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BackgroundVoxel-mirrored homotopic connectivity (VMHC) is utilized to assess the functional connectivity of neural networks by quantifying the similarity between corresponding regions in the bilateral hemispheres of the brain. The exploration of VMHC abnormalities in basal ganglia ischemic stroke (BGIS) patients across different cerebral hemispheres has been limited. This study seeks to establish a foundation for understanding the functional connectivity status of both brain hemispheres in BGIS patients through the utilization of VMHC analysis utilizing resting-state functional magnetic resonance imaging (rs-fMRI).MethodsThis study examined a total of 38 patients with left basal ganglia ischemic stroke (LBGIS), 44 patients with right basal ganglia ischemic stroke (RBGIS), and 41 individuals in a healthy control (HC) group. Rs-fMRI studies were performed on these patients, and the pre-processed rs-fMRI data were analyzed using VMHC method. Subsequently, the VMHC values were compared between three groups using a one-way ANOVA and post hoc analysis. Correlation analysis with clinical scales was also conducted.ResultsThe results indicated that compared to the HC group, significant differences were detected in postcentral gyrus, extending to precentral gyrus in both BGIS groups. Post hoc analysis showed that in the pairwise ROI-based comparison, individuals with LBGIS and RBGIS exhibited reduced VMHC values compared to HC groups. There was no significant difference between the LBGIS and RBGIS groups. In the LBGIS group, the VMHC value showed a negative correlation with NIHSS and a positive correlation with BI.ConclusionThe analysis of VMHC in rs-fMRI revealed a pattern of brain functional remodeling in patients with unilateral BGIS, marked by reduced synchronization and coordination between hemispheres. This may contribute to the understanding of the neurological mechanisms underlying motor dysfunction in these patients.

BackgroundThe optimal dose of tenecteplase vs. alteplase for acute ischemic stroke (AIS) has yet to be established. Therefore, we included the latest randomized controlled trials (RCT) to assess the efficacy and safety of different doses of tenecteplase vs. alteplase for AIS within 4.5 hours of symptom onset.MethodsLiterature was searched in PubMed, Cochrane Library, Embase, Web of Science, and clinical trial registries until February 12, 2023. Odds ratios (OR) with 95% credible intervals (CrI) were estimated using Bayesian network meta-analysis (NMA). Treatments were ranked based on efficacy and safety using the surface under the cumulative ranking curve (SUCRA).ResultsEleven RCTs with 5,475 patients were included. Tenecteplase 0.25 mg/kg and alteplase 0.9 mg/kg had significantly higher rates of excellent functional outcome (tenecteplase: OR, 1.85; 95% CrI, 1.44–2.37; alteplase: OR, 1.60; 95% CrI, 1.29–1.97) and good functional outcome (tenecteplase: OR, 1.54; 95% CrI, 1.19–1.98; alteplase: OR, 1.40; 95% CrI, 1.14–1.74) than placebo, despite an increased risk of symptomatic intracranial hemorrhage. Furthermore, the NMA (OR, 1.16; 95% CrI, 1.01–1.33) and the pairwise meta-analysis (OR, 1.16; 95% CI, 1.02–1.33; P = 0.03) indicated that tenecteplase 0.25 mg/kg was superior to alteplase 0.9 mg/kg in excellent functional outcome. Alteplase 0.9 mg/kg (OR, 2.54; 95% CrI, 1.45–8.08) significantly increased the risk of any intracranial hemorrhage compared with placebo. SUCRA results demonstrated that tenecteplase 0.25 mg/kg ranked first and tenecteplase 0.4 mg/kg ranked last in efficacy outcomes.ConclusionsThe NMA indicated that tenecteplase 0.25 mg/kg and alteplase 0.9 mg/kg are safe and significantly improve clinical outcomes in patients with AIS within 4.5 h of symptom onset. Furthermore, tenecteplase 0.25 mg/kg provides more benefit and has the potential to replace alteplase 0.9 mg/kg in AIS treatment.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/index.php, identifier: CRD42022343948.

(1) Background: Minimal hepatic encephalopathy (MHE) is an important complication of decompensated cirrhosis. Previous studies have demonstrated spontaneous brain activity alterations in cirrhotic patients with MHE. However, the reported results are inconsistent, which has limited our understanding of the potential neural mechanisms. Thus, we conducted a quantitative meta-analysis of resting-state functional imaging studies to identify the regional activity alterations consistently involved in MHE. (2) Methods: We searched six databases to include resting-state functional imaging studies and compared spontaneous brain activity patterns between MHE patients and healthy controls (HCs), and between cirrhotic patients without minimal hepatic encephalopathy (NMHE) and HCs. Then, a separate whole-brain voxel-wise meta-analysis between MHE or NMHE patients and HCs was conducted using seed-based d mapping with permutation of subject images. We further conducted the conjunction analysis to assess the distinct regional activity alterations between MHE and NMHE patients as compared to HCs. (3) Results: Thirteen studies with twenty datasets were included in this meta-analysis. Compared with HCs, MHE patients showed decreased spontaneous brain activity in the left superior frontal gyrus, left median cingulate/paracingulate gyri, and right precuneus. Compared with NMHE patients, MHE patients indicated decreased spontaneous brain activity in the left superior frontal gyrus, left median cingulate/paracingulate gyri, and right precuneus. (4) Conclusions: MHE is associated with spontaneous brain activity alterations involving the left superior frontal gyrus and median cingulate/paracingulate gyri, which may implicate primarily in spatial working memory and emotional disorders. These findings may contribute to a better understanding of the potential neural mechanisms, and guide further research.

Objective. The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p

The widespread Early Cretaceous plutons intruding along the southern Great Xing'an Range (SGXR) provide evidence for tectonic evolution of the region. Petrological, geochemical, zircon U-Pb geochronology, and zircon Hf isotopic studies are conducted on intrusions from Bianjiadayuan and Hongling areas. These suites classify as A2-type granites and monzodiorites, respectively. The 138-133 Ma A2-type granites originated from partial melting of continental crustal materials at high temperatures and shallow depths with significant addition of juvenile mafic lower crust sourced from a metasomatized mantle. The 136-134 Ma monzodiorites originated from the partial melting of an enriched mantle that was modified by melts of a previously subducted slab coupled with crustal contamination. The Early Cretaceous magmatism in the SGXR occurred in two periods: ~145-136 Ma (peak at ~139 Ma; [[epsilon].sub.Hf] (t) = 5 to 10) and ~136-130 Ma (peak at ~131 Ma; [[epsilon].sub.Hf] (t) = -10 to 15). The Early Cretaceous granite--monzodiorite suite in the SGXR suggests a bimodal magmatism in an extensional setting. The ~145-130 Ma magmatism may have been triggered by asthenospheric upwelling induced by the Mongol--Okhotsk oceanic slab breakoff and large-scale lithospheric delamination resulting from post-orogenic extension. The variation of subduction direction of the Paleo-Pacific Ocean likely triggered a change in stress regime at ca. 136 Ma and likely promoted the lithospheric delamination beneath the SGXR resulting in intense magmatism originating from various sources. As such, the Paleo-Pacific Oceanic subduction likely played an important role in the Early Cretaceous magmatism in the SGXR. Key words: southern Great Xing'an Range, the Early Cretaceous, A2-type granite, bimodal magmatism, asthenospheric upwelling, lithospheric delamination. Les nombreux plutons d'âge crétacé précoce mis en place le long de la chaîne du Grand Khingan méridionale (CGKM) témoignent de l'évolution tectonique de la région. Des études pétrologiques, géochimiques, de géochronologie U-Pb sur zircons et d'isotopes de Hf sur zircons sont effectuées sur des intrusions des secteurs de Bianjiadayuan et Hongling. Ces suites sont, respectivement, des granites de type A2 et des monzodiorites. Les granites de type A2 de 138-133 Ma sont issus de la fusion partielle de matériaux de la croûte continentale à des températures élevées et de faibles profondeurs, avec un ajout important de matériau mafique juvénile de la croûte inférieure prenant sa source dans du manteau métaso-matisé. Les monzodiorites de 136-134 Ma sont issues de la fusion partielle de manteau enrichi modifié par des magmas issus d'une plaque préalablement subductée, jumelés à une conttion crustale. Le magmatisme crétacé précoce dans la CGKM s'est effectué en deux phases, soit à ~145-136 Ma (apogée à ~139 Ma; [[epsilon].sub.Hf] (t) = 5 à 10) et ~136-130 Ma (apogée ~131 Ma; [[epsilon].sub.Hf] (t) = -10 à 15). La suite de granite-monzodiorite d'âge crétacé précoce dans la CGKM indiquerait un magmatisme bimodal dans un milieu d'extension. Le magmatisme à ~145-130 Ma pourrait avoir été déclenché par la remontée asthénosphérique induite par le bris de la plaque océanique de Mongolie-Okhotsk et une délamination lithosphérique à grande échelle résultant de l'extension postorogénique. Les variations de la direction de subduction de l'océan Paléo-Pacifique ont vraisemblablement engendré un changement du régime de contraintes vers 136 Ma et favorisé la délamination lithosphérique sous la CGKM, ce qui s'est traduit par un magmatisme intense de sources variées. Ainsi, la subduction de l'océan Paléo-Pacifique a probablement joué un important rôle dans le magmatisme dans la CGKM au Crétacé précoce. [Traduit par la Rédaction] Mots-clés : chaîne du Grand Khingan méridionale, Crétacé précoce, granite de type A2, magmatisme bimodal, remontée asthénosphérique, délamination lithosphérique., Introduction Northeastern China is located between the North China Craton and the Siberian Craton and is a part of the eastern segment of the Central Asian Orogenic Belt (CAOB) (Fig. [...]

Building clustering is a key problem that needs to be solved in the realization of the automatic synthesis of large-scale maps. The selection of different feature and spatial distance calculation methods has a great impact on the clustering results, and the need to manually select appropriate feature and distance metrics leads to the problem of not being able to fully consider the complexity and diversity of buildings. In this paper, we propose a multi-scale clustering method for buildings that takes visual perception into account using the Gestalt principle to simulate how humans classify buildings through visual perception. Moreover, by analyzing the spatial features and texture attributes of buildings, a visual distance is designed to be used as a condition for building classification to assess the similarity between buildings, solving the complexity of manually selecting feature vectors and spatial distances and realizing the adaptive selection of features. Through experimental validation at different scales (macro, meso and micro), the present method is able to achieve the accurate clustering of buildings, and a frequency threshold of 91% is found, which is able to determine the optimal clustering results. The experimental results show that the proposed method can not only fully consider the complexity and diversity of buildings but also effectively support the understanding and analysis of urban spatial structure and provide a scientific decision-making basis for urban planning and management. [ABSTRACT FROM AUTHOR]

In the rapid development of urban construction, underground pipelines play a crucial role. However, the current underground pipelines have poor association with relevant management departments, and there are deficiencies in data completeness, accuracy, and information content. Managing and sharing information resources is relatively difficult, transforming the constructed 3D underground pipeline geographic information systems into an 'Information silo'. This results in redundant construction and resource wastage of underground utilities. The complex distribution characteristics of underground utilities make rapid batch modeling and post-model maintenance challenging. Therefore, researching a 3D spatial data fusion model for urban underground utilities becomes particularly important. Given the above problem, this paper proposes a spatial data fusion model for underground pipeline scene modeling. It elaborates on the geometric, semantic, and temporal characteristics of underground pipelines, encapsulating these features. With underground pipeline objects as the core and pipeline characteristics as the foundation, a spatial data fusion model integrating multiple characteristics of underground pipelines has been constructed. Through software development, the data model designed in this paper facilitates rapid construction of underground pipeline scenes. This further enhances the consistency and integrity of underground pipeline data, enabling shared resources and comprehensive supervision of facility operations on a daily basis. [ABSTRACT FROM AUTHOR]

The three-dimensional morphological analysis of urban buildings constitutes a pivotal component of urban planning and sustainable development. Nevertheless, the majority of current research is two-dimensional in nature, which constrains the comprehensive understanding of urban spatial–temporal evolution. The existing body of three-dimensional studies frequently fails to consider the temporal dimension of architectural change and lacks a detailed examination of micro areas such as communities and streets. In order to accurately identify the patterns of spatial–temporal evolution in urban architectural morphology, this study focuses on the Yau Tsim Mong District in Hong Kong, utilizing three-dimensional data. By innovatively integrating temporal factors, constructing a spatial–temporal weight matrix, and applying the spatial–temporal Moran's I, this study conducts an in-depth quantitative analysis of Coverage, Staggeredness, and Duty Cycle at the community scale, neighborhood scale, and urban scale. From 2014 to 2023, the global spatial–temporal Moran's I of key urban morphology indicators in Yau Tsim Mong District has exhibited a marked increase, underscoring the close interrelationship and significant optimization between urban morphology and overall development. The findings illustrate that urban architecture is undergoing a process of agglomeration and high homogeneity, with strategic shifts emphasizing efficient spatial utilization and refined design. The analysis at the neighborhood scale is of particular importance, as its independent and complete spatial structure effectively captures local dynamics, revealing high-value agglomeration and low-value dispersion characteristics. This suggests that buildings in the Yau Tsim Mong District are being constructed in a more compact manner at the neighborhood level, which reflects the precision and efficiency of urban planning and the rationality of spatial planning. These significant findings provide valuable references for the development planning and governance of sustainable cities. They enhance urban governance capabilities and promote the optimization of urban development strategies, ensuring steady progress on the path of efficiency, harmony, and sustainability. [ABSTRACT FROM AUTHOR]

Objectives: The study aimed to introduce and evaluate a new customized temporomandibular joint‐mandible combined prosthesis with 3D printing fabrication. Materials and Methods: This was a prospective study including patients with temporomandibular joint‐mandible combined lesions. A 3D‐printed customized temporomandibular joint‐mandible combined prosthesis was implanted to repair the joint and jaw defect. Clinical follow‐up and radiographic examinations were taken to assess the clinical efficacy. The assessment indices were compared by the Wilcoxon signed rank test. Results: Eight patients were treated with the combined prosthesis and included in this study. All prostheses were accurately positioned and fixed without wound infection, prosthesis exposure, displacement, loosening, or fracture. All cases had no mass recurrence at the last follow‐up point. Pain, diet, mandibular function, lateral mandibular movement to the diseased side, and maximal interincisal opening showed significant improvements at every follow‐up point and went to a stable condition at 6 months after the operation. But the lateral movement to the non‐operated side was still limited following surgery. Conclusion: The 3D‐printed combined prosthesis may be an alternative to other well‐established reconstructions for temporomandibular joint and mandible defects. [ABSTRACT FROM AUTHOR]