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4. Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

Author

Ubil, Eric, Caskey, Laura, Holtzhausen, Alisha, Hunter, Debra, Story, Charlotte, and Earp, H. Shelton

Subjects
Macrophages -- Research, Transcription (Genetics) -- Research, Immune response -- Research, Cellular signal transduction -- Research, Health care industry
Abstract

Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tumor cells with CRISPR-based deletion of Pros1 failed to inhibit M1 polarization. Tumor cell-associated Pros1 action was abrogated in macrophages from Mer- and Tyro3-but not Axl-KO mice. In addition, several other murine and human tumor cell lines suppressed macrophage M1 cytokine expression induced by IFN-[gamma] and LPS. Investigation of the suppressive pathway demonstrated a role for PTP1b complexing with Mer. Substantiating the role of PTP1b, M1 cytokine suppression was also lost in macrophages from PTP1b-KO mice. Mice bearing Pros1-deficient tumors showed increased innate and adaptive immune infiltration, as well as increased median survival. TAM activation can also inhibit TLR-mediated M1 polarization. Treatment with resiquimod, a TLR7/8 agonist, did not improve survival in mice bearing Pros1-secreting tumors but doubled survival for Pros1-deleted tumors. The tumor-derived Pros1 immune suppressive system, like PD-L1, was cytokine responsive, with IFN-[gamma] inducing Pros1 transcription and secretion. Inhibition of Pros1/TAM interaction represents a potential novel strategy to block tumor-derived immune suppression., Introduction Certain cancer cells subvert the immune response by eliciting an environment that favors immunologic tolerance. This immune-privileged status is achieved by mimicking existing homeostatic processes that mitigate immune responses, [...]

Published
2018
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5. Supplemental Figure Legends from TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma

Author

Holtzhausen, Alisha, primary, Harris, William, primary, Ubil, Eric, primary, Hunter, Debra M., primary, Zhao, Jichen, primary, Zhang, Yuewei, primary, Zhang, Dehui, primary, Liu, Qingyang, primary, Wang, Xiaodong, primary, Graham, Douglas K., primary, Frye, Stephen V., primary, and Earp, H. Shelton, primary

Published
2023
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6. Supplementary Figures from TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma

Author

Holtzhausen, Alisha, primary, Harris, William, primary, Ubil, Eric, primary, Hunter, Debra M., primary, Zhao, Jichen, primary, Zhang, Yuewei, primary, Zhang, Dehui, primary, Liu, Qingyang, primary, Wang, Xiaodong, primary, Graham, Douglas K., primary, Frye, Stephen V., primary, and Earp, H. Shelton, primary

Published
2023
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8. Supplementary Figure 3 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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9. Supplementary Figure 2 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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10. Supplementary Figure 4 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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11. Supplementary Figure 1 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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12. Data from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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13. Supplementary Figure 5 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, primary, Schlegel, Jennifer, primary, Frazer, J. Kimble, primary, Batchelor, Lance A., primary, Trakhimets, Alesia Y., primary, Sather, Susan, primary, Hunter, Debra M., primary, Cummings, Christopher T., primary, Liu, Jing, primary, Yang, Chao, primary, Kireev, Dmitri, primary, Simpson, Catherine, primary, Norris-Drouin, Jacqueline, primary, Hull-Ryde, Emily A., primary, Janzen, William P., primary, Johnson, Gary L., primary, Wang, Xiaodong, primary, Frye, Stephen V., primary, Earp, H. Shelton, primary, and Graham, Douglas K., primary

Published
2023
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14. UNC1062, a new and potent Mer inhibitor

Author

Liu, Jing, Zhang, Weihe, Stashko, Michael A., DeRyckere, Deborah, Cummings, Christopher T., Hunter, Debra, Yang, Chao, Jayakody, Chatura N., Cheng, Nancy, Simpson, Catherine, Norris-Drouin, Jacqueline, Sather, Susan, Kireev, Dmitri, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., and Wang, Xiaodong

Published
2013
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15. Developing Policies about Uncivil Workplace Behavior

Author

Bandow, Diane and Hunter, Debra

Abstract

Workplace incivility, including aggression and bullying, is a troubling phenomenon. Uncivil behaviors not only harm individuals but also diminish employee performance and sometimes result in legal action against companies. Thus, it behooves organizations and management to become vigilant and responsive to such behaviors. Yet the evidence shows that with the recent exception of attempted legislation in Hawaii (Chiem, 2007), few companies or jurisdictions in the United State have policies and procedures aimed at addressing uncivil behavior. In this article, the authors outline some points to consider when developing policies to counteract uncivil behavior in the workplace. In the process, they incorporate the views of two corporate representatives (a diversity manager at Georgia Power and a human resource manager at PepsiCo) and an attorney with the U.S. military. The authors conclude that the driving principles of the policy should be that every employee has a right to be treated with respect and that false accusations are taken as a serious offense. Some organizations have already included respect for each other in organizational mission statements, so providing linkage to the mission statement could further strengthen any policy developed on uncivil behavior. Most important, managers need to be aware of how uncivil behaviors affect working relationships and lead to legal, psychological, and retention issues.

Published
2008
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19. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

Author

Cook, Rebecca S., Jacobsen, Kristen M., Wofford, Anne M., DeRyckere, Deborah, Stanford, Jamie, Prieto, Anne L., Redente, Elizabeth, Sandahl, Melissa, Hunter, Debra M., Strunk, Karen E., Graham, Douglas K., and Earp, H. Shelton

Subjects
Tumors -- Growth -- Control -- Genetic aspects, Tyrosine metabolism -- Research -- Physiological aspects, Metastasis -- Control -- Genetic aspects, Leukocytes -- Research, Company growth, Health care industry
Abstract

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using [...]

Published
2013
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20. NBA player: money tree or money pit

Author

Sale, Martha Lair and Hunter, Debra Renee

Subjects
Sports -- Compensation and benefits, Sports -- United States, Sports marketing -- Research, Financial management -- Analysis, Basketball (Professional) -- Economic aspects, Business, general, National Basketball Association -- Compensation and benefits
Abstract

According to popular perception and the assertions of franchise managers, sports franchises in the United States are operated as for-profit businesses. One premise of operating a business for profit is that investments in the business are undertaken with the expectation of producing a profit either now or in the future. The choice of inputs and their cost is a strategic choice in the management of a business. This research examines player salaries in the NBA and the choice of player salary cost level as a strategic variable. It compares player salary cost and operating income to determine if there is a positive relationship between these two elements., INTRODUCTION While abundant research is available on certain aspects of sports marketing and on the relationship between winning records and various measures of success, there is little, if any research [...]

Published
2009

21. Public Sector Expenditure to Agriculture, Bank Credits, and Aggregate Output: A Causality Analysis of the Nigerian Evidence.

Author

Achumu, James, Ezirim, Ucheoma I., Ezirim, Chinedu B., Chekwa, Charles, and Hunter, Debra

Subjects
PUBLIC spending, PUBLIC sector, AGRICULTURAL credit, GROSS domestic product, COOPERATIVE societies, BANK loans, AGRICULTURE, REGRESSION analysis
Abstract

This paper investigates the existence or otherwise of causal relationships between direct budgetary government expenditure on agriculture, indirect government funding through credit guarantees, and straight-bank-loans-and-advances to the agricultural sector, on one part, and the gross domestic product of the economy, on the other. It utilized descriptive statistical tools, regression analysis, diagnostic tests, and pairwise Granger causality technique against annual time-series Nigerian data from 1981 through 2019. The results indicates that agricultural credit guaranteed funding and direct credits from such banks like bank of industry and the commercial banks positively and significantly cause, as in affecting and boosting, the country’s GDP. Quite surprisingly, direct government budgetary expenditure on agriculture was revealed to cause and affect GDP, but negatively. The recommendations favor encouraging and increasing the indirect guaranteed funding and straight loans and advances by relevant banks in the country. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Managing the Mind, Body, and Soul--Closing the Gap Between Managers and Young Employees With Anxiety Disorders.

Author

Hunter, Debra and Chekwa, Charles

Subjects
YOUNG workers, ANXIETY disorders, ACADEMIC accommodations, TRAINING of executives, PERSONNEL management, DISCRIMINATION lawsuits
Abstract

Younger generational cohorts are entering the workforce with much higher rates of reported mental illnesses than their predecessors. Academic stress, anxiety, and depression are a major cause of concern among college students. The 2019 Center for Collegiate Mental Health reported that anxiety is one of the most common diagnosis of students seeking services at university counseling centers. The workplace environment operates under different standards with less flexibility. In fact, educational institutions may be marginally preparing students with accommodations to operate in the real world. Companies required to adhere to Title I of the American Disabilities must only provide "reasonable accommodations" for documented disabilities and the interpretation of what is reasonable is determined by management. Yet, many anxiety-related disabilities are undisclosed to management. Employees fear stigmatization and being shunned for sharing their conditions. In some cases, the anxiety could affect workplace productivity and possibly pre-mature termination if misunderstood. The lack of communication between employees and managers creates a "gap" leading to possible unemployment or discrimination suits. In fact, EEOC discrimination charges filed on behalf of employees who suffer from anxiety increased from 65 in 2006 to 371 in 2019. This increase leads one to believe that managers are not properly addressing employees' mental health. Proper training and development opportunities in mental health related issues may curtail additional lawsuits imposed on organizations. To provide an inclusive workplace environment, managers must be proactive in assessing the holistic needs of employees including support for mental and emotional disabilities. This research contends that Generation Z will have higher expectations than previous cohorts for workplace accommodations to support anxiety, stress, autism, and other mental challenges. These expectations have implications for universities and management training programs designed to embrace the needs of individuals with mental health related issues. Greater attention is warranted on closing the existing gap between management and employees with anxiety related disorders. [ABSTRACT FROM AUTHOR]

Published
2021

25. TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma

Author

Holtzhausen, Alisha, primary, Harris, William, additional, Ubil, Eric, additional, Hunter, Debra M., additional, Zhao, Jichen, additional, Zhang, Yuewei, additional, Zhang, Dehui, additional, Liu, Qingyang, additional, Wang, Xiaodong, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Earp, H. Shelton, additional

Published
2019
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26. Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology

Author

Da, Chenxiao, primary, Zhang, Dehui, additional, Stashko, Michael, additional, Vasileiadi, Eleana, additional, Parker, Rebecca E., additional, Minson, Katherine A., additional, Huey, Madeline G., additional, Huelse, Justus M., additional, Hunter, Debra, additional, Gilbert, Thomas S. K., additional, Norris-Drouin, Jacqueline, additional, Miley, Michael, additional, Herring, Laura E., additional, Graves, Lee M., additional, DeRyckere, Deborah, additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, Wang, Xiaodong, additional, and Kireev, Dmitri, additional

Published
2019
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28. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Author

Asquith, Christopher R. M., primary, Berger, Benedict-Tilman, additional, Wan, Jing, additional, Bennett, James M., additional, Capuzzi, Stephen J., additional, Crona, Daniel J., additional, Drewry, David H., additional, East, Michael P., additional, Elkins, Jonathan M., additional, Fedorov, Oleg, additional, Godoi, Paulo H., additional, Hunter, Debra M., additional, Knapp, Stefan, additional, Müller, Susanne, additional, Torrice, Chad D., additional, Wells, Carrow I., additional, Earp, H. Shelton, additional, Willson, Timothy M., additional, and Zuercher, William J., additional

Published
2019
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29. Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group

Author

Zhao, Jichen, primary, Zhang, Dehui, additional, Zhang, Weihe, additional, Stashko, Michael A., additional, DeRyckere, Deborah, additional, Vasileiadi, Eleana, additional, Parker, Rebecca E., additional, Hunter, Debra, additional, Liu, Qingyang, additional, Zhang, Yuewei, additional, Norris-Drouin, Jacqueline, additional, Li, Bing, additional, Drewry, David H., additional, Kireev, Dmitri, additional, Graham, Douglas K., additional, Earp, Henry Shelton, additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2018
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30. SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

Author

Asquith, Christopher R. M., primary, Berger, Benedict-Tilman, additional, Wan, Jing, additional, Bennett, James M., additional, East, Michael P., additional, Elkins, Jonathan M., additional, Fedorov, Oleg, additional, Godoi, Paulo H., additional, Hunter, Debra M., additional, Knapp, Stefan, additional, Müller, Susanne, additional, Wells, Carrow I., additional, Earp, H. Shelton, additional, Willson, Timothy M., additional, and Zuercher, William J., additional

Published
2018
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31. EDUCATORS SPEAK OUT.

Author

Putnam, Julia, Fedele, Lynn, Ricketts-Lindsay, Marilyn, Hunter, Debra, McGhee, Shalonda, Abo-Zena, Mona M., Patterson, Tiffany Mitchell, Stanhope, Sally, and Varpaul, Kawal

Subjects
EDUCATORS, ASIAN American students, BLACK Lives Matter movement
Abstract

COVER STORIES The Diverse World that Awaits By Julia Putnam This year, our school launched a discussion series for our white parents based on the podcast Nice White Parents. Both of these students, like the vast majority of my students, support the 13 principles of the Black Lives Matter movement and value their teachers. After advocacy by parents, teachers, and other stakeholders, a mask mandate order was implemented making it possible for teachers to have some modicum of safety in schools. An Asian American student was also ridiculed by Black classmates for her mention of Asian American Pacific Islander Month because those classmates had never heard of it: "Who do they even celebrate?". [Extracted from the article]

Published
2022

32. UNC2025 , a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

Author

Lee, Minjung, Glaros, Trevor G., Zhang, Weihe, Zhang, Dehui, Cummings, Christopher T., Frye, Stephen V., Hunter, Debra, Sather, Susan, Wang, Xiaodong, and Newton, Dianne L.

Abstract

We previously reported a potent small molecule Mer tyrosine kinase inhibitor UNC1062. However, its poor PK properties prevented further assessment in vivo. We report here the sequential modification of UNC1062 to address DMPK properties and yield a new potent and highly orally bioavailable Mer inhibitor, 11, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.

Published
2014
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33. Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Author

Zhou, Yingqiu, Wang, Xiaodong, Zhang, Weihe, Norris-Drouin, Jacqueline, Frye, Stephen V., Lee, Minjung, Machius, Mischa, and Hunter, Debra

Abstract

Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer therapeutic target. A structure-based drug design approach using a pseudo-ring replacement strategy was developed and validated to discover a new family of pyridinepyrimidine analogs as potent Mer inhibitors. Through SAR studies, 10 (UNC2250) was identified as the lead compound for further investigation based on high selectivity against other kinases and good pharmacokinetic properties. When applied to live cells, 10 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with 10 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional anti-tumor activity. The results provide a rationale for further investigation of this compound for therapeutic application in patients with cancer.

Published
2013
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34. Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Author

Zhang, Weihe, Branchford, Brian R., Wang, Xiaodong, Zhou, Yingqiu, Machius, Mischa, Sather, Susan, Frye, Stephen V., and Hunter, Debra

Abstract

The role of Mer kinase in regulating the second phase of platelet activation generates an opportunity to use Mer inhibitors for preventing thrombosis with diminished likelihood for bleeding as compared to current therapies. Toward this end, we have discovered a novel, Mer kinase specific substituted-pyrimidine scaffold using a structure-based drug design and a pseudo-ring replacement strategy. The co-crystal structure of Mer with two compounds (7 & 22) possessing distinct activity have been determined. Subsequent SAR studies identified compound 23 (UNC2881) as a lead compound for in vivo evaluation. When applied to live cells, 23 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with 23 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, 23 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.

Published
2013
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35. Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation

Author

Earp, H. Shelton, Sandahl, Melissa, Strunk, Karen E, and Hunter, Debra M

Abstract

Background Mammary glands harbor a profound burden of apoptotic cells (ACs) during post-lactational involution, but little is known regarding mechanisms by which ACs are cleared from the mammary gland, or consequences if this process is interrupted. We investigated AC clearance, also termed efferocytosis, during post-lactational remodeling, using mice deficient for MerTK, Axl, and Tyro3, three related receptor tyrosine kinases (RTKs) regulating macrophage-mediated efferocytosis in monocytes. MerTK expression, apoptosis and the accumulation of apoptotic debris were examined in histological sections of MerTK-deficient, Axl/Tyro3-deficient, and wild-type mammary glands harvested at specific time points during lactation and synchronized involution. The ability of primary mammary epithelial cells (MECs) to engulf ACs was assessed in culture. Transplant of MerTK-deficient mammary epithelium into cleared WT mammary fat pads was used to assess the contribution of WT mammary macrophages to post-lactational efferocytosis. Results ACs induced MerTK expression in MECs, resulting in elevated MerTK levels at the earliest stages of involution. Loss of MerTK resulted in AC accumulation in post-lactational MerTK-deficient mammary glands, but not in Axl and Tyro3-deficient mammary glands. Increased vascularization, fibrosis, and epithelial hyperproliferation were observed in MerTK-deficient mammary glands through at least 60 days post-weaning, due to failed efferocytosis after lactation, but did not manifest in nulliparous mice. WT host-derived macrophages failed to rescue efferocytosis in transplanted MerTK-deficient mammary epithelium. Conclusion Efferocytosis by MECs through MerTK is crucial for mammary gland homeostasis and function during the post-lactational period. Efferocytosis by MECs thus limits pathologic consequences associated with the apoptotic load following lactation.

Published
2010
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36. Correction to Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Author

Zhang, Weihe, primary, Zhang, Dehui, additional, Stashko, Michael A., additional, DeRyckere, Deborah, additional, Hunter, Debra, additional, Kireev, Dmitri, additional, Miley, Michael J., additional, Cummings, Christopher, additional, Lee, Minjung, additional, Norris-Drouin, Jacqueline, additional, Stewart, Wendy M., additional, Sather, Susan, additional, Zhou, Yingqiu, additional, Kirkpatrick, Gregory, additional, Machius, Mischa, additional, Janzen, William P., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2014
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37. Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Author

Zhang, Weihe, primary, McIver, Andrew L., additional, Stashko, Michael A., additional, DeRyckere, Deborah, additional, Branchford, Brian R., additional, Hunter, Debra, additional, Kireev, Dmitri, additional, Miley, Michael J., additional, Norris-Drouin, Jacqueline, additional, Stewart, Wendy M., additional, Lee, Minjung, additional, Sather, Susan, additional, Zhou, Yingqiu, additional, Di Paola, Jorge A., additional, Machius, Mischa, additional, Janzen, William P., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2014
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38. Correction to Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

Author

Liu, Jing, primary, Yang, Chao, additional, Simpson, Catherine, additional, DeRyckere, Deborah, additional, Deusen, Amy Van, additional, Miley, Michael J., additional, Kireev, Dmitri, additional, Norris-Drouin, Jacqueline, additional, Sather, Susan, additional, Hunter, Debra, additional, Korboukh, Victoria K., additional, Patel, Hari S., additional, Janzen, William P., additional, Machius, Mischa, additional, Johnson, Gary L., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2014
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39. UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

Author

Zhang, Weihe, primary, DeRyckere, Deborah, additional, Hunter, Debra, additional, Liu, Jing, additional, Stashko, Michael A., additional, Minson, Katherine A., additional, Cummings, Christopher T., additional, Lee, Minjung, additional, Glaros, Trevor G., additional, Newton, Dianne L., additional, Sather, Susan, additional, Zhang, Dehui, additional, Kireev, Dmitri, additional, Janzen, William P., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2014
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40. Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Author

Zhang, Weihe, primary, Zhang, Dehui, additional, Stashko, Michael A., additional, DeRyckere, Deborah, additional, Hunter, Debra, additional, Kireev, Dmitri, additional, Miley, Michael J., additional, Cummings, Christopher, additional, Lee, Minjung, additional, Norris-Drouin, Jacqueline, additional, Stewart, Wendy M., additional, Sather, Susan, additional, Zhou, Yingqiu, additional, Kirkpatrick, Gregory, additional, Machius, Mischa, additional, Janzen, William P., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2013
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41. Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Author

Zhang, Weihe, primary, McIver, Andrew L., additional, Stashko, Michael A., additional, DeRyckere, Deborah, additional, Branchford, Brian R., additional, Hunter, Debra, additional, Kireev, Dmitri, additional, Miley, Michael J., additional, Norris-Drouin, Jacqueline, additional, Stewart, Wendy M., additional, Lee, Minjung, additional, Sather, Susan, additional, Zhou, Yingqiu, additional, Di Paola, Jorge A., additional, Machius, Mischa, additional, Janzen, William P., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2013
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42. UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

Author

Christoph, Sandra, primary, DeRyckere, Deborah, additional, Schlegel, Jennifer, additional, Frazer, J. Kimble, additional, Batchelor, Lance A., additional, Trakhimets, Alesia Y., additional, Sather, Susan, additional, Hunter, Debra M., additional, Cummings, Christopher T., additional, Liu, Jing, additional, Yang, Chao, additional, Kireev, Dmitri, additional, Simpson, Catherine, additional, Norris-Drouin, Jacqueline, additional, Hull-Ryde, Emily A., additional, Janzen, William P., additional, Johnson, Gary L., additional, Wang, Xiaodong, additional, Frye, Stephen V., additional, Earp, H. Shelton, additional, and Graham, Douglas K., additional

Published
2013
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44. Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

Author

Liu, Jing, primary, Yang, Chao, additional, Simpson, Catherine, additional, DeRyckere, Deborah, additional, Van Deusen, Amy, additional, Miley, Michael J., additional, Kireev, Dmitri, additional, Norris-Drouin, Jacqueline, additional, Sather, Susan, additional, Hunter, Debra, additional, Korboukh, Victoria K., additional, Patel, Hari S., additional, Janzen, William P., additional, Machius, Mischa, additional, Johnson, Gary L., additional, Earp, H. Shelton, additional, Graham, Douglas K., additional, Frye, Stephen V., additional, and Wang, Xiaodong, additional

Published
2012
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49. Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1

Author

Muraoka-Cook, Rebecca S., primary, Caskey, Laura S., additional, Sandahl, Melissa A., additional, Hunter, Debra M., additional, Husted, Carty, additional, Strunk, Karen E., additional, Sartor, Carolyn I., additional, Rearick, William A., additional, McCall, Wesley, additional, Sgagias, Magdalene K., additional, Cowan, Kenneth H., additional, and Earp, H. Shelton, additional

Published
2006
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