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5 results on '"Hutanasu, Catalin"'

1. Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis

Author

Trifan, Anca, Sfarti, Catalin, Cojocariu, Camelia, Dimache, Mihaela, Cretu, Maria, Hutanasu, Catalin, and Stanciu, Carol

Subjects
Transient elastography, Extrahepatic cholestasis, Case Report, Liver stiffness
Abstract

Background Extrahepatic cholestasis that is caused by benign and malignant diseases has been reported to increase liver stiffness (LS), as measured by transient elastography (TE). Objectives The aim of this study was to evaluate LS in patients with extrahepatic cholestasis due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal. Patients and Methods LS was measured by TE (Fibroscan) in patients with extrahepatic cholestasis that was caused by choledocholithiasis before and 1 month after endoscopic sphincterotomy and successful stone removal. Results We studied 12 patients (7 females, 5 males), aged 36 to 76 years (mean age 57.1 ± 11.6 years), with extrahepatic cholestasis that was caused by choledocholithiasis. LS was increased in all patients (range: 6.2-18.4 kPa; mean: 8.9 ± 3.5 kPa) before endoscopic therapy. Successful biliary drainage was effected by sphincterotomy and stone removal in all patients, which led to a significant decline in LS to 3.9-8.1 kPa (Mean: 5.6 ± 1.2 kPa; p < 0.001) within a mean observation time of 29 days. The decrease in LS values correlated significantly with a decline in serum total bilirubin levels (r = 0.691; p < 0.0001). Conclusions Extrahepatic cholestasis due to choledocholithiasis increases LS and should be excluded before assesing liver fibrosis by transient elastography.

Published
2011

4. Prevalence of Gastroparesis in Type 1 Diabetes Mellitus and its Relationship to Dyspeptic Symptoms.

Author

Sfarti, Catalin, Trifan, Anca, Hutanasu, Catalin, Cojocariu, Camelia, Singeap, Ana-Maria, and Stanciu, Carol

Subjects
*DIABETES, *DISEASE prevalence, *OCTANOIC acid, *HELICOBACTER pylori, *GASTRIC emptying
Abstract

Background and Aim: Gastroparesis and/or dyspeptic symptoms occur in around 50% of type 1 diabetic patients. The aim of our study was to evaluate the prevalence of gastroparesis in patients with type 1 diabetes using 13Coctanoic acid breath test (13C-OBT) and the relationship between dyspeptic symptoms and gastric emptying. Methods: Gastric emptying of solids was evaluated prospectively in euglycemic conditions in 69 type 1 diabetic patients (male/female: 36/33; mean age 49.5 ± 14.2 years; mean duration of diabetes 20.4 ± 8.2 years) and 40 healthy volunteers (male/female 17/23; mean age 34.3 ± 16 years) using 13C-OBT. Dyspeptic symptoms, autonomic nerve function and Helicobacter pylori (H. pylori) status were assessed. Results: Solid gastric emptying was slower in diabetic patients (T1/2=125.36 ± 31.5min) than in healthy subjects (T1/2=88.5 ± 27.3 min) (p<0.05). Gastric emptying was slower in diabetic female compared to diabetic male patients (p<0.05). Body mass index (BMI) was the only independent predictor for delayed solid gastric emptying in a logistic regression model testing HbA1c, BMI, age, diabetes duration, H. pylori status, peripheral neuropathy, retinopathy, nephropathy, and autonomic neuropathy. Abdominal bloating and upper abdominal pain were associated with delayed gastric emptying. Conclusions: We found that 33.7% of type 1 diabetic patients had delayed gastric emptying that correlated with female gender, increased BMI, abdominal bloating and upper abdominal pain. [ABSTRACT FROM AUTHOR]

Published
2010

5. Guide-Wire versus Conventional Contrast Cannulation of the Common Bile Duct for the Prevention of Post-ERCP Pancreatitis in Patients with Choledocholithiasis.

Author

Trifan, Anca, Sfarti, Catalin, Cretu, Maria, Cojocariu, Camelia, Hutanasu, Catalin, Singeap, Ana-Maria, Dimache, Mihaela, and Stanciu, Carol

Subjects
*PANCREATIC duct, *CHOLANGIOCARCINOMA, *CATHETERIZATION, *ENDOSCOPIC retrograde cholangiopancreatography, *PANCREATITIS, *THERAPEUTICS, *DIAGNOSIS, *PREVENTION, *DISEASES
Abstract

Background. Inadvertent injection of a contrast agent into the pancreatic duct is an important contributor factor to post-ERCP pancreatitis. Aim. To compare the incidence of post-ERCP pancreatitis and the success rate of biliary cannulation using guide-wire cannulation or the standard contrast injection technique. Methods. A total of 128 patients with choledocholithiasis who underwent either guide-were cannulation (n=70) or contrast injection (n=58) were retrospectively reviewed. Outcome measurements were post-ERCP pancreatitis and rate of successful common bile duct (CBD) cannulation. Results. Three patients (4.3%) in the guide-wire cannulation group and five patients (8.6%) in the contrast injection group had post-ERCP pancreatitis (p>0.05). Successful CBD cannulation was achieved in 91.4% with guide-wire cannulation and in 88% with conventional contrast cannulation (p>0.05). Conclusion. Our study failed to show significant reduction in the rate of post-ERCP pancreatitis with the use of guide-wire, although there was a downward trend. The success rate of cannulation was comparable between the two techniques. [ABSTRACT FROM AUTHOR]

Published
2011

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