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263 results on '"Hurley, Rachel"'

7. Low-Energy Wearable Cooling Strategy for Thermal Comfort at a Warm Environment

Author

Belyamani, Mohamed A., Hurley, Rachel F., Zhang, Hui, Djamasbi, Soussan, Somasse, Gbetonmasse B., Strauss, Sarah, Smith, Matthew J., Liu, Shichao, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Wang, Liangzhu Leon, editor, Ge, Hua, editor, Zhai, Zhiqiang John, editor, Qi, Dahai, editor, Ouf, Mohamed, editor, Sun, Chanjuan, editor, and Wang, Dengjia, editor

Published
2023
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8. Do We Overestimate the Impact of Carbon Dioxide on Cognition and Decision-Making? Preliminary Evidence

Author

Hurley, Rachel F., Belyamani, Mohamed A., Djamasbi, Soussan, Somasse, Gbetonmasse B., Strauss, Sarah, Liu, Shichao, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Wang, Liangzhu Leon, editor, Ge, Hua, editor, Zhai, Zhiqiang John, editor, Qi, Dahai, editor, Ouf, Mohamed, editor, Sun, Chanjuan, editor, and Wang, Dengjia, editor

Published
2023
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19. A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovarian or triple-negative breast cancer

Author

Manzo, Julia, Puhalla, Shannon, Pahuja, Shalu, Ding, Fei, Lin, Yan, Appleman, Leonard, Tawbi, Hussein, Stoller, Ronald, Lee, James J., Diergaarde, Brenda, Kiesel, Brian F., Yu, Jing, Tan, Antoinette R., Belani, Chandra P., Chew, Helen, Garcia, Agustin A., Morgan, Robert J., Wahner Hendrickson, Andrea E., Visscher, Daniel W., Hurley, Rachel M., Kaufmann, Scott H., Swisher, Elizabeth M., Oesterreich, Steffi, Katz, Tiffany, Ji, Jiuping, Zhang, Yiping, Parchment, Ralph E., Chen, Alice, Duan, Wenrui, Giranda, Vincent, Shepherd, Stacie P., Ivy, S. Percy, Chu, Edward, and Beumer, Jan H.

Published
2022
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22. Metals and microplastics in the 'first industrial city' : fluvial sediment contamination in the upper Mersey and Irwell catchments, UK

Author

Hurley, Rachel, Rothwell, James, and Woodward, Jamie

Subjects
550, metals, microplastic, river, river sediment, environmental contamination, Manchester, Irwell, Mersey
Abstract

Rivers have been the recipients of waste for millennia. However, since the onset of industrial and urban development, major degradation of fluvial systems has been observed globally. This has encompassed a wide range of contaminants from numerous potential sources. Despite efforts to reduce inputs, contamination continues to persist in many catchments. Metal contamination of fluvial sediments is a well-established problem. Conversely, microplastics are an emerging contaminant, for which there is a paucity of data regarding their sources, behaviour, and fate. Based on the onset of industrialisation, Manchester is often heralded the 'first industrial city'. During the industrial period, the fluvial network became heavily contaminated. By the 1970s, it was amongst the most polluted river systems in Europe. Despite this background, no study has thus far undertaken a systematic, catchment-wide survey of sediment-associated contamination. This study assesses patterns of metal and microplastic contamination in fluvial sediments of the Irwell and upper Mersey catchments (1527 km2), which comprise the Manchester river network, from the onset of the industrial period to the present day. Five metal(loid)s have been studied and microplastics are assessed by type, size, and density for the first time. Metal concentrations in fine-grained bed sediments are heavily enriched across the entire fluvial network, even in headwater reaches. By examining spatial patterns, it is possible to attribute a portion of this to the reworking of historically-contaminated material; although, modern, urban sources are also important. Sources of metals to channel beds are numerous and spatially complex. This is also the case for microplastic contamination; although, microplastic particles are not bound to natural sediments and exert more transient behaviour in fluvial systems. Following an extreme flood event on Boxing Day 2015 and a sustained period of high flows (winter 2015/16), metal contamination was shown to present markedly conservative behaviour despite significant reworking of bed sediments. Metal mobility was generally low and was not affected in the long-term by hydrological processes. Despite this, the results indicate that bed sediment-associated metal contamination is likely to persist into the future at levels that exceed sediment quality guidelines. In contrast, flooding is very effective in flushing high concentrations of microplastics from channel beds. This suggests that microplastic contamination can be effectively reduced through source control. The environmental significance of microplastic contamination was directly observed through the ingestion of microplastics by freshwater Tubifex worms at the distal end of the Irwell system (Salford Quays). Microplastic concentrations within worm tissue were high, indicating an increased risk for trophic transfer. This also presents a potential link to the human food chain. Furthermore, both metals and microplastics accumulate in floodplain deposits. Floodplains are effective in preserving microplastics, recording the temporal evolution of microplastic contamination over the last 75 years. Maximum values are observed in the late 1960s/early 1970s. Conversely, elevated metal concentrations occur much earlier and reflect catchment-wide patterns of industrialisation and urban growth. Reworking of channel banks forms a secondary source of metals and microplastics to the active river channel and downstream environments that will persist long into the future. Thus far, microplastics have passed under the monitoring radar and sediment contamination is rarely given due consideration in assessments of river quality, such as in the Water Framework Directive. However, this study shows that both metals and microplastics within fluvial sediments are important contaminants and have significant implications for the health of the entire aquatic system.

Published
2018

23. Moving forward in microplastic research: A Norwegian perspective

Author

Lusher, Amy L., Hurley, Rachel, Arp, Hans Peter H., Booth, Andy M., Bråte, Inger Lise N., Gabrielsen, Geir W., Gomiero, Alessio, Gomes, Tânia, Grøsvik, Bjørn Einar, Green, Norman, Haave, Marte, Hallanger, Ingeborg G., Halsband, Claudia, Herzke, Dorte, Joner, Erik J., Kögel, Tanja, Rakkestad, Kirsten, Ranneklev, Sissel B., Wagner, Martin, and Olsen, Marianne

Published
2021
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28. Drivers and Buffers of Stream Flashiness in the Mid‐Atlantic United States.

Author

Hurley, Rachel, Brandes, David, and Kelleher, Christa

Subjects
URBAN watersheds, URBAN hydrology, WATERSHED hydrology, GEOMORPHOLOGY, LAND cover, WATERSHEDS
Abstract

Flashiness is a hydrologic signature used to describe the responsiveness of streamflow to precipitation. In practise, flashiness has most often been correlated with rainfall intensity and the presence of urban land cover or imperviousness. However, a number of watershed characteristics can influence flashiness, necessitating further investigation of how this particular watershed behaviour and its associated drivers vary at regional scales. We investigated how ten measurable watershed characteristics are empirically related to flashiness of 195 gauged streams in the Mid‐Atlantic region using linear regression analysis. The selected gauges had drainage areas ranging in size from 15 to 250 km2. To explore multiple quantifications of flashiness, we determined both the Richards‐Baker flashiness index, calculated from the continuous hydrograph, and number of peaks‐over‐threshold, for all watersheds for a 10‐year period. As found in other studies, the percentage of watershed development was strongly correlated with stream flashiness, though significant inverse relationships also existed for forest cover, water and wetlands and carbonate geology. Differences in flashiness values between rural and suburban watersheds were not significant, with a significant increase in flashiness (p < 0.01) occurring at 80% development or ~ 25% imperviousness. In addition, we found significant differences in relationships between watershed characteristics and flashiness when differentiated by physiographic regions. For the study area and each of its five physiographic sub‐regions, we identified the four most important predictors through multiple regression. The overall mid‐Atlantic model suggested that development, wetlands and compactness ratio as the most important predictors (adj R2 = 0.57). Significant predictors of stream flashiness varied among regions; however, wetlands served as a significant buffer of flashiness in four of five sub‐regions demonstrating the importance of wetlands in modulating flash‐flooding. In all physiographic regions, empirical models of flashiness values outperformed the Mid‐Atlantic regional model, underscoring the value of local landscape characteristics in augmenting or modulating flashy watershed responses. Our findings suggest the potential for improvements to operational flash‐flood forecasting using hydrologic characteristics of the landscape. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Abstract B098: Impact of dexamethasone on chemotherapy response in ovarian cancer

Author

Venkatachalam, Annapoorna, primary, Correia, Cristina, additional, Mcgehee, Cordelia, additional, Finstuen-Magro, Sarah, additional, Schneider, Paula A., additional, Hurley, Rachel, additional, Peterson, Kevin L., additional, Heinzen, Ethan, additional, Larson, Melissa C., additional, Hou, Xiaonon, additional, Oberg, Ann L., additional, Weroha, Saravut, additional, and Kaufmann, Scott H., additional

Published
2024
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37. 53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

Author

Hurley, Rachel M., Wahner Hendrickson, Andrea E., Visscher, Daniel W., Ansell, Peter, Harrell, Maria I., Wagner, Jill M., Negron, Vivian, Goergen, Krista M., Maurer, Matthew J., Oberg, Ann L., Meng, X. Wei, Flatten, Karen S., De Jonge, Maja J.A., Van Herpen, Carla D., Gietema, Jourik A., Koornstra, Rutger H.T., Jager, Agnes, den Hollander, Martha W., Dudley, Matthew, Shepherd, Stacie P., Swisher, Elizabeth M., and Kaufmann, Scott H.

Published
2019
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44. Contributors

Author

Akenji, Lewis, primary, Bartl, Andreas, additional, Bengtsson, Magnus, additional, Buekens, Alfons, additional, Chandran, Mohanraj, additional, Cook, Cayla R., additional, Crescenzi, Irene, additional, Dumbili, Emeka, additional, Elliott, Tim, additional, Feil, Alexander, additional, Gabbott, Sarah, additional, George, Sharon, additional, Gerassimidou, Spyridoula, additional, Geyer, Roland, additional, Gillie, Hannah, additional, Hahladakis, John N., additional, Halden, Rolf U., additional, Havstad, Maja Rujnić, additional, Henderson, Lesley, additional, Hengesbaugh, Matthew, additional, Horton, Alice, additional, Hotta, Yasuhiko, additional, Hurley, Rachel, additional, Iacovidou, Eleni, additional, Kabasci, Stephan, additional, Kato, Mizuki, additional, Key, Sarah, additional, Kosior, Edward, additional, Letcher, Trevor M., additional, Lusher, Amy, additional, Mitchell, Jonathan, additional, Murugesan, Chandrasekar, additional, Nizzetto, Luca, additional, Nomura, Seiji, additional, Peake, Libby, additional, Pohjakallio, Maija, additional, Pretz, Thomas, additional, Russell, Catherine, additional, Tamilkolundu, Senthilkumar, additional, Thomson, Alice, additional, Vuorinen, Tommi, additional, Welden, Natalie A., additional, Yonan, Yasmin, additional, and Zalasiewicz, Jan, additional

Published
2020
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47. In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma

Author

AlHilli, Mariam M., Becker, Marc A., Weroha, S. John, Flatten, Karen S., Hurley, Rachel M., Harrell, Maria I., Oberg, Ann L., Maurer, Matt J., Hawthorne, Kieran M., Hou, Xiaonan, Harrington, Sean C., McKinstry, Sarah, Meng, X. Wei, Wilcoxen, Keith M., Kalli, Kimberly R., Swisher, Elizabeth M., Kaufmann, Scott H., and Haluska, Paul

Published
2016
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48. Addressing Microplastics in a Global Agreement on Plastic Pollution

Author

Rognerud, Idun, Hurley, Rachel, Lusher, Amy, Nerland Bråte, Inger Lise, Hovland Steindal, Eirik, Rognerud, Idun, Hurley, Rachel, Lusher, Amy, Nerland Bråte, Inger Lise, and Hovland Steindal, Eirik

Abstract

The report provides a reference for how microplastics may be addressed under a global agreement to end plastic pollution. It elaborates on how microplastics are currently regulated and managed, and potential measures and modalities to address microplastics. The report is intended to inform and inspire stakeholders and policymakers, including negotiators and delegates in the Intergovernmental Negotiating Committee (INC), to consider microplastics holistically. The report introduces key concepts and summarises the knowledge base and gaps that remain for a science-policy interface on microplastic pollution. It analyses existing measures on the regional and national level and shows how different measures are required to address various sources and pathways. A chapter is dedicated to lessons learnt from existing multilateral environmental agreements of relevance for microplastic pollution.

Published
2023
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49. Focus on plastics from land to aquatic ecosystems

Author

van Emmerik, Tim H.M., González-Fernández, Daniel, Laufkötter, Charlotte, Blettler, Martin, Lusher, Amy, Hurley, Rachel, Ryan, Peter G., van Emmerik, Tim H.M., González-Fernández, Daniel, Laufkötter, Charlotte, Blettler, Martin, Lusher, Amy, Hurley, Rachel, and Ryan, Peter G.

Abstract

Plastic pollution in oceans and rivers is of growing concern. Aquatic ecosystems play an important role in transport and storage of plastic waste from land-based storage to riverine and marine environments. This focus issue brings together new insights on the sources, transport dynamics, fate, and impact of plastic pollution through aquatic environments. The work collected in this focus issue shows that urban areas, transportation infrastructure, and wastewater treatment plants are consistently identified as sources for micro-, meso-, and macroplastics. Transport dynamics of plastics over land and through rivers were found to be driven by human factors, flood and storm events, and hydrodynamics, and combinations thereof. Most plastics were found not to make it to the open sea, but rather beach, float in coastal waters, or accumulate on land and within river systems. When exposed to the environment, both conventional and biodegradable plastics degrade into smaller pieces. Yet, the degradation and fragmentation of plastics in the environment remain unresolved. Future work should focus on transferability of new river and region specific insights, collection and exploration of large-scale and novel datasets, source and entry point identification, and understanding fundamental transport mechanisms. This focus issue provides new insights on sources, transport, fate, and impact of plastics, but also emphasizes that need for further work on plastics in aquatic ecosystems.

Published
2023

50. Supplementary Tables from Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma

Author

Nesic, Ksenija, primary, Kondrashova, Olga, primary, Hurley, Rachel M., primary, McGehee, Cordelia D., primary, Vandenberg, Cassandra J., primary, Ho, Gwo-Yaw, primary, Lieschke, Elizabeth, primary, Dall, Genevieve, primary, Bound, Nirashaa, primary, Shield-Artin, Kristy, primary, Radke, Marc, primary, Musafer, Ashan, primary, Chai, Zi Qing, primary, Ghamsari, Mohammad Reza Eftekhariyan, primary, Harrell, Maria I., primary, Kee, Damien, primary, Olesen, Inger, primary, McNally, Orla, primary, Traficante, Nadia, primary, Study, Australian Ovarian Cancer, primary, DeFazio, Anna, primary, Bowtell, David D.L., primary, Swisher, Elizabeth M., primary, Weroha, S. John, primary, Nones, Katia, primary, Waddell, Nicola, primary, Kaufmann, Scott H., primary, Dobrovic, Alexander, primary, Wakefield, Matthew J., primary, and Scott, Clare L., primary

Published
2023
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