1. Double-blind comparison of ciprofloxacin with cefotaxime in the treatment of skin and skin structure infections.
- Author
-
Pérez-Ruvalcaba JA, Quintero-Pérez NP, Morales-Reyes JJ, Huitrón-Ramírez JA, Rodríguez-Chagollán JJ, and Rodríguez-Noriega E
- Subjects
- Administration, Oral, Adult, Aged, Bacterial Infections complications, Cefotaxime administration & dosage, Ciprofloxacin administration & dosage, Clinical Trials as Topic, Diabetes Complications, Double-Blind Method, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Skin Diseases, Infectious complications, Bacterial Infections drug therapy, Cefotaxime therapeutic use, Ciprofloxacin therapeutic use, Skin Diseases, Infectious drug therapy
- Abstract
Oral ciprofloxacin (750 mg twice daily) was compared with intravenous cefotaxime (2 g three times daily) as therapy for 61 episodes of skin and skin structure infections occurring in adult patients. A variety of infections including cellulitis, infected ulcers, abscesses, and other miscellaneous infections were treated. Clinical cure was achieved in 77 percent (24 patients) of 31 patients treated with ciprofloxacin and in 76 percent (22 patients) of 28 patients treated with cefotaxime. The response was slower in infected diabetic patients than in non-diabetic patients in both groups. Side effects were minimal and appeared only in the cefotaxime group. Ciprofloxacin taken twice daily was as effective as cefotaxime administered intravenously three times daily in the treatment of skin and skin structure infections.
- Published
- 1987