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Byline: Shri. Sharma, Nalini. Sharma, Masaraf. Hussain, Hibung. Mobing, Yasmeen. Hynniewta Background and Purpose: Epilepsy during pregnancy is a therapeutic challenge. Since the 1990s, the number of licensed antiepileptic drugs [...]

Byline: Shri. Sharma, Masaraf. Hussain, Debojit. Roy The manifestations of CNS syphilis are unfamiliar to a differential of patients with dementia to many physicians today as of the relative rarity [...]

Spontaneous intracranial hypotension (SIH) is a condition characterized by orthostatic headache associated with nausea, vomiting, tinnitus, vertigo, hypoacusis, neck pain/stiffness, and photophobia. Usual treatment includes bed rest, hydration, caffeine, analgesics, epidural blood patch, steroids, fibrin glue (N-butyl-cyanoacrylate), and surgical repair. In this series, we report two cases, who presented to us with features of SIH and were managed successfully with sphenopalatine ganglion block. This is a novel modality of management of SIH and has not been reported before. [ABSTRACT FROM AUTHOR]

Background: Guillain-Barré syndrome (GBS) is rare in pregnancy with an estimated incidence between 1.2 and 1.9 cases per 100,000 people annually, and it is generally accepted that it carries a high maternal risk. Most reports of GBS with pregnancy are case reports only. Aim: Purpose of this retrospective study was to find the correlation between pregnancy and GBS. Settings and Design: Records of patients admitted in neurology division were analyzed in a tertiary care teaching hospital in the northeastern Indian pregnant female population with GBS between 15-49 years during the period of 2009-2013. Materials and Methods: We analyzed the records of 47 patients with pregnancy and GBS, evaluated and treated in our institute from August 2009 to December 2013. This is retrospective observational study done in North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), India. Result: Predominant form of GBS was acute inflammatory demyelinating polyneuropathy (AIDP). The weakness started from the lower limbs in majority of patients. Ten percent of women had bifacial weakness. Most of patients had good maternal and fetal outcome. Two patients received intravenous immunoglobulin (IVIG). Only two patient required ventilator supports and one patient had intrauterine death (IUD) and died due to respiratory failure. Conclusion: Our results indicate that risk of GBS increases in third trimester and first 2 weeks after delivery. Demyelinating variety of GBS was common in our population. GBS natural course during pregnancy is mild and showed quick recovery. Maternal and perinatal outcome was good.

Byline: Masaraf. Hussain, Shri. Sharma, M. Jamil Introduction: A study of stroke among young adults and children has recently become a subject of interest. This is because it has a [...]

Byline: Shri. Sharma, Masaraf. Hussain, Hibo. Hibong High-voltage electrical injuries are uncommonly reported and may predispose to both immediate and delayed neurologic complications. We present a case of 27-year-old male [...]

Byline: Shri. Sharma, Masaraf. Hussain, Hibu. Habung Background: The nervous system is among the most frequent and serious targets of human immunodeficiency virus (HIV) infection. The infection usually occurs in [...]

Byline: Shri. Sharma, Hibu. Habung, Masaraf. Hussain A 6-year-old Nepali girl presented to us with recurrent intracranial hemorrhage. She had a normal birth history and developmental milestones. She has been [...]

Byline: Shri. Sharma, Arvind. Nongpiur, Masaraf. Hussain, Hibu. Habung Sir, Postictal psychosis occurs in 6-10% of patients, particularly with temporal lobe epilepsy,[sup][1] typically after a cluster of complex partial seizures [...]

Byline: Masaraf. Hussain, S. Sharma, Mesasheba. Rupsi Sir, Symmetrical peripheral gangrene is a rare clinical syndrome characterized by sudden onset of symmetrical distal ischemic changes, leading to gangrene of two [...]

Introduction: Neurological manifestations although common in Systemic Lupus Erythematosus (SLE), are often not recognized due to their diversed and varied presentation. Therefore, the study was planned to highlight the pattern of neurological involvement in SLE to help in early recognition. Aim: To study the pattern of neurological involvement in SLE and its correlation with disease activity and different investigation. Materials and Methods: This hospital based prospective observational study was carried out from August 2009 to July 2010. Diagnosed cases of SLE [based upon American Rheumatism Association (ARA) criteria] who presented with neurological manifestations at the time of diagnosis or develop during the course of the disease were included in the study. They were assessed clinically and investigated with neuroimaging and neurophysiological tests as applicable. Results: In total, 52 consecutive patients with SLE were evaluated, 92% were female. The most common age group was 21 to 25 years. Nervous system involvement was found in 19 (36.54%) patients. Cognitive impairment was the most frequent manifestation, present in 11 (57.89%) patients followed by seizure disorder in eight patients (42.1%). Peripheral neuropathy was diagnosed in eight (42.1%), acute confusional state in six (31.57%) and headache and depression was diagnosed in five (26.31%) patients each. Less common manifestations were psychosis, movement disorder and aseptic meningitis. Percentage of neurological manifestations directly correlated with disease activity. A significant difference was found in Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score between the patients with Neuro Psychiatric Systemic Lupus Erythematosus (NPSLE) and those without NPSLE (32.42±16.34 Vs 17.3±10.6). Conclusion: Neurological involvement in SLE is seen relatively early in the course of the disease with cognitive impairment being the most common manifestation and correlate with disease activity. [ABSTRACT FROM AUTHOR]

Objectives: To study the different clinical manifestations and complications associated with scrub typhus., Methods: A hospital based prospective observational study of patients of acute febrile illness above 18 years age. Diagnosis was based on clinical and serological data., Results: A total of 61 patients were diagnosed with scrub typhus, with males more than females. Most (42.37%) belonged to 18 to 30 years age group. Fever with headache was the commonest presentation (94.91%). Multiorgan dysfunction syndrome was the most common complication (16.94%). The mortality rate was 8.47%., Conclusion: The study reveals the clinical manifestations and complications of a well known mite borne disease in the state of Meghalaya. The varied presentations and high mortality requires a high index of suspicion. The study highlights the clustering of cases during the months of September to November.