20 results on '"Hui-ming Zhong"'
Search Results
2. Clinical Effectiveness of a Pneumatic Compression Device Combined with Low-Molecular-Weight Heparin for the Prevention of Deep Vein Thrombosis in Trauma Patients: a Retrospective Cohort Study
- Author
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Nan Li, Mao Zhang, Peng-chao Guo, Guang-feng Zhao, and Hui-ming Zhong
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medicine.medical_specialty ,Clinical effectiveness ,business.industry ,medicine.drug_class ,Deep vein ,Low molecular weight heparin ,Retrospective cohort study ,Compression device ,medicine.disease ,Thrombosis ,Surgery ,medicine.anatomical_structure ,medicine ,business - Abstract
Purpose: To investigate the clinical effectiveness of a pneumatic compression device (PCD) combined with low-molecular-weight heparin (LMWH) for the prevention and treatment of deep vein thrombosis (DVT) in trauma patients.Materials and Methods: This study retrospectively analyzed 286 patients with mild craniocerebral injury and clavicular fractures admitted to our department from January 2016 to February 2020. Patients treated with only LMWH were used as the control group, and patients treated with a PCD combined with LMWH were used as the observation group. The incidence of DVT, the postoperative change in the visual analog scale (VAS) score and coagulation function were observed and compared between the two groups. Excluding the influence of other single factors, binary logistic regression analysis can indicate whether the use of a PCD effectively improves the patient's postoperative coagulation function.Result: The incidence of DVT in the observation group was significantly lower than that in the control group (7.1% vs. 16.7%, respectively, χ2=4.605, P0.05). According to binary logistic regression analysis, the postoperative risk of DVT in patients with LMWH alone was 1.764 times that with the combination of LMWH+PCD (P Conclusion: Compared with LMWH alone, PCD combined with LMWH can improve blood rheology and coagulation function in patients with traumatic brain injury and clavicular fracture, significantly reduce the incidence of DVT, shorten the hospital stay and improve the clinical effectiveness of treatment.
- Published
- 2021
3. Clinical effectiveness of a pneumatic compression device combined with low-molecular-weight heparin for the prevention of deep vein thrombosis in trauma patients: A single-center retrospective cohort study.
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Peng-chao Guo, Nan Li, Hui-ming Zhong, and Guang-feng Zhao
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VENOUS thrombosis ,LOW-molecular-weight heparin ,PNEUMATIC machinery ,HEMORHEOLOGY ,CLAVICLE fractures - Abstract
BACKGROUND: To investigate the clinical effectiveness of a pneumatic compression device (PCD) combined with low-molecular-weight heparin (LMWH) for the prevention and treatment of deep vein thrombosis (DVT) in trauma patients. METHODS: This study retrospectively analyzed 286 patients with mild craniocerebral injury and clavicular fractures admitted to our department from January 2016 to February 2020. Patients treated with only LMWH served as the control group, and patients treated with a PCD combined with LMWH as the observation group. The incidence of DVT, postoperative changes in the visual analogue scale (VAS) score, and coagulation function were observed and compared between the two groups. Excluding the influence of other single factors, binary logistic regression analysis was used to evaluate the use of a PCD in the patient's postoperative coagulation function. RESULTS: After excluding 34 patients who did not meet the inclusion criteria, 252 patients were were included. The incidence of DVT in the observation group was significantly lower than that in the control group (5.6% vs. 15.1%, x²=4.605, P<0.05). The postoperative VAS scores of the two groups were lower than those before surgery (P<0.05). The coagulation function of the observation group was significantly higher than that of the control group, with a better combined anticoagulant effect (P<0.05). There were no significant differences between the two groups in preoperative or postoperative Glasgow Coma Scale scores, intraoperative blood loss, postoperative infection rate, or length of hospital stay (P>0.05). According to logistic regression analysis, the postoperative risk of DVT in patients who received LMWH alone was 1.764 times that of patients who received LMWH+PCD (P<0.05). The area under the receiver operating characteristic (AUROC) curve of partial thromboplastin time (APTT) and platelet (PLT) were greater than 0.5, indicating that they were the influence indicators of adding PCD to prevent DVT. Excluding the influence of other variables, LMWH+PCD effectively improved the coagulation function of patients. CONCLUSIONS: Compared with LMWH alone, LMWH+PCD could improve blood rheology and coagulation function in patients with traumatic brain injury and clavicular fracture, reduce the incidence of DVT, shorten the length of hospital stay, and improve the clinical effectiveness of treatment. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
4. A case of rhabdomyolysis with compartment syndrome in the right upper extremity
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Peng-chao Guo, Hui-Ming Zhong, and Guang-Feng Zhao
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business.industry ,Right upper extremity ,Emergency Medicine ,medicine ,Anatomy ,Case Letter ,Compartment (pharmacokinetics) ,medicine.disease ,business ,Rhabdomyolysis - Published
- 2020
5. Intra-Articular Steroid Injection for Patients with Hip Osteoarthritis: A Systematic Review and Meta-Analysis
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Jun-Fan Lin, Tiao Lin, Zhi-Jun Pan, Si-Qi Zhao, Xin-Xin Zhang, Hui-Ming Zhong, Guang-Feng Zhao, and Xin-Yu Li
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medicine.medical_specialty ,MEDLINE ,Pain ,Review Article ,Osteoarthritis ,Osteoarthritis, Hip ,General Biochemistry, Genetics and Molecular Biology ,Injections, Intra-Articular ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Intra articular ,Randomized controlled trial ,law ,Synovitis ,Internal medicine ,Hip osteoarthritis ,Humans ,Medicine ,Randomized Controlled Trials as Topic ,030203 arthritis & rheumatology ,General Immunology and Microbiology ,business.industry ,General Medicine ,Evidence-based medicine ,medicine.disease ,Meta-analysis ,Steroids ,business - Abstract
Purpose. The aim of this current review was to confirm the efficacy of intra-articular steroid therapy (IAST) for patients with hip osteoarthritis (OA) and discuss the duration and influential factors of IAST. Methods. Online databases (Medline, EMBASE, and Web of Science) were searched from inception to May 2019. Both randomized controlled trials (RCTs) and noncontrolled trials assessing the efficacy of hip IAST on pain were included. Common demographics data were extracted using a standardized form. Quality was assessed on the basis of Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. Results. 12 trials met the inclusion criteria. According to data from individual trials, IAST had significant efficacy on hip OA in both immediate and delay pain reduction, which persisted up to 12 weeks after IAST. The influences of the baseline severity of hip OA or synovitis and injection dose or volume on the clinical outcome of IAST were still controversial. The IAST appeared to be well tolerant by most of the participants. Conclusion. IAST was proved to be an efficacious therapy in both immediate and delay pain reduction for hip OA patients within 12 weeks. The longer follow-up data of efficacy and safety and potentially influential factors are still unclear and needed further confirmation.
- Published
- 2020
6. Metabolomic Analysis Reveals That the Mechanism of Astaxanthin Improves the Osteogenic Differentiation Potential in Bone Marrow Mesenchymal Stem Cells
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Guang-Feng Zhao, Zhi-Jun Pan, Taiwen Rao, and Hui-Ming Zhong
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Aging ,Article Subject ,Cellular differentiation ,Phenylalanine ,Bone Marrow Cells ,Xanthophylls ,Biochemistry ,chemistry.chemical_compound ,Metabolomics ,Downregulation and upregulation ,Fibrinolytic Agents ,Astaxanthin ,Osteogenesis ,Animals ,Humans ,Tyrosine ,QH573-671 ,Mesenchymal stem cell ,Cell Differentiation ,Mesenchymal Stem Cells ,Cell Biology ,General Medicine ,Cell biology ,Rats ,Metabolic pathway ,chemistry ,Cytology ,Research Article - Abstract
At present, little research has been done on the metabolic phenotype of the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. In this study, the effect of astaxanthin on improving osteogenic differentiation potential of mesenchymal stem cells was studied by metabolomics. Results showed that L-methionine, L-tyrosine, and 2-hydroxycinnamic acid were upregulated in MSCs treated with astaxanthin, while L-lysine, L-pipecolic acid, L-histidine, L-arginine, D-fructose, and L-aspartic acid were downregulated in samples treated with astaxanthin. In addition, astaxanthin exhibited a significant dose-dependent relationship with these markers. Metabolic pathway enrichment analysis revealed that AST mainly regulated phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis; and pantothenate and CoA biosynthesis during the process of osteogenic differentiation of MSCs. Furthermore, the staining results showed that astaxanthin could actively promote the osteogenic differentiation of mesenchymal stem cells. These findings clearly indicate that astaxanthin plays an important role in inducing osteogenic differentiation of mesenchymal stem cells. In addition, the changed metabolites can be used to monitor the differentiation process.
- Published
- 2019
7. Use of a tourniquet in total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials
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Guangfeng Zhao, Yucai Hong, Fang-zhen Jiang, and Hui-ming Zhong
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medicine.medical_specialty ,medicine.medical_treatment ,Deep vein ,Blood Loss, Surgical ,Postoperative Hemorrhage ,Cochrane Library ,law.invention ,Randomized controlled trial ,law ,medicine ,Humans ,Orthopedics and Sports Medicine ,Arthroplasty, Replacement, Knee ,Randomized Controlled Trials as Topic ,Tourniquet ,business.industry ,Tourniquets ,medicine.disease ,Thrombosis ,Arthroplasty ,Hemostasis, Surgical ,Pulmonary embolism ,Surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Anesthesia ,Meta-analysis ,business - Abstract
Background A tourniquet is commonly used in total knee arthroplasty (TKA). However, the effectiveness and safety of tourniquets are debated. We performed this study to investigate whether patients benefit from the use of tourniquets in TKA. Methods The literature search was conducted using Pub-Med, Cochrane Library, MEDLINE, Embase, and other medical databases. After a literature search, 26 randomized controlled trials involving 1,450 knees were analyzed. Results Tourniquet use significantly decreased intraoperative blood loss, transfusion rate, and operation time but not postoperative blood loss, measurable total blood loss, calculated total blood loss, transfusion volume, incidence of pulmonary embolism, or duration of hospital stay. It also slowed down joint functional recovery in the short term and increased the incidence of deep vein thrombosis and other minor wound complications. Conclusions Data from this meta-analysis indicate that patients may benefit from the use of a tourniquet in TKA; however, it use is accompanied by disadvantages and complications. Because of the very low-evidence quality and lower grading of recommendations, assessment, development, and evaluation recommendation strength, no guidelines can be developed based on current evidence.
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- 2015
8. Evidence for Using Alendronate to Treat Adult Avascular Necrosis of the Femoral Head: A Systematic Review
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Ru-Bin Luo, Shigui Yan, Tiao Lin, Hui-Ming Zhong, and Jian-An Wang
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Avascular necrosis ,Young Adult ,Femoral head ,Femur Head Necrosis ,medicine ,Humans ,Young adult ,Adverse effect ,Review Articles ,Aged ,Demography ,Alendronate ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Clinical trial ,Review Literature as Topic ,Treatment Outcome ,medicine.anatomical_structure ,Meta-analysis ,Inclusion and exclusion criteria ,Cohort ,Female ,business - Abstract
Osteonecrosis or avascular osteonecrosis (AVN) of the femoral head is a devastating multifactorial disease that affects 20 000 persons each year in the United States. The purpose of this systematic review was to determine the efficacy and safety of alendronate for adult AVN during short- and long-term follow-up. Electronic databases were searched for randomized or nonrandomized clinical trials, cohort, case-control studies, and series of cases in which alendronate was used for treatment of adult AVN of the femoral head. Relevant articles with adequate data on reduction of pain, improvement of articular function, slowing of bone collapse progression, or need for total hip arthroplasty (THA) were included after applying inclusion and exclusion criteria. Eight articles involving 788 hips with evidence level 1b to 3b were included in this systematic review. Most studies suggested a positive short-term efficacy of alendronate treatment in reducing pain, improving articular function, slowing of bone collapse progression, and delaying the need for THA for adult AVN patients. The favorable long-term results were also presented in those treated patients after 10-year follow-up. In addition, there were no severe adverse effects associated with alendronate treatment observed during short- and long-term follow-up, and most of the included studies suggested use of alendronate in early AVN with small necrotic lesion to achieve better outcomes. The findings support consideration of alendronate use for adult AVN, particularly with early stage and small necrotic size. The lack of large-scale, randomized, and double-blind studies justifies new studies to demonstrate the detailed indication and the optimized strategy of alendronate treatment. Level of evidence: Level 3a.
- Published
- 2014
9. Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation
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Ru-bin Luo, Wei-Ping Chen, Hui-ming Zhong, and Qian-hai Ding
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MAPK/ERK pathway ,p38 mitogen-activated protein kinases ,Interleukin-1beta ,Immunology ,Active Transport, Cell Nucleus ,Nitric Oxide Synthase Type II ,Hydroxamic Acids ,p38 Mitogen-Activated Protein Kinases ,Nitric oxide ,chemistry.chemical_compound ,Chondrocytes ,Western blot ,Matrix Metalloproteinase 13 ,Osteoarthritis ,medicine ,Humans ,Immunology and Allergy ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,Vorinostat ,Cells, Cultured ,Aged ,Cell Nucleus ,Pharmacology ,Tissue Inhibitor of Metalloproteinase-1 ,biology ,medicine.diagnostic_test ,NF-kappa B ,NF-κB ,Middle Aged ,Molecular biology ,Histone Deacetylase Inhibitors ,Nitric oxide synthase ,chemistry ,Mitogen-activated protein kinase ,Cancer research ,biology.protein ,Matrix Metalloproteinase 1 ,Signal Transduction ,medicine.drug - Abstract
Overproduction of nitric oxide (NO) and matrix metalloproteinases (MMPs) plays an important role in the pathogenesis of osteoarthritis (OA). In present study, we investigated whether vorinostat can inhibit the catabolic effects of IL-1β in vitro, especially the inhibition of MMPs and inducible nitric oxide synthase (iNOS) through the attenuation of nuclear factor kappa-B (NF-κB) and mitogen activated protein kinase (MAPK) pathways in human chondrocytes. Human OA chondrocytes were either left untreated or treated with various concentrations of vorinostat followed by incubation with IL-1β (5ng/mL). Effects of vorinostat on IL-1β-induced gene and protein expression of iNOS, MMP-1, MMP-13 and tissue inhibitors of metalloproteinase-1 (TIMP-1) were verified by quantitative real time-PCR and Western blot analysis. Production of NO, MMP-1, MMP-13 and TIMP-1 released in culture supernatant was estimated using commercially available kits. The roles of NF-κB and MAPK pathways in the regulation of targeted genes and the mechanism involved in vorinostat mediated modulation of these genes were determined by Western blot using specific antibodies. We found that vorinostat down-regulated iNOS, MMP-1 and MMP-13 expression and up-regulated TIMP-1 expression in human OA chondrocytes. In addition, the release of NO, MMP-1 and MMP-13 secreted from IL-1β stimulated chondrocytes was also suppressed by vorinostat. Interestingly, vorinostat selectively inhibited IL-1β-induced p38 and ERK1/2 activation without affecting JNK activation. Furthermore, we observed that vorinostat inhibited NF-κB pathway by suppressing the degradation of I-κBα and attenuating NF-κB p65 translocation to the nucleus. These results suggest that vorinostat may be a promising therapeutic agent for the prevention and treatment of OA.
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- 2013
10. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea
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Peter Proksch, Hao-Fu Dai, Wen-Hua Dong, Jiu-Li Huang, Hui-Ming Zhong, Xun-Li Wu Chen, Yan-Bo Zeng, You-Xing Zhao, Bo Zheng, and Wen-Li Mei
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marine endophyte ,Guignardia sp ,lcsh:Biology (General) ,meroterpenes ,Staphylococcus aureus ,MRSA ,Scyphiphora hydrophyllacea ,lcsh:QH301-705.5 - Abstract
Four new meroterpenes, guignardones F–I (1–4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1–6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.
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- 2012
11. Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model
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Xiang-hua Wang, Qian-hai Ding, Shigui Yan, Weijun Li, Ye Cheng, Hui-ming Zhong, and Yi-ying Qi
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Cartilage, Articular ,medicine.medical_specialty ,Cell Survival ,Anterior cruciate ligament ,Interleukin-1beta ,Immunology ,ved/biology.organism_classification_rank.species ,Osteoarthritis ,Matrix metalloproteinase ,Pharmacology ,Crocin ,chemistry.chemical_compound ,Chondrocytes ,Internal medicine ,Crocus sativus ,medicine ,Animals ,Cells, Cultured ,ved/biology ,Cartilage ,NF-kappa B ,Rabbit (nuclear engineering) ,Anatomy ,medicine.disease ,Carotenoids ,Matrix Metalloproteinases ,Rheumatology ,medicine.anatomical_structure ,chemistry ,Female ,Rabbits - Abstract
Interleukin-1β-mediated production of matrix metalloproteinases (MMPs) plays a pivotal role in the process of osteoarthritis. Crocin, a pharmacologically active component of Crocus sativus L. (saffron), has been used in Chinese traditional medicine. In this study, we aimed to investigate the effects of crocin on MMP-1, MMP-3 and MMP-13 expression in rabbit chondrocytes induced by interleukin-1β (IL-1β) and in an experimental rabbit model induced by anterior cruciate ligament transection.Chondrocytes isolated from the articular cartilage of 4-week-old rabbits were cultured and passaged. Confluent chondrocytes were treated with various concentrations of crocin in the presence or absence of IL-1β (10 ng/ml) for 24 h. Quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blotting were used to investigate the expression of inducible MMP-1, MMP-3 and MMP-13. In addition, the in-vivo effects of crocin were assessed by morphological and histological analysis.IL-1β markedly upregulated the expression of MMP-1, -3 and -13 in chondrocytes, and this activation was inhibited by co-incubation with crocin in a dose-dependent manner, in contrast with the control group. Moreover, crocin inhibited IL-1β-induced activation of the nuclear factor kappa B pathway through suppressing degradation of inhibitory-kappa-B-α. In-vivo investigations showed that crocin ameliorated cartilage degeneration and that expression of the MMP-1, -3 and -13 genes in cartilage was significantly inhibited by crocin.Taken together, our findings suggest that the anti-inflammatory activity of crocin may be of potential value in the prevention and treatment of osteoarthritis.
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- 2012
12. A new prenylated xanthone from the branches ofCalophyllum inophyllum
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Hui-Ming Zhong, Yan-Bo Zeng, Xu-Dong Wu, Wen-Li Mei, Hao-Fu Dai, and Dai-Jing Wei
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Stereochemistry ,Xanthones ,Pharmaceutical Science ,Analytical Chemistry ,Calophyllum inophyllum ,chemistry.chemical_compound ,Prenylation ,Drug Discovery ,Xanthone ,Humans ,Calophyllum ,Nuclear Magnetic Resonance, Biomolecular ,Pyrans ,Pharmacology ,Molecular Structure ,Plant Stems ,biology ,Organic Chemistry ,Clusiaceae ,General Medicine ,biology.organism_classification ,Caloxanthone Q ,Xanthenes ,Complementary and alternative medicine ,chemistry ,Chemical constituents ,Molecular Medicine ,K562 Cells ,Two-dimensional nuclear magnetic resonance spectroscopy ,Drugs, Chinese Herbal - Abstract
The investigation of chemical constituents from the branches of Calophyllum inophyllum Linn led to the isolation of a new prenylated xanthone, named caloxanthone Q (1), together with three known compounds, 2-deprenylrheediaxanthone B (2), jacareubin (3), and 6-deoxyjacareubin (4). Their structures were completely elucidated on the basis of spectroscopic methods (UV, IR, HR-ESI-MS, 1D NMR, and 2D NMR).
- Published
- 2011
13. Comparison of core decompression and conservative treatment for avascular necrosis of femoral head at early stage: a meta-analysis
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Yu-Cai, Hong, Hui-Ming, Zhong, Tiao, Lin, and Jian-Bin, Shi
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Original Article - Abstract
The purpose of the current meta-analysis was to compare the efficacy of core decompression (CD) and conservative treatment (CT) for saving femoral heads in patients with avascular necrosis of femoral head (ANFH). Four RCTs and two CCTs involving 323 hips with 24- to 48-months follow-up were included in this review. Our results suggested CD had a trend of favorable results in contrast to other CT (OR 3.28; 95% CI 0.77-14.02; P = 0.11) but saved much less hips compared to biophysical treatments [odds ratio (OR) 0.37; 95% CI 0.18-0.74; P = 0.005]. In the stratified survival rate analysis by ANFH stage, interestingly, CD group got a significantly higher successful rate of hip joint conservation than other CT group in both stage I and stage II-III (stage I: OR 4.43; 95% CI 1.34-14.65; P = 0.01; stage II-III: OR 6.75; 95% CI 2.18-20.90; P = 0.0009). In the biophysical stimulation subgroup, however, an even higher frequency of survived hips were observed compared to CD group at stage II-III (CD vs. biophysical stimulation: OR 0.34; 95% CI 0.17-0.67; P = 0.002). In conclusion, performing CD for ANFH is effective for preventing femoral collapse within a short-term follow-up, but an even higher successful rate were expected by biophysical stimulations. Nevertheless, the short-term follow-up, the small sample size of the current meta-analysis only provide limited quality of evidence, which required confirmation from further large-scale, well-designed RCT with longer follow-up.
- Published
- 2015
14. Comment on 'Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis'
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Hui-Ming Zhong, Jian-Bin Shi, Yu-Cai Hong, Ru-Bin Luo, and Tiao Lin
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medicine.medical_specialty ,medicine.medical_treatment ,lcsh:Medicine ,Review Article ,Lithotripsy ,Placebo ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Femoral head ,Hyperbaric oxygen ,Randomized controlled trial ,law ,medicine ,Humans ,Hip pain ,Letter to the Editor ,Collapse (medical) ,Alendronate ,Bone Density Conservation Agents ,General Immunology and Microbiology ,Adult patients ,business.industry ,lcsh:R ,Osteonecrosis ,Femur Head ,General Medicine ,Extracorporeal shock wave ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Extracorporeal shockwave therapy ,Level ii ,medicine.symptom ,business - Abstract
The purpose of the current review was to determine the efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic avascular osteonecrosis of femoral head (ANFH). Five randomized controlled trials (RCTs) involving 305 hips were included in this review, of which 3 studies investigated alendronate versus control/placebo and the other 2 studies compared the combination of alendronate and extracorporeal shockwave therapy (ESWT) with ESWT alone. Our results suggested that even the patients with extensive necrosis encountered much less collapse in the alendronate group than control group. In these RCTs, their data also indicated a positive short- and middle-term efficacy of alendronate treatment in joint function improvement and hip pain diminishment. With the presence of the outlier study, only insignificant overall efficacy of alendronate could be observed with substantial heterogeneities. In addition, we did not find any additive benefits of alendronate in combination with ESWT for preventing collapse compared to ESWT alone. In conclusion, there is still lack of strong evidence for supporting application of alendronate in adult patients with nontraumatic ANFH, which justified that large scale, randomized, and double-blind studies should be developed to demonstrate the confirmed efficacies, detailed indication, and optimized strategy of alendronate treatment.
- Published
- 2015
15. A case of rhabdomyolysis with compartment syndrome in the right upper extremity.
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Hui-ming Zhong, Guang-feng Zhao, and Peng-chao Guo
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ARM , *COMPARTMENT syndrome , *CARDIOVASCULAR system , *NECROTIZING fasciitis , *SYMPTOMS , *PATHOLOGY , *SKELETAL muscle injuries - Published
- 2020
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16. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea
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Hui-Ming Zhong, Wen-Hua Dong, You-Xing Zhao, Peter Proksch, Yan-Bo Zeng, Wen-Li Mei, Bo Zheng, Hao-Fu Dai, Jiu-Li Huang, and Xun-Li Wu Chen
- Subjects
Methicillin-Resistant Staphylococcus aureus ,Staphylococcus aureus ,Pharmaceutical Science ,Rubiaceae ,Microbial Sensitivity Tests ,MRSA ,Crystallography, X-Ray ,medicine.disease_cause ,Article ,Microbiology ,Terpene ,Scyphiphora hydrophyllacea ,Drug Discovery ,Botany ,medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,lcsh:QH301-705.5 ,Guignardia sp ,marine endophyte ,biology ,Terpenes ,Fungi ,meroterpenes ,Endophytic fungus ,biology.organism_classification ,Methicillin-resistant Staphylococcus aureus ,Anti-Bacterial Agents ,lcsh:Biology (General) ,Mangrove - Abstract
Four new meroterpenes, guignardones F–I (1–4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1–6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.
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- 2012
- Full Text
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17. Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.
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Ding-Qian Wu, Hui-ming Zhong, Qian-hai Ding, and Li Ba
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OSTEOARTHRITIS ,ANALYSIS of variance ,ANIMAL experimentation ,ARTICULAR cartilage ,BIOLOGICAL assay ,BIOLOGICAL models ,BIOPHYSICS ,CARTILAGE cells ,CELL culture ,ENZYME-linked immunosorbent assay ,INTERLEUKINS ,RESEARCH methodology ,POLYMERASE chain reaction ,RABBITS ,RESEARCH funding ,STATISTICS ,TOXICITY testing ,WESTERN immunoblotting ,DNA-binding proteins ,ISOFLAVONES ,DATA analysis ,DESCRIPTIVE statistics ,MATRIX metalloproteinases ,IN vitro studies ,CHEMICAL inhibitors ,PREVENTION - Abstract
Background Increased production of matrix metalloproteinases (MMPs) is closely related to the progression of osteoarthritis (OA). The present study was performed to investigate the potential value of biochanin A in inhibition of MMP expression in both rabbit chondrocytes and an animal model of OA. Methods MTT assay was performed to assess chondrocyte survival in monolayers. The mRNA and protein expression of MMPs (including MMP-1, MMP-3, and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in interleukin-1 < beta > (IL-1β)-induced rabbit chondrocytes were determined by quantitative real-time PCR and enzyme-linked immunosorbent assay (ELISA), respectively. The involvement of the NF-kappaB (NF-κB) pathway activated by IL-1β was determined by western blotting. The in vivo effects of biochanin A were evaluated by intra-articular injection in an experimental OA rabbit model induced by anterior cruciate ligament transection (ACLT). Results Biochanin A downregulated the expression of MMPs and upregulated TIMP-1 at both the mRNA and protein levels in IL-1β-induced chondrocytes in a dose-dependent manner. In addition, IL-1β-induced activation of NF-κB was attenuated by biochanin A, as determined by western blotting. Moreover, biochanin A decreased cartilage degradation as determined by both morphological and histological analyses in vivo. Conclusions Taken together, these findings suggest that biochanin A may be a useful agent in the treatment and prevention of OA. [ABSTRACT FROM AUTHOR]
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- 2014
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18. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea.
- Author
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Wen-Li Mei, Bo Zheng, You-Xing Zhao, Hui-Ming Zhong, Xun-Li Wu Chen, Yan-Bo Zeng, Wen-Hua Dong, Jiu-Li Huang, Peter Proksch, and Hao-Fu Dai
- Abstract
Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
19. Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies
- Author
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Qian-hai Ding, Li Ba, Hui-ming Zhong, and Ding-Qian Wu
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Cartilage, Articular ,Pathology ,medicine.medical_specialty ,Interleukin-1beta ,Enzyme-Linked Immunosorbent Assay ,In Vitro Techniques ,Matrix metalloproteinase ,Real-Time Polymerase Chain Reaction ,Biochanin A ,Chondrocyte ,Injections, Intra-Articular ,chemistry.chemical_compound ,Chondrocytes ,In vivo ,Osteoarthritis ,Matrix Metalloproteinase 13 ,medicine ,Animals ,MTT assay ,RNA, Messenger ,Cells, Cultured ,Anterior cruciate ligament transection (ACLT) ,Tissue Inhibitor of Metalloproteinase-1 ,Plant Extracts ,Chemistry ,NF-kappa B ,General Medicine ,Genistein ,Molecular biology ,Matrix Metalloproteinases ,In vitro ,Chondroprotection ,Blot ,Real-time polymerase chain reaction ,medicine.anatomical_structure ,Complementary and alternative medicine ,Trifolium ,Rabbits ,Research Article ,Phytotherapy - Abstract
Background Increased production of matrix metalloproteinases (MMPs) is closely related to the progression of osteoarthritis (OA). The present study was performed to investigate the potential value of biochanin A in inhibition of MMP expression in both rabbit chondrocytes and an animal model of OA. Methods MTT assay was performed to assess chondrocyte survival in monolayers. The mRNA and protein expression of MMPs (including MMP-1, MMP-3, and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in interleukin-1 (IL-1β)-induced rabbit chondrocytes were determined by quantitative real-time PCR and enzyme-linked immunosorbent assay (ELISA), respectively. The involvement of the NF-kappaB (NF-κB) pathway activated by IL-1β was determined by western blotting. The in vivo effects of biochanin A were evaluated by intra-articular injection in an experimental OA rabbit model induced by anterior cruciate ligament transection (ACLT). Results Biochanin A downregulated the expression of MMPs and upregulated TIMP-1 at both the mRNA and protein levels in IL-1β-induced chondrocytes in a dose-dependent manner. In addition, IL-1β-induced activation of NF-κB was attenuated by biochanin A, as determined by western blotting. Moreover, biochanin A decreased cartilage degradation as determined by both morphological and histological analyses in vivo. Conclusions Taken together, these findings suggest that biochanin A may be a useful agent in the treatment and prevention of OA.
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20. Microdetermination of alkaloids in organic solvents by potentiometric titration
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Chang-Yi, Wang, primary, Dong-Hua, Zhang, additional, Yong-Li, Guo, additional, Hui-Ming, Zhong, additional, and Meng-Liang, Wen, additional
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- 1987
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