Lo, Fu Hang, additional, Shan, Edwin H. S., additional, Li, Michael K. K., additional, Wu, Justin C. Y., additional, Sung, Joseph J. Y., additional, and Ng, Siew C., additional

Published
2015
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28. Sa1159 Infection-Related HospitalIzations in Patients Newly Diagnosed With Inflammatory Bowel Disease: Results From a Population-Based Registry

Author

Leung, Wai K., primary, Mak, Lung-Yi, additional, To, Wai Pan, additional, Ko, Kwan-Lung Michael, additional, Shi, Hai Yun, additional, Hung, Ivan F., additional, Li, Michael K., additional, Lo, Fu Hang, additional, Ng, Carmen Ka Man, additional, Lao, Wai Cheung, additional, Tsang, Steve, additional, Chan, Kam Hon, additional, HUI, Yee Tak, additional, Shan, Edwin Hok Shing, additional, Loo, Ching Kong, additional, Hui, Aric J., additional, Iu, Catherine YY, additional, and Ng, Siew C, additional

Published
2015
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29. Su1303 Prevalence and Disease Characteristics of Inflammatory Bowel Disease (IBD) in Chinese: Results From a Nationwide Population-Based Registry

Author

Ng, Siew C, primary, Leung, Wai K., additional, Li, Michael K., additional, Leung, Chi Man, additional, HUI, Yee Tak, additional, Ng, Carmen Ka Man, additional, Lo, Fu Hang, additional, Tsang, Steve, additional, Loo, Ching Kong, additional, Chan, Yiu Kay, additional, Chan, Kam Hon, additional, Hui, Aric J., additional, Chow, Wai Hung, additional, Ching, Jessica, additional, Chung, Tiffany ML, additional, Iu, Catherine YY, additional, Harbord, Marcus, additional, Hung, Ivan Fan Ngai, additional, Lao, Wai Cheung, additional, Sze, Shun Fung, additional, Wong, Marc Tin Long, additional, Leung, Rita, additional, Tsang, Vivian W., additional, Lam, Belsy Chung Yan, additional, Tong, Raymond Wai Hung, additional, Shan, Edwin Hok Shing, additional, Mak, Lai Yee, additional, Wong, Sai Ho, additional, Wu, Justin C., additional, Chan, Francis K.L., additional, and Sung, Joseph J.Y., additional

Published
2015
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30. Sa1859 - 5-Aminosalicylic Acid and Statin use are Associated with Reduced Risk of Cancers in Patients with Inflammatory Bowel Disease: A Population-Based Cohort Study

Author

So, Jacqueline, Tang, Whitney, Chan, Francis K., Leung, Wai K., Li, Michael K., Leung, Chi Man, Lao, Wai-Cheung, Ng, Carmen Ka Man, Lo, Fu H, Sze, Shun Fung Alex, Hui, Yee Tak, Tsang, Steve, Shan, Edwin HS, Loo, Ching K, Chan, Kam H, Hui, Aric J, Chow, Wai Hung, Wu, Justin C., Sung, Joseph J., and Ng, Siew C.

Published
2017
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31. Response

Author

Hui, Yee Tak, primary, Lam, Wai Ming, additional, and Lam, Ting Wa, additional

Published
2008
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35. Prevalence and Disease Characteristics of Inflammatory Bowel Disease (IBD) in Chinese: Results From a Nationwide Population-Based Registry

Author

Ng, Siew C., Leung, Wai K., Li, Michael K., Leung, Chi Man, Hui, Yee Tak, Ng, Carmen Ka Man, Lo, Fu Hang, Tsang, Steve, Loo, Ching Kong, Chan, Yiu Kay, Chan, Kam Hon, Hui, Aric J., Chow, Wai Hung, Ching, Jessica, Chung, Tiffany M. L., Iu, Catherine Y. Y., Harbord, Marcus, Hung, Ivan Fan Ngai, Lao, Wai Cheung, Sze, Shun Fung, Wong, Marc Tin Long, Leung, Rita, Tsang, Vivian W., Lam, Belsy Chung Yan, Tong, Raymond Wai Hung, Shan, Edwin Hok Shing, Mak, Lai Yee, Wong, Sai Ho, Wu, Justin C., Francis K.L. Chan, and Sung, Joseph J. Y.

36. Natural History of Elderly-Onset Ulcerative Colitis in Chinese: A Population-Based Cohort Study

Author

Shi, Hai Yun, Ng, Siew C., Leung, Wai K., Li, Michael K., Leung, Chi Man, Sze, Shun Fung, Ching, Jessica, Chung, Tiffany M. L., Iu, Catherine Y. Y., Lo, Fu Hang, Tsang, Steve, Hok, Edwin, Shan, Shing, Mak, Lai Yee, Lam, Belsy Chung Yan, Hui, Aric J., Wong, Sai Ho, Wong, Marc Tin Long, Hung, Ivan Fan Ngai, Hui, Yee Tak, Chan, Yiu Kay, Chan, Kam Hon, Loo, Ching Kong, Tong, Raymond Wai Hung, Chow, Wai Hung, Ng, Carmen Ka Man, Lao, Wai Cheung, Harbord, Marcus, Wu, Justin C., Joseph J Y SUNG, and Chan, Francis K. L.

37. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

Author

Mei Hsuan Lee, Maurizia Rossana Brunetto, Stefan Mauss, Sabahattin Kaymakoglu, CE Omuemu, Danjuma Adda, Philip Bruggmann, Beat Müllhaupt, Trân D Quang, Peter Jarcuska, Man-Fung Yuen, George V. Papatheodoridis, Rohani Jahis, Ding-Shinn Chen, Necati Örmeci, Christophe Moreno, Angelos Hatzakis, Antoine Abou Rached, Boris Lukšić, Thomas Berg, Renovat Ntagirabiri, Kathryn Razavi-Shearer, Sarah Blach, Gabriela Rjaskova, Samantha M Brandon, Jen Layden, Ohene Opare-Sem, Maria C Mendes Correa, Stefano Vella, Jan Sperl, Vincent Wai-Sun Wong, Hwai I. Yang, Stephen Oguche, Richard Njouom, Cielo Yaneth Rios, Yee Tak Hui, Behzad Hajarizadeh, Andy I. M. Hoepelman, Javier García-Samaniego, Ammal M. Metwally, Ivane Gamkrelidze, Julia A. Scott, Said A. Al-Busafi, Valentina Liakina, Zaigham Abbas, Olga Sagalova, Rifaat Safadi, Michael Manns, William Sievert, Seyed M Alavian, Kakharman Yesmembetov, Manal H El-Sayed, Juan Francisco Sánchez-Ávila, Wan-Long Chuang, Peter Stärkel, Ziv Ben-Ari, Chris Cunningham, Homie Razavi, Erkin Musabaev, Ulus Salih Akarca, Petr Urbánek, Gamal Shiha, Muhammed Aasim M Yusuf, Nina Weis, Hossein Poustchi, Ilias Gountas, E. A. Croes, Ayman Yosry, Reza Malekzadeh, Kostas Athanasakis, Agustín Albillos, Faleh Z. Al-Faleh, Christoph Sarrazin, Maria Buti, Arif Nawaz, Chung-Lin Yang, Kimberly Murphy, Adriana Vince, Aliya Konysbekova, Soek Siam Tan, Loreta A. Kondili, Mojca Matičič, Karolin Falconer, Hailemichael Desalegn, Alexander Nersesov, Ogu Omede, N. N. Pimenov, Nahum Méndez-Sánchez, Benjamin C Cowie, Helen Nde, Wai-cheung C Lao, Jordan Genov, Imam Waked, Joël Mossong, Ala I. Sharara, Henry Lik-Yuen Chan, Vivek A. Saraswat, Diego Alberto Cuellar, Devin Razavi-Shearer, Abraham O. Malu, Rui Tato Marinho, Huma Qureshi, Markus Cornberg, Faisal M. Sanai, Ching-kong K Loo, David Kershenobich, Pavol Kristian, Paulo R. Ferreira, Mel Krajden, Moon Seok Choi, Junko Tanaka, Faryal Al Lawati, Jonathan Schmelzer, Ann-Sofi Duberg, Jan Gerstoft, Lewis R. Roberts, Francesco Negro, Khalid Al Naamani, Wim Laleman, Solomon Obekpa, Henk W. Reesink, Tesia Shin, Richard Gray, Alnoor Ramji, Fadi H. Mourad, Abdul Rahman Bizri, Joop E. Arends, Shahin Merat, Krzysztof Tomasiewicz, Adkhamjon Mamatkulov, Jerzy Jaroszewicz, Peer Brehm Christensen, Adriaan J. van der Meer, Maheeba Abdulla, Frank Tacke, Cesar Yaghi, Pierre Van Damme, Christopher K Opio, Yasir Waheed, Joseph Woodring, Ponsiano Ocama, Zuridin Nurmatov, Bisi Bright, Van Thi Thuy Nguyen, Perttu Arkkila, Nick Walsh, Catherine A.M. Stedman, Mette Rye Clausen, Vladimir Chulanov, Antonio Craxì, Christophe Hézode, Abdulrahman Aljumah, Jeffrey V. Lazarus, Fuad Hasan, Sarah Robbins, Sona Frankova, Adrian Goldis, Rong-Nan Chien, Chris Estes, Stephen D. Ryder, Nguyen Thu Anh, Abate Bane, Muhammad S. Memon, Ken Pasini, Ivan Schréter, Sameer Alawadhi, Stuart K. Roberts, Steve S Egeonu, Anil C. Anand, Riina Salupere, Massimo Colombo, Giovanni Battista Gaeta, Maria Lucia Gomes Ferraz, Rosmawati Mohamed, Sylvia Drazilova, Hans Van Vlierberghe, Soo Aleman, Naveed Z. Janjua, Irena Hrstić, Manik Sharma, Carlos E Brandão Mello, Mario G. Pessoa, Berhane Redae, Mindie H. Nguyen, Petr Husa, Vana Sypsa, Samir Shah, Jacques E Mokhbat, Robert Flisiak, Carole Seguin-Devaux, Asad Chaudhry, Inka Aho, Sayed Himatt, Hamad I. Al-Ashgar, Young-Suk Lim, Stefan Zeuzem, University of Zurich, Polaris Observatory Collaborators, Polaris Observ Collaborators, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Experimental Immunology, Gastroenterology & Hepatology, Razavi-Shearer D, Gamkrelidze I, Nguyen MH, Chen DS, Van Damme P, Abbas Z, Abdulla M, Abou Rached A, Adda D, Aho I, Akarca U, Hasan F, Al Lawati F, Al Naamani K, Al-Ashgar HI, Alavian SM, Alawadhi S, Albillos A, Al-Busafi SA, Aleman S, Alfaleh FZ, Aljumah AA, Anand AC, Anh NT, Arends JE, Arkkila P, Athanasakis K, Bane A, Ben-Ari Z, Berg T, Bizri AR, Blach S, Brandão Mello CE, Brandon SM, Bright B, Bruggmann P, Brunetto M, Buti M, Chan HLY, Chaudhry A, Chien RN, Choi MS, Christensen PB, Chuang WL, Chulanov V, Clausen MR, Colombo M, Cornberg M, Cowie B, Craxi A, Croes EA, Cuellar DA, Cunningham C, Desalegn H, Drazilova S, Duberg AS, Egeonu SS, El-Sayed MH, Estes C, Falconer K, Ferraz MLG, Ferreira PR, Flisiak R, Frankova S, Gaeta GB, García-Samaniego J, Genov J, Gerstoft J, Goldis A, Gountas I, Gray R, Guimarães Pessôa M, Hajarizadeh B, Hatzakis A, Hézode C, Himatt SM, Hoepelman A, Hrstic I, Hui YT, Husa P, Jahis R, Janjua NZ, Jarčuška P, Jaroszewicz J, Kaymakoglu S, Kershenobich D, Kondili LA, Konysbekova A, Krajden M, Kristian P, Laleman W, Lao WC, Layden J, Lazarus JV, Lee MH, Liakina V, Lim YS, Loo CK, Lukšić B, Malekzadeh R, Malu AO, Mamatkulov A, Manns M, Marinho RT, Maticic M, Mauss S, Memon MS, Mendes Correa MC, Mendez-Sanchez N, Merat S, Metwally AM, Mohamed R, Mokhbat JE, Moreno C, Mossong J, Mourad FH, Müllhaupt B, Murphy K, Musabaev E, Nawaz A, Nde HM, Negro F, Nersesov A, Nguyen VTT, Njouom R, Ntagirabiri R, Nurmatov Z, Obekpa S, Ocama P, Oguche S, Omede O, Omuemu C, Opare-Sem O, Opio CK, Örmeci N, Papatheodoridis G, Pasini K, Pimenov N, Poustchi H, Quang TD, Qureshi H, Ramji A, Razavi-Shearer K, Redae B, Reesink HW, Rios CY, Rjaskova G, Robbins S, Roberts LR, Roberts SK, Ryder SD, Safadi R, Sagalova O, Salupere R, Sanai FM, Sanchez-Avila JF, Saraswat V, Sarrazin C, Schmelzer JD, Schréter I, Scott J, Seguin-Devaux C, Shah SR, Sharara AI, Sharma M, Shiha GE, Shin T, Sievert W, Sperl J, Stärkel P, Stedman C, Sypsa V, Tacke F, Tan SS, Tanaka J, Tomasiewicz K, Urbanek P, van der Meer AJ, Van Vlierberghe H, Vella S, Vince A, Waheed Y, Waked I, Walsh N, Weis N, Wong VW, Woodring J, Yaghi C, Yang HI, Yang CL, Yesmembetov K, Yosry A, Yuen MF, Yusuf MAM, Zeuzem S, Razavi H., Negro, Francesco, Razavi-Shearer, Devin, Gamkrelidze, Ivane, Nguyen, Mindie H, Chen, Ding-Shinn, Van Damme, Pierre, Abbas, Zaigham, Abdulla, Maheeba, Abou Rached, Antoine, Adda, Danjuma, Aho, Inka, Akarca, Ulu, Hasan, Fuad, Al Lawati, Faryal, Al Naamani, Khalid, Al-Ashgar, Hamad Ibrahim, Alavian, Seyed M, Alawadhi, Sameer, Albillos, Agustin, Al-Busafi, Said A, Aleman, Soo, Alfaleh, Faleh Z, Aljumah, Abdulrahman A, Anand, Anil C, Anh, Nguyen Thu, Arends, Joop E, Arkkila, Perttu, Athanasakis, Kosta, Bane, Abate, Ben-Ari, Ziv, Berg, Thoma, Bizri, Abdul R, Blach, Sarah, Brandão Mello, Carlos E, Brandon, Samantha M, Bright, Bisi, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Chan, Henry L Y, Chaudhry, Asad, Chien, Rong-Nan, Choi, Moon S, Christensen, Peer B, Chuang, Wan-Long, Chulanov, Vladimir, Clausen, Mette R, Colombo, Massimo, Cornberg, Marku, Cowie, Benjamin, Craxi, Antonio, Croes, Esther A, Cuellar, Diego Alberto, Cunningham, Chri, Desalegn, Hailemichael, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve S, El-Sayed, Manal H, Estes, Chri, Falconer, Karolin, Ferraz, Maria L G, Ferreira, Paulo R, Flisiak, Robert, Frankova, Sona, Gaeta, Giovanni B, García-Samaniego, Javier, Genov, Jordan, Gerstoft, Jan, Goldis, Adrian, Gountas, Ilia, Gray, Richard, Guimarães Pessôa, Mário, Hajarizadeh, Behzad, Hatzakis, Angelo, Hézode, Christophe, Himatt, Sayed M, Hoepelman, Andy, Hrstic, Irena, Hui, Yee-Tak T, Husa, Petr, Jahis, Rohani, Janjua, Naveed Z, Jarčuška, Peter, Jaroszewicz, Jerzy, Kaymakoglu, Sabahattin, Kershenobich, David, Kondili, Loreta A, Konysbekova, Aliya, Krajden, Mel, Kristian, Pavol, Laleman, Wim, Lao, Wai-cheung C, Layden, Jen, Lazarus, Jeffrey V, Lee, Mei-Hsuan, Liakina, Valentina, Lim, Young-Suk S, Loo, Ching-kong K, Lukšić, Bori, Malekzadeh, Reza, Malu, Abraham O, Mamatkulov, Adkhamjon, Manns, Michael, Marinho, Rui T, Maticic, Mojca, Mauss, Stefan, Memon, Muhammad S, Mendes Correa, Maria C, Mendez-Sanchez, Nahum, Merat, Shahin, Metwally, Ammal M, Mohamed, Rosmawati, Mokhbat, Jacques E, Moreno, Christophe, Mossong, Joel, Mourad, Fadi H, Müllhaupt, Beat, Murphy, Kimberly, Musabaev, Erkin, Nawaz, Arif, Nde, Helen M, Nersesov, Alexander, Nguyen, Van Thi Thuy, Njouom, Richard, Ntagirabiri, Renovat, Nurmatov, Zuridin, Obekpa, Solomon, Ocama, Ponsiano, Oguche, Stephen, Omede, Ogu, Omuemu, Casimir, Opare-Sem, Ohene, Opio, Christopher K, Örmeci, Necati, Papatheodoridis, George, Pasini, Ken, Pimenov, Nikolay, Poustchi, Hossein, Quang, Trân D, Qureshi, Huma, Ramji, Alnoor, Razavi-Shearer, Kathryn, Redae, Berhane, Reesink, Henk W, Rios, Cielo Yaneth, Rjaskova, Gabriela, Robbins, Sarah, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Safadi, Rifaat, Sagalova, Olga, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek, Sarrazin, Christoph, Schmelzer, Jonathan D, Schréter, Ivan, Scott, Julia, Seguin-Devaux, Carole, Shah, Samir R, Sharara, Ala I, Sharma, Manik, Shiha, Gamal E, Shin, Tesia, Sievert, William, Sperl, Jan, Stärkel, Peter, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek S, Tanaka, Junko, Tomasiewicz, Krzysztof, Urbanek, Petr, van der Meer, Adriaan J, Van Vlierberghe, Han, Vella, Stefano, Vince, Adriana, Waheed, Yasir, Waked, Imam, Walsh, Nichola, Weis, Nina, Wong, Vincent W, Woodring, Joseph, Yaghi, Cesar, Yang, Hwai-I, Yang, Chung-Lin, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yusuf, Muhammed Aasim M, Zeuzem, Stefan, and Razavi, Homie

Subjects
0301 basic medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, HBsAg, Pediatrics, Delphi Technique, Infectious Disease Transmission, CHRONIC HBV INFECTION, NATURAL-HISTORY, FOLLOW-UP, HBSAG, CARRIERS, AGE, COUNTRIES, DISEASE, ANTIGEN, COHORT, ddc:616.07, Global Health, medicine.disease_cause, 0302 clinical medicine, Prevalence, HBV, Child, ddc:616, Antiviral Agents/therapeutic use, education.field_of_study, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Chronic/drug therapy/epidemiology/prevention & control/transmission, Gastroenterology, Hepatitis B Surface Antigens/blood, Hepatitis B, 10219 Clinic for Gastroenterology and Hepatology, Child, Preschool, 030211 gastroenterology & hepatology, Viral hepatitis, Viral load, Adult, medicine.medical_specialty, Hepatitis B vaccine, Population, 610 Medicine & health, Antiviral Agents, Mass Vaccination, Hepatology, 03 medical and health sciences, Hepatitis B, Chronic, SDG 3 - Good Health and Well-being, medicine, Humans, 2715 Gastroenterology, Preschool, education, Disease burden, Hepatitis B virus, Hepatitis B Surface Antigens, business.industry, Viral Vaccines, medicine.disease, Infectious Disease Transmission, Vertical, Vertical/prevention & control, 030104 developmental biology, 2721 Hepatology, Human medicine, business
Abstract

PubMed: 29599078, 2-s2.0-85044540918, Background: The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods: In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings: We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3·9% (95% uncertainty interval [UI] 3·4–4·6), corresponding to 291 992 000 (251 513 000–341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4·8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1·8 (1·6–2·2) million infections were in children aged 5 years, with a prevalence of 1·4% (1·2–1·6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation: Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding: John C Martin Foundation. © 2018 Elsevier Ltd, H28-kansei-ippan-001 National Academy of Sciences, NAS Novartis Roche World Health Organization, WHO Gilead Sciences Alnylam Pharmaceuticals AbbVie Meso Scale Diagnostics, MSD British Microcirculation Society, BMS Japan Society for the Promotion of Science, JSPS: 17H03589 Ministry of Health, Labour and Welfare, MHLW Vetenskapsrådet, VR Siemens Universiteit Antwerpen OLL-683801, DR-S, IGa, SB, SMB, CE, KM, HMN, KP, KR-S, SR, JDS, and HR report grants from John C Martin Foundation, during the conduct of the study, and grants from Gilead Sciences, AbbVie, WHO, National Academy of Sciences, Intercept Pharmaceuticals, and Boehringer Ingelheim, outside the submitted work. MHN reports grants and personal fees from Bristol-Myers Squibb (BMS), Gilead Sciences, and Janssen, and personal fees from Novartis, Anylam, and Dynavax, outside the submitted work. PVD acts as chief and principal investigator for vaccine trials done on behalf of the University of Antwerp, Belgium, for which the University obtains research grants from vaccine manufacturers; speaker's fees for presentations on vaccines are paid directly to an educational fund held by the University of Antwerp, and PVD receives no personal remuneration for this work. ACA reports personal fees from Mylan Pharmaceuticals, outside the submitted work. JEA reports fees paid to his hospital for participation on the advisory boards of Gilead Sciences, ViiV Healthcare, BMS, Janssen, and AbbVie, and grants from BMS, Merck Sharp & Dohme (MSD), AbbVie, and ViiV Healthcare, outside the submitted work. TB reports grants, personal fees, and non-financial support from AbbVie and Gilead Sciences; grants and personal fees from BMS, Janssen, Roche, MSD, and Sequana Medical; and personal fees from Bayer, Vertex, Tibotec, Intercept, Sirtex, and Alexion, outside the submitted work. PB reports grants and personal fees from AbbVie, Gilead Sciences, and MSD, outside the submitted work. MBr reports personal fees from BMS, Gilead Sciences, and Janssen, and grants from BMS, outside the submitted work. HLYC reports personal fees from Gilead Sciences, BMS, AbbVie, Roche, MedImmune, and Intellia, outside the submitted work. PBC reports grants from AbbVie, Gilead Sciences, and MSD, outside the submitted work. VC reports personal fees from AbbVie, BMS, Gilead Sciences, and MSD, and grants from BMS, outside the submitted work. MCor reports personal fees from AbbVie, BMS, Boehringer Ingelheim, Biogen Idec, Falk Foundation, Gilead Sciences, Janssen, MSD, Roche Diagnostics, Roche Pharma, and Siemens, outside the submitted work. SD and PJ report personal fees and non-financial support from AbbVie and Gilead Sciences, and personal fees from MSD, outside the submitted work. MHE-S is an advisory board member for Perspectum Diagnostics, and reports grants and non-financial support from Gilead Sciences, and non-financial support from AbbVie and Quadri Pharma, outside the submitted work. RF reports grants, personal fees, and non-financial support from Roche and Gilead Sciences, and personal fees and non-financial support from BMS, outside the submitted work. GBG reports grants and personal fees from Gilead Sciences, outside the submitted work. JG-S reports grants and personal fees from Gilead Sciences, and personal fees from MSD, Abbvie, Janssen, and BMS, outside the submitted work. JGer reports grants and personal fees from AbbVie, Gilead Sciences, Janssen, MSD, BMS, and ViiV Healthcare, outside the submitted work. RG reports grants from New South Wales Ministry of Health and provided project advice regarding viral hepatitis treatment to Gilead Sciences, outside the submitted work. AHa reports unrestricted grants from AbbVie, MSD, Gilead Sciences, BMS, and Novartis, and non-financial support from Gilead Sciences, outside the submitted work; he was also on advisory boards for AbbVie, Gilead Sciences, and BMS. CH reports personal fees from AbbVie, BMS, Gilead Sciences, Janssen, and MSD, outside the submitted work. JJ reports personal fees and non-financial support from Gilead Sciences and AbbVie, and personal fees from Roche and BMS, outside the submitted work. MK reports grants from Roche, Siemens, Hologic, and Boerhinger Ingleheim, outside the submitted work. JVL reports grants and personal fees from Gilead Sciences and personal fees from Cepheid, outside the submitted work. MMan reports personal fees from Roche, BMS, GlaxoSmithKline, Aevi Genomic Medicine, ENYO Pharma, and CureVac, and grants and personal fees from Gilead Sciences and Novartis, outside the submitted work. SMau reports personal fees and non-financial support from Gilead Sciences and BMS, outside the submitted work. CM reports grants and personal fees from AbbVie, Gilead Sciences, and BMS; personal fees from MSD; and grants from Roche, outside the submitted work. BM reports grants and personal fees from Gilead Sciences and personal fees from AbbVie, MSD, BMS, Bayer, Intercept, and Sigma-Tau, during the conduct of the study. FN reports personal fees and non-financial support from Gilead Sciences, during the conduct of the study. AR reports grants and personal fees from AbbVie, Gilead, and MSD, and personal fees form BMS, Celgene, Janssen, Intercept, and Lupin, outside the submitted work. HWR reports grants and personal fees from AbbVie, BMS, Boehringer Ingelheim, ENYO Pharma, Gilead Sciences, Janssen, MSD, PRA Health Sciences, Regulus, and Roche; personal fees from Alnylam and R-Pharm; and grants from Replicor, outside the submitted work. LRR reports grants from the Center for Clinical and Translational Science and the Swedish Research Council (Ghana), during the conduct of the study. LRR also reports grants from Gilead Sciences, BTG, Ariad, and Wako, outside the submitted work, and was a consultant and advisory board member for Wako, Medscape, Axis, OncLive, Bayer, Tavec, and Grail. SDR has served as an advisory board member and speaker for Gilead Sciences, AbbVie, and MSD. OS has served as a consultant and on advisory boards for MSD; received research grants from AbbVie, BMS, MSD, Boehringer Ingelheim, R-Pharm, and Hepatera; and served as a speaker for Abbott, AbbVie, BMS, Gilead Sciences, Janssen, MSD, and R-Pharm. JFS-A reports personal fees from AbbVie and grants from Gilead Sciences and Janssen, outside the submitted work. CSa reports personal fees from Gilead Sciences and BMS, outside the submitted work. PS reports grants and personal fees from Gilead Sciences, AbbVie, and BMS, and personal fees from Intercept, outside the submitted work. CSt has consulted with and served on advisory boards for Gilead Sciences, AbbVie, and MSD. VSy reports grants and personal fees from Gilead Sciences, personal fees and non-financial support from AbbVie, and personal fees from Janssen, outside the submitted work. KT reports grants and personal fees from AbbVie, Gilead Sciences, and BMS; personal fees from MSD and Alfa Wasserman; and grants from Janssen, outside the submitted work. AJvdM reports grants and personal fees from Gilead Sciences and personal fees from AbbVie, outside the submitted work. IW reports personal fees from AbbVie, Gilead Sciences, Janssen, Marcyrl, Mylan, Onxio, and Pharco, outside the submitted work. NW reports personal fees paid to her department from AbbVie, BMS, Gilead Sciences, and MSD, outside the submitted work. VWW reports personal fees from Gilead Sciences, BMS, and MSD, outside the submitted work. M-FY was a speaker or advisory board member for AbbVie, BMS, Gilead Sciences, Roche, GlaxoSmithKline, Fujirebio, Biocartis, and MSD, outside the submitted work. SZ reports consultancy and lecture fees from AbbVie, Gilead Sciences, and MSD, and consultancy fees from Intercept, outside the submitted work. All other authors declare no competing interests., This study was funded by the John C Martin Foundation through the Polaris Observatory. We thank the Research on Hepatitis group (H28-kansei-ippan-001 and H25-kanen-ippan-010; led by JT), funded by the Ministry of Health, Labour and Welfare of Japan, for their provision of country-level data for Japan, and Örebro County Council for providing ALF grants (OLL-683801) to A-SD, which allowed collection of country-level data for Sweden.

Published
2018

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