1. Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China
- Author
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Yuelong Shu, Lei Yang, Zifeng Yang, Joseph S. M. Peiris, Wenfei Zhu, Dayan Wang, Qinhan Lin, Changwen Ke, Haibo Zhou, Chris Ka Pun Mok, Wenjun Song, Jiexiong Liu, Nanshan Zhong, Jie Wu, Wenda Guan, Daniel Ka Wing Chu, and Jianfeng He
- Subjects
0301 basic medicine ,Male ,Epidemiology ,lcsh:Medicine ,viral pneumonia ,Hemagglutinin Glycoproteins, Influenza Virus ,neuraminidase ,Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China ,HPAI ,medicine.disease_cause ,Influenza A Virus, H7N9 Subtype ,Fatal Outcome ,oseltamivir resistance ,Neuraminidase inhibitor ,CMV reactivation ,poultry ,Middle Aged ,Infectious Diseases ,Viral pneumonia ,Cytomegalovirus Infections ,influenza ,Microbiology (medical) ,China ,Meat ,medicine.drug_class ,Biology ,H5N1 genetic structure ,Virus ,lcsh:Infectious and parasitic diseases ,H7N9 ,03 medical and health sciences ,Antibiotic resistance ,Influenza, Human ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Amino Acid Sequence ,hemagglutinin ,highly pathogenic avian influenza ,antimicrobial resistance ,Poultry Diseases ,hypoxia ,Research ,lcsh:R ,acute respiratory distress syndrome ,medicine.disease ,Virology ,Influenza A virus subtype H5N1 ,zoonoses ,030104 developmental biology ,Influenza in Birds ,biology.protein ,R292K mutation ,chickens ,Neuraminidase ,Transmission and infection of H5N1 - Abstract
The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.
- Published
- 2017