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305 results on '"Hwang, Eung‐Soo"'

1. Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea

Author

Kim, Byung-Joon, primary, Shin, Jun-Seop, additional, Min, Byoung-Hoon, additional, Kim, Jong-Min, additional, Park, Chung-Gyu, additional, Kang, Hee-Jung, additional, Hwang, Eung Soo, additional, Lee, Won-Woo, additional, Kim, Jung-Sik, additional, Kim, Hyun Je, additional, Kwon, Iov, additional, Kim, Jae Sung, additional, Kim, Geun Soo, additional, Moon, Joonho, additional, Shin, Du Yeon, additional, Cho, Bumrae, additional, Yang, Heung-Mo, additional, Kim, Sung Joo, additional, and Kim, Kwang-Won, additional

Published
2024
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7. Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015

Author

Kim, Yeon-Sook, Aigerim, Abdimadiyeva, Park, Uni, Kim, Yuri, Rhee, Ji-Young, Choi, Jae-Phil, Park, Wan Beom, Park, Sang Won, Kim, Yeonjae, Lim, Dong-Gyun, Inn, Kyung-Soo, Hwang, Eung-Soo, Choi, Myung-Sik, Shin, Hyoung-Shik, and Cho, Nam-Hyuk

Subjects
Virulence (Microbiology) -- Analysis, Medical research -- Analysis, Middle East respiratory syndrome -- Genetic aspects -- Analysis, Epidemiology -- Analysis, Antigens, Travelers, Health
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging zoonotic pathogen that causes an acute and fatal respiratory disease (1). The viral pathogen was first identified in September 2012 [...]

Published
2019
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9. Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications

Author

Liu, Wing Kam, Adnan, Ashfaq, Kopacz, Adrian M., Hallikainen, Michelle, Ho, Dean, Lam, Robert, Lee, Jessica, Belytschko, Ted, Schatz, George, Tzeng, Yonhua, Kim, Young-Jin, Baik, Seunghyun, Kim, Moon Ki, Kim, Taesung, Lee, Junghoon, Hwang, Eung-Soo, Im, Seyoung, Ōsawa, Eiji, Barnard, Amanda, Chang, Huan-Cheng, Chang, Chia-Ching, Oñate, Eugenio, and Ho, Dean, editor

Published
2010
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12. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

Author

Kim, Mee Kum, Choi, Hyuk Jin, Kwon, Ivo, Pierson, Richard N., III, Cooper, David K. C., Soulillou, Jean-Paul, OʼConnell, Philip J., Vabres, Bertrand, Maeda, Naoyuki, Hara, Hidetaka, Scobie, Linda, Gianello, Pierre, Takeuchi, Yasuhiro, Yamada, Kazuhiko, Hwang, Eung-Soo, Kim, Sang Joon, and Park, Chung-Gyu

Published
2014
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19. Reactive oxygen species‐induced parthanatos of immunocytes by human cytomegalovirus‐associated substance

Author

Kim, Jung Heon, Kim, Jiyeon, Roh, Jin, Park, Chan‐Sik, Seoh, Ju‐Young, and Hwang, Eung‐Soo

Subjects
CD4-Positive T-Lymphocytes, THP-1 Cells, Cytomegalovirus, Cell Line, Jurkat Cells, Mice, Viral Proteins, parthanatos, Virology, Leukocytes, Animals, Humans, Intestine, Large, Immune Evasion, reactive oxygen species, Mice, Knockout, Cell Death, Caspase 3, Apoptosis Inducing Factor, Original Articles, Mice, Inbred C57BL, Oxidative Stress, human cytomegalovirus, Original Article, Female, Poly(ADP-ribose) Polymerases, DNA Damage
Abstract

Previous studies have examined various immune evasion strategies of human cytomegalovirus (HCMV) to gain understanding of its pathogenesis. Although the mechanism that underlies immunocyte destruction near HCMV‐infected lesions has yet to be established, it is here shown that substances produced by HCMV‐infected cells induce death in several types of immunocytes, but not in fibroblasts or astrocytomas. These substances contain HCMV proteins and were termed HCMV‐associated insoluble substance (HCMVAIS). The mechanism by which HCMVAIS induces cell death was characterized to improve understanding the death of immunocytes near HCMV‐infected lesions. HCMVAIS were found to trigger production of intracellular nicotinamide adenine dinucleotide phosphate oxidase‐derived reactive oxygen species (ROS), resulting in cell death, this effect being reversed following treatment with ROS inhibitors. Cell death was not induced in splenocytes from NOX‐2 knockout mice. It was hypothesized that DNA damage induced by oxidative stress initiates poly ADP‐ribose polymerase‐1 (PARP‐1)‐mediated cell death, or parthanatos. HCMVAIS‐induced cell death is accompanied by PARP‐1 activation in a caspase‐independent manner, nuclear translocation of apoptosis‐inducing factor (AIF), and DNA fragmentation, which are typical features of parthanatos. Treatment with an AIF inhibitor decreased the rate of HCMVAIS‐induced cell death, this being confirmed by hematoxylin and eosin staining; cell death in most HCMV‐positive foci in serial section samples of a large intestine with HCMV infection was TUNEL‐positive, cleaved caspase 3‐negative and CD45‐positive. Taken together, these data suggest that HCMV inhibits local immune responses via direct killing of immunocytes near HCMV‐infected cells through ROS‐induced parthanatos by HCMVAIS.

Published
2018

24. Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications

Author

Liu, Wing Kam, primary, Adnan, Ashfaq, additional, Kopacz, Adrian M., additional, Hallikainen, Michelle, additional, Ho, Dean, additional, Lam, Robert, additional, Lee, Jessica, additional, Belytschko, Ted, additional, Schatz, George, additional, Tzeng, Yonhua, additional, Kim, Young-Jin, additional, Baik, Seunghyun, additional, Kim, Moon Ki, additional, Kim, Taesung, additional, Lee, Junghoon, additional, Hwang, Eung-Soo, additional, Im, Seyoung, additional, Ōsawa, Eiji, additional, Barnard, Amanda, additional, Chang, Huan-Cheng, additional, Chang, Chia-Ching, additional, and Oñate, Eugenio, additional

Published
2009
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41. Klassevirus infection in children, South Korea

Author

Han, Tae-Hee, Kim, Cheol-Hwan, Chung, Ju-Young, Park, Sang-Hun, and Hwang, Eung-Soo

Subjects
Picornaviruses -- Research -- Health aspects -- Genetic aspects, Gastroenteritis -- Research -- Risk factors -- Genetic aspects, Health
Abstract

Identification of new picornaviruses (family Picornaviridae) in fecal samples has increased because of new molecular methods (1,2), but clinical significance is not clear. The genus Kobuvirus belongs to the family [...]

Published
2010
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42. Human bocavirus 2 in children, South Korea

Author

Han, Tae-Hee, Chung, Ju-Young, and Hwang, Eung-Soo

Subjects
Parvoviruses -- Health aspects, Parvoviruses -- Genetic aspects, Parvoviruses -- Research, Prevalence studies (Epidemiology) -- Usage, Prevalence studies (Epidemiology) -- Methods, Respiratory tract infections -- Risk factors, Respiratory tract infections -- Care and treatment, Respiratory tract infections -- Research
Abstract

To the Editor: In 2009, Kapoor et al. and Arthur et al. published reports on the prevalence of the newly identified parvovirus, human bocavirus 2 (HBoV-2), in fecal samples (1,2). [...]

Published
2009
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43. Three-year outcome of rapid HIV testing at public health centers in Seoul, Republic of Korea: a short report.

Author

Yang, Hye-Jin, Kim, Jungmee, Bang, Ji Hwan, Kang, Cho Ryork, Cho, Sung-Il, Oh, Myoung-don, Hwang, Eung Soo, and Lee, Jong-Koo

Subjects
HIV infections, EVALUATION of medical care, PUBLIC health administration, MEDICAL screening, PRIMARY health care, AIDS serodiagnosis, ENZYME-linked immunosorbent assay
Abstract

Before 2014, the only test used for anonymous voluntary human immunodeficiency virus (HIV) screening at public health centers (PHCs) in the Republic of Korea was an enzyme-linked immunosorbent assay (ELISA), which takes around 3 days to obtain results. In 2014, to encourage voluntary anonymous HIV screening tests, the Seoul Metropolitan Government adopted a rapid HIV screening test at PHCs. The rapid HIV screening test was introduced at four PHCs in 2014 and all 25 PHCs after 2015. We compared the numbers of HIV screening tests and confirmed positive individuals before and after introduction of the rapid HIV screening test. In 2012–2013, before the introduction of rapid HIV screening test, an average of 330 HIV screening tests were performed monthly (355 in 2012 and 305 in 2013) and 69 individuals were confirmed to have HIV in 2012 and 93 in 2013. After the introduction of the rapid HIV screening test, anonymous voluntary HIV screening increased to a monthly average of 447 tests in 2014, 2099 in 2015, and 2409 in 2016. These identified 38 new cases in 2014, 116 in 2015, and 143 in 2016. Adoption of the rapid HIV screening test has increased the number of HIV screening tests and confirmed cases. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Long‐term porcine islet graft survival in diabetic non‐human primates treated with clinically available immunosuppressants.

Author

Kim, Jong‐Min, Hong, So‐Hee, Chung, Hyunwoo, Shin, Jun‐Seop, Min, Byoung‐Hoon, Kim, Hyun Je, Kim, Jiyeon, Hwang, Eung Soo, Kang, Hee‐Jung, Ha, Jongwon, and Park, Chung‐Gyu

Subjects
TYPE 1 diabetes, IMMUNOSUPPRESSIVE agents, PRIMATES, ISLANDS of Langerhans, CIRCOVIRUS diseases, GRAFT survival
Abstract

Background: Although pancreatic islet transplantation is becoming an effective therapeutic option for patients with type 1 diabetes (T1D) who suffer from a substantially impaired awareness of hypoglycemia, its application is limited due to the lack of donors. Thus, pig‐to‐human islet xenotransplantation has been regarded as a promising alternative due to the unlimited number of "donor organs." Long‐term xenogeneic islet graft survival in pig‐to‐non‐human primate (NHP) models has mainly been achieved by administering the anti‐CD154 mAb‐based immunosuppressant regimen. Since the anti‐CD154 mAb treatment has been associated with unexpected fatal thromboembolic complications in clinical trials, the establishment of a new immunosuppressant regimen that is able to be directly applied in clinical trials is an urgent need. Methods: We assessed an immunosuppressant regimen composed of clinically available agents at porcine islet transplantation in consecutive diabetic NHPs. Results: Porcine islet graft survival in consecutive diabetic NHPs (n = 7; >222, >200, 181, 89, 62, 55, and 34 days) without severe adverse events. Conclusion: We believe that our study could contribute greatly to the initiation of islet xenotransplantation clinical trials. [ABSTRACT FROM AUTHOR]

Published
2021
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45. WU polyomavirus in children with acute lower respiratory tract infections, South Korea

Author

Han, Tae Hee, Chung, Ju-Young, Koo, Ja Wook, Kim, Sang Woo, and Hwang, Eung-Soo

Subjects
Respiratory tract diseases -- Health aspects, Infection -- Health aspects
Abstract

In South Korea, WU polyomavirus (WUPyV) was detected in 34 (7%) of 486 children with acute lower respiratory tract infections, 3 (4.2%) of 72 asymptomatic children, and as coinfection with [...]

Published
2007

46. Small Anellovirus infections in Korean children

Author

Chung, Ju-Young, Han, Tae Hee, Koo, Ja Wook, Kim, Sang Woo, Seo, Jeong Kee, and Hwang, Eung Soo

Abstract

To the Editor: Recently, Jones et al. (1) identified circular DNA sequences, classified as Anellovirus genus, in plasma from patients with acute viral infection syndromes. These anelloviruses were then labeled [...]

Published
2007

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