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16 results on '"Huijun Shu"'

1. The influence of sleep factors and dietary habits on the disease pattern of ulcerative colitis patients with long and short disease courses – a multicentre cross-sectional analysis

Author

Mingyue Guo, Gechong Ruan, Xueli Ding, Yanbo Yu, Linglin Tian, Jun Shen, Xiaoyin Bai, Lingjuan Jiang, Weiyang Zheng, Huijun Shu, Xiaolan Zhang, and Hong Yang

Subjects
Ulcerative colitis, disease pattern, sleep, dietary habits, Medicine
Abstract

AbstractBackground Ulcerative colitis (UC) is a disease characterized by chronic relapsing-remitting inflammatory disorders and is associated with environmental changes.Aim To explore the disease patterns of Chinese UC patients and to determine controllable related environmental factors.Methods This multicentre cross-sectional study was performed using a questionnaire survey. Data on clinical characteristics and environmental factors were collected. Patients with a disease course ≥5 years were defined as the long course group, and those with a disease course < 5 years were defined as the short course group.Results A total of 588 effective questionnaires were collected. The proportion of the chronic continuous pattern was the highest among patients with a long disease course (46.8%), and in patients with a short disease course, the proportion of the active to remission pattern was the highest (53.3%). In patients with a long disease course, a higher proportion of patients with adequate sleep was found in the active to remission pattern than in the chronic intermittent (72.1% vs. 43.3%, p = 0.008) and chronic continuous (72.1% vs. 52.4%, p = 0.016) patterns. In patients with a short disease course, the frequency of shellfish and shrimp was higher in the chronic continuous pattern group than in the active to remission pattern group (P = 0.001 and 0.017 respectively).Conclusions For early diagnosis patients, dietary guidance should be actively carried out. With the prolongation of the disease course, attention should be given to the sleep quality of patients.

Published
2024
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2. Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome

Author

Xiaomin Hu, Ziying Han, Ruilin Zhou, Wan Su, Liang Gong, Zihan Yang, Xiao Song, Shuyang Zhang, Huijun Shu, and Dong Wu

Subjects
acute pancreatitis, acute respiratory distress syndrome, gut microbiota, disease prediction, biomarker, Microbiology, QR1-502
Abstract

BackgroundAcute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes in the gut microbiota have been shown to influence progression of acute pancreatitis. We aimed to determine whether early alterations in the gut microbiota is related to and could predict ARDS occurrence in AP patients.MethodsIn this study, we performed 16S rRNA sequencing analysis in 65 AP patients and 20 healthy volunteers. The AP patients were further divided into two groups: 26 AP-ARDS patients and 39 AP-nonARDS patients based on ARDS occurrence during hospitalization.ResultsOur results showed that the AP-ARDS patients exhibited specific changes in gut microbiota composition and function as compared to subjects of AP-nonARDS group. Higher abundances of Proteobacteria phylum, Enterobacteriaceae family, Escherichia-Shigella genus, and Klebsiella pneumoniae, but lower abundances of Bifidobacterium genus were found in AP-ARDS group compared with AP-nonARDS groups. Random forest modelling analysis revealed that the Escherichia-shigella genus was effective to distinguish AP-ARDS from AP-nonARDS, which could predict ARDS occurrence in AP patients.ConclusionsOur study revealed that alterations of gut microbiota in AP patients on admission were associated with ARDS occurrence after hospitalization, indicating a potential predictive and pathogenic role of gut microbiota in the development of ARDS in AP patients.

Published
2023
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3. Neostigmine for the treatment of acute pancreatitis: a protocol for a systematic review and meta-analysis

Author

Yuelun Zhang, Dong Wu, Huijun Shu, Kun He, Xiaxiao Yan, and Zihan Yang

Subjects
Medicine
Abstract

Introduction Acute pancreatitis (AP) is a common disease with substantial mortality. Gut dysfunction may result in abdominal compartment syndrome (ACS) and delay enteral nutrition, worsening AP condition. Neostigmine is used as a prokinetic drug for the treatment of AP. But there are no recommendations from guidelines due to the lack of evidence. Therefore, we plan to conduct a systematic review and meta-analysis to explore the efficacy and safety of neostigmine for AP, aiming to provide current evidence for clinical practice.Methods and analysis We prepared this protocol following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. We will search the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang, conference proceedings and ongoing trials registers for eligible studies comparing neostigmine plus conventional therapy with conventional therapy. Primary outcomes include new-onset ACS and serious adverse events caused by neostigmine. Evaluation of the risk of bias, heterogeneity and quality of evidence will follow recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. Trial sequential analysis will be used to control the risk of random errors and assess conclusions in the meta-analysis.Ethics and dissemination Ethics approval is unnecessary as the systematic review is based on published studies. Study findings will be published in a peer-reviewed journal.PROSPERO registration number CRD42022369536.

Published
2023
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7. Serum immunoinflammation-related protein complexes discriminate between inflammatory bowel disease and colorectal cancer

Author

Zhili Li, Jingnan Li, Jiaming Qian, Sun Yinghao, and Huijun Shu

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Serum protein, Blood Sedimentation, Disease, Sensitivity and Specificity, Gastroenterology, Inflammatory bowel disease, Diagnosis, Differential, Crohn Disease, Internal medicine, Biomarkers, Tumor, medicine, Humans, Early Cancer Detection, Early Detection of Cancer, Haptoglobins, business.industry, Complement System Proteins, General Medicine, Middle Aged, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, digestive system diseases, C-Reactive Protein, ROC Curve, Oncology, Complement Factor H, Colitis, Ulcerative, Female, Inflammation Mediators, Colorectal Neoplasms, business, Area under the roc curve
Abstract

Inflammatory bowel disease (IBD) is an important risk factor for colon cancer. Novel serum immunoinflammation-related protein complexes (IIRPCs) have shown associations with early cancer detection. Herein, we investigated the potential of serum IIRPCs for discriminating between IBD and colorectal cancer (CRC) patients. Serum protein complexes of 65 healthy controls, 57 CRC, 69 (ulcerative colitis) UC, and 67 (Crohn's disease) CD patients were isolated by native-PAGE. The gray values of serum IIRPCs bands in the gel were quantified using Quantity One software. The receiver-operating characteristic (ROC) curves were constructed to assess the discriminating ability by calculating the area under the ROC curve. The serum IIRPCs levels in IBD and CRC patients were significantly elevated compared to healthy controls. ROC analysis indicated certain diagnostic ability of serum IIRPCs in differentiating IBD from CRC. Specifically, “a3” complex discriminated UC from CRC, with an AUC value of 0.722, sensitivity of 69.4% and specificity of 63.8%. Similarly, “b4” complex discriminated UC from CRC, with an AUC value of 0.709, sensitivity of 70.4%, and specificity of 60.0%. In addition, the “a3” complex also discriminated CD from CRC, with an AUC value of 0.785, sensitivity of 73.1%, and specificity of 74.1%, while the “b4” complex showed a tendency to discriminate CD from CRC, with an AUC value of 0.663, sensitivity of 67.9% and specificity of 50.0%. Thus, an equation based on multiple IIRPCs was built to further improve the discriminating power. Serum IIRPCs can be used to discriminate IBD from CRC and may also be associated with early screening of colitis-associated cancer.

Published
2019
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9. The Association Between CMV Viremia or Endoscopic Features and Histopathological Characteristics of CMV Colitis in Patients with Underlying Ulcerative Colitis

Author

Meng Jin, Dongsheng Wu, Hong Yang, Weixun Zhou, Huijun Shu, Dong Wu, Hong Lv, Yunlu Feng, Jiaming Qian, Jie Chen, Lingling Hu, and Qiang Wang

Subjects
Adult, Male, medicine.medical_specialty, Colon, Cytomegalovirus, Viremia, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Immunology and Allergy, Humans, Colitis, Pathological, Ulcer, business.industry, virus diseases, Histology, Colonoscopy, Middle Aged, Viral Load, medicine.disease, Ulcerative colitis, 030220 oncology & carcinogenesis, Predictive value of tests, Cytomegalovirus Infections, 030211 gastroenterology & hepatology, Colitis, Ulcerative, Female, business, Viral load
Abstract

BACKGROUND Cytomegalovirus (CMV) infection has been shown to be related to severe or steroid-refractory ulcerative colitis (UC) flare-ups. The aim of this study was to evaluate the endoscopic and pathological characteristics of CMV colitis in patients with UC and to assess the predictive value of the endoscopic and pathological features of CMV colitis. METHODS A total of 50 consecutive UC patients with CMV infection who were admitted to Peking Union Medical College Hospital from 2010 to 2015 were enrolled in this study. RESULTS Twenty-five UC patients with CMV infection (50.0%) had concurrent CMV colitis. When the cutoff value was set at 1150 copies, the sensitivity and specificity of blood CMV DNAq polymerase chain reaction for predicting CMV colitis were 44.4% and 78.9%, respectively. A higher proportion of endoscopic punched-out ulcers, irregular ulcers, and cobblestone-like appearance were observed among the patients in the CMV colitis group than those in the non-CMV colitis group (52.0% versus 20.0%, 60.0% versus 16.0%, and 20.0% versus 0%, respectively, P < 0.05). The number of CMV inclusion bodies per high-power field was significantly higher in those with punch-out ulcerations (25.7% versus 60.0%, P < 0.05). A higher grade of pathological inflammation was observed in the CMV colitis group than in the control group (68.0% versus 44.0%). CONCLUSIONS Characteristic endoscopic features with punch-out ulcers and high CMV viremia load may be useful for predicting the presence of CMV colitis in histology. Punch-out ulcers were found to be associated with a higher number of inclusion bodies on histology, suggesting a role of targeted biopsy for endoscopist.

Published
2017

10. [Esophageal motility abnormalities and their impact on esophageal acid exposure in patients with gastroesophageal reflux disease]

Author

Yuantao, Hou, Xiaohong, Sun, Xiaoqing, Li, Zhifeng, Wang, Liming, Zhu, Huijun, Shu, Guijun, Fei, Meiyun, Ke, and Xiucai, Fang

Subjects
Esophageal pH Monitoring, Esophagus, Manometry, Case-Control Studies, Gastroesophageal Reflux, Humans, Esophageal Motility Disorders, Prospective Studies
Abstract

To identify the characteristics of esophageal motility abnormalities in patients with gastroesophageal reflux disease (GERD) and its influence on esophageal acid exposure.Patients with typical reflux symptoms and diagnosis of reflux esophagitis (RE) or non-erosive reflux disease (NERD), and healthy subject were enrolled in this prospective controlled study. The esophageal manometry and esophageal 26 hours pH monitoring were performed. GERD patients were divided into 3 groups according to their esophageal motility abnormalities: ① low lower esophageal sphincter pressure (LESP) group, ② ineffective esophageal motivation (IEM) group, ③ IEM and low LESP group. Esophageal acid exposure was analyzed among different groups.A total of 27 GERD patients (15 RE, 12 NERD) and 10 healthy subjects were enrolled in this study. The esophageal motility abnormalities in GERD patients mainly presented as the decrease of LESP and distal esophageal body pressure. The proportion of 3 kinds of esophageal motility abnormalities has significant difference between RE and NERD patients (P = 0.017). In IEM and low LESP group, all patients suffered from RE, with the total number of acid exposure, the total acid exposure time and the acid exposure time in fasting higher than those in low LESP group [98.0 (63.3, 282.8) times vs 41.0 (25.0, 82.0) times, P = 0.029; 11.7% (4.1%, 30.0%) vs 2.2% (1.4%, 9.6%), P = 0.045; 2.6% (0.9%, 4.9%) vs 0.0 (0.0, 1.2%), P = 0.015].Esophageal motility abnormalities in GERD patients are characterized as low LESP and IEM in distal esophagus. The coexistence of low LESP and IEM exacerbates esophageal acid exposure, which might explain the mechanism of esophageal mucosal injury in RE patients.

Published
2015

11. Cell-ELISA detection of antineuronal antibodies in central nervous system involvement in systemic lupus erythematosus

Author

Xinping Tian, Yi Dong, Fengchun Zhang, Huijun Shu, and Xuan Zhang

Subjects
Adult, Male, Systemic disease, Pathology, medicine.medical_specialty, Concise Report, Adolescent, Immunology, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Cerebrospinal fluid, Rheumatology, immune system diseases, Immunopathology, Humans, Lupus Erythematosus, Systemic, Immunology and Allergy, Medicine, Lupus vasculitis, skin and connective tissue diseases, Autoantibodies, Neurons, Lupus erythematosus, biology, business.industry, Lupus Vasculitis, Central Nervous System, Autoantibody, Middle Aged, medicine.disease, Connective tissue disease, biology.protein, Female, Antibody, business, Biomarkers
Abstract

To develop a cell-ELISA method to detect antineuronal antibodies (anti-Ns) and evaluate the diagnostic value of anti-Ns in central nervous system involvement in systemic lupus erythematosus (CNS-SLE).Anti-N was assessed in both serum and cerebrospinal fluid (CSF) samples from 38 patients with CNS-SLE, 29 with SLE without CNS involvement (non-CNS-SLE), 36 with other rheumatic diseases and 59 with non-rheumatic diseases with the CNS manifestations using a cell-ELISA method with 1% paraformaldehyde-fixed SK-N-MC neuroblastoma cells as substrate. Serum samples from 37 healthy donors were also included in this study. Patients with CNS-SLE who were anti-N positive in CSF were studied serially for CSF anti-N levels at times of treatment-associated improvement in CNS symptoms.Serum anti-N levels were significantly increased in patients with SLE compared with other groups, with a sensitivity of 61.2% (41/67) and a specificity of 91.8% (p0.001). CSF anti-N levels were significantly increased in patients with CNS-SLE, with a sensitivity of 47.4% (18/38) and a specificity of 89.7%, whereas only 10.3% (3/29) of patients with non-CNS-SLE had increased anti-N in CSF (p0.001). CSF anti-N levels decreased significantly after effective treatment of CNS-SLE (p0.05).Serum anti-N is relatively specific to SLE. CSF anti-N is a sensitive and relatively specific antibody in diagnosing CNS-SLE and correlates with CNS-SLE activity.

Published
2006
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12. Identification of two novel PBGD mutations in acute intermittent porphyria patients accompanying anemia in mainland China

Author

Huijun Shu, Jiaming Qian, Xiaoqing Li, Yu lin Hu, Greg J. Anderson, Guangjun Nie, and Gang Liu

Subjects
Mainland China, Pediatrics, medicine.medical_specialty, China, Anemia, White People, Young Adult, Asian People, medicine, Humans, Young adult, Molecular Biology, Acute intermittent porphyria, business.industry, Cell Biology, Hematology, medicine.disease, Hydroxymethylbilane Synthase, Porphyria, Porphyria, Acute Intermittent, Mutation (genetic algorithm), Mutation, Molecular Medicine, Identification (biology), Female, business
Published
2011

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