Search

Your search keyword '"Huupponen, R. K."' showing total 11 results
Start Over Author "Huupponen, R. K."
11 results on '"Huupponen, R. K."'

1. EurOP2E – the European open platform for prescribing education, a consensus study among clinical pharmacology and therapeutics teachers

Author

Bakkum, Michiel J., Richir, Milan C., Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, João N., Maciulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Tichelaar, Jelle, van Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I.I., Matanovic, S. Mimica, Vitezic, D., Wozniak, Greta, Kmonickova, E., Urbanek, Karel, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan-Angoulvant, T., Chouchana, Laurent, Cracowski, Jean-Luc, Drici, M. D., Faillie, J. L., Geniaux, Hélène, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y-M, Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko, Jan J., Kocic, I., Breitenfeld, Luiza, Castelo-Branco, M., Conea, Simona, Magyar, Ioan, Bevc, S., Krzan, Mojca, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez-Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, de Waard-Siebinga, I., Janssen, Ben J. A., Knol, Wilma, Pandit, Rahul, van Rosse, F., Dent, G., Ferro, Albert, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Okorie, Michael, Plumb, Richard David, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield, Jonathan P., Wilson, Kurt, Bakkum M.J., Richir M.C., Papaioannidou P., Likic R., Sanz E.J., Christiaens T., Costa J.N., Maciulaitis R., Dima L., Coleman J., Tichelaar J., van Agtmael M.A., Atanasova I., Ganeva M., Gatchev E., Kostadinova I.I., Matanovic S.M., Vitezic D., Wozniak G., Kmonickova E., Urbanek K., Damkier P., Huupponen R.K., Auffret M., Bejan-Angoulvant T., Chouchana L., Cracowski J.-L., Drici M.D., Faillie J.L., Geniaux H., Molimard M., Orlikowski D., Palin K., Pers Y.-M., Picard N., Simon N., Toussirot E., Boger R.H., Cascorbi I., Mueller S.C., Regenthal R., Schwab M., Schwaninger M.S., Thuermann P.A., Wojnowski L., Kouvelas D., Riba P., Kerins D.M., Williams D.J., Cosentino M., De Ponti F., Filippelli A., Leone R., Locatelli V., Jansone B., Gulbinovic R., Mifsud J., Braszko J.J., Kocic I., Breitenfeld L., Castelo-Branco M., Conea S., Magyar I., Bevc S., Krzan M., Bernal M.L., Capella D., Carcas A., De Abajo F.J., Lopez-Rico M., Lucena M.I., Pontes C., Bottiger Y., Le Greves M., de Waard-Siebinga I., Janssen B.J.A., Knol W., Pandit R., van Rosse F., Dent G., Ferro A., Hitchings A.W., Kapil V., Linton K.D., Loke Y.K., Okorie M., Plumb R.D., Pontefract S., Ranmuthu S., Sampson A.P., Thanacoody H.K.R., Whitfield J.P., Wilson K., Internal medicine, Other Research, CCA - Cancer Treatment and quality of life, Bakkum, M, Richir, M, Papaioannidou, P, Likic, R, Sanz, E, Christiaens, T, Costa, J, Mačiulaitis, R, Dima, L, Coleman, J, Tichelaar, J, van Agtmael, M, and Locatelli, V

Subjects
Medical education, Open platform, Quality management, Pharmacoepidemiology and Prescription, Teaching Materials, media_common.quotation_subject, Language barrier, 030226 pharmacology & pharmacy, Open educational resources, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Political science, Copyright, ComputingMilieux_COMPUTERSANDEDUCATION, Humans, Pharmacology (medical), Quality (business), Cooperative Behavior, Adaptation (computer science), Schools, Medical, media_common, Pharmacology, Clinical pharmacology, 05 social sciences, Open educational resource, 050301 education, General Medicine, Quality Improvement, Clinical pharmacology and therapeutic, Europe, Digital education, Educational resources, Pharmacology, Clinical, clinical pharmacology and therapeutics, digital education, medical education, open educational resources, 0503 education, Clinical pharmacology and therapeutics, Human
Abstract

Purpose Sharing and developing digital educational resources and open educational resources has been proposed as a way to harmonize and improve clinical pharmacology and therapeutics (CPT) education in European medical schools. Previous research, however, has shown that there are barriers to the adoption and implementation of open educational resources. The aim of this study was to determine perceived opportunities and barriers to the use and creation of open educational resources among European CPT teachers and possible solutions for these barriers. Methods CPT teachers of British and EU medical schools completed an online survey. Opportunities and challenges were identified by thematic analyses and subsequently discussed in an international consensus meeting. Results Data from 99 CPT teachers from 95 medical schools were analysed. Thirty teachers (30.3%) shared or collaboratively produced digital educational resources. All teachers foresaw opportunities in the more active use of open educational resources, including improving the quality of their teaching. The challenges reported were language barriers, local differences, lack of time, technological issues, difficulties with quality management, and copyright restrictions. Practical solutions for these challenges were discussed and include a peer review system, clear indexing, and use of copyright licenses that permit adaptation of resources. Conclusion Key challenges to making greater use of CPT open educational resources are a limited applicability of such resources due to language and local differences and quality concerns. These challenges may be resolved by relatively simple measures, such as allowing adaptation and translation of resources and a peer review system.

Published
2021
Full Text
View/download PDF

3. Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics

Author

Bakkum, Michiel J., Tichelaar, Jelle, Papaioannidou, Paraskevi, Likic, Robert, Sanz Alvarez, Emilio J., Christiaens, Thierry, Costa, João N., Mačiulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Richir, Milan C., Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I. I., Mimica Matanovic, S., Vitezic, D, Greta, Wozniak, Kmonickova, E., Karel, Urbanek, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan‐ Angoulvant, T., Laurent, Chouchana, Jean‐Luc, Cracowski, Drici, M. D., Faillie, J. L., Hélène, Geniaux, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y.‐M., Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko Jan, J., Kocic, I., Luiza, Breitenfeld, Castelo‐Branco, M., Simona, Conea, Ioan, Magyar, Bevc, S., Mojca, Krzan, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez‐Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, Waard‐Siebinga, I., Janssen Ben, J. A., Wilma, Knol, Rahul, Pandit, Rosse, F., Dent, G., Albert, Ferro, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Michael, Okorie, David, Plumb Richard, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield Jonathan, P., Wilson, Kurt, for the Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP), Bakkum, M, Tichelaar, J, Papaioannidou, P, Likic, R, Sanz Alvarez, E, Christiaens, T, Costa, J, Mačiulaitis, R, Dima, L, Coleman, J, Richir, M, van Agtmael, M, Locatelli, V, Internal medicine, Other Research, Bakkum M.J., Tichelaar J., Papaioannidou P., Likic R., Sanz Alvarez E.J., Christiaens T., Costa J.N., Maciulaitis R., Dima L., Coleman J., Richir M.C., van Agtmael M.A., Atanasova I., Ganeva M., Gatchev E., Kostadinova I.I., Mimica Matanovic S., Vitezic D., Greta W., Kmonickova E., Karel U., Damkier P., Huupponen R.K., Auffret M., Bejan-Angoulvant T., Laurent C., Jean-Luc C., Drici M.D., Faillie J.L., Helene G., Molimard M., Orlikowski D., Palin K., Pers Y.-M., Picard N., Simon N., Toussirot E., Boger R.H., Cascorbi I., Mueller S.C., Regenthal R., Schwab M., Schwaninger M.S., Thuermann P.A., Wojnowski L., Kouvelas D., Riba P., Kerins D.M., Williams D.J., Cosentino M., De Ponti F., Filippelli A., Leone R., Locatelli V., Jansone B., Gulbinovic R., Mifsud J., Braszko Jan J., Kocic I., Luiza B., Castelo-Branco M., Simona C., Ioan M., Bevc S., Mojca K., Bernal M.L., Capella D., Carcas A., De Abajo F.J., Lopez-Rico M., Lucena M.I., Pontes C., Bottiger Y., Le Greves M., de Waard-Siebinga I., Janssen Ben J.A., Wilma K., Rahul P., van Rosse F., Dent G., Albert F., Hitchings A.W., Kapil V., Linton K.D., Loke Y.K., Michael O., David P.R., Pontefract S., Ranmuthu S., Sampson A.P., Thanacoody H.K.R., Whitfield Jonathan P., and Wilson K.

Subjects
Computer-Assisted Instruction, Harmonization, 030226 pharmacology & pharmacy, law.invention, open educational resource, 03 medical and health sciences, 0302 clinical medicine, Medicaments -- Prescripció, law, clinical pharmacology and therapeutic, Humans, Learning, Pharmacology (medical), Narrative, 030212 general & internal medicine, Curriculum, Schools, Medical, Cross-Sectional Studie, Pharmacology, education, Medical education, Prescribing, clinical pharmacology and therapeutics, digital, open educational resources, Clinical pharmacology, Drugs -- Prescribing, Principal (computer security), Open educational resources, Variety (cybernetics), Cross-Sectional Studies, Pharmacology, Clinical, Psychology, Human
Abstract

CONTRIBUTORS IN THE NETWORK OF TEACHERS IN PHARMACOTHERAPY (NOTIP) (ALPHABETIZED BY COUNTRY): Atanasova, Ivanka (Sofia University St. Kliment Ohridski, Sofia, Bulgaria); Ganeva, Maria (Trakia University, Stara Zagora, Bulgaria); Gatchev, Emil (Medical University of Sofia, Sofia, Bulgaria); Kostadinova, II (Medical University Plovdiv, Plovdiv, Bulgaria); Mimica Matanovic, S (University of Osijek, Osijek, Croatia); Vitezic, D (University of Rijeka Medical School, Rijeka, Croatia); Wozniak, Greta (University of Cyprus, Nicosia, Cyprus); Kmonickova, E (Charles University, Pilsen, Czech Republic); Urbanek, Karel (Palacky University, Olomouc, Czech Republic); Damkier, P (University of Southern Denmark, Odense, Denmark); Huupponen, RK (University of Turku, Turku, Finland); Auffret, Marine (Hospices civils de Lyon, Lyon, France); Bejan-Angoulvant, T (Université de Tours, Tours, France); Chouchana, Laurent (Hospital Cochin, Paris, France); Cracowski, Jean-Luc (University Grenoble Alpes, La Tronche, France); Drici, MD (University of Nice Côte d'Azur, Nice, France); Faillie, JL (CHU Montpellier, Montpellier, France); Geniaux, Hélène (CHU de Limoges, Limoges, France); Molimard, M (Université de Bordeaux, Bordeaux, France); Orlikowski, D (Versailles Saint-Quentin-en-Yvelines University, Versailles, France); Palin, Karine (University of Bordeaux, Bordeaux, France); Pers, Y-M (CHU Montpellier, Montpellier, France); Picard, Nicolas (CHU de Limoges, Limoges, France); Simon, N (Aix-Marseille University, Marseille, France); Toussirot, E (CHU de Besancon, Besancon, France); Boger, RH (University Medical Center Hamburg-Eppendorf, Hamburg, Germany); Cascorbi, I (University of Kiel, Kiel, Germany); Mueller, SC (University Medicine Rostock, Rostock, Germany); Regenthal, R (University of Leipzig, Leipzig, Germany); Schwab, M (Eberhard Karl University of Tübingen, Tübingen, Germany); Schwaninger, MS (University of Luebeck, Luebeck, Germany); Thuermann, PA (University Witten/Herdecke, Witten, Germany); Wojnowski, L (University Medical Center Mainz, Mainz, Germany); Kouvelas, D (Aristotle University of Thessaloniki, Thessaloniki, Greece); Riba, P (Semmelweis University, Budapest, Hungary); Kerins, David M (University College, Cork, Ireland); Williams, David J (Royal College of Surgeons in Ireland, Dublin, Ireland); Cosentino, M (University of Insubria, Varese, Italy); De Ponti, Fabrizio (University of Bologna, Bologna, Italy); Filippelli, Amelia (University of Salerno, Baronissi, Italy); Leone, R (University of Verona, Verona, Italy); Locatelli, Vittorio (University of Milano - Bicocca, Monza, Italy); Jansone, Baiba (University of Latvia, Riga, Latvia); Gulbinovic, Romaldas (Vilnius University, Vilnius, Lithuania); Mifsud, Janet (University of Malta, Msida, Malta); Braszko, Jan J (Medical University of Bialystok, Bialystok, Poland); kocic, I (Medical University of Gdansk, Gdansk, Poland); Breitenfeld, Luiza (Beira Interior University, Covilh~a, Portugal); Castelo-Branco, M (University of Beira Interior, Covilh~a, Portugal); Conea, Simona (“Vasile Goldis” Western University of Arad, Arad, Romania); Magyar, Ioan (University of Oradea, Oradea, Romania); Bevc, S (University of Maribor, Maribor, Slovenia); Krzan, Mojca (University of Ljubljana, Ljubljana, Slovenia); Bernal, ML (University of Zaragoza, Zaragoza, Spain); Capellà, D (University of Girona, Girona, Spain); Carcas, A (Universidad Autónoma de Madrid, University of Maribor, Spain); De Abajo, FJ (University of Alcalá, Alcalá de Henares, Spain); Lopez-Rico, M (University of Salamanca, Salamanca, Spain); Lucena, MI (University of Malaga, Malaga, Spain); Pontes, C (Universitat Autonoma de Barcelona, Sabadell, Spain); Sanz, EJ (Universidad de La Laguna, La Laguna, Spain); Böttiger, Y (Linköping University, Linköping, Sweden); Le Grevès, Madeleine (Uppsala University, Uppsala, Sweden); de Waard-Siebinga, I (University Medical Center Groningen, Groningen, The Netherlands); Janssen, Ben JA (Maastricht University, Maastricht, The Netherlands); Knol, Wilma (University Medical Center Utrecht, Utrecht, The Netherlands); Pandit, Rahul (University Medical Center Utrecht, Utrecht, The Netherlands); van Rosse, F (Erasmus Medical Center, Rotterdam, The Netherlands); Dent, G (Keele University, Keele, United Kingdom); Ferro, Albert (King's College London, London, United Kingdom); Hitchings, AW (St George's, University of London, London, United Kingdom); Kapil, V (Queen Mary University London, London, United Kingdom); Linton, KD (University of Sheffield, Sheffield, United Kingdom); Loke, YK (University of East Anglia, Norwich, United Kingdom); Okorie, Michael (Brighton and Sussex Medical School, Brighton, United Kingdom); Plumb, Richard David (Queen's University Belfast, Belfast, United Kingdom); Pontefract, Sarah (University of Birmingham, Birmingham, United Kingdom); Ranmuthu, S (Queen Mary University London, London, United Kingdom); Sampson, AP (University of Southampton, Southampton, United Kingdom); Thanacoody, HKR (Newcastle University, Newcastle upon Tyne, United Kingdom); Whitfield, Jonathan P (University of Aberdeen, Aberdeen, United Kingdom); Wilson, Kurt (University of Manchester, Manchester, United Kingdom) Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational resources can be easily shared, adapted to local situations and re‐used widely across a variety of educational systems, they may be ideally suited for this purpose Methods With a cross‐sectional survey among principal CPT teachers in 279 out of 304 European medical schools, an overview and classification of digital resources was compiled. Results Teachers from 95 (34%) medical schools in 26 of 28 EU countries responded, 66 (70%) of whom used digital educational resources in their CPT curriculum. A total of 89 of such resources were described in detail, including e‐learning (24%), simulators to teach pharmacokinetics and/or pharmacodynamics (10%), virtual patients (8%), and serious games (5%). Together, these resources covered 235 knowledge‐based learning objectives, 88 skills, and 13 attitudes. Only one third (27) of the resources were in‐part or totally free and only two were licensed open educational resources (free to use, distribute and adapt). A narrative overview of the largest, free and most novel resources is given. Conclusion Digital educational resources, ranging from e‐learning to virtual patients and games, are widely used for CPT education in EU medical schools. Learning objectives are based largely on knowledge rather than skills or attitudes. This may be improved by including more real‐life clinical case scenarios. Moreover, the majority of resources are neither free nor open. Therefore, with a view to harmonizing international CPT education, more needs to be learned about why CPT teachers are not currently sharing their educational materials.

Published
2020
Full Text
View/download PDF

5. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Author

Kilpelainen, TO, Carli, J F M, Skowronski, A A, Sun, Q, Kriebel, J, Feitosa, MF, Hedman, AK, Drong, AW, Hayes, J E, Zhao, JH, Pers, TH, Schick, U, Grarup, N, Kutalik, Z, Trompet, S, Mangino, M, Kristiansson, K, Beekman, M, Lyytikainen, LP, Eriksson, J, Henneman, Peter, Lahti, J, Tanaka, T, Luan, JA, Del Greco, F, Pasko, D, Renstrom, F, Willems, SM, Mahajan, A, Rose, LM, Guo, XQ, Liu, YM, Kleber, ME, Perusse, L, Gaunt, T, Ahluwalia, TS, Sung, YJ, Ramos, YF, Amin, Najaf, Amuzu, A, Barroso, I, Bellis, C, Blangero, J, Buckley, BM, Bohringer, S, Chen, YDI, de Craen, A J N, Crosslin, DR, Dale, CE, Dastani, Z, Day, FR, Deelen, J, Delgado, GE, Demirkan, Ayse, Finucane, FM, Ford, I, Garcia, ME, Gieger, C, Gustafsson, S, Hallmans, G, Hankinson, SE, Havulinna, AS, Herder, Cindy, Hernandez, D, Hicks, AA, Hunter, DJ, Illig, T, Ingelsson, E, Ioan-Facsinay, A, Jansson, JO, Jenny, NS, Jorgensen, ME, Jorgensen, T, Karlsson, M, Koenig, W, Kraft, P, Kwekkeboom, J, Laatikainen, T, Ladwig, KH, LeDuc, C A, Lowe, G, Lu, YC, Marques-Vidal, P, Meisinger, C, Menni, C, Morris, AP, Myers, RH, Mannisto, S, Nalls, MA, Paternoster, L, Peters, A, Pradhan, A D, Rankinen, T, Rasmussen-Torvik, LJ, Rathmann, W, Rice, TK, Richards, JB, Ridker, PM, Sattar, N, Savage, DB, Soderberg, S, Timpson, NJ, Vandenput, L, van Heemst, D, Uh, HW, Vohl, MC, Walker, M, Wichmann, HE, Widen, E, Wood, AR, Yao, J, Zeller, T, Zhang, YY, Meulenbelt, I, Kloppenburg, M, Astrup, A, Sorensen, TIA, Sarzynski, MA, Rao, DC, Jousilahti, P, Vartiainen, E, Hofman, Bert, Rivadeneira, Fernando, Uitterlinden, André, Kajantie, E, Osmond, C, Palotie, A, Eriksson, JG, Heliovaara, M, Knekt, PB, Koskinen, S, Jula, A, Perola, M, Huupponen, R K, Viikari, JS, Kahonen, M, Lehtimaki, T, Raitakari, OT, Mellstrom, D, Lorentzon, M, Casas, JP, Bandinelli, S, Marz, W, Isaacs, Aaron, van Dijk, KW, Duijn, Cornelia, Harris, TB, Bouchard, C, Allison, MA, Chasman, DI, Ohlsson, C, Lind, L, Scott, RA, Langenberg, C, Wareham, NJ, Ferrucci, L, Frayling, TM, Pramstaller, PP, Borecki, IB, Waterworth, DM, Bergmann, S, Waeber, G, Vollenweider, P, Vestergaard, H, Hansen, T, Pedersen, O, Hu, FB, Slagboom, PE (Eline), Grallert, H, Spector, TD, Jukema, JW, Klein, RJ, Schadt, EE, Franks, PW, Lindgren, CM, Leibel, R L, Loos, RJF, Kilpelainen, TO, Carli, J F M, Skowronski, A A, Sun, Q, Kriebel, J, Feitosa, MF, Hedman, AK, Drong, AW, Hayes, J E, Zhao, JH, Pers, TH, Schick, U, Grarup, N, Kutalik, Z, Trompet, S, Mangino, M, Kristiansson, K, Beekman, M, Lyytikainen, LP, Eriksson, J, Henneman, Peter, Lahti, J, Tanaka, T, Luan, JA, Del Greco, F, Pasko, D, Renstrom, F, Willems, SM, Mahajan, A, Rose, LM, Guo, XQ, Liu, YM, Kleber, ME, Perusse, L, Gaunt, T, Ahluwalia, TS, Sung, YJ, Ramos, YF, Amin, Najaf, Amuzu, A, Barroso, I, Bellis, C, Blangero, J, Buckley, BM, Bohringer, S, Chen, YDI, de Craen, A J N, Crosslin, DR, Dale, CE, Dastani, Z, Day, FR, Deelen, J, Delgado, GE, Demirkan, Ayse, Finucane, FM, Ford, I, Garcia, ME, Gieger, C, Gustafsson, S, Hallmans, G, Hankinson, SE, Havulinna, AS, Herder, Cindy, Hernandez, D, Hicks, AA, Hunter, DJ, Illig, T, Ingelsson, E, Ioan-Facsinay, A, Jansson, JO, Jenny, NS, Jorgensen, ME, Jorgensen, T, Karlsson, M, Koenig, W, Kraft, P, Kwekkeboom, J, Laatikainen, T, Ladwig, KH, LeDuc, C A, Lowe, G, Lu, YC, Marques-Vidal, P, Meisinger, C, Menni, C, Morris, AP, Myers, RH, Mannisto, S, Nalls, MA, Paternoster, L, Peters, A, Pradhan, A D, Rankinen, T, Rasmussen-Torvik, LJ, Rathmann, W, Rice, TK, Richards, JB, Ridker, PM, Sattar, N, Savage, DB, Soderberg, S, Timpson, NJ, Vandenput, L, van Heemst, D, Uh, HW, Vohl, MC, Walker, M, Wichmann, HE, Widen, E, Wood, AR, Yao, J, Zeller, T, Zhang, YY, Meulenbelt, I, Kloppenburg, M, Astrup, A, Sorensen, TIA, Sarzynski, MA, Rao, DC, Jousilahti, P, Vartiainen, E, Hofman, Bert, Rivadeneira, Fernando, Uitterlinden, André, Kajantie, E, Osmond, C, Palotie, A, Eriksson, JG, Heliovaara, M, Knekt, PB, Koskinen, S, Jula, A, Perola, M, Huupponen, R K, Viikari, JS, Kahonen, M, Lehtimaki, T, Raitakari, OT, Mellstrom, D, Lorentzon, M, Casas, JP, Bandinelli, S, Marz, W, Isaacs, Aaron, van Dijk, KW, Duijn, Cornelia, Harris, TB, Bouchard, C, Allison, MA, Chasman, DI, Ohlsson, C, Lind, L, Scott, RA, Langenberg, C, Wareham, NJ, Ferrucci, L, Frayling, TM, Pramstaller, PP, Borecki, IB, Waterworth, DM, Bergmann, S, Waeber, G, Vollenweider, P, Vestergaard, H, Hansen, T, Pedersen, O, Hu, FB, Slagboom, PE (Eline), Grallert, H, Spector, TD, Jukema, JW, Klein, RJ, Schadt, EE, Franks, PW, Lindgren, CM, Leibel, R L, and Loos, RJF

Published
2016

10. The effects of glycopyrrolate on oral mucous host defenses in healthy volunteers.

Author

Lähteenmäki MT, Salo MS, Tenovuo JO, Helminen AV, Vilja PJ, and Huupponen RK

Subjects
Adjuvants, Anesthesia administration & dosage, Adult, Amylases analysis, Cross-Over Studies, Double-Blind Method, Glycopyrrolate administration & dosage, Humans, Immunoglobulins analysis, Injections, Intravenous, Lactoferrin analysis, Male, Mouth Mucosa drug effects, Muramidase analysis, Peroxidase analysis, Saliva chemistry, Saliva immunology, Saliva metabolism, Salivary Proteins and Peptides analysis, Thiocyanates analysis, Adjuvants, Anesthesia pharmacology, Glycopyrrolate pharmacology, Mouth Mucosa immunology, Saliva drug effects
Abstract

Unlabelled: We studied the effects of glycopyrrolate on oral mucous host defenses. Single IV doses of glycopyrrolate (4 microg/kg) or placebo were administered to 12 healthy volunteers in a randomized, double-blinded, cross-over study. Salivary flow rates and the concentrations/activities of total protein, amylase, and nonimmunologic (lysozyme, lactoferrin, myeloperoxidase, total salivary peroxidase, and thiocyanate) and immunologic (total immunoglobulin A, immunoglobulin G, and immunoglobulin M) mucous host defense factors were determined for paraffin-stimulated whole saliva before and 1, 3, 6, 12, 24, and 48 h after drug administration. Glycopyrrolate serum concentrations were determined before and 2, 4, 6, 10, 15, and 30 min and 1, 2, 3, 6, 12, and 24 h after IV drug injection. Salivary flow rates were decreased significantly for 12 h after glycopyrrolate injection, compared with saline injection. The concentrations of immunologic and nonimmunologic defense factors were increased in the glycopyrrolate group, and differences between the groups were found for all factors (P < 0.05-0.001) except lysozyme and total salivary peroxidase. In contrast, because of the reduced flow rate, the output of all defense factors into the saliva was decreased after glycopyrrolate injection, compared with saline injection. Glycopyrrolate thus decreases the output of salivary host defense factors into the oral cavity., Implications: Glycopyrrolate induces long-lasting hyposalivation and decreases the secretion of salivary immunologic and nonimmunologic defense factors in healthy volunteers.

Published
2000
Full Text
View/download PDF

11. Ethanol and the absorption of oral penicillin in man.

Author

Lindberg RL, Huupponen RK, Viljanen S, and Pihlajamäki KK

Subjects
Administration, Oral, Adult, Chromatography, High Pressure Liquid, Drug Interactions, Ethanol administration & dosage, Female, Half-Life, Humans, Male, Penicillin V blood, Penicillin V urine, Ethanol pharmacology, Penicillin V pharmacokinetics
Abstract

The effect of alcohol on the pharmacokinetics of phenoxymethylpenicillin was studied in six healthy volunteers. Ethanol had no influence on peak penicillin serum concentrations, times of the penicillin peaks, elimination half-lives (t1/2), AUC0-8h values and 24-h urinary excretion.

Published
1987

Catalog

Books, media, physical & digital resources
See catalog results