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With the advent of the COVID-19 pandemic, the level of concern regarding employee digital competence has increased significantly. Several studies provide different surveys, but they cannot describe the relationship between digital autonomy and innovative work behaviour concerning the impact of employee digital competence. Hence, it is necessary to conduct a survey that provides a deeper understanding of these concerns and suggests a suitable study for other researchers. Using scientific publication databases and adhering to the PRISMA statement, this systematic literature review aims to offer a current overview of employee digital competence impact on the relationship between digital autonomy and innovative work behaviour from 2015 to 2022, covering definitions, research purposes, methodologies, outcomes, and limitations. When reviewing the selected articles, 18 articles were examined under relationship topics, and 12 articles reported on impact topics under different tasks. The main findings highlight the significance of digital competence and autonomy in promoting employee creativity, learning, and sharing knowledge. According to the review findings, employees with greater digital autonomy are more likely to engage in innovative work, leading to improved job performance and empowerment. Therefore, the development of digital autonomy prioritizes organizations by providing access to digital tools, training, and a supportive work environment. Overall, the current review indicates a strong positive correlation between digital autonomy, innovative work behaviour, and employee impact. This underscores the importance for organizations to not only participate in digital competence and skills, but also to create a culture that values autonomy, creativity, and innovation among its employees., Competing Interests: Conflict of interestI declare that the authors have no competing interests as defined by Springer, or other interests that might be perceived to influence the results and/or discussion reported in this paper., (© The Author(s), under exclusive licence to Springer Nature B.V. 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

Background: The protective or pathogenic role of T lymphocytes during the acute phase of dengue virus (DENV) infection has not been fully understood despite its importance in immunity and vaccine development. Objectives: This study aimed to clarify the kinetics of T lymphocyte subsets during the clinical course of acute dengue patients. Study design: In this hospital-based cohort study, 59 eligible Vietnamese dengue patients were recruited and admitted. They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from the hospital. Results: We described for the first time the kinetics of T cell response during the clinical course of DENV infection. Severe cases showed significantly lower levels of effector CD8 + T cells compared to mild cases at day -1 ( p = 0.017) and day 0 ( p = 0.033) of defervescence. After defervescence, these cell counts in severe cases increased rapidly to equalize with the levels of mild cases. Our results also showed a decline in total CD4 + T, Th1, Th1/17 cells during febrile phase of dengue patients compared to normal controls or convalescent phase. On the other hand, Th2 cells increased during DENV infection until convalescent phase. Cytokines such as interferon-γ, IL-12p70, IL-5, IL-23, IL-17A showed tendency to decrease on day 0 and 1 compared with convalescence and only IL-5 showed significance indicating the production during acute phase was not systemic. Conclusion: With a rigorous study design, we uncovered the kinetics of T cells in natural DENV infection. Decreased number of effector CD8 + T cells in the early phase of infection and subsequent increment after defervescence day probably associated with the T cell migration in DENV infection., (Copyright © 2020 Manh, Weiss, Thuong, Mizukami, Dumre, Luong, Thanh, Thang, Huu, Phuc, Nhung, Mai, Truong, Ngu, Quoc, Ha, Ton, An, Halhouli, Quynh, Kamel, Karbwang, Huong, Huy and Hirayama.)