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Your search keyword '"Hungria, Emerith Mayra"' showing total 11 results
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11 results on '"Hungria, Emerith Mayra"'

6. Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)

Author

Hungria, Emerith Mayra, primary, Bührer-Sékula, Samira, additional, de Oliveira, Regiane Morillas, additional, Aderaldo, Lúcio Cartaxo, additional, Pontes, Araci de Andrade, additional, Cruz, Rossilene, additional, Gonçalves, Heitor de Sá, additional, Penna, Maria Lúcia Fernandes, additional, Penna, Gerson Oliveira, additional, and Stefani, Mariane Martins de Araújo, additional

Published
2017
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7. Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil

Author

Hungria, Emerith Mayra, primary, Oliveira, Regiane Morillas, additional, Penna, Gerson Oliveira, additional, Aderaldo, Lúcio Cartaxo, additional, Pontes, Maria Araci de Andrade, additional, Cruz, Rossilene, additional, Gonçalves, Heitor de Sá, additional, Penna, Maria Lúcia Fernandes, additional, Kerr, Ligia Regina Franco Sansigolo, additional, Stefani, Mariane Martins de Araújo, additional, and Bührer-Sékula, Samira, additional

Published
2016
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8. Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions

Author

Mizoguti, Danielle de Freitas, primary, Hungria, Emerith Mayra, additional, Freitas, Aline Araújo, additional, Oliveira, Regiane Morillas, additional, Cardoso, Ludimila Paula Vaz, additional, Costa, Mauricio Barcelos, additional, Sousa, Ana Lúcia Maroclo, additional, Duthie, Malcolm S, additional, and Stefani, Mariane Martins Araújo, additional

Published
2015
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10. Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil

Author

Hungria, Emerith Mayra, primary, Oliveira, Regiane Morillas de, additional, Souza, Ana Lúcia Osório Maroclo de, additional, Costa, Maurício Barcelos, additional, Souza, Vânia Nieto Brito de, additional, Silva, Eliane Aparecida, additional, Moreno, Fátima Regina Vilani, additional, Nogueira, Maria Esther Salles, additional, Costa, Maria Renata Sales Nogueira, additional, Silva, Sônia Maria Usó Ruiz, additional, Bührer-Sékula, Samira, additional, Reed, Steven G, additional, Duthie, Malcolm S, additional, and Stefani, Mariane Martins de Araújo, additional

Published
2012
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11. Development of a quantitative rapid diagnostic test for multibacillary leprosy using smart phone technology.

Author

Vaz Cardoso, Ludimila Paula, Ferreira Dias, Ronaldo, Araújo Freitas, Aline, Hungria, Emerith Mayra, Morillas Oliveira, Regiane, Collovati, Marco, Reed, Steven G., Duthie, Malcolm S., and Martins Araújo Stefani, Mariane

Subjects
ROUTINE diagnostic tests, PUBLIC health, HANSEN'S disease, CHROMATOGRAPHIC analysis, NITROCELLULOSE, SERODIAGNOSIS, PREVENTION of infectious disease transmission, PREVENTION
Abstract

Background Despite efforts to eliminate leprosy as public health problem, delayed diagnosis and disabilities still occur in many countries. Leprosy diagnosis remains based on clinical manifestations and the number of clinicians with expertise in leprosy diagnosis is in decline. We have developed a new immunochromatographic test with the goal of producing a simple and rapid system that can be used, with a minimal amount of training, to provide an objective and consistent diagnosis of multibacillary leprosy. Methods The test immobilizes two antigens that have been recognized as excellent candidates for serologic diagnosis (the PGL-I mimetic, ND-O, and LID-1), on a nitrocellulose membrane. This allows the detection of specific IgM and IgG antibodies within 20 minutes of the addition of patient sera. Furthermore, we coupled the NDO-LID® rapid tests with a new cell phone-based test reader platform (Smart Reader®) to provide objective interpretation that was both quantifiable and consistent. Results Direct comparison of serologic responses indicated that the rapid test detected a greater proportion of leprosy patients than a lab-based PGL-I ELISA. While positive responses were detected by PGL-I ELISA in 83.3% of multibacillary patients and 15.4% of paucibacillary patients, these numbers were increased to 87% and 21.2%, respectively, when a combination of the NDO-LID® test and Smart Reader® was used. Among multibacillary leprosy the sensitivity of NDO-LID® test assessed by Smart Reader® was 87% (95% CI, 79.2-92.7%) and the specificity was 96.1% (95% CI, 91.7- 98.6%). The positive predictive value and the negative predictive value of NDO-LID® tests were 94% (95% CI, 87.4-97.8%) and 91.4% (95% CI, 85.9-95.2%), respectively. Conclusion The widespread provision of rapid diagnostic tests to facilitate the diagnosis or prognosis of multibacillary leprosy could impact on leprosy control programs by aiding early detection, directing appropriate treatment and potentially interrupting Mycobacterium leprae transmission. [ABSTRACT FROM AUTHOR]

Published
2013
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