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Your search keyword '"Huie, W."' showing total 21 results
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21 results on '"Huie, W."'

1. Photoassociative Spectroscopy of $^{87}$Sr

Author

Hill, J. C., Huie, W., Lunia, P., Whalen, J. D., Kanungo, S. K., Lu, Y., and Killian, T. C.

Subjects
Physics - Atomic Physics, Quantum Physics
Abstract

We demonstrate photoassociation (PA) of ultracold fermionic $^{87}$Sr atoms. The binding energies of a series of molecular states on the $^1\Sigma^+_u$ $5s^2\,^1$S$_0+5s5p\,^1$P$_1$ molecular potential are fit with the semiclassical LeRoy-Bernstein model, and PA resonance strengths are compared to predictions based on the known $^1$S$_0+^1$S$_0$ ground state potential. Similar measurements and analysis were performed for the bosonic isotopes $^{84}$Sr and $^{86}$Sr, allowing a combined analysis of the long-range portion of the excited-state potential and determination of the $5s5p\,^1$P$_1$ atomic state lifetime of $5.20 \pm 0.02$ ns. The results enable prediction of PA rates across a wide range of experimental conditions., Comment: 5 pages, 4 figures

Published
2020
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15. LETTERS FROM READERS.

Author

Huie, W. Stell, Hardwick, Max, Wilson, Roger, and Leverett, Mary

Abstract

Several letters to the editor are presented in response to the article "The Origins of a Trout Fly," in the March/April 2012 issue, a paper about lightning, in the May/June 2012 issue, and changes in the periodical.

Published
2012

18. Improvement in assay sensitivity for plasma dolastatin-10 using capillary electrophoresis at elevated temperatures.

Author

Huie WR and Wong SS

Subjects
Animals, Depsipeptides, Hot Temperature, Humans, Mice, Reference Standards, Reproducibility of Results, Sensitivity and Specificity, Spectrophotometry, Ultraviolet, Antineoplastic Agents blood, Electrophoresis, Capillary methods, Oligopeptides blood
Abstract

The very potent antimitotic and anticancer agent, dolastatin-10 (DOL-10), currently undergoing testing in a phase II clinical trial, has been quantitated previously in human plasma by high-performance capillary electrophoresis (HPCE). This method provides a lower limit of detection of 25 ng/ml DOL-10 from extracted patient samples. Without changes in preconcentration techniques, we report a significant improvement in the sensitivity of this method using elevated temperatures with conventional UV absorbance detection and liquid-liquid extraction which lowers the detection limit to 3 ng/ml of the drug. An elevated separation temperature of 50 degrees C was critical in achieving this 8x improvement in the detection limit. Partial validation of the method at this temperature gave excellent linearity (0-100 ng/ml; y=0.018x+0.085, r=0.993), limit of quantitation (5 ng/ml), and good overall recovery of the drug (>85%). We have applied this improved method towards the in vivo quantitation of DOL-10 in mice and in a patient receiving the drug in a phase I clinical study. From these analyses we conclude that this method is suitable for clinical studies where plasma levels of DOL-10 are > or = 5 ng/ml.

Published
1999
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