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114 results on '"Hyde, Derek"'

1. Should organs at risk (OARs) be prioritized over target volume coverage in stereotactic ablative radiotherapy (SABR) for oligometastases? a secondary analysis of the population-based phase II SABR-5 trial

Author

Eufemon Cereno, Reno, Mou, Benjamin, Baker, Sarah, Chng, Nick, Arbour, Gregory, Bergman, Alanah, Liu, Mitchell, Schellenberg, Devin, Matthews, Quinn, Huang, Vicky, Mestrovic, Ante, Hyde, Derek, Alexander, Abraham, Carolan, Hannah, Hsu, Fred, Miller, Stacy, Atrchian, Siavash, Chan, Elisa, Ho, Clement, Mohamed, Islam, Lin, Angela, Berrang, Tanya, Bang, Andrew, Jiang, Will, Lund, Chad, Pai, Howard, Valev, Boris, Lefresne, Shilo, Tyldesley, Scott, and Olson, Robert A.

Published
2023
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2. Semi‐automated vertex placement for lattice radiotherapy and dosimetric verification using 3D polymer gel dosimetry.

Author

Kunkyab, Tenzin, Magliari, Anthony, Jirasek, Andrew, Mou, Benjamin, and Hyde, Derek

Subjects
CONE beam computed tomography, VOLUMETRIC-modulated arc therapy, MEDICAL dosimetry, POLYMER colloids, DOSIMETERS, PHARMACEUTICAL gels
Abstract

Purpose: To evaluate the feasibility of an open‐source, semi‐automated, and reproducible vertex placement tool to improve the efficiency of lattice radiotherapy (LRT) planning. We used polymer gel dosimetry with a Cone Beam CT (CBCT) readout to commission this LRT technique. Material and methods: We generated a volumetric modulated arc therapy (VMAT)‐based LRT plan on a 2 L NIPAM polymer gel dosimeter using our Eclipse Acuros version 15.6 AcurosXB beam model, and also recalculated the plan with a pre‐clinical Acuros v18.0 dose calculation algorithm with the enhanced leaf modelling (ELM). With the assistance of the MAAS‐SFRThelper software, a lattice vertex diameter of 1.5 cm and center‐to‐center spacing of 3 cm were used to place the spheres in a hexagonal, closed packed structure. The verification plan included four gantry arcs with 15°, 345°, 75°, 105° collimator angles. The spheres were prescribed 20 Gy to 50% of their combined volume. The 6 MV Flattening Filter Free beam energy was used to deliver the verification plan. The dosimetric accuracy of the LRT delivery was evaluated with 1D dose profiles, 2D isodose maps, and a 3D global gamma analysis. Results: Qualitative comparisons between the 1D dose profiles of the Eclipse plan and measured gel showed good consistency at the prescription dose mark. The average diameter measured 13.3 ± 0.2 mm (gel for v15.6), 12.6 mm (v15.6 plan), 13.1 ± 0.2 mm (gel for v18.0), and 12.3 mm (v18.0 plan). 3D gamma analysis showed that all gamma pass percent were > 95% except at 1% and 2% at the 1 mm distance to agreement criteria. Conclusion: This study presents a novel application of gel dosimetry in verifying the dosimetric accuracy of LRT, achieving excellent 3D gamma results. The treatment planning was facilitated by publicly available software that automatically placed the vertices for consistency and efficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Clinical applicability of Linac-integrated CBCT based NIPAM 3D dosimetry: a dual-institutional investigation.

Author

Kunkyab, Tenzin, Lakrad, Kawtar, Jirasek, Andrew, Oldham, Mark, Quinn, Benjamin, Hyde, Derek, and Adamson, Justus

Subjects
CONE beam computed tomography, MEDICAL dosimetry, LINEAR accelerators, POLYMER colloids, PHARMACEUTICAL gels, DOSIMETERS
Abstract

Objective. To develop and benchmark a novel 3D dose verification technique consisting of polymer gel dosimetry (PGD) with cone-beam-CT (CBCT) readout through a two-institution study. The technique has potential for wide and robust applicability through reliance on CBCT readout. Approach. Three treatment plans (3-field, TG119-C-shape spine, 4-target SRS) were created by two independent institutions (Institutions A and B). A Varian Truebeam linear accelerator was used to deliver the plans to NIPAM polymer gel dosimeters produced at both institutions using an identical approach. For readout, a slow CBCT scan mode was used to acquire pre- and post-irradiation images of the gel (1 mm slice thickness). Independent gel analysis tools were used to process the PGD images (A: VistaAce software, B: in-house MATLAB code). Comparing planned and measured doses, the analysis involved a combination of 1D line profiles, 2D contour plots, and 3D global gamma maps (criteria ranging between 2%1 mm and 5%2 mm, with a 10% dose threshold). Main results. For all gamma criteria tested, the 3D gamma pass rates were all above 90% for 3-field and 88% for the SRS plan. For the C-shape spine plan, we benchmarked our 2% 2 mm result against previously published work using film analysis (93.4%). For 2%2 mm, 99.4% (Institution A data), and 89.7% (Institution B data) were obtained based on VistaAce software analysis, 83.7% (Institution A data), and 82.9% (Institution B data) based on MATLAB. Significance. The benchmark data demonstrate that when two institutions follow the same rigorous procedures gamma passing rates up to 99%, for 2%2 mm criteria can be achieved for substantively different treatment plans. The use of different software and calibration techniques may have contributed to the variation in the 3D gamma results. By sharing the data across institutions, we observe the gamma passing rate is more consistent within each pipeline, indicating the need for standardized analysis methods. [ABSTRACT FROM AUTHOR]

Published
2024
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7. 31 Prospective Longitudinal Assessment of Quality of Life After Stereotactic Ablative Radiotherapy for Oligometastases: Analysis of the Population-Based SABR-5 Phase II Trial

Author

Cruz-Lim, Ella Mae, primary, Mou, Benjamin, additional, Baker, Sarah, additional, Arbour, Gregory, additional, Stefanyk, Kelsey, additional, Jiang, Will, additional, Liu, Mitchell, additional, Bergman, Alanah, additional, Schellenberg, Devin, additional, Alexander, Abraham, additional, Berrang, Tanya, additional, Bang, Andrew, additional, Chng, Nick, additional, Matthews, Quinn, additional, Carolan, Hannah, additional, Hsu, Fred, additional, Miller, Stacy, additional, Atrchian, Siavash, additional, Chan, Elisa, additional, Ho, Clement, additional, Mohamed, Islam, additional, Lin, Angela, additional, Huang, Vicky, additional, Mestrovic, Ante, additional, Hyde, Derek, additional, Lund, Chad, additional, Pai, Howard, additional, Valev, Boris, additional, Lefresne, Shilo, additional, Tyldesley, Scott, additional, and Olson, Robert, additional

Published
2023
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8. 58 Should Organs at Risk (OARS) be Prioritized Over Target Volume Coverage in Stereotactic Ablative Radiotherapy (SABR) for Oligometastases? a Secondary Analysis of the Population-Based Phase II SABR-5 Trial

Author

Cereno, Reno Eufemon, primary, Mou, Benjamin, additional, Baker, Sarah, additional, Chng, Nick, additional, Arbour, Gregory, additional, Bergman, Alanah, additional, Liu, Mitchell, additional, Schellenberg, Devin, additional, Matthews, Quinn, additional, Huang, Vicky, additional, Mestrovic, Ante, additional, Hyde, Derek, additional, Alexander, Abraham, additional, Carolan, Hannah, additional, Hsu, Fred, additional, Miller, Stacy, additional, Atrchian, Siavash, additional, Chan, Elisa, additional, Ho, Clement, additional, Mohamed, Islam, additional, Lin, Angela, additional, Berrang, Tanya, additional, Bang, Andrew, additional, Jiang, Will, additional, Lund, Chad, additional, Pai, Howard, additional, Valev, Boris, additional, Lefresne, Shilo, additional, Tyldesley, Scott, additional, and Olson, Robert, additional

Published
2023
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17. Treatment With Stereotactic Ablative Radiotherapy for Up to 5 Oligometastases in Patients With Cancer

Author

Olson, Robert, primary, Jiang, Will, additional, Liu, Mitchell, additional, Bergman, Alanah, additional, Schellenberg, Devin, additional, Mou, Benjamin, additional, Alexander, Abraham, additional, Carolan, Hannah, additional, Hsu, Fred, additional, Miller, Stacy, additional, Atrchian, Siavash, additional, Chan, Elisa, additional, Ho, Clement, additional, Mohamed, Islam, additional, Lin, Angela, additional, Berrang, Tanya, additional, Bang, Andrew, additional, Chng, Nick, additional, Matthews, Quinn, additional, Baker, Sarah, additional, Huang, Vicky, additional, Mestrovic, Ante, additional, Hyde, Derek, additional, Lund, Chad, additional, Pai, Howard, additional, Valev, Boris, additional, Lefresene, Shilo, additional, and Tyldesley, Scott, additional

Published
2022
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21. Assessment of intrafraction motion for spine and non-spine bone metastases treated with image-guided stereotactic body radiotherapy without 6 degrees-of-freedom couch correction

Author

Cereno, Reno Eufemon, Bartlett, Quinn, Lamey, Michael, Hyde, Derek, and Mou, Benjamin

Subjects
Technical Report
Abstract

Stereotactic body radiotherapy (SBRT) planning target volume (PTV) margins are influenced by multiple factors. Data is limited on intrafraction motion in bone SBRT, particularly non-spine lesions. We analyzed intrafraction motion in bone SBRT patients treated on a standard treatment couch without 6 degrees-of-freedom (6-DOF) correction. Extracranial bone SBRT patients were included. Patients were treated using two volumetric-modulated arcs and targets were localized using daily cone-beam computed tomography (CBCT) prior to each arc. Alignments between the first and second CBCT images yielded intrafraction positional shift values used to compute translational 3-dimensional vector shifts. 125 fractions from 43 patients were reviewed. Median vector shift for all SABR fractions was 0.7 mm (range 0-6.6 mm); spine 0.7 mm (range:0-2.3 mm) and non-spine 0.9 mm (range:0-6.6 mm). Of the 125 fractions, 95% had IFM vectors within the prescribed PTV margin. Intrafraction motion is small for bone SBRT patients treated on a standard couch without 6-DOF correction capabilities. Intrafraction motion was slightly larger for non-spine sites and may require treatment with larger PTV margins than spine cases.

Published
2022

22. 2: Population Based Phase II Trial of Stereotactic Ablative Radiotherapy (SABR) for Up to Five Oligometastases: Preliminary Results of the SABR-5 Trial

Author

Olson, Robert, primary, Jiang, Will, additional, Liu, Mitchell, additional, Bergman, Alanah, additional, Schellenberg, Devin, additional, Mou, Benjamin, additional, Alexander, Abraham, additional, Carolan, Hannah, additional, Hsu, Fred, additional, Miller, Stacy, additional, Atrchian, Siavash, additional, Chan, Elisa, additional, Ho, Clement, additional, Mohamed, Islam, additional, Lin, Angela, additional, Berrang, Tanya, additional, Bang, Andrew, additional, Chng, Nick, additional, Matthews, Quinn, additional, Mestrovic, Ante, additional, Hyde, Derek, additional, Huang, Vicky, additional, Lund, Chad, additional, Pai, Howard, additional, Valev, Boris, additional, Lefresne, Shilo, additional, and Tyldesley, Scott, additional

Published
2021
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24. In reply to Masjedi et al.

Author

Carlone, Marco, Yang, Ray, Hyde, Derek, Becker, Nathan, and Cocarell, John

Subjects
NEUTRON measurement, NEUTRON counters, PHOTON beams, LINEAR accelerators, ACTIVATION energy
Abstract

The article is a response to a review of a paper titled "Measurement of neutron yield for a medical linear accelerator below 10 MV." The authors express gratitude for the review and acknowledge the need for more experimental data on neutron doses from medical linear accelerators at intermediate energies. They admit that the experimental methodology can be improved and hope that other researchers will conduct further experiments to increase the availability of data in this energy range. The authors also agree with the reviewer's comments on the limitations of their experiment and encourage future investigations to improve the accuracy of neutron dose measurements. [Extracted from the article]

Published
2024
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34. Additional file 1: of Population-based phase II trial of stereotactic ablative radiotherapy (SABR) for up to 5 oligometastases: SABR-5

Author

Olson, Robert, Liu, Mitchell, Bergman, Alanah, Lam, Sonya, Hsu, Fred, Mou, Benjamin, Berrang, Tanya, Mestrovic, Ante, Chng, Nick, Hyde, Derek, Matthews, Quinn, Lund, Chad, Glick, Daniel, Pai, Howard, Basran, Parminder, Carolan, Hannah, Valev, Boris, Shilo Lefresene, Tyldesley, Scott, and Schellenberg, Devin

Abstract

Dose constraints used for SABR-5 trial. These are based on the AAPM TG 101, SABR-COMET, SC-24 trials as well as most updated references. If any structure is not listed, the constraints may be calculated using the linear quadratic formula from accepted QUANTEC doses, using an alpha-beta ratio of 3 (except neural structure: alpha-beta of 2) for late effects. (DOCX 134 kb)

Published
2018
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38. A Diffusion Theory Model Of Spatially Resolved Fluorescence from Depth Dependent Fluorophore Concentrations

Author

Hyde, Derek E., Farrell, Dr. T.J., and Medical Physics

Subjects
spatially resolved fluorescence, diffusion theory model, concentrations, depth dependent fluorophore
Abstract

Photodynamic therapy (PDT) currently utilizes drug and light doses which are primarily based on clinical experience. This can lead to a dose which is not sufficient to destroy the entire tumor, or alternatively, it can lead to the undesirable destruction of healthy tissue around the treatment area. PDT of topically applied photosensitizers is one focus of this research. This concerns the diffusion of an externally applied drug into the tissue, as well as its subsequent destruction during the irradiation procedure. This work involves the non-invasive measurement of the inherent fluorescence of the photosensitizer, allowing the determination of the concentration and distribution of drug within the tissue, and thus optimizing this treatment. To do this, one must be able to describe the propagation of light within the tissue. Consequently, a photon diffusion model has been developed to calculate the steady-state spatially resolved fluorescence from a pencil beam excitation in a depth dependent medium. The validity of this model was then verified by comparison with Monte Carlo simulations and measurements made on phantoms with optical properties similar to those of human tissue. Theoretical conditions were then explored, and potential uses of the model were demonstrated. Thesis Master of Science (MS)

Published
1999

41. Positional Accuracy of Treating Multiple Versus Single Vertebral Metastases With Stereotactic Body Radiotherapy

Author

Chang, Joe H., Sangha, Arnjeet, Hyde, Derek, Soliman, Hany, Myrehaug, Sten, Ruschin, Mark, Lee, Young, Sahgal, Arjun, and Korol, Renee

Abstract

The aim of this study is to determine whether stereotactic body radiotherapy for multiple vertebral metastases treated with a single isocenter results in greater intrafraction errors than stereotactic body radiotherapy for single vertebral metastases and to determine whether the currently used spinal cord planning organ at risk volume and planning target volume margins are appropriate. Intrafraction errors were assessed for 65 stereotactic body radiotherapy treatments for vertebral metastases. Cone beam computed tomography images were acquired before, during, and after treatment for each fraction. Residual translational and rotational errors in patient positioning were recorded and planning organ at risk volume and planning target volume margins were calculated in each direction using this information. The mean translational residual errors were smaller for single (0.4 (0.4) mm) than for multiple vertebral metastases (0.5 (0.7) mm; P= .0019). The mean rotational residual errors were similar for single (0.3° (0.3°) and multiple vertebral metastases (0.3° (0.3°); P= .862). The maximum calculated planning organ at risk volume margin in any direction was 0.83 mm for single and 1.22 for multiple vertebral metastases. The maximum calculated planning target volume margin in any direction was 1.4 mm for single and 1.9 mm for multiple vertebral metastases. Intrafraction errors were small for both single and multiple vertebral metastases, indicating that our strategy for patient immobilization and repositioning is robust. Calculated planning organ at risk volume and planning target volume margins were smaller than our clinically employed margins, indicating that our clinical margins are appropriate.

Published
2017
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42. Apparatus-Dependent Dosimetric Differences in Spine Stereotactic Body Radiotherapy

Author

Ma, Lijun, primary, Sahgal, Arjun, additional, Cozzi, Luca, additional, Chang, Eric, additional, Shiu, Almon, additional, Létourneau, Daniel, additional, Yin, Fang-Fang, additional, Fogliata, Antonella, additional, Kaissl, Wolfgang, additional, Hyde, Derek, additional, Laperriere, Normand J., additional, Shrieve, Dennis C., additional, and Larson, David A., additional

Published
2010
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