1. Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units
- Author
-
Chung, Ha Uk, Rwei, Alina Y, Hourlier-Fargette, Aurélie, Xu, Shuai, Lee, KunHyuck, Dunne, Emma C, Xie, Zhaoqian, Liu, Claire, Carlini, Andrea, Kim, Dong Hyun, Ryu, Dennis, Kulikova, Elena, Cao, Jingyue, Odland, Ian C, Fields, Kelsey B, Hopkins, Brad, Banks, Anthony, Ogle, Christopher, Grande, Dominic, Park, Jun Bin, Kim, Jongwon, Irie, Masahiro, Jang, Hokyung, Lee, JooHee, Park, Yerim, Kim, Jungwoo, Jo, Han Heul, Hahm, Hyoungjo, Avila, Raudel, Xu, Yeshou, Namkoong, Myeong, Kwak, Jean Won, Suen, Emily, Paulus, Max A, Kim, Robin J, Parsons, Blake V, Human, Kelia A, Kim, Seung Sik, Patel, Manish, Reuther, William, Kim, Hyun Soo, Lee, Sung Hoon, Leedle, John D, Yun, Yeojeong, Rigali, Sarah, Son, Taeyoung, Jung, Inhwa, Arafa, Hany, Soundararajan, Vinaya R, Ollech, Ayelet, Shukla, Avani, Bradley, Allison, Schau, Molly, Rand, Casey M, Marsillio, Lauren E, Harris, Zena L, Huang, Yonggang, Hamvas, Aaron, Paller, Amy S, Weese-Mayer, Debra E, Lee, Jong Yoon, and Rogers, John A
- Subjects
Cardiovascular ,Clinical Research ,Perinatal Period - Conditions Originating in Perinatal Period ,Bioengineering ,Pediatric ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Skin ,Generic health relevance ,Biosensing Techniques ,Blood Pressure Monitoring ,Ambulatory ,Child ,Child ,Preschool ,Electrocardiography ,Equipment Design ,Humans ,Infant ,Newborn ,Intensive Care Units ,Neonatal ,Intensive Care Units ,Pediatric ,Monitoring ,Physiologic ,Photoplethysmography ,Time Factors ,Wireless Technology ,Medical and Health Sciences ,Immunology - Abstract
Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.
- Published
- 2020